Pyridazinone compound and herbicide

ABSTRACT

There is provided an agricultural chemical (in particular, a herbicide). A pyridazinone compound of the following Formula (1):[wherein W1 and X are each independently an oxygen atom or a sulfur atom; R1 and R2 are each independently such as C1-6 alkyl; R3 is such as D-1 to D-8; Y1 is such as a halogen atom; G is such as a hydrogen atom; Z1 is such as C1-6 alkyl; n is an integer of 0, 1, 2, 3, or 4; p5 is an integer of 0, 1, 2, 3, 4, or 5; p4 is an integer of 0, 1, 2, 3, or 4; and p3 is an integer of 0, 1, 2, or 3] and a herbicide including the same.

TECHNICAL FIELD

The present invention relates to a novel pyridazinone compound or a salt thereof, and an agricultural chemical (in particular, a herbicide) containing the compound as an active ingredient.

BACKGROUND ART

For example, Patent Documents 1 and 2 disclose a certain type of pyridazinone compound. However, the pyridazinone compound according to the present invention has not been disclosed at all.

PRIOR ART DOCUMENTS Patent Documents

-   Patent Document 1: International Publication WO 2017/074992 -   Patent Document 2: International Publication WO 2015/168010

SUMMARY OF THE INVENTION Problems to be Solved by the Invention

An object of the present invention is to provide a chemical substance which reliably exhibits effects on various weeds even when applied in a small amount, which is less likely to cause problems (e.g., land pollution and adverse effects on succeeding crops), and which exhibits high safety and is useful as an active ingredient of a herbicide.

Means for Solving the Problem

The present inventors have conducted extensive studies for solving the aforementioned problems, and as a result have found that a novel pyridazinone compound of Formula (1) described below is a very useful compound having excellent herbicidal activity as a herbicide and high safety against target crops, and exhibiting almost no adverse effects on non-target living organisms (e.g., such as mammals, fishes, beneficial insects, and natural enemies). The present invention has been accomplished on the basis of this finding.

Accordingly, the present invention is directed to the following [1] to [152].

[1]

A pyridazinone compound of the following Formula (1) or a salt thereof:

[wherein W¹ is an oxygen atom or a sulfur atom;

X is an oxygen atom or a sulfur atom;

Z¹ is a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R²², (C₂₋₆) alkynyl substituted with R¹⁹, (C₃₋₆) cycloalkyl substituted with R⁴⁴, phenyl, phenyl substituted with (Z⁴)_(p5c), Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-10, Q-11, Q-12, Q-13, —NR¹⁵R¹⁶, —OR³⁵, —S(O)_(r1)R³⁶, —CN, —NO₂, —C(O)OH, —C(═W³)R²⁰, or —N═C(C₆H₅)₂, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

G is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R⁴, —C(═W⁴)R⁵, or —S(O)₂R^(6;)

R¹ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, or C₁₋₆ alkyl substituted with R^(34;)

R² is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₁₋₆ alkoxy, C₃₋₆ cycloalkyl, or —NR³⁰R^(31;)

R³ is D-1, D-2, D-3, D-4, D-5, D-6, D-7, D-8, D-9, D-10, D-11, D-12, D-13, D-14, D-15, D-16, D-17, D-18, D-19, D-20, D-21, D-22, D-23, D-24, D-25, D-26, D-27, D-28, D-29, D-30, D-31, D-32, D-33, D-34, D-35, D-36, D-37, D-38, D-39, D-40, D-41, D-42, D-43, D-44, D-45, D-46, D-47, D-48, D-49, D-50, D-51, D-52, D-53, D-54, D-55, or D-56;

D-1, D-2, D-3, D-4, D-5, D-6, D-7, D-8, D-9, D-10, D-11, D-12, D-13, D-14, D-15, D-16, D-17, D-18, D-19, D-20, D-21, D-22, D-23, D-24, D-25, D-26, D-27, D-28, D-29, D-30, D-31, D-32, D-33, D-34, D-35, D-36, D-37, D-38, D-39, D-40, D-41, D-42, D-43, D-44, D-45, D-46, D-47, D-48, D-49, D-50, D-51, D-52, D-53, D-54, D-55, and D-56 are respectively the following structures:

Y¹ is substituted on the aromatic ring of each of D-1 to D-56, and Y³ is substituted on the aliphatic ring of D-19, D-20, D-21, D-22, D-24, D-29, D-30, D-31, or D-32;

Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, (C₁₋₆) alkyl substituted with R¹⁰, C₃₋₆ cycloalkyl substituted with R⁴⁴, —OR¹¹, —S(O)_(r2)R³⁸, —NR⁸R⁹, —CN, —NO₂, —C(O)OH, —C(═W²)R¹³, phenyl, phenyl substituted with (Z⁴)_(p5c), tri(C₁₋₆ alkyl)silyl, Q-6, Q-7, Q-10, Q-11, Q-12, or Q-13, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other;

R⁴ is a halogen atom, —CN, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, —OR²⁴, —S(O)_(r4)R⁵⁴, —C(O)R²³, phenyl, phenyl substituted with (Z⁴)_(p5c), U-1, U-2, U-3, U-4, U-5, U-9, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, U-35, Q-1, Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, or Q-36;

R⁵ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R²⁶, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₁₋₆ alkoxy, —OR⁵⁸, —SR⁵⁹, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, —NR⁵⁶R⁵⁷, U-1, U-2, U-3, U-4, U-5, U-6, U-7, U-8, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29U-30, U-31, U-32, U-33, U-34, U-35, Q-1, Q-2, Q-3, Q-4, Q-5, Q-7, Q-8, Q-9, Q-10, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, Q-36, Q-37, Q-38, Q-39, Q-40, phenyl, phenyl substituted with (Z²)_(p5a), or —C(O)R^(53;)

R⁶ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, phenyl, phenyl substituted with (Z²)_(p5a), U-6, U-7, U-8, Q-10, or —NR²⁸R^(29;)

R⁷ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy (C₁₋₂) alkyl, C₁₋₆ alkylthio (C₁₋₂) alkyl, C₃₋₆ cycloalkyl (C₁₋₂) alkyl, benzyl, or benzyl substituted with (Z⁴)_(p5c);

R⁸ and R⁹ are each independently a hydrogen atom, or C₁₋₆ alkyl;

R¹⁰ is a halogen atom, —OR⁴⁰, —S(O)_(r3)R⁴¹, —CN, C₃₋₆ cycloalkyl, (C₃₋₆ cycloalkyl substituted with R⁴⁴, Q-6, Q-7, Q-10, Q-11, Q-12, or Q-13;

R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆ alkyl substituted with R¹², C₃₋₆ cycloalkyl, (C₁₋₆ cycloalkyl substituted with R⁴⁴, phenyl, phenyl substituted with (Z⁴)_(p5c), tri(C₁₋₄ alkyl)silyl, C₁₋₆ alkylcarbonyl, C₁₋₆ alkoxycarbonyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, —C(═W²)R¹³, —S(O)_(r5)R⁴⁹, U-1, U-2, U-3, U-4, U-5, U-12, U-14, U-15, U-16, Q-17, Q-18, Q-19, or Q-20;

R¹² is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₁₋₆ cycloalkyl substituted with R⁴⁵, —OR⁴⁸, —S(O)_(r5)R⁴⁹, —CN, phenyl, phenyl substituted with (Z³)_(p5b), —C(═W²)R¹³, U-1, U-2, U-3, U-4, U-5, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, U-35, Q-1, Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, Q-36, or —ON═CR⁴²R^(43;)

Q-1, Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, Q-36, Q-37, Q-38, Q-39, and Q-40 are respectively the following structures:

Y² is substituted on the aromatic ring of each of Q-1 to Q-40;

U-1, U-2, U-3, U-4, U-5, U-6, U-7, U-8, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, and U-35 are respectively the following structures:

R¹³ is a hydrogen atom, C₁₋₆ alkyl, C₁₋₆ alkoxy, C₁₋₆ alkylamino, di(C₁₋₆) alkylamino, C₁₋₆ haloalkylamino, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, or —NH₂;

R¹⁴ is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, C₁₋₆ alkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkoxy, C₁₋₆ haloalkylthio, C₁₋₆ haloalkylsulfinyl, C₁₋₆ haloalkylsulfonyl, phenyl, phenyl substituted with (Z⁴)_(p5c), —CN, U-1, U-2, U-3, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, U-35, Q-1, Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, or Q-36;

R¹⁵ and R¹⁶ are each independently a hydrogen atom, C₁₋₆ alkyl, —C(O)R¹⁷, or —S(O)₂R^(18;)

R¹⁷ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or C₁₋₆ alkoxy (C₁₋₂) alkyl;

R¹⁸ is C₁₋₆ alkyl or C₁₋₆ haloalkyl;

R¹⁹ is C₃₋₆ cycloalkyl or tri(C₁₋₆ alkyl)silyl;

R²⁰ is a hydrogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy;

R²¹ is a hydrogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy (C₁₋₂) alkyl, or C₁₋₆ alkylthio (C₁₋₂) alkyl;

R²² is a halogen atom, —OH, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylthio, —CN, or Q-7;

R²³ is C₁₋₆ alkyl, C₁₋₆ alkoxy, di(C₁₋₆) alkylamino, phenyl, phenyl substituted with (Z⁴)_(p5c), U-6, U-7, or U-8;

R²⁴ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, C₃₋₆ haloalkenyl, C₃₋₆ alkynyl, C₃₋₆ haloalkynyl, (C₁₋₆) alkoxy (C₁₋₂) alkyl, —C(O)R²⁵, —S(O)₂R³³, phenyl, or phenyl substituted with (Z⁴)_(p5c;)

R²⁵ is C₁₋₆ alkyl, C₁₋₆ alkoxy, phenyl, phenyl substituted with (Z⁴)_(p5c), di(C₁₋₆) alkylamino, U-6, U-7, or U-8;

R²⁶ is a halogen atom, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, —CN, —OR³², phenyl, phenyl substituted with (Z⁴)_(p5c), Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, Q-36, U-1, U-2, U-3, U-4, U-5, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, or U-35;

R²⁷ is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₃₋₆ cycloalkyl, C₃₋₆ halocycloalkyl, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, —CN, phenyl, phenyl substituted with (Z³)_(p5b), 9-fluorenyl, Q-2, Q-3, Q-4, Q-5, Q-17, U-1, U-2, U-3, U-4, U-5, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, or U-35;

R²⁸ and R²⁹ are each independently a hydrogen atom or C₁₋₆ alkyl;

R³⁰ and R³¹ are each independently a hydrogen atom, C₁₋₆ alkyl, or benzyl;

R³² is phenyl, phenyl substituted with (Z⁴)_(p5c), or Q-17;

R³³ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, or di(C₁₋₆ alkyl)amino;

R³⁴ is a halogen atom, C₁₋₆ alkoxy, phenyl, or —CN;

R³⁵ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R¹⁴, (C₁₋₆) cycloalkyl substituted with R⁴⁴, or —S(O)₂R^(33;)

R³⁶ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R³⁷, C₃₋₆ cycloalkyl, or (C₁₋₆) cycloalkyl substituted with R^(44;)

R³⁷ is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₃₋₆ cycloalkyl, C₃₋₆ halocycloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, phenyl, phenyl substituted with (Z⁴)_(p5c), —CN, U-1, U-2, U-3, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, U-35, Q-1, Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, or C₁₋₁₀ alkoxycarbonyl;

R³⁸ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₃₋₆ cycloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, (C₁₋₆) alkyl substituted with R³⁹, (C₃₋₆) cycloalkyl substituted with R⁴⁴, U-1, U-2, U-4, U-5, U-6, U-7, U-8, U-12, U-14, U-15, U-16, or —NR⁶⁰R^(61;)

R³⁹ is a halogen atom, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, —OR⁵¹, —S(O)R⁵², —C(═W²)R¹³, —CN, phenyl, phenyl substituted with (Z)_(p5b), U-1, U-2, U-3, U-4, U-5, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, U-35, Q-1, Q-2, Q-3, Q-4, Q-5, Q-8, Q-9, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, Q-36, or —ON═CR⁴²R^(43;)

R⁴⁰ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R⁴⁶, (C₃₋₆) cycloalkyl substituted with R⁴⁴, or U-4;

R⁴¹ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, or (C₁₋₆) alkyl substituted with R^(47;)

R⁴² and R⁴³ are each independently a hydrogen atom, C₁₋₆ alkyl, phenyl, or phenyl substituted with (Z⁴)_(p5c), or R⁴² and R⁴³ form C₃₋₆ cycloalkyl together with the carbon atom to which R⁴² and R⁴³ are bonded;

R⁴⁴ is a halogen atom, C₁₋₆ alkyl, or —CN;

R⁴⁵ is a halogen atom, C₁₋₆ alkyl, or —CN;

R⁴⁶ is C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, —CN, U-1, U-2, U-3, U-4, U-5, U-9, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, Q-1, Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, or Q-36;

R⁴⁷ is C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, U-1, U-2, U-3, U-4, U-5, U-9, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, Q-1, Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, Q-36, or —CN; R⁴⁸ is a hydrogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, C₃₋₆ haloalkenyl, C₃₋₆ alkynyl, C₃₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, —C(O)R⁵⁰, or —S(O)₂R^(33;)

R⁴⁹ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, C₃₋₆ haloalkenyl, C₃₋₆ alkynyl, C₃₋₆ haloalkynyl, C₃₋₆ cycloalkyl, or (C₃₋₆) cycloalkyl substituted with R^(44;)

R⁵⁰ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or di(C₁₋₆ alkyl)amino;

R⁵¹ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₃₋₆ haloalkenyl, or C₃₋₆ haloalkynyl;

R⁵² is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, or C₃₋₆ cycloalkyl; R⁵³ is C₁₋₆ alkyl, C₁₋₆ alkoxy, phenyl, or phenyl substituted with (Z⁴)_(p5c;)

R⁵⁴ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, phenyl, or phenyl substituted with (Z⁴)_(p5c;)

R⁵⁵ is C₁₋₆ alkyl, C₁₋₆ alkoxy, —OH, or NR⁵⁶R^(57;)

R⁵⁶ and R⁵⁷ are each independently a hydrogen atom or C₁₋₆ alkyl;

R⁵⁸ is (C₁₋₆) alkyl substituted with R²⁷, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, phenyl, or phenyl substituted with (Z³)_(p5b;)

R⁵⁹ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkenyl, C₁₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, phenyl, or phenyl substituted with (Z³)_(p5b;)

R⁶⁰ and R⁶¹ are each independently a hydrogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy (C₁₋₆) alkyl, phenyl, phenyl substituted with (Z⁴)_(p5c), benzyl, or benzyl substituted with (Z⁴)_(p5c;)

R^(N) is a hydrogen atom or C₁₋₆ alkyl;

Y² is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆haloalkylthio, —CN, —NH₂, or —NO₂, and when q4, q3, or q2 is an integer of 2 or more, each Y² is the same as or different from each other;

Y³ is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkoxycarbonyl, —CN, —C(O)OH, —OH, or —NH₂, and when t is 2, each Y³ is the same as or different from each other;

Z² is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, —S(O)₂NR⁵⁶R⁵⁷, —OH, —NH₂, —CN, —NO₂, or —C(O)R⁵⁵, and when p5a is an integer of 2 or more, each Z² is the same as or different from each other;

Z³ is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, —CN, C₁₋₆ alkoxycarbonyl, or —NO₂, and when p5b is an integer of 2 or more, each Z³ is the same as or different from each other;

Z⁴ is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, —CN, —NO₂, or C₁₋₆ alkoxycarbonyl, and when p5c is an integer of 2 or more, each Z⁴ is the same as or different from each other;

W² is an oxygen atom or N—OR^(7;)

W³ is an oxygen atom or N—OR^(21;)

W⁴ is an oxygen atom or a sulfur atom;

r1 is an integer of 0, 1, or 2;

r2 is an integer of 0, 1, or 2;

r3 is an integer of 0, 1, or 2;

r4 is an integer of 0, 1, or 2;

r5 is an integer of 0, 1, or 2;

r6 is an integer of 0, 1, or 2;

n is an integer of 0, 1, 2, 3, or 4;

t is an integer of 0, 1, or 2;

p2 is an integer of 0, 1, or 2;

p3 is an integer of 0, 1, 2, or 3;

p4 is an integer of 0, 1, 2, 3, or 4;

p5 is an integer of 0, 1, 2, 3, 4, or 5;

p6 is an integer of 0, 1, 2, 3, 4, 5, or 6;

p7 is an integer of 0, 1, 2, 3, 4, 5, 6, or 7;

p5a is an integer of 1, 2, 3, 4, or 5;

p5b is an integer of 1, 2, 3, 4, or 5;

p5c is an integer of 1, 2, 3, 4, or 5;

q1 is an integer of 0 or 1;

q2 is an integer of 0, 1, or 2;

q3 is an integer of 0, 1, 2, or 3; and

q4 is an integer of 0, 1, 2, 3, or 4].

[2]

The pyridazinone compound and a salt thereof according to [1], wherein:

W¹ is an oxygen atom;

Z¹ is a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R²², (C₂₋₆) alkynyl substituted with R¹⁹, (C₃₋₆) cycloalkyl substituted with R⁴⁴, phenyl, phenyl substituted with (Z⁴)_(p5c), Q-3, —NR¹⁵R¹⁶, —OR³⁵, —S(O)_(r1)R³⁶, —CN, —NO₂, —C(O)OH, —C(═W³)R²⁰, or —N═C(C₆H₅)₂, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

R¹ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, or C₁₋₆ alkyl substituted with R^(34;)

R² is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₁₋₆ alkoxy, or —NR³⁰R³¹; R³ is D-1, D-2, D-3, D-4, D-5, D-6, D-7, D-8, D-9, D-10, D-13, D-14, D-15, D-16, D-17, D-18, D-19, D-20, D-21, D-22, D-23, D-24, D-25, D-26, D-27, or D-28;

Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, (C₁₋₆) alkyl substituted with R¹⁰, C₃₋₆ cycloalkyl substituted with R⁴⁴, —OR¹¹, —S(O)_(r2)R³⁸, —NR⁸R⁹, —CN, —NO₂, —C(O)OH, —C(═W²)R¹³, phenyl, phenyl substituted with (Z⁴)_(p5c), or tri(C₁₋₆ alkyl)silyl, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other;

R⁴ is a halogen atom, —CN, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, —OR²⁴, —S(O)_(r4)R54, —C(O)R²³, phenyl, or phenyl substituted with (Z⁴)_(p5c;)

R⁵ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R²⁶, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ alkoxy, —OR⁵⁸, C₃₋₆ cycloalkyl, C₃₋₆ cycloalkyl substituted with R⁴⁴, —NR⁵⁶R⁵⁷, U-1, U-6, U-7, U-8, Q-1, Q-2, Q-3, Q-4, Q-5, Q-7, Q-8, Q-9, Q-10, Q-17, Q-18, Q-19, Q-20, phenyl, phenyl substituted with (Z²)_(p5a), or —C(O)R^(53;)

R⁶ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, phenyl, phenyl substituted with (Z²)_(p5a), or —NR²⁸R^(29;)

R⁷ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy (C₁₋₂) alkyl, or C₁₋₆ alkylthio (C₁₋₂) alkyl;

R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, phenyl, phenyl substituted with (Z⁴)_(p5c), C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, U-2, U-4, Q-17, Q-18, or Q-19;

R¹² is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, —OR⁴⁸, —S(O)_(r5)R⁴⁹, —CN, phenyl, phenyl substituted with (Z³)_(p5b), —C(═W²)R¹³, U-1, U-2, U-3, Q-1, Q-2, Q-3, Q-4, Q-5, Q-18, or —ON═CR⁴²R^(43;)

R¹⁴ is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, C₁₋₆ alkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, phenyl, phenyl substituted with (Z⁴)_(p5c), —CN, U-1, U-2, U-3, U-9, Q-17, Q-18, Q-19, or Q-20;

R¹⁹ is tri(C₁₋₆ alkyl)silyl; R²² is a halogen atom, —OH, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, or —CN;

R²³ is C₁₋₆ alkyl, C₁₋₆ alkoxy, di(C₁₋₆) alkylamino, phenyl, phenyl substituted with (Z⁴)_(p5c), U-7, or U-8;

R²⁴ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, (C₁₋₆) alkoxy (C₁₋₂) alkyl, —C(O)R²⁵, or —S(O)₂R33;

R²⁵ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or di(C₁₋₆) alkylamino;

R²⁶ is a halogen atom, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, —OR³², phenyl, or phenyl substituted with (Z⁴)_(p5c;)

R²⁷ is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ alkoxy, or C₁₋₆ alkylthio;

R³⁶ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R³⁷, or C₃₋₆ cycloalkyl;

R³⁷ is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₁₋₆ alkoxy, C₁₋₆ alkylthio, or C₁₋₁₀ alkoxycarbonyl;

R³⁸ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₃₋₆ cycloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, (C₁₋₆) alkyl substituted with R³⁹, or (C₃₋₆) cycloalkyl substituted with R^(44;)

R³⁹ is a halogen atom, C₃₋₆ cycloalkyl, —OR⁵¹, —S(O)_(r6)R⁵², —C(═W²)R¹³, —CN, phenyl, phenyl substituted with (Z³)_(p5b), U-1, U-3, U-9, Q-1, or Q-18;

R⁴⁰ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R⁴⁶, or U-4;

R⁴¹ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, C₃₋₆ cycloalkyl, or (C₁₋₆) alkyl substituted with R^(47;)

R⁴⁶ is C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, C₃₋₆ cycloalkyl, —CN, U-1, U-3, or U-9;

R⁴⁷ is C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, or —CN;

R⁴⁸ is a hydrogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, C₃₋₆ haloalkenyl, C₃₋₆ alkynyl, C₃₋₆ haloalkynyl, or C₃₋₆ cycloalkyl;

R⁴⁹ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, or C₃₋₆ alkynyl;

R⁵¹ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, or C₁₋₆ haloalkyl;

R⁵² is C₁₋₆ alkyl, C₃₋₆ alkenyl, or C₃₋₆ alkynyl;

R⁵⁴ is C₁₋₆ alkyl or C₃₋₆ alkenyl;

R⁵⁹ is C₁₋₆ alkyl, C₁₋₆ alkenyl, or phenyl;

Y² is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, or C₁₋₆ haloalkylthio; and

Z² is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, —OH, —NH₂, —CN, —NO₂, or —C(O)R⁵⁵, and when p5a is an integer of 2 or more, each Z² is the same as or different from each other.

[3]

The pyridazinone compound and a salt thereof according to [2], wherein:

Z¹ is a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R²², (C₂₋₆) alkynyl substituted with R¹⁹, phenyl, phenyl substituted with (Z⁴)_(p5c), Q-3, —N¹⁵R¹⁶, —OR³⁵, —S(O)_(r1)R³⁶, —CN, —C(═W³)R²⁰, or —N═C(C₆H₅)₂, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

R¹ is a hydrogen atom, C₁₋₆ alkyl, or C₁₋₆ alkyl substituted with R^(34;)

R³ is D-1, D-2, D-3, D-4, D-6, D-7, D-8, D-9, D-10, D-17, D-18, D-19, D-20, D-21, D-22, D-23, D-24, D-25, D-26, or D-28;

Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, (C₁₋₆) alkyl substituted with R¹⁰, —C(O)OH, —OR¹¹, —S(O)_(r2)R³⁸, —NR⁸R⁹, —CN, —NO₂, —C(═W²)R¹³, phenyl, or tri(C₁₋₆ alkyl)silyl, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other;

R⁴ is a halogen atom, —CN, C₂₋₆ alkenyl, C₂₋₆ alkynyl, —OR²⁴, —S(O)_(r4)R⁵⁴, —C(O)R²³, or phenyl;

R⁵ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R²⁶, C₂₋₆ alkenyl, C₁₋₆ alkoxy, —OR⁵⁸, —SR⁵⁹, C₃₋₆ cycloalkyl, —NR⁵⁶R⁵⁷, U-1, U-6, Q-2, Q-4, phenyl substituted with (Z²)_(p5a), or —C(O)R^(53;)

R⁶ is C₁₋₆ alkyl, phenyl substituted with (Z²)_(p5a), or —NR²⁸R^(29;)

R⁷ is a hydrogen atom or C₁₋₆ alkyl;

R⁸ and R⁹ are each independently C₁₋₆ alkyl;

R¹⁰ is a halogen atom, —OR⁴⁰, or —S(O)_(r3)R^(41;)

R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², C₃₋₆ cycloalkyl, phenyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, U-2, U-4, or Q-17;

R¹² is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, —OR⁴⁸, —CN, phenyl, —C(═W²)R¹³, U-3, Q-1, or —ON═CR⁴²R^(43;)

R¹³ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or C₁₋₆ haloalkylamino;

R¹⁴ is a halogen atom, C₂₋₆ alkenyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, C₁₋₆ alkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfonyl, phenyl, or U-1;

R¹⁸ is C₁₋₆ alkyl;

R²¹ is a hydrogen atom or C₁₋₆ alkyl;

R²² is a halogen atom, —OH, or C₁₋₆ alkoxy;

R²³ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or phenyl;

R²⁴ is C₁₋₆ alkyl, (C₁₋₆) alkoxy (C₁₋₂) alkyl, or —C(O)R^(25;)

R²⁵ is C₁₋₆ alkoxy;

R²⁶ is C₁₋₆ alkoxy, —OR³², or phenyl;

R²⁷ is a halogen atom, C₂₋₆ alkenyl, or C₁₋₆ alkoxy;

R²⁸ and R²⁹ are each independently C₁₋₆ alkyl;

R³⁰ and R³¹ are each independently a hydrogen atom or benzyl;

R³² is phenyl;

R³³ is C₁₋₆ haloalkyl or di(C₁₋₆) alkylamino;

R³⁴ is C₁₋₆ alkoxy, phenyl, or —CN;

R³⁵ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R¹⁴, or —S(O)₂R^(33;)

R³⁶ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R^(37;)

R³⁷ is a halogen atom or (C₁₋₁₀) alkoxycarbonyl;

R³⁸ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₃₋₆ cycloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, or (C₁₋₆) alkyl substituted with R^(39;)

R³⁹ is a halogen atom, —OR⁵¹, —S(O)_(r6)R⁵², —C(═W²)R¹³, or —CN;

R⁴⁰ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₁₋₆ haloalkyl, or (C₁₋₆) alkyl substituted with R^(46;)

R⁴¹ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, or (C₁₋₆) alkyl substituted with R^(47;)

R⁴² and R⁴³ are each independently C₁₋₆ alkyl;

R⁴⁵ is a halogen atom;

R⁴⁶ is C₁₋₆ alkoxy or C₁₋₆ alkylthio;

R⁴⁷ is C₁₋₆ alkoxy or C₁₋₆ alkylthio;

R⁴⁸ is C₁₋₆ alkyl or C₁₋₆ haloalkyl;

R⁴⁹ is C₁₋₆ alkyl;

R⁵¹ is C₁₋₆ alkyl;

R⁵² is C₁₋₆ alkyl;

R⁵³ is phenyl;

R⁵⁴ is C₁₋₆ alkyl;

R⁵⁶ and R⁵⁷ are each independently C₁₋₆ alkyl;

R⁵⁸ is (C₁₋₆) alkyl substituted with R²⁷ or phenyl;

R⁵⁹ is C₁₋₆ alkyl or phenyl;

Y² is a halogen atom or C₁₋₆ haloalkyl;

Z² is a halogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy, and when p5a is an integer of 2 or more, each Z² is the same as or different from each other;

Z⁴ is a halogen atom or C₁₋₆ alkoxy, and when p5c is an integer of 2 or more, each Z⁴ is the same as or different from each other; and

t is 0.

[4]

The pyridazinone compound and a salt thereof according to [3], wherein:

Z¹ is a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R²², (C₂₋₆) alkynyl substituted with R¹⁹, —NR¹⁵R¹⁶, —OR³⁵, —S(O)_(r1)R³⁶, or —CN, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

R² is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy;

R³ is D-1, D-2, D-3, D-4, D-6, D-7, D-8, D-9, D-10, D-17, D-18, D-20, D-21, D-22, D-23, D-24, or D-28;

Y¹ is a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, (C₁₋₆) alkyl substituted with R¹⁰, —OR¹¹, —S(O)_(r2)R³⁸, —NR⁸R⁹, —CN, —NO₂, or —C(═W²)R¹³, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other;

R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², C₃₋₆ cycloalkyl, phenyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, U-2, or U-4; and

R³⁷ is a halogen atom.

[5]

The pyridazinone compound or a salt thereof according to [3] or [4], wherein X is a sulfur atom.

[6]

The pyridazinone compound or a salt thereof according to [2], wherein:

X is an oxygen atom;

Z¹ is a halogen atom, C₁₋₆ alkyl, —OR³⁵, or —S(O)_(r1)R³⁶, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

R¹ is C₁₋₆ alkyl;

R² is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy;

R³ is D-1, D-3, D-7, D-20, D-21, D-22, or D-24;

Y¹ is a halogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹⁰, —OR¹¹, or —S(O)_(r2)R³⁸, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other;

R⁴ is —OR²⁴ or —S(O)_(r4)R^(54;)

R⁵ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R²⁶, or C₁₋₆ alkoxy;

R⁶ is C₁₋₆ alkyl or —NR²⁸R^(29;)

R¹⁰ is a halogen atom, —OR⁴⁰, or —S(O)_(r3)R^(41;)

R¹¹ is a hydrogen atom, C₁₋₆ alkyl, or (C₁₋₆) alkyl substituted with R^(12;)

R¹² is a halogen atom, C₂₋₆ alkenyl, —OR⁴⁸, —S(O)_(r5)R⁴⁹, phenyl, or —C(═W²)R^(13;)

R¹³ is a hydrogen atom or C₁₋₆ alkyl;

R¹⁴ is a halogen atom, C₂₋₆ alkenyl, C₁₋₆ alkoxy, or C₁₋₆ alkylthio;

R²⁴ is C₁₋₆ alkyl;

R²⁶ is C₁₋₆ alkoxy;

R²⁸ and R²⁹ are each independently C₁₋₆ alkyl;

R³⁴ is C₁₋₆ alkoxy or —CN;

R³⁵ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R^(14;)

R³⁶ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R^(37;)

R³⁷ is a halogen atom, C₁₋₆ alkoxy, or C₁₋₆ alkylthio;

R³⁸ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, or (C₁₋₆) alkyl substituted with R^(39;)

R³⁹ is —OR⁵¹ or —S(O)_(r6)R^(52;)

R⁴⁰ is C₁₋₆ alkyl, C₃₋₆ alkenyl, or C₃₋₆ alkynyl;

R⁴¹ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, or (C₁₋₆) alkyl substituted with R^(47;)

R⁴⁸ is C₁₋₆ alkyl;

r1 is an integer of 0, 1, or 2;

r4 is an integer of 0, 1, or 2;

r5 is an integer of 0, 1, or 2;

r6 is an integer of 0, 1, or 2;

n is an integer of 0, 1, 2, 3, or 4;

p3 is an integer of 0, 1, 2, or 3;

p4 is an integer of 0, 1, 2, 3, or 4; and

p5 is an integer of 0, 1, 2, 3, 4, or 5.

[7]

The pyridazinone compound or a salt thereof according to [6], wherein: Z¹ is a halogen atom, C₁₋₆ alkyl, or —OR^(35;)

R¹ is C₁₋₆ alkyl;

R² is C₁₋₆ alkyl or C₁₋₆ alkoxy;

R³ is D-1, D-7, or D-24;

Y¹ is a halogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹⁰, —OR¹¹, or —S(O)_(r2)R^(38;)

G is a hydrogen atom, C₁₋₆ alkyl, or —C(═W⁴)R^(5;)

R⁵ is C₁₋₆ alkyl;

R¹⁰ is a halogen atom or —OR^(40;)

R¹² is a halogen atom, C₂₋₆ alkenyl, —OR⁴⁸, —S(O)_(r5)R⁴⁹, or phenyl;

R³⁵ is C₁₋₆ alkyl;

R³⁸ is C₁₋₆ alkyl;

R⁴⁰ is C₁₋₆ alkyl;

R⁴⁸ is C₁₋₆ alkyl; and

R⁴⁹ is C₁₋₆ alkyl.

[8]

The pyridazinone compound and a salt thereof according to [5], wherein:

Z¹ is a halogen atom, C₁₋₆ alkyl, —OR³⁵, or —S(O)_(r1)R³⁶, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

R¹ is C₁₋₆ alkyl;

R² is a hydrogen atom, a halogen atom, or C₁₋₆ alkyl;

R³ is D-1 or D-3;

R⁴ is —OR^(24;)

Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹⁰, —OR¹¹, —S(O)_(r2)R³⁸, or —C(═W²)R¹³, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other;

R⁷ is C₁₋₆ alkyl;

R¹¹ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², or C₃₋₆ cycloalkyl;

R¹² is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R45, —OR⁴⁸, —CN, —C(═W²)R¹³, or —ON═CR⁴²R⁴³,

R¹⁴ is a halogen atom, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, C₁₋₆ alkylthio, C₁₋₆ alkylsulfonyl, or U-1;

R²⁴ is C₁₋₆ alkyl or (C₁₋₆) alkoxy (C₁₋₂) alkyl;

R³⁵ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R^(14;)

R³⁸ is C₁₋₆ alkyl, C₃₋₆ cycloalkyl, or (C₁₋₆) alkyl substituted with R^(39;)

R³⁹ is a halogen atom, —OR⁵¹, —S(O)_(r6)R⁵², —C(═W²)R¹³, or —CN;

R⁴⁰ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₁₋₆ haloalkyl, or (C₁₋₆) alkyl substituted with R46;

R⁴¹ is a hydrogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, or (C₁₋₆) alkyl substituted with R^(47;)

R⁴⁶ is C₁₋₆ alkoxy or C₁₋₆ alkylthio; and

W² is N—OR⁷.

[9]

The pyridazinone compound and a salt thereof according to [8], wherein:

G is a hydrogen atom;

R¹¹ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R^(12;)

R¹² is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, —OR⁴⁸, —S(O)_(r5)R⁴⁹, or —C(═W²)R^(13;)

R³⁶ is C₁₋₆ alkyl;

R³⁸ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R³⁹; and n is an integer of 0 or 1.

[10]

The pyridazinone compound and a salt thereof according to [3], wherein:

W¹ is an oxygen atom;

Z¹ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R²², phenyl substituted with (Z)_(p5c), —NR¹⁵R¹⁶, —OR³⁵, —C(═W³)R²⁰, or —N═C(C₆H₅)₂, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

G is a hydrogen atom, C₁₋₆ alkyl, or (C₁₋₆) alkyl substituted with R^(4;)

R¹ is a hydrogen atom, C₁₋₆ alkyl, or C₁₋₆ alkyl substituted with R^(34;)

R² is a hydrogen atom, C₁₋₆ alkyl, C₁₋₆ alkoxy, or —NR³⁰R^(31;)

R³ is D-1, D-3, D-4, or D-6;

Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹⁰, —C(O)OH, —CN, —C(═W²)R¹³, phenyl, or tri(C₁₋₆ alkyl)silyl, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other;

R⁴ is a halogen atom, —CN, C₂₋₆ alkenyl, C₂₋₆ alkynyl, or phenyl;

R⁷ is a hydrogen atom or C₁₋₆ alkyl;

R⁸ and R⁹ are each independently C₁₋₆ alkyl;

R¹⁰ is a halogen atom, —OR⁴⁰, or —S(O)_(r3)R⁴¹;

R¹³ is C₁₋₆ alkyl or C₁₋₆ alkoxy;

R¹⁴ is a halogen atom, C₂₋₆ alkenyl, C₁₋₆ alkoxy, C₁₋₆ alkylthio, or C₁₋₆ alkylsulfonyl;

R¹⁵ and R¹⁶ are each independently a hydrogen atom or C₁₋₆ alkyl;

R²⁰ is a hydrogen atom or C₁₋₆ alkyl;

R²¹ is a hydrogen atom or C₁₋₆ alkyl;

R²² is —OH or C₁₋₆ alkoxy;

R²⁷ is a halogen atom or C₁₋₆ alkoxy;

R³⁰ and R³¹ are a hydrogen atom;

R³³ is C₁₋₆ haloalkyl or di(C₁₋₆) alkylamino;

R³⁴ is C₁₋₆ alkoxy or —CN;

R³⁵ is a hydrogen atom, C₁₋₆ alkyl, or (C₁₋₆) alkyl substituted with R^(14;)

R⁴⁰ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, or C₁₋₆ haloalkyl;

R⁴¹ is a hydrogen atom, C₁₋₆ alkyl, or C₁₋₆ haloalkyl;

Z⁴ is a halogen atom or C₁₋₆ alkoxy, and when p5c is an integer of 2 or more, each Z⁴ is the same as or different from each other;

W² is an oxygen atom or N—OR⁷; and

W³ is an oxygen atom or N—OR²¹.

[11]

The pyridazinone compound and a salt thereof according to [3], wherein:

n is 0.

[12]

The pyridazinone compound and a salt thereof according to [4], wherein:

G is a hydrogen atom;

R¹ is C₁₋₆ alkyl;

R² is a halogen atom or C₁₋₆ alkyl;

R³ is D-1;

Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹⁰, —OR¹¹, or —S(O)_(r2)R³⁸, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other;

Z¹ is a halogen atom or —OR³⁵, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

R¹⁰ is a halogen atom;

R¹¹ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R^(12;)

R¹² is a halogen atom, —OR⁴⁸, or S(O)_(r5)R^(49;)

R³⁵ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R^(14;)

R³⁸ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R^(39;)

R³⁹ is a halogen atom; and

n is 0 or 1.

[13]

The pyridazinone compound and a salt thereof according to [3], wherein:

Z¹ is —OR³⁵, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

R¹ is C₁₋₆ alkyl;

R² is a hydrogen atom, a halogen atom, or C₁₋₆ alkyl;

R³ is D-1, D-3, or D-7;

Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹⁰, —OR¹¹, —S(O)_(r2)R³⁸, —CN, or —C(═W²)R¹³, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other;

R⁷ is C₁₋₆ alkyl; and

W² is N—OR⁷.

[14]

The pyridazinone compound and a salt thereof according to [3], wherein:

X is a sulfur atom;

Z¹ is a halogen atom, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

R¹ is C₁₋₆ alkyl;

R² is a hydrogen atom, a halogen atom, or C₁₋₆ alkyl;

R³ is D-1;

Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹⁰, —OR¹¹, —S(O)_(r2)R³⁸, —CN, or —C(═W²)R¹³, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other;

R⁷ is C₁₋₆ alkyl;

R¹³ is C₁₋₆ alkyl; and

W² is N—OR⁷.

[15]

The pyridazinone compound and a salt thereof according to [3], wherein:

Z¹ is C₃₋₆ cycloalkyl, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

R¹ is C₁₋₆ alkyl;

R² is a hydrogen atom, a halogen atom, or C₁₋₆ alkyl;

R³ is D-1 or D-3;

Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹⁰, —OR¹¹, —S(O)_(r2)R³⁸, —CN, or —C(═W²)R¹³, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other;

R⁷ is C₁₋₆ alkyl; and

W² is N—OR⁷.

[16]

The pyridazinone compound and a salt thereof according to [7], wherein:

R³ is D-1;

R¹⁰ is a halogen atom; and

n is an integer of 0 or 1.

[17]

The pyridazinone compound and a salt thereof according to [9], wherein:

Y¹ is a hydrogen atom, a halogen atom, or —OR¹¹, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other;

Z¹ is a halogen atom, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

R¹¹ is (C₁₋₆) alkyl substituted with R^(12;)

R¹² is a halogen atom; and

-   -   n is 0 or 1.

[18]

The pyridazinone compound and a salt thereof according to [9], wherein:

Y¹ is a hydrogen atom, C₁₋₆ alkyl, or (C₁₋₆) alkyl substituted with R¹⁰, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other;

Z¹ is C₁₋₆ alkyl or —OR³⁵, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

R¹⁴ is a halogen atom or C₁₋₆ alkoxy;

R³⁵ is a hydrogen atom, C₁₋₆ alkyl, or (C₁₋₆) alkyl substituted with R¹⁴; and

n is 0 or 1.

[19]

The pyridazinone compound or a salt thereof according to any of [1] to [3], wherein:

Z^(a) is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, or —OR^(35;)

Z^(b) is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, or (C₁₋₆) alkyl substituted with R^(22;)

Z^(c) is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R²², (C₂₋₆) alkynyl substituted with R¹⁹, phenyl, phenyl substituted with (Z⁴)_(p5c), Q-3, —NR¹⁵R¹⁶, —OR³⁵, —S(O)_(r1)R³⁶, —CN, —C(═W³)R²⁰, or —N═C(C₆H₅)_(2;)

Z^(d) is a hydrogen atom or a halogen atom;

R¹⁴ is a halogen atom, C₂₋₆ alkenyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, C₁₋₆ alkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfonyl, phenyl, or U-1;

R¹⁵ and R¹⁶ are each independently a hydrogen atom, C₁₋₆ alkyl, —C(O)R¹⁷, or —S(O)₂R^(18;)

R¹⁷ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or C₁₋₆ alkoxy (C₁₋₂) alkyl;

R¹⁸ is C₁₋₆ alkyl;

R¹⁹ is tri(C₁₋₆ alkyl)silyl;

R²⁰ is a hydrogen atom or C₁₋₆ alkyl;

R²¹ is a hydrogen atom or C₁₋₆ alkyl;

R²² is a halogen atom, —OH, or C₁₋₆ alkoxy;

R³³ is di(C₁₋₆) alkylamino;

R³⁵ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R¹⁴, or —S(O)₂R^(33;)

R³⁶ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R^(37;)

R³⁷ is a halogen atom or (C₁₋₁₀) alkoxycarbonyl;

R⁴⁵ is a halogen atom;

Z⁴ is a halogen atom or C₁₋₆ alkoxy, and when p5c is an integer of 2 or more, each Z⁴ is the same as or different from each other;

W³ is an oxygen atom or N—OR^(21;)

r1 is an integer of 0 or 2;

p5c is an integer of 1 or 2; and

q3 is 0.

[20]

The pyridazinone compound or a salt thereof according to any of [1] to [19], wherein:

W¹ is an oxygen atom.

[21]

The pyridazinone compound or a salt thereof according to any of [1] to [19], wherein:

W¹ is a sulfur atom.

[22]

The pyridazinone compound or a salt thereof according to any of [1] to [21], wherein:

Z¹ is a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R²², (C₂₋₆) alkynyl substituted with R¹⁹, (C₃₋₆) cycloalkyl substituted with R⁴⁴, phenyl, phenyl substituted with (Z⁴)_(p5c), Q-3, —NR¹⁵R¹⁶, —OR³⁵, —S(O)_(r1)R³⁶, —CN, —NO₂, —C(O)OH, —C(═W³)R²⁰, or —N═C(C₆H₅)₂, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other.

[23]

The pyridazinone compound or a salt thereof according to [22], wherein:

Z¹ is a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R²², (C₂₋₆) alkynyl substituted with R¹⁹, phenyl, phenyl substituted with (Z⁴)_(p5c), Q-3, —N¹⁵R¹⁶, —OR³⁵, —S(O)_(r1)R³⁶, —CN, —C(═W³)R²⁰, or —N═C(C₆H₅)₂, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other.

[24]

The pyridazinone compound or a salt thereof according to [22], wherein:

Z¹ is a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R²², (C₂₋₆) alkynyl substituted with R¹⁹, —NR¹⁵R¹⁶, —OR³⁵, —S(O)_(r1)R³⁶, or —CN, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other.

[25]

The pyridazinone compound or a salt thereof according to [22], wherein:

Z¹ is a halogen atom, C₁₋₆ alkyl, —OR³⁵, or —S(O)_(r1)R³⁶, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other.

[26]

The pyridazinone compound or a salt thereof according to [22], wherein:

Z¹ is a halogen atom, C₁₋₆ alkyl, or —OR³⁵, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other.

[27]

The pyridazinone compound or a salt thereof according to any of [1] to [26], wherein:

G is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R⁴, —C(═W⁴)R⁵, or —S(O)₂R⁶.

[28]

The pyridazinone compound or a salt thereof according to [27], wherein:

G is a hydrogen atom, C₁₋₆ alkyl, or —C(═W⁴)R⁵.

[29]

The pyridazinone compound or a salt thereof according to [27], wherein:

G is a hydrogen atom or C₁₋₆ alkyl.

[30]

The pyridazinone compound or a salt thereof according to any of [1] to [29], wherein:

R¹ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, or C₁₋₆ alkyl substituted with R³⁴.

[31]

The pyridazinone compound or a salt thereof according to [30], wherein:

R¹ is a hydrogen atom, C₁₋₆ alkyl, or C₁₋₆ alkyl substituted with R³⁴.

[32]

The pyridazinone compound or a salt thereof according to [30], wherein:

R¹ is C₁₋₆ alkyl.

[33]

The pyridazinone compound or a salt thereof according to any of [1] to [32], wherein:

R² is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₁₋₆ alkoxy, or —NR³⁰R³¹.

[34]

The pyridazinone compound or a salt thereof according to [33], wherein:

R² is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy.

[35]

The pyridazinone compound or a salt thereof according to [33], wherein:

R² is C₁₋₆ alkyl or C₁₋₆ alkoxy.

[36]

The pyridazinone compound or a salt thereof according to [33], wherein:

R² is C₁₋₆ alkoxy, C₃₋₆ cycloalkyl, or —NR³⁰R³¹.

[37]

The pyridazinone compound or a salt thereof according to [33], wherein:

R² is C₃₋₆ cycloalkyl or —NR³⁰R³¹.

[38]

The pyridazinone compound or a salt thereof according to any of [1] to [37], wherein:

R³ is D-1, D-2, D-3, D-4, D-5, D-6, D-7, D-8, D-9, D-10, D-13, D-14, D-15, D-16, D-17, D-18, D-19, D-20, D-21, D-22, D-23, D-24, D-25, D-26, D-27, or D-28.

[39]

The pyridazinone compound or a salt thereof according to [38], wherein:

R³ is D-1, D-2, D-3, D-4, D-6, D-7, D-8, D-9, D-10, D-17, D-18, D-19, D-20, D-21, D-22, D-23, D-24, D-25, D-26, or D-28.

[40]

The pyridazinone compound or a salt thereof according to [38], wherein:

R³ is D-1, D-2, D-3, D-4, D-5, D-6, D-7, D-8, D-9, D-10, D-17, D-18, D-20, D-21, D-22, D-23, D-24, or D-28.

[41]

The pyridazinone compound or a salt thereof according to [38], wherein:

R³ is D-1, D-3, D-7, D-20, D-21, D-22, or D-24.

[42]

The pyridazinone compound or a salt thereof according to [38], wherein:

R³ is D-1, D-7, or D-24.

[43]

The pyridazinone compound or a salt thereof according to [38], wherein:

R³ is D-1.

[44]

The pyridazinone compound or a salt thereof according to [38], wherein:

R³ is D-3.

[45]

The pyridazinone compound or a salt thereof according to [38], wherein:

R³ is D-7.

[46]

The pyridazinone compound or a salt thereof according to [38], wherein:

R³ is D-24.

[47]

The pyridazinone compound or a salt thereof according to any of [1] to [46], wherein:

Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, (C₁₋₆) alkyl substituted with R¹⁰, C₃₋₆ cycloalkyl substituted with R⁴⁴, —OR¹¹, —S(O)_(r2)R³⁸, —NR⁸R⁹, —CN, —NO₂, —C(O)OH, —C(═W²)R¹³, phenyl, phenyl substituted with (Z⁴)_(p5c), or tri(C₁₋₆ alkyl)silyl, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other.

[48]

The pyridazinone compound or a salt thereof according to [47], wherein:

Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, (C₁₋₆) alkyl substituted with R¹⁰, —C(O)OH, —OR¹¹, —S(O)_(r2)R³⁸, —NR⁸R⁹, —CN, —NO₂, —C(═W²)R¹³, phenyl, or tri(C₁₋₆ alkyl)silyl, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other.

[49]

The pyridazinone compound or a salt thereof according to [47], wherein:

Y¹ is a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, (C₁₋₆) alkyl substituted with R¹⁰, —OR¹¹, —S(O)_(r2)R³⁸, —NR⁸R⁹, —CN, —NO₂, or —C(═W²)R¹³, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other.

[50]

The pyridazinone compound or a salt thereof according to [47], wherein:

Y¹ is a halogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹⁰, —OR¹¹, or —S(O)_(r2)R³⁸, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other.

[51]

The pyridazinone compound or a salt thereof according to [47], wherein: Y¹ is a halogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹⁰, or —OR¹¹, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other.

[52]

The pyridazinone compound or a salt thereof according to [47], wherein:

Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹⁰, —C(O)OH, —CN, —C(═W²)R¹³, phenyl, or tri(C₁₋₆ alkyl)silyl, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other.

[53]

The pyridazinone compound or a salt thereof according to [47], wherein:

Y¹ is a hydrogen atom, C₁₋₆ alkyl, or (C₁₋₆) alkyl substituted with R¹⁰, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other.

[54]

The pyridazinone compound or a salt thereof according to [47], wherein:

Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, phenyl, or tri(C₁₋₆ alkyl)silyl, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other.

[55]

The pyridazinone compound or a salt thereof according to [47], wherein:

Y¹ is —OR¹¹ or —S(O)_(r2)R³⁸, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other.

[56]

The pyridazinone compound or a salt thereof according to [47], wherein:

Y¹ is a hydrogen atom, a halogen atom, or —OR¹¹, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other.

[57]

The pyridazinone compound or a salt thereof according to any of [1] to [56], wherein:

R⁴ is a halogen atom, —CN, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, —OR²⁴, —S(O)_(r4)R⁵⁴, —C(O)R²³, phenyl, or phenyl substituted with (Z⁴)_(p5c).

[58]

The pyridazinone compound or a salt thereof according to [57], wherein:

R⁴ is a halogen atom, —CN, C₂₋₆ alkenyl, C₂₋₆ alkynyl, —OR²⁴, —S(O)_(r4)R⁵⁴, —C(O)R²³, or phenyl.

[59]

The pyridazinone compound or a salt thereof according to [57], wherein:

R⁴ is —OR²⁴ or —S(O)_(r4)R⁵⁴.

[60]

The pyridazinone compound or a salt thereof according to any of [1] to [59], wherein:

R⁵ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R²⁶, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ alkoxy, —OR⁵⁸, —SR⁵⁹, C₃₋₆ cycloalkyl, C₃₋₆ cycloalkyl substituted with R⁴⁴, —NR⁵⁶R⁵⁷, U-1, U-6, U-7, U-8, Q-1, Q-2, Q-3, Q-4, Q-5, Q-7, Q-8, Q-9, Q-10, Q-17, Q-18, Q-19, Q-20, phenyl, phenyl substituted with (Z²)_(p5a), or —C(O)R⁵³.

[61]

The pyridazinone compound or a salt thereof according to [60], wherein:

R⁵ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R²⁶, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ alkoxy, —OR⁵⁸, —SR⁵⁹, C₃₋₆ cycloalkyl, —NR⁵⁶R⁵⁷, U-1, U-6, Q-2, Q-4, phenyl, phenyl substituted with (Z²)_(p5a), or —C(O)R⁵³.

[62]

The pyridazinone compound or a salt thereof according to [60], wherein:

R⁵ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R²⁶, or C₁₋₆ alkoxy.

[63]

The pyridazinone compound or a salt thereof according to [60], wherein:

R⁵ is C₁₋₆ alkyl.

[64]

The pyridazinone compound or a salt thereof according to any of [1] to [63], wherein:

R⁶ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, phenyl, phenyl substituted with (Z²)_(p5a), or —NR²⁸R²⁹.

[65]

The pyridazinone compound or a salt thereof according to [64], wherein:

R⁶ is C₁₋₆ alkyl, phenyl substituted with (Z²)_(p5a), or —NR²⁸R²⁹.

[66]

The pyridazinone compound or a salt thereof according to [64], wherein:

R⁶ is C₁₋₆ alkyl or —NR²⁸R²⁹.

[67]

The pyridazinone compound or a salt thereof according to any of [1] to [66], wherein:

R⁷ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy (C₁₋₂) alkyl, or C₁₋₆ alkylthio (C₁₋₂) alkyl.

[68]

The pyridazinone compound or a salt thereof according to [67], wherein:

R⁷ is a hydrogen atom or C₁₋₆ alkyl.

[69]

The pyridazinone compound or a salt thereof according to any of [1] to [68], wherein:

R^(m) is a halogen atom, —OR⁴⁰, —S(O)_(r3)R⁴¹, C₃₋₆ cycloalkyl, or (C₃₋₆) cycloalkyl substituted with R⁴⁴.

[70]

The pyridazinone compound or a salt thereof according to [69], wherein: R¹⁰ is a halogen atom, —OR⁴⁰, or —S(O)_(r3)R⁴¹.

[71]

The pyridazinone compound or a salt thereof according to [69], wherein: R¹⁰ is a halogen atom or —OR⁴⁰.

[72]

The pyridazinone compound or a salt thereof according to any of [1] to [71], wherein:

R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, phenyl, phenyl substituted with (Z⁴)_(p5c), C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, U-2, U-4, Q-17, Q-18, or Q-19.

[73]

The pyridazinone compound or a salt thereof according to [72], wherein:

R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², C₃₋₆ cycloalkyl, phenyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, U-2, U-4, or Q-17.

[74]

The pyridazinone compound or a salt thereof according to [72], wherein:

R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², C₃₋₆ cycloalkyl, phenyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, U-2, or U-4.

[75]

The pyridazinone compound or a salt thereof according to [72], wherein:

R¹¹ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R¹².

[76]

The pyridazinone compound or a salt thereof according to any of [1] to [75], wherein:

R¹² is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, —OR⁴⁸, —S(O)_(r5)R⁴⁹, —CN, phenyl, phenyl substituted with (Z³)_(p5b), —C(═W²)R¹³, U-1, U-2, U-3, Q-1, Q-2, Q-3, Q-4, Q-5, Q-18, or —ON═CR⁴²R⁴³.

[77]

The pyridazinone compound or a salt thereof according to [76], wherein:

R¹² is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, —OR⁴⁸, —S(O)_(r5)R⁴⁹, —CN, phenyl, —C(═W²)R¹³, U-3, Q-1, or —ON═CR⁴²R⁴³.

[78]

The pyridazinone compound or a salt thereof according to [76], wherein:

R¹² is a halogen atom, C₂₋₆ alkenyl, —OR⁴⁸, —S(O)_(r5)R⁴⁹, or —C(═W²)R¹³.

[79]

The pyridazinone compound or a salt thereof according to [76], wherein:

R¹² is a halogen atom, C₂₋₆ alkenyl, —OR⁴⁸, or —S(O)_(r5)R⁴⁹.

[80]

The pyridazinone compound or a salt thereof according to any of [1] to [79], wherein:

R¹³ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or C₁₋₆ haloalkylamino.

[81]

The pyridazinone compound or a salt thereof according to [80], wherein:

R¹³ is a hydrogen atom or C₁₋₆ alkyl.

[82]

The pyridazinone compound or a salt thereof according to any of [1] to [81], wherein:

R¹⁴ is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, C₁₋₆ alkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, phenyl, phenyl substituted with (Z⁴)_(p5c), —CN, U-1, U-2, U-3, U-9, Q-17, Q-18, Q-19, or Q-20.

[83]

The pyridazinone compound or a salt thereof according to [82], wherein:

R¹⁴ is a halogen atom, C₂₋₆ alkenyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, C₁₋₆ alkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfonyl, phenyl, or U-1.

[84]

The pyridazinone compound or a salt thereof according to [82], wherein:

R¹⁴ is a halogen atom, C₂₋₆ alkenyl, C₁₋₆ alkoxy, or C₁₋₆ alkylthio.

[85]

The pyridazinone compound or a salt thereof according to any of [1] to [84], wherein:

R¹⁵ and R¹⁶ are each independently a hydrogen atom, C₁₋₆ alkyl, —C(O)R¹⁷, or —S(O)₂R¹⁸.

[86]

The pyridazinone compound or a salt thereof according to [85], wherein:

R¹⁵ and R¹⁶ are each independently a hydrogen atom or C₁₋₆ alkyl.

[87]

The pyridazinone compound or a salt thereof according to any of [1] to [86], wherein:

R¹⁷ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or C₁₋₆ alkoxy (C₁₋₂) alkyl.

[88]

The pyridazinone compound or a salt thereof according to any of [1] to [87], wherein:

R²² is a halogen atom, —OH, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, or —CN.

[89]

The pyridazinone compound or a salt thereof according to [88], wherein:

R²² is a halogen atom, —OH, or C₁₋₆ alkoxy.

[90]

The pyridazinone compound or a salt thereof according to any of [1] to [89], wherein:

R²³ is C₁₋₆ alkyl, C₁₋₆ alkoxy, di(C₁₋₆) alkylamino, phenyl, phenyl substituted with (Z⁴)_(p5c), U-7, or U-8.

[91]

The pyridazinone compound or a salt thereof according to [90], wherein:

R²³ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or phenyl.

[92]

The pyridazinone compound or a salt thereof according to any of [1] to [91], wherein:

R²⁴ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, (C₁₋₆) alkoxy (C₁₋₂) alkyl, —C(O)R²⁵, or —S(O)₂R³³.

[93]

The pyridazinone compound or a salt thereof according to [92], wherein:

R²⁴ is C₁₋₆ alkyl, (C₁₋₆) alkoxy (C₁₋₂) alkyl, or —C(O)R²⁵.

[94]

The pyridazinone compound or a salt thereof according to [92], wherein: R²⁴ is C₁₋₆ alkyl.

[95]

The pyridazinone compound or a salt thereof according to any of [1] to [94], wherein:

R²⁵ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or di(C₁₋₆) alkylamino.

[96]

The pyridazinone compound or a salt thereof according to any of [1] to [95], wherein:

R²⁶ is a halogen atom, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, —OR³², phenyl, or phenyl substituted with (Z⁴)_(p5c).

[97]

The pyridazinone compound or a salt thereof according to [96], wherein:

R²⁶ is C₁₋₆ alkoxy, —OR³², or phenyl.

[98]

The pyridazinone compound or a salt thereof according to [96], wherein:

R²⁶ is C₁₋₆ alkoxy.

[99]

The pyridazinone compound or a salt thereof according to any of [1] to [98], wherein:

R²⁷ is a halogen atom, C₂₋₆ alkenyl, or C₁₋₆ alkoxy.

[100]

The pyridazinone compound or a salt thereof according to any of [1] to [99], wherein:

R³⁴ is C₁₋₆ alkoxy, phenyl, or —CN.

[101]

The pyridazinone compound or a salt thereof according to [100], wherein:

R³⁴ is C₁₋₆ alkoxy or —CN.

[102]

The pyridazinone compound or a salt thereof according to any of [1] to [101], wherein:

R³⁵ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R¹⁴, or —S(O)₂R³³.

[103]

The pyridazinone compound or a salt thereof according to [102], wherein:

R³⁵ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R¹⁴.

[104]

The pyridazinone compound or a salt thereof according to [102], wherein:

R³⁵ is C₁₋₆ alkyl.

[105]

The pyridazinone compound or a salt thereof according to any of [1] to [104], wherein:

R³⁶ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R³⁷, or C₃₋₆ cycloalkyl.

[106]

The pyridazinone compound or a salt thereof according to [105], wherein:

R³⁶ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R³⁷.

[107]

The pyridazinone compound or a salt thereof according to any of [1] to [106], wherein:

R³⁷ is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₁₋₆ alkoxy, C₁₋₆ alkylthio, or C₁₋₁₀ alkoxycarbonyl.

[108]

The pyridazinone compound or a salt thereof according to [107], wherein:

R³⁷ is a halogen atom or (C₁₋₁₀) alkoxycarbonyl.

[109]

The pyridazinone compound or a salt thereof according to [107], wherein:

R³⁷ is a halogen atom.

[110]

The pyridazinone compound or a salt thereof according to any of [1] to [109], wherein:

R³⁸ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₃₋₆ cycloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, (C₁₋₆) alkyl substituted with R³⁹, or (C₃₋₆) cycloalkyl substituted with R⁴⁴.

[111]

The pyridazinone compound or a salt thereof according to [110], wherein:

R³⁸ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, or (C₁₋₆) alkyl substituted with R³⁹.

[112]

The pyridazinone compound or a salt thereof according to [110], wherein:

R³⁸ is C₁₋₆ alkyl.

[113]

The pyridazinone compound or a salt thereof according to any of [1] to [112], wherein:

R³⁹ is a halogen atom, C₃₋₆ cycloalkyl, —OR⁵¹, —S(O)_(r6)R⁵², —C(═W²)R¹³, —CN, phenyl, phenyl substituted with (Z³)_(p5b), U-1, U-3, U-9, Q-1, or Q-18.

[114]

The pyridazinone compound or a salt thereof according to [113], wherein:

R³⁹ is a halogen atom, —OR⁵¹, —S(O)_(r6)R⁵², —C(═W²)R¹³, or —CN.

[115]

The pyridazinone compound or a salt thereof according to [113], wherein:

R³⁹ is —OR⁵¹ or —S(O)_(r6)R⁵².

[116]

The pyridazinone compound or a salt thereof according to any of [1] to [115], wherein:

R⁴⁰ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R⁴⁶, or U-4.

[117]

The pyridazinone compound or a salt thereof according to [116], wherein:

R⁴⁰ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₁₋₆ haloalkyl, or (C₁₋₆) alkyl substituted with R⁴⁶.

[118]

The pyridazinone compound or a salt thereof according to [116], wherein:

R⁴⁰ is C₁₋₆ alkyl, C₃₋₆ alkenyl, or C₃₋₆ alkynyl.

The pyridazinone compound or a salt thereof according to [116], wherein:

R⁴⁰ is C₁₋₆ alkyl.

[120]

The pyridazinone compound or a salt thereof according to any of [1] to [119], wherein:

R⁴¹ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, C₃₋₆ cycloalkyl, or (C₁₋₆) alkyl substituted with R⁴⁷.

[121]

The pyridazinone compound or a salt thereof according to [120], wherein:

R⁴¹ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, or (C₁₋₆) alkyl substituted with R47.

[122]

The pyridazinone compound or a salt thereof according to [120], wherein:

R⁴¹ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, or (C₁₋₆) alkyl substituted with R⁴⁷.

[123]

The pyridazinone compound or a salt thereof according to any of [1] to [122], wherein:

R⁴⁸ is a hydrogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, C₃₋₆ haloalkenyl, C₃₋₆ alkynyl, C₃₋₆ haloalkynyl, or C₃₋₆ cycloalkyl.

[124]

The pyridazinone compound or a salt thereof according to [123], wherein:

R⁴⁸ is C₁₋₆ alkyl or C₁₋₆ haloalkyl.

[125]

The pyridazinone compound or a salt thereof according to [123], wherein:

R⁴⁸ is C₁₋₆ alkyl.

[126]

The pyridazinone compound or a salt thereof according to any of [1] to [125], wherein:

R⁴⁹ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, or C₃₋₆ alkynyl.

[127]

The pyridazinone compound or a salt thereof according to [126], wherein:

R⁴⁹ is C₁₋₆ alkyl.

[128]

The pyridazinone compound or a salt thereof according to any of [1] to [127], wherein: Y² is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, or C₁₋₆ haloalkylthio.

[129]

The pyridazinone compound or a salt thereof according to [128], wherein: Y² is a halogen atom or C₁₋₆ haloalkyl.

[130]

The pyridazinone compound or a salt thereof according to any of [1] to [129], wherein:

Z² is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, —OH, —NH₂, —CN, —NO₂, or —C(O)R⁵⁵, and when p5a is an integer of 2 or more, each Z² is the same as or different from each other.

[131]

The pyridazinone compound or a salt thereof according to [130], wherein: Z² is a halogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy, and when p5a is an integer of 2 or more, each Z² is the same as or different from each other.

[132]

The pyridazinone compound or a salt thereof according to any of [1] to [131], wherein:

Z⁴ is a halogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy, and when p5c is an integer of 2 or more, each Z³ is the same as or different from each other.

[133]

The pyridazinone compound or a salt thereof according to [132], wherein: Z⁴ is a halogen atom or C₁₋₆ alkoxy, and when p5c is an integer of 2 or more, each Z³ is the same as or different from each other.

[134]

The pyridazinone compound or a salt thereof according to any of [1] to [133], wherein:

r1 is an integer of 0 or 2;

r2 is an integer of 0, 1, or 2;

r3 is an integer of 0, 1, or 2;

r5 is an integer of 0, 1, or 2; and

r6 is 0.

[135]

The pyridazinone compound or a salt thereof according to any of [1] to [134], wherein:

n is an integer of 0, 1, or 2.

[136]

The pyridazinone compound or a salt thereof according to any of [1] to [135], wherein:

p2 is an integer of 0 or 1;

p3 is an integer of 0, 1, 2, or 3;

p4 is an integer of 0, 1, or 2;

p5 is an integer of 0, 1, 2, 3, or 4;

p6 is an integer of 0, 1, or 2; and

p7 is an integer of 0, 1, or 2.

[137]

The pyridazinone compound or a salt thereof according to [136], wherein:

p2 is an integer of 1;

p3 is an integer of 0, 1, or 2;

p4 is an integer of 1;

p5 is an integer of 0, 1, 2, or 3;

p6 is an integer of 0; and

p7 is an integer of 0.

[138] The number of substituents (corresponding to Examples+a)

The pyridazinone compound or a salt thereof according to any of [1] to [137], wherein:

p5a is an integer of 1;

p5b is an integer of 1 or 2; and

p5c is an integer of 1 or 2.

[139]

The pyridazinone compound or a salt thereof according to [138], wherein:

p5a is an integer of 1; and

p5c is an integer of 1 or 2.

[140]

The pyridazinone compound or a salt thereof according to any of [1] to [139], wherein:

q1 is an integer of 0 or 1;

q2 is an integer of 0 or 1;

q3 is an integer of 0 or 1; and

q4 is an integer of 0 or 2.

[141]

The pyridazinone compound or a salt thereof according to [140], wherein:

q2 is an integer of 1;

q3 is 0; and

q4 is an integer of 2.

[142]

A production intermediate of the pyridazinone compound or a salt thereof according to any of [1] to [141], the production intermediate being of the following formula A:

[wherein X is an oxygen atom or a sulfur atom;

Z¹ is a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R²², (C₂₋₆) alkynyl substituted with R¹⁹, phenyl, phenyl substituted with (Z⁴)_(p5c), Q-3, —NR¹⁵R¹⁶, —OR³⁵, —S(O)_(r1)R³⁶, —CN, —C(═W³)R²⁰, or —N═C(C₆H₅)₂, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, (C₁₋₆) alkyl substituted with R¹⁰, —C(O)OH, —OR¹¹, —S(O)_(r2)R³⁸, —NR⁸R⁹, —CN, —NO₂, —C(═W²)R¹³, phenyl, or tri(C₁₋₆ alkyl)silyl, and when p5 is an integer of 2 or more, each Y¹ is the same as or different from each other;

R⁷ is a hydrogen atom or C₁₋₆ alkyl;

R⁸ and R⁹ are each independently C₁₋₆ alkyl;

R¹⁰ is a halogen atom, —OR⁴⁰, or —S(O)_(r3)R^(41;)

R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², C₃₋₆ cycloalkyl, phenyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, U-2, U-4, or Q-17;

R¹² is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, —OR⁴⁸, —S(O)_(r5)R⁴⁹, —CN, phenyl, —C(═W²)R¹³, U-3, Q-1, or —ON═CR⁴²R^(43;)

R¹³ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or C₁₋₆ haloalkylamino;

R¹⁴ is a halogen atom, C₂₋₆ alkenyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with

R⁴⁵, C₁₋₆ alkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfonyl, phenyl, or U-1;

R¹⁵ and R¹⁶ are each independently a hydrogen atom, C₁₋₆ alkyl, —C(O)R¹⁷, or —S(O)₂R^(18;)

R¹⁷ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or C₁₋₆ alkoxy (C₁₋₂) alkyl;

R¹⁸ is C₁₋₆ alkyl;

R¹⁹ is tri(C₁₋₆ alkyl)silyl;

R²⁰ is a hydrogen atom or C₁₋₆ alkyl;

R²¹ is a hydrogen atom or C₁₋₆ alkyl;

R²² is a halogen atom, —OH, or C₁₋₆ alkoxy;

R³³ is C₁₋₆ haloalkyl or di(C₁₋₆) alkylamino;

R³⁵ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R¹⁴, or —S(O)₂R^(33;)

R³⁶ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R^(37;)

R³⁷ is a halogen atom or (C₁₋₁₀) alkoxycarbonyl;

R³⁸ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₃₋₆ cycloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, or (C₁₋₆) alkyl substituted with R^(39;)

R³⁹ is a halogen atom, —OR⁵¹, —S(O)_(r6)R⁵², —C(═W²)R¹³, or —CN;

R⁴⁰ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₁₋₆ haloalkyl, or (C₁₋₆) alkyl substituted with R^(46;)

R⁴¹ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, or (C₁₋₆) alkyl substituted with R^(47;)

R⁴² and R⁴³ are each independently C₁₋₆ alkyl;

R⁴⁴ is a halogen atom, C₁₋₆ alkyl, or —CN;

R⁴⁵ is a halogen atom;

R⁴⁶ is C₁₋₆ alkoxy or C₁₋₆ alkylthio;

R⁴⁷ is C₁₋₆ alkoxy or C₁₋₆ alkylthio;

R⁴⁸ is C₁₋₆ alkyl or C₁₋₆ haloalkyl;

R⁴⁹ is C₁₋₆ alkyl;

R⁵¹ is C₁₋₆ alkyl;

R⁵² is C₁₋₆ alkyl;

R^(a) is —OH, C₁₋₆ alkoxy, or —NR^(a1)R^(a2;)

R^(a1) is a hydrogen atom or C₁₋₆ alkyl;

R^(a2) is a hydrogen atom, —NH₂, or —N═C(R^(a3))R^(a4;)

R^(a3) is a hydrogen atom or C₁₋₆ alkyl;

R^(a4) is C₁₋₆ alkyl or C₁₋₆ alkoxycarbonyl;

Y² is a halogen atom or C₁₋₆ haloalkyl;

W² is an oxygen atom or N—OR^(7;)

W³ is an oxygen atom or N—OR^(21;)

Z⁴ is a halogen atom or C₁₋₆ alkoxy, and when p5c is an integer of 2 or more, each Z⁴ is the same as or different from each other;

n is an integer of 0, 1, or 2;

p5 is an integer of 0, 1, 2, 3, 4, or 5;

q3 is 0; and

p5c is an integer of 1 or 2].

[143]

The production intermediate of the pyridazinone compound or a salt thereof according to [142], wherein:

Z¹ is a halogen atom, C₁₋₆ alkyl, or —OR³⁵, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

Y¹ is a hydrogen atom, a halogen atom, or —OR¹¹, and when p5 is an integer of 2 or more, each Y¹ is the same as or different from each other;

R¹¹ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R^(12;)

R¹² is a halogen atom;

R¹⁴ is phenyl;

R³⁵ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R^(14;)

R^(a) is —OH, C₁₋₆ alkoxy, or —NR^(a1)R^(a2;)

R^(a1) is C₁₋₆ alkyl;

R^(a2) is —NH₂ or —N═C(R^(a3))R^(a4;)

R^(a3) is C₁₋₆ alkyl;

R^(a4) is C₁₋₆ alkoxycarbonyl;

p5 is an integer of 0, 1, or 2; and

n is an integer of 0, 1, or 2.

[144]

The production intermediate of the pyridazinone compound or a salt thereof according to [143], wherein:

X is a sulfur atom; and

R^(a) is —OH or C₁₋₆ alkoxy.

[145]

The production intermediate of the pyridazinone compound or a salt thereof according to [143], wherein:

X is a sulfur atom;

R³⁵ is C₁₋₆ alkyl; and

R^(a) is —NR^(a1)R^(a2).

[146]

The production intermediate of the pyridazinone compound or a salt thereof according to [143], wherein:

X is an oxygen atom;

Z¹ is —OR^(35;)

Y¹ is —OR^(11;)

R¹¹ is C₁₋₆ alkyl;

R³⁵ is C₁₋₆ alkyl;

R^(a) is —OH;

p5 is an integer of 1; and

n is an integer of 1.

[147]

A pyridazinone compound of the following Formula (1) or a salt thereof:

[wherein W¹ is an oxygen atom or a sulfur atom;

X is an oxygen atom or a sulfur atom;

Z¹ is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, —OH, —NH₂, —CN, —NO₂, or —CO₂H, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

G is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R⁴, —C(O)R⁵, or —S(O)₂R^(6;)

R¹ is C₁₋₆ alkyl, C₃₋₆ alkenyl, or C₃₋₆ alkynyl;

R² is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy;

R³ is D-1, D-2, D-3, D-4, D-5, D-6, D-7, D-8, D-9, D-10, D-17, D-20a, D-22a, D-24a, D-25, D-23, D-21a, or D-19a;

D-1, D-2, D-3, D-4, D-5, D-6, D-7, D-8, D-9, D-10, D-17, D-20a, D-22a, D-24a, D-25, D-23, D-21a, and D-19a are respectively the following structures:

Y¹ is substituted on the aromatic ring of each of D-1 to D-25;

Y¹ is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, —NR⁸R⁹, —CN, —NO₂, —CO₂H, —C(═W²)R¹³, phenyl, (C₁₋₆) alkyl substituted with R¹⁰, or —OR¹¹, and when p7, p5, p4, or p3 is an integer of 2 or more, each Y¹ is the same as or different from each other;

W² is an oxygen atom or N—OR^(7;)

R⁴ is phenyl;

R⁵ is C₁₋₆ alkyl, C₁₋₆ alkoxy, C₁₋₆ alkylthio, phenyl, or phenyl substituted with (Z²)_(p5a);

R⁶ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, phenyl, or phenyl substituted with (Z²)_(p5a;)

R⁷ is a hydrogen atom or C₁₋₆ alkyl;

R⁸ and R⁹ are each independently a hydrogen atom or C₁₋₆ alkyl;

R¹⁰ is C₁₋₆ alkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, or —CN;

R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², phenyl, tri(C₁₋₄ alkyl)silyl, C₁₋₆ alkylcarbonyl, or C₁₋₆ alkylsulfonyl;

R¹² is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₃₋₆ cycloalkyl, C₃₋₆ halocycloalkyl, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, alkylsulfonyl, —CN, phenyl, phenyl substituted with (Z³)_(p5b), —C(═W²)R¹³, U-1a, U-2a, U-3a, or U-4a;

U-1a, U-2a, U-3a, and U-4a are respectively the following structures:

R¹³ is a hydrogen atom or C₁₋₆ alkyl;

Z² is a halogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy, and when p5a is an integer of 2 or more, each Z² is the same as or different from each other;

Z³ is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, —CN, or —NO₂, and when p5b is an integer of 2 or more, each Z³ is the same as or different from each other;

n is an integer of 0, 1, 2, 3, or 4;

p3 is an integer of 0, 1, 2, or 3;

p4 is an integer of 0, 1, 2, 3, or 4;

p5 is an integer of 0, 1, 2, 3, 4, or 5;

p7 is an integer of 0, 1, 2, 3, 4, 5, 6, or 7;

p5a is an integer of 1, 2, 3, 4, or 5; and

p5b is an integer of 1, 2, 3, 4, or 5].

[148]

The pyridazinone compound or a salt thereof according to [147], wherein:

W¹ is an oxygen atom;

Z¹ is a halogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

G is a hydrogen atom, C₁₋₆ alkyl, —C(O)R⁵, or —S(O)₂R^(6;)

R¹ is C₁₋₆ alkyl;

R² is a hydrogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy;

R³ is D-1, D-3, D-6, D-8, D-9, D-10, D-17, D-20a, D-22a, D-24a, D-25, D-23, D-21a, or D-19a;

Y¹ is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkylthio, C₁₋₆ alkylsulfonyl, —NR⁸R⁹, —CN, —NO₂, —C(═W²)R¹³, phenyl, or —OR¹¹, and when p7, p5, p4, or p3 is an integer of 2 or more, each Y¹ is the same as or different from each other;

R⁵ is C₁₋₆ alkyl, C₁₋₆ alkoxy, C₁₋₆ alkylthio, or phenyl substituted with (Z²)_(p5a;)

R⁶ is C₁₋₆ alkyl;

R⁸ and R⁹ are each independently C₁₋₆ alkyl;

R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², or phenyl;

R¹² is a halogen atom;

R¹³ is C₁₋₆ alkyl;

Z² is C₁₋₆ alkyl;

n is an integer of 0, 1, or 2;

p3 is an integer of 0 or 1;

p4 is an integer of 0, 1, or 2;

p5 is an integer of 0, 1, 2, or 3;

p7 is an integer of 0; and

p5a is an integer of 1.

[149]

A pyridazinone compound of the following Formula (1) or a salt thereof:

[wherein W¹ is an oxygen atom or a sulfur atom;

X is an oxygen atom or a sulfur atom;

Z¹ is a halogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R²², C₂₋₆ alkenyl, C₂₋₆ alkynyl, (C₂₋₆) alkynyl substituted with R¹⁹, C₃₋₆ cycloalkyl, C₁₋₆ alkoxy, (C₁₋₆) alkoxy substituted with R¹⁴, phenyl, phenyl substituted with (Z⁴)_(p5c), Q-3a, —OH, —NR¹⁵R¹⁶, —OR³⁵, —CN, —NO₂, —CO₂H, or —C(═W³)R²⁰, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

G is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R⁴, —C(O)R⁵, or —S(O)₂R^(6;)

R¹ is C₁₋₆ alkyl, C₃₋₆ alkenyl, or C₃₋₆ alkynyl;

R² is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₁₋₆ alkoxy, or —NR³⁰R^(31;)

R³ is D-1, D-2, D-3, D-4, D-5, D-6, D-7, D-8, D-9, D-10, D-17, D-20a, D-22a, D-24a, D-25, D-23, D-21a, D-19a, D-26, or D-18;

D-1, D-2, D-3, D-4, D-5, D-6, D-7, D-8, D-9, D-10, D-17, D-20a, D-22a, D-24a, D-25, D-23, D-21a, D-19a, D-26, and D-18 are respectively the following structures:

Y¹ is substituted on the aromatic ring of each of D-1 to D-26;

Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₂₋₆ alkenyl, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, —NR⁸R⁹, —CN, —NO₂, —CO₂H, —C(═W²)R¹³, phenyl, (C₁₋₆) alkyl substituted with R¹⁰, or —OR¹¹, or tri(C₁₋₆ alkyl)silyl, and when p7, p6, p5, p4, or p3 is an integer of 2 or more, each Y¹ is the same as or different from each other;

R⁴ is a halogen atom, —CN, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ alkoxy, C₁₋₆ alkylthio, —C(O)R²³, —OR²⁴, or phenyl;

R⁵ is C₁₋₆ alkyl, C₁₋₆ alkyl substituted with R²⁶, C₁₋₆ alkoxy, (C₁₋₆) alkoxy substituted with R²⁷, C₁₋₆ alkylthio, U-6a, Q-2a, phenyl, or phenyl substituted with (Z²)_(p5a);

R⁶ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, phenyl, phenyl substituted with (Z²)_(p5a), or —NR²⁸R^(29;)

W² is an oxygen atom or N—OR^(7;)

R⁷ is a hydrogen atom or C₁₋₆ alkyl;

R⁸ and R⁹ are each independently a hydrogen atom, or C₁₋₆ alkyl;

R¹⁰ is C₁₋₆ alkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, or —CN;

R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², C₃₋₆ cycloalkyl, phenyl, tri(C₁₋₄ alkyl)silyl, C₁₋₆ alkylcarbonyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, U-2a, or U-4a;

R¹² is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₃₋₆ cycloalkyl, C₃₋₆ halocycloalkyl, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, —CN, phenyl, phenyl substituted with (Z³)_(p5b), —C(═W²)R¹³, U-1a, U-2a, U-3a, U-4a, U-5a, or Q-1a;

U-1a, U-2a, U-3a, U-4a, U-5a, U-6a, Q-1a, Q-2a, and Q-3a are respectively the following structures:

R¹³ is a hydrogen atom, C₁₋₆ alkyl, C₁₋₆ alkoxy, or C₁₋₆ haloalkylamino;

R¹⁴ is a halogen atom, C₃₋₆ cycloalkyl, C₃₋₆ halocycloalkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ alkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, phenyl, or U-1a;

R¹⁵ and R¹⁶ are each independently a hydrogen atom, C₁₋₆ alkyl, —C(O)R¹⁷, or —S(O)₂R18;

R¹⁷ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or C₁₋₆ alkoxy (C₁₋₂) alkyl;

R¹⁸ is C₁₋₆ alkyl or C₁₋₆ haloalkyl;

R¹⁹ is tri(C₁₋₆ alkyl)silyl;

R²⁰ is a hydrogen atom or C₁₋₆ alkyl;

W³ is an oxygen atom or N—OR^(21;)

R²¹ is a hydrogen atom or C₁₋₆ alkyl;

R²² is a halogen atom, —OH, or C₁₋₆ alkoxy;

R²³ is phenyl;

R²⁴ is (C₁₋₆) alkoxy (C₁₋₂) alkyl or —C(O)R^(25;)

R²⁵ is C₁₋₆ alkyl or C₁₋₆ alkoxy;

R²⁶ is a halogen atom, (C₁₋₆) alkoxy, or —OR^(32;)

R²⁷ is (C₁₋₆) alkoxy;

R²⁸ and R²⁹ are each independently a hydrogen atom or C₁₋₆ alkyl;

R³⁰ and R³¹ are each independently a hydrogen atom or benzyl;

R³² is phenyl;

R³³ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, or di(C₁₋₆) alkylamino;

R³⁵ is —SO₂R^(33;)

Z² is a halogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy, and when p5a is an integer of 2 or more, each Z² is the same as or different from each other;

Z³ is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, —CN, or —NO₂, and when p5b is an integer of 2 or more, each Z³ is the same as or different from each other;

Z⁴ is a halogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy, and when p5c is an integer of 2 or more, each Z³ is the same as or different from each other;

n is an integer of 0, 1, 2, 3, or 4;

p3 is an integer of 0, 1, 2, or 3;

p4 is an integer of 0, 1, 2, 3, or 4;

p5 is an integer of 0, 1, 2, 3, 4, or 5;

p6 is an integer of 0, 1, 2, 3, 4, 5, or 6;

p7 is an integer of 0, 1, 2, 3, 4, 5, 6, or 7;

p5a is an integer of 1, 2, 3, 4, or 5;

p5b is an integer of 1, 2, 3, 4, or 5; and

p5c is an integer of 1, 2, 3, 4, or 5].

[150]

The pyridazinone compound or a salt thereof according to [149], wherein:

W¹ is an oxygen atom;

Z¹ is a halogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R²², C₂₋₆ alkenyl, C₂₋₆ alkynyl, (C₂₋₆) alkynyl substituted with R¹⁹, C₃₋₆ cycloalkyl, C₁₋₆ alkoxy, (C₁₋₆) alkoxy substituted with R¹⁴, phenyl, phenyl substituted with (Z⁴)_(p5c), Q-3a, —OH, —NR¹⁵R¹⁶, —OR³⁵, —CN, or —C(═W³)R²⁰, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other;

R¹ is C₁₋₆ alkyl;

R³ is D-1, D-3, D-6, D-8, D-9, D-10, D-17, D-20a, D-22a, D-24a, D-25, D-23, D-21a, D-19a, D-26, or D-18;

Y¹ is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₂₋₆ alkenyl, C₁₋₆ alkylthio, C₁₋₆ alkylsulfonyl, —NR⁸R⁹, —CN, —NO₂, —CO₂H, —C(═W²)R¹³, phenyl, (C₁₋₆) alkyl substituted with R¹⁰, —OR¹¹, or tri(C₁₋₆ alkyl)silyl, and when p7, p6, p5, p4, or p3 is an integer of 2 or more, each Y¹ is the same as or different from each other;

R⁴ is C₂₋₆ alkynyl, C₁₋₆ alkoxy, —C(O)R²³, —OR²⁴, or phenyl;

R⁵ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R²⁶, C₁₋₆ alkoxy, (C₁₋₆) alkoxy substituted with R²⁷, C₁₋₆ alkylthio, U-6a, Q-2a, or phenyl substituted with (Z²)_(p5a;)

R⁶ is C₁₋₆ alkyl, phenyl substituted with (Z²)_(p5a), or —NR²⁸R^(29;)

R⁸ and R⁹ are each independently C₁₋₆ alkyl;

R¹⁰ is C₁₋₆ alkoxy;

R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², C₃₋₆ cycloalkyl, phenyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, U-2a, or U-4a;

R¹² is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ alkoxy, C₃₋₆ cycloalkyl, C₃₋₆ halocycloalkyl, C₁₋₆ alkylthio, —CN, phenyl, —C(═W²)R¹³, or Q-1a;

R¹³ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or C₁₋₆ haloalkylamino;

R¹⁴ is a halogen atom, C₃₋₆ cycloalkyl, C₃₋₆ halocycloalkyl, C₂₋₆ alkenyl, C₁₋₆ alkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfonyl, phenyl, or U-1a;

R¹⁸ is C₁₋₆ alkyl;

R²⁰ is C₁₋₆ alkyl;

R²⁵ is C₁₋₆ alkoxy;

R²⁶ is C₁₋₆ alkoxy, or —OR^(32;)

R²⁸ and R²⁹ are C₁₋₆ alkyl;

R³³ is di(C₁₋₆) alkylamino;

R³⁵ is —SO₂R^(33;)

Z² is a halogen atom or C₁₋₆ alkyl;

Z⁴ is a halogen atom or C₁₋₆ alkoxy;

n is an integer of 0, 1, or 2;

p3 is an integer of 0 or 1;

p4 is an integer of 0, 1, or 2;

p5 is an integer of 0, 1, 2, or 3;

p6 is an integer of 0;

p7 is an integer of 0; and

p5a is an integer of 1.

[151]

An agricultural chemical comprising, as an active ingredient, one or more selected from the pyridazinone compound and a salt thereof according to any of [1] to [141].

[152]

A herbicide comprising, as an active ingredient, one or more selected from the pyridazinone compound and a salt thereof according to any of [1] to [141].

Effects of the Invention

The compound of the present invention exhibits excellent herbicidal activity against various weeds, and has high safety to target crops. Furthermore, the compound has almost no adverse effect on non-target living organisms, such as mammals, fishes, and beneficial insects, and has low environmental burden because of its low residual property.

Thus, the present invention can provide a herbicide useful in the agricultural and horticultural fields, such as paddy fields, farmlands, and orchards.

MODES FOR CARRYING OUT THE INVENTION

The compound of the present invention may include geometrical isomers (i.e., E-form and Z-form) depending on the types of substituents. The present invention includes an E-form, a Z-form, and a mixture containing an E-form and a Z-form in any proportions.

The compound of the present invention may include, depending on the types of substituents, optically active substances attributed to the presence of one or more asymmetric carbon atoms. The present invention includes all optically active substances or racemates.

The compound of the present invention may include tautomers depending on the types of substituents. The present invention includes all tautomers or a mixture containing tautomers in any proportions. For example, among compounds of Formula (1) (hereinafter will be referred to “compounds (1)”), the compound of the following Formula (1-1a), in which G is a hydrogen atom and W¹ is an oxygen atom, may include a tautomer such as a compound of the following Formula (1-1a-1) or a compound of the following Formula (1-1a-2). Thus, in the case of introduction of the substituent G¹ (G¹ corresponds to structures represented by G (except for a hydrogen atom)) the enol structure (1-1a) is formed into a structure (1-1a-3), and the enol structure (1-1a-2) is formed into a structure (1-1a-4). The present invention includes all these structures.

The compound of the present invention may include one or more rotational isomers attributed to limited bond rotation caused by the steric hindrance between substituents. The present invention includes all rotational isomers or a mixture containing diastereomers in any proportions.

The compound of the present invention may be formed into an acid addition salt by any common method. Examples of the acid addition salt include salts of hydrohalic acids such as hydrogen fluoride, hydrogen chloride, hydrogen bromide, and hydrogen iodide; salts of inorganic acids such as nitric acid, sulfuric acid, phosphoric acid, chloric acid, and perchloric acid; salts of sulfonic acids such as methanesulfonic acid, ethanesulfonic acid, trifluoromethanesulfonic acid, benzenesulfonic acid, and p-toluenesulfonic acid; salts of carboxylic acids such as formic acid, acetic acid, propionic acid, trifluoroacetic acid, fumaric acid, tartaric acid, oxalic acid, maleic acid, malic acid, succinic acid, benzoic acid, mandelic acid, ascorbic acid, lactic acid, gluconic acid, and citric acid; or salts of amino acids such as glutamic acid and aspartic acid.

Alternatively, the compound of the present invention may be formed into a metal salt by any common method. Examples of the metal salt include salts of alkali metals such as lithium, sodium, and potassium; salts of alkaline earth metals such as calcium, barium, and magnesium; salt of aluminum; or quaternary ammonium salts such as tetramethylammonium salt, tetrabutylammonium salt, and benzyltrimethylammonium salt.

The terms or phrases as used herein have the meanings or usages described below.

The term “agricultural chemical” as used herein refers to a insecticide, a miticides, a nematicide, a herbicide, and a fungicide in the agricultural and horticultural fields.

Examples of the “halogen atom” as used herein include a fluorine atom, a chlorine atom, a bromine atom, and an iodine atom. The term “halo” as used herein also refers to such a halogen atom.

In the specific description of substituents in the present specification, the term “n-” refers to “normal”; the term “i-” refers to “iso”; the term “sec-” refers to “secondary”; and the term “tert-” refers to “tertiary.”

The expression “C_(a-b) alkyl” as used herein refers to a linear or branched hydrocarbon group having a carbon atom number of a to b. Specific examples of the C_(a-b) alkyl include methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, sec-butyl, tert-butyl, n-pentyl, 1-ethylpropyl, 2,2-dimethylpropyl, and n-hexyl. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) haloalkyl” as used herein refers to a linear or branched hydrocarbon group having a carbon atom number of a to b wherein a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. When the hydrocarbon group is substituted with two or more halogen atoms, these halogen atoms may be identical to or different from one another. Specific examples of the C_(a-b) haloalkyl include fluoromethyl, chloromethyl, bromomethyl, iodomethyl, difluoromethyl, dichloromethyl, trifluoromethyl, chlorodifluoromethyl, trichloromethyl, bromodifluoromethyl, 1-fluoroethyl, 2-fluoroethyl, 2-chloroethyl, 2-bromoethyl, 1,1-difluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2,2-trichloroethyl, 2-bromo-2,2-difluoroethyl, 1,1,2,2-tetrafluoroethyl, 2-chloro-1,1,2-trifluoroethyl, pentafluoroethyl, 2,2-difluoropropyl, 3,3,3-trifluoropropyl, 3-bromo-3,3-difluoropropyl, 2,2,3,3-tetrafluoropropyl, 2,2,3,3,3-pentafluoropropyl, 1,1,2,3,3,3-hexafluoropropyl, heptafluoropropyl, 2,2,2-trifluoro-1-methylethyl, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl, 1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl, 2,2,2-trifluoro-1,1-dimethylethyl, 2,2,3,4,4,4-hexafluorobutyl, 2,2,3,3,4,4,4-heptafluorobutyl, and nonafluorobutyl. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) alkenyl” as used herein refers to a linear or branched unsaturated hydrocarbon group having a carbon atom number of a to b and having one or more double bonds in the molecule. Specific examples of the C_(a-b) alkenyl include vinyl, 1-propenyl, 2-propenyl, 1-methylethenyl, 1-butenyl, 2-butenyl, 1-methyl-1-propenyl, 2-methyl-1-propenyl, 2-methyl-2-propenyl, and 3-methyl-3-butenyl. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) haloalkenyl” as used herein refers to a linear or branched unsaturated hydrocarbon group having a carbon atom number of a to b and having one or more double bonds in the molecule wherein a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. When the hydrocarbon group is substituted with two or more halogen atoms, these halogen atoms may be identical to or different from one another. Specific examples of the C_(ab) haloalkenyl include 2,2-difluorovinyl, 2,2-dichlorovinyl, 2-fluoro-2-propenyl, 2-chloro-2-propenyl, 3-chloro-2-propenyl, 2-bromo-2-propenyl, 3,3-difluoro-2-propenyl, 2,3-dichloro-2-propenyl, 3,3-dichloro-2-propenyl, 2,3,3-trifluoro-2-propenyl, 2,3,3-trichloro-2-propenyl, 1-(trifluoromethyl)ethenyl, 4,4-difluoro-3-butenyl, 3,4,4-trifluoro-3-butenyl, and 3-chloro-4,4,4-trifluoro-2-butenyl. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) alkynyl” as used herein refers to a linear or branched unsaturated hydrocarbon group having a carbon atom number of a to b and having one or more triple bonds in the molecule. Specific examples of the C_(ab) alkynyl include ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 1-hexynyl, 3-hexynyl, 3-methyl-1-pentynyl, 4-methyl-1-pentynyl, and 3,3-dimethyl-1-butynyl. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) haloalkynyl” as used herein refers to a linear or branched unsaturated hydrocarbon group having a carbon atom number of a to b and having one or more triple bonds in the molecule wherein a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom. When the hydrocarbon group is substituted with two or more halogen atoms, these halogen atoms may be identical to or different from one another. Specific examples of the C_(ab) haloalkynyl include 2-chloroethynyl, 2-bromoethynyl, 2-iodoethynyl, 3-chloro-2-propynyl, 3-bromo-2-propynyl, and 3-iodo-2-propynyl. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) alkoxy” as used herein refers to an alkyl-O— group wherein the alkyl has the same meaning as defined above and has a carbon atom number of a to b. Specific examples of the C_(a-b) alkoxy include methoxy, ethoxy, n-propyloxy, i-propyloxy, n-butyloxy, i-butyloxy, sec-butyloxy, tert-butyloxy, n-pentyloxy, and n-hexyloxy. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) haloalkoxy” as used herein refers to a haloalkyl-O-group wherein the haloalkyl has the same meaning as defined above and has a carbon atom number of a to b. Specific examples of the C_(a-b) haloalkoxy include difluoromethoxy, trifluoromethoxy, chlorodifluoromethoxy, bromodifluoromethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2,2,2-trifluoroethoxy, 1,1,2,2-tetrafluoroethoxy, 2-chloro-1,1,2-trifluoroethoxy, and 1,1,2,3,3,3-hexafluoropropyloxy. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) alkylthio” as used herein refers to an alkyl-S— group wherein the alkyl has the same meaning as defined above and has a carbon atom number of a to b. Specific examples of the C_(a-b) alkylthio include methylthio, ethylthio, n-propylthio, i-propylthio, n-butylthio, i-butylthio, sec-butylthio, and tert-butylthio. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(ab) haloalkylthio” as used herein refers to a haloalkyl-S-group wherein the haloalkyl has the same meaning as defined above and has a carbon atom number of a to b. Specific examples of the C_(a-b) haloalkylthio include difluoromethylthio, trifluoromethylthio, chlorodifluoromethylthio, trichloromethylthio, bromodifluoromethylthio, 2,2,2-trifluoroethylthio, 1,1,2,2-tetrafluoroethylthio, 2-chloro-1,1,2-trifluoroethylthio, pentafluoroethylthio, 1,1,2,3,3,3-hexafluoropropylthio, heptafluoropropylthio, 1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethylthio, and nonafluorobutylthio. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(ab) alkylsulfinyl” as used herein refers to an alkyl-S(O)-group wherein the alkyl has the same meaning as defined above and has a carbon atom number of a to b. Specific examples of the C_(ab) alkylsulfinyl include methylsulfinyl, ethylsulfinyl, n-propylsulfinyl, i-propylsulfinyl, n-butylsulfinyl, i-butylsulfinyl, sec-butylsulfinyl, and tert-butylsulfinyl. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) haloalkylsulfinyl” as used herein refers to a haloalkyl-S(O)— group wherein the haloalkyl has the same meaning as defined above and has a carbon atom number of a to b. Specific examples of the C_(a-b) haloalkylsulfinyl include difluoromethylsulfinyl, trifluoromethylsulfinyl, chlorodifluoromethylsulfinyl, bromodifluoromethylsulfinyl, 2,2,2-trifluoroethylsulfinyl, 1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethylsulfinyl, and nonafluorobutylsulfinyl. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) alkylsulfonyl” as used herein refers to an alkyl-S(O)₂— group wherein the alkyl has the same meaning as defined above and has a carbon atom number of a to b. Specific examples of the C_(a-b) alkylsulfonyl include methylsulfonyl, ethylsulfonyl, n-propylsulfonyl, i-propylsulfonyl, n-butylsulfonyl, i-butyl sulfonyl, sec-butyl sulfonyl, and tert-butyl sulfonyl. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) haloalkylsulfonyl” as used herein refers to a haloalkyl-S(O)₂— group wherein the haloalkyl has the same meaning as defined above and has a carbon atom number of a to b. Specific examples of the C_(a-b) haloalkylsulfonyl include difluoromethylsulfonyl, trifluoromethylsulfonyl, chlorodifluoromethylsulfonyl, bromodifluoromethylsulfonyl, 2,2,2-trifluoroethylsulfonyl, 1,1,2,2-tetrafluoroethylsulfonyl, and 2-chloro-1,1,2-trifluoroethylsulfonyl. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) cycloalkyl” as used herein refers to a cyclic hydrocarbon group having a carbon atom number of a to b, and the hydrocarbon group can form a monocyclic or multi-cyclic structure of a 3-membered to 10-membered ring. Each ring is optionally substituted with alkyl within a range of the specified number of carbon atoms. Specific examples of the C_(a-b) cycloalkyl include cyclopropyl, 1-methylcyclopropyl, 2-methylcyclopropyl, 2,2-dimethylcyclopropyl, cyclobutyl, cyclopentyl, and cyclohexyl. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) halocycloalkyl” as used herein refers to a cyclic hydrocarbon group having a carbon atom number of a to b wherein a hydrogen atom bonded to a carbon atom is optionally substituted with a halogen atom, and the hydrocarbon group can form a monocyclic or multi-cyclic structure of a 3-membered to 10-membered ring. Each ring is optionally substituted with alkyl within a range of the specified number of carbon atoms, and the halogen atom may be substituted on a cyclic structure moiety, a side chain moiety, or both of these moieties. When the hydrocarbon group is substituted with two or more halogen atoms, these halogen atoms may be identical to or different from one another. Specific examples of the C_(a-b) halocycloalkyl include 2,2-difluorocyclopropyl, 2,2-dichlorocyclopropyl, 2,2-dibromocyclopropyl, 2,2-difluoro-1-methylcyclopropyl, 2,2-dichloro-1-methylcyclopropyl, 2,2-dibromo-1-methylcyclopropyl, and 2,2,3,3-tetrafluorocyclobutyl. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “benzyl” as used herein refers to “C₆H₅—CH₂—.”

The expression “(C_(a-b)) alkyl substituted with R⁴”, “(C_(a-b)) alkyl substituted with R¹⁰”, “(C_(a-b)) alkyl substituted with R¹²”, “(C_(a-b)) alkyl substituted with R¹⁴”, “(C_(a-b)) alkyl substituted with R²²”, “(C_(a-b)) alkyl substituted with R²⁶”, “(C_(a-b)) alkyl substituted with R²⁷”, “(C_(a-b)) alkyl substituted with R³⁴”, “(C_(a-b)) alkyl substituted with R³⁷”, “(C_(a-b)) alkyl substituted with R³⁹”, “(C_(a-b)) alkyl substituted with R⁴⁶”, or “(C_(a-b)) alkyl substituted with R⁴⁷” as used herein refers to an alkyl group having a carbon atom number of a to b wherein any hydrogen atom bonded to a carbon atom is partially or completely substituted with one or more substituents R⁴, R¹⁰, R¹², R¹⁴, R²², R²⁶, R²⁷, R³⁴, R³⁷, R³⁹, R⁴⁶, or R⁴⁷, and the alkyl has the same meaning as defined above. Each group is selected within a range of the specified number of carbon atoms. When two or more substituents R4, R¹⁰, R¹², R¹⁴, R²², R²⁶, R²⁷, R³⁴, R³⁷, R³⁹, R⁴⁶ or R⁴⁷ are present, the substituents R⁴, R¹⁰, R¹², R¹⁴, R²², R²⁶, R²⁷, R³⁴, R³⁷, R³⁹, R⁴⁶ or R⁴⁷ may be identical to or different from one another.

The expression “(C_(a-b)) alkynyl substituted with R¹⁹” as used herein refers to an alkynyl group having a carbon atom number of a to b wherein any hydrogen atom bonded to a carbon atom is partially or completely substituted with one or more substituents R¹⁹, and the alkynyl has the same meaning as defined above. Each group is selected within a range of the specified number of carbon atoms. When two or more substituents R¹⁹ are present, the substituents R¹⁹ may be identical to or different from one another.

The expression “(C_(a-b)) cycloalkyl substituted with R⁴⁴” or “(C_(a-b)) cycloalkyl substituted with R⁴⁵” as used herein refers to a cycloalkyl group having a carbon atom number of a to b wherein any hydrogen atom bonded to a carbon atom is partially or completely substituted with one or more substituents R⁴⁴ or R⁴⁵, and the cycloalkyl has the same meaning as defined above. Each group is selected within a range of the specified number of carbon atoms. When two or more substituents R⁴⁴ or R⁴⁵ are present, the substituents R⁴⁴ or R⁴⁵ may be identical to or different from one another.

The expression “C_(a-b) cycloalkyl (C_(d-e)) alkyl” as used herein refers to an alkyl group having a carbon atom number of d to e and the same meaning as defined above wherein a hydrogen atom bonded to a carbon atom is optionally substituted with a C_(a-b) cycloalkyl group having the same meaning as defined above. Each group is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) alkoxy (C_(d-e)) alkyl” as used herein refers to an alkyl group having a carbon atom number of d to e and the same meaning as defined above wherein a hydrogen atom bonded to a carbon atom is optionally substituted with a C_(a-b) alkoxy group having the same meaning as defined above. Each group is selected within a range of the specified number of carbon atoms.

The expression “tri(C_(a-b) alkyl)silyl” as used herein refers to a silyl group substituted with alkyl groups having a carbon atom number of a to b and having the same meaning as defined above wherein the alkyl groups may be identical to or different from one another. Specific examples of the tri(C_(a-b) alkyl)silyl include trimethylsilyl, triethylsilyl, tri(n-propyl)silyl, ethyldimethylsilyl, n-propyldimethylsilyl, n-butyldimethylsilyl, i-butyldimethylsilyl, and tert-butyldimethylsilyl. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) alkylcarbonyl” as used herein refers to an alkyl-C(O)— group wherein the alkyl has the same meaning as defined above and has a carbon atom number of a to b. Specific examples of the C_(a-b) alkylcarbonyl include acetyl, n-propionyl, n-butyryl, i-butyryl, n-valeryl, i-valeryl, 2-methylbutanoyl, pivaloyl, n-hexanoyl, and n-heptanoyl. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) alkoxycarbonyl” as used herein refers to an alkyl-O—C(O)— group wherein the alkyl has the same meaning as defined above and has a carbon atom number of a to b. Specific examples of the C_(a-b) alkoxycarbonyl include methoxycarbonyl, ethoxycarbonyl, n-propyloxycarbonyl, i-propyloxycarbonyl, n-butoxycarbonyl, i-butoxycarbonyl, sec-butoxycarbonyl, tert-butoxycarbonyl, and 2-ethylhexyloxycarbonyl. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) alkylamino” as used herein refers to an amino group wherein one hydrogen atom is substituted with alkyl having the same meaning as defined above and having a carbon atom number of a to b. Specific examples of the C_(a-b) alkylamino include methylamino, ethylamino, n-propylamino, i-propylamino, n-butylamino, i-butylamino, and tert-butylamino. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) haloalkylamino” as used herein refers to an amino group wherein one hydrogen atom is substituted with haloalkyl having the same meaning as defined above and having a carbon atom number of a to b. Specific examples of the C_(a-b) haloalkylamino include 2,2,2-trifluoroethylamino, 2-chloro-2,2-difluoroethylamino, and 3,3,3-trifluoropropylamino. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “di(C_(a-b)) alkylamino” as used herein refers to an amino group wherein both hydrogen atoms are substituted with alkyl groups which have the same meaning as defined above and have a carbon atom number of a to b and which may be identical to or different from each other. Specific examples of the di(C_(ab)) alkylamino include dimethylamino, ethyl(methyl)amino, diethylamino, n-propyl(methyl)amino, i-propyl(methyl)amino, di(n-propyl)amino, and di(n-butyl)amino. Each of these groups is selected within a range of the specified number of carbon atoms.

The expression “C_(a-b) alkylthio (C_(d-e)) alkyl” as used herein refers to an alkyl group having the same meaning as defined above and having a carbon atom number of d to e wherein a hydrogen atom bonded to a carbon atom is optionally substituted with a C_(ab) alkylthio group having the same meaning as defined above. Each group is selected within a range of the specified number of carbon atoms.

The expression “phenyl substituted with (Z²)_(p5a)”, “phenyl substituted with (Z³)_(p5b)”, or “phenyl substituted with (Z⁴)_(p5c)” as used herein refers to a phenyl group wherein p5a, p5b, or p5c hydrogen atoms bonded to carbon atoms of the benzene ring are substituted with substituents Z², Z³, or Z⁴ at any positions.

The expression “benzyl substituted with (Z⁴)_(p5c)” as used herein refers to a benzyl group (C₆H₅—CH₂—) wherein p5c hydrogen atoms bonded to carbon atoms of the benzene ring are substituted with substituents Z⁴ at any positions.

The production method of the present invention will next be described. In the following description, the symbol Ph denotes phenyl, and the symbol Bn denotes a benzyl group.

The compound of the present invention may include geometrical isomers (i.e., E-form and Z-form) depending on the types of substituents. In the following description, a mixture containing an E-form and a Z-form in any proportions is represented as a bond of a wavy line shown below.

The compound of the present invention of Formula (1) can be produced by, for example, any of the methods described below.

Production Method A

A compound of Formula (1) [wherein G, W¹, X, R¹, R², R³, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1)”] can be produced by reacting a compound of Formula (2) [wherein G, W¹, X, R¹, R², Z¹, and n have the same meanings as defined above, and J¹ is a chlorine atom, a bromine atom, or an iodine atom] [hereinafter the compound will be referred to as “compound (2)”] with a compound of Formula (3) [wherein R³ has the same meaning as defined above] [hereinafter the compound will be referred to as “compound (3)”] or a compound of Formula (4) [wherein R³ has the same meaning as defined above] [hereinafter the compound will be referred to as “compound (4)”] in the presence of a palladium catalyst (e.g., palladium(II) acetate, tetrakis(triphenylphosphine)palladium(0), or [1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloride) in an amount of 0.001 to 0.5 equivalents by mole relative to compound (2) at a temperature ranging from room temperature to the reflux temperature of the reaction mixture for one hour to 48 hours, with optional use of a solvent (e.g., benzene, toluene, methanol, ethanol, propanol, 1,4-dioxane, tetrahydrofuran, dimethoxyethane, N,N-dimethylformamide, N,N-dimethylacetamide, dimethyl sulfoxide, water, or a mixture containing two or more of these in any proportions), with optional use of a base (e.g., sodium carbonate, potassium carbonate, cesium carbonate, potassium phosphate, sodium hydrogen carbonate, potassium hydrogen carbonate, triethylamine, or N,N-diisopropylethylamine) in an amount of 1 to 10 equivalents by mole relative to compound (2), and with optional addition of a ligand (e.g., triphenylphosphine, tricyclohexylphosphine, 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl, 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl, or 1,1′-bis(diphenylphosphino)ferrocene) in an amount of 0.001 to 0.5 equivalents by mole relative to compound (2).

Some of compounds (3) and compounds (4) used herein are known compounds and are available as commercial products. The other compounds can also be synthesized by known methods described in literature, for example, methods described in Japanese Unexamined Patent Application Publication No. 2002-47292 (JP 2002-47292 A), Tetrahedron, 2006, Vol. 62, page 2831, and European Journal of Organic Chemistry, 2009, Vol. 2009, No. 23, page 3964.

Production Method B

A compound of Formula (1-3) [wherein W¹, X, R¹, R², R³, R⁵, Z¹, same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-3)”], which is a type of compound (1) wherein G is —C(O)R⁵, can be produced by reacting a compound of Formula (1-1) [wherein W¹, X, R¹, R², R³, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-1)”], which is a type of compound (1) wherein G is a hydrogen atom, with a compound of Formula (5) [wherein R⁵ has the same meaning as defined above, and J² is a chlorine atom, a bromine atom, a C₁₋₄ alkylcarbonyloxy group (e.g., pivaloyl), a C₁₋₄ alkoxycarbonyloxy group (e.g., isobutyloxycarbonyloxy), or an azolyl group (e.g., imidazol-1-yl)] [hereinafter the compound will be referred to as “compound (5)”] at a temperature ranging from 0° C. to the reflux temperature of the reaction mixture for 30 minutes to 24 hours, with optional use of a solvent (e.g., benzene, toluene, dichloromethane, chloroform, 1,2-dichloroethane, diethyl ether, tert-butyl methyl ether, tetrahydrofuran, 1,4-dioxane, ethyl acetate, N,N-dimethylformamide, N,N-dimethylacetamide, acetonitrile, water, or a mixture containing two or more of these in any proportions), and optionally in the presence of a base (e.g., sodium carbonate, potassium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, triethylamine, N,N-diisopropylethylamine, pyridine, or 4-(dimethylamino)pyridine) in an amount of 1 to 3 equivalents by mole relative to compound (1-1).

Some of compounds (5) used herein are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds.

Production Method C

A compound of Formula (1-4) [wherein W¹, X, R¹, R². R³, R⁶, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-4)”], which is a type of compound (1) wherein G is —S(O)₂R⁶, can be produced by reacting compound (1-1) with a compound of Formula (6) [wherein R⁶ has the same meaning as defined above, and J³ is a fluorine atom, a chlorine atom, a bromine atom, or —OS(O)₂R⁶] [hereinafter the compound will be referred to as “compound (6)”] at a temperature ranging from 0° C. to the reflux temperature of the reaction mixture for 30 minutes to 24 hours, with optional use of a solvent (e.g., benzene, toluene, dichloromethane, chloroform, 1,2-dichloroethane, diethyl ether, tert-butyl methyl ether, tetrahydrofuran, 1,4-dioxane, ethyl acetate, N,N-dimethylformamide, N,N-dimethylacetamide, acetonitrile, water, or a mixture containing two or more of these in any proportions), and optionally in the presence of a base (e.g., sodium carbonate, potassium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, triethylamine, N,N-diisopropylethylamine, pyridine, or 4-(dimethylamino)pyridine) in an amount of 1 to 3 equivalents by mole relative to compound (1-1).

Some of compounds (6) used herein are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds.

Production Method D

A compound of Formula (1-2) [wherein G², W¹, X, R¹, R², R³, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-2)”], which is a type of compound (1) wherein G is G², can be produced by reacting compound (1-1) with a compound of Formula (7) [wherein G² is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R⁴; J⁴ is a chlorine atom, a bromine atom, an iodine atom, C₁₋₆ alkylsulfonyloxy, or C₁₋₆ haloalkylsulfonyloxy; and R⁴ has the same meaning as defined above] [hereinafter the compound will be referred to as “compound (7)”] at a temperature ranging from −78° C. to the reflux temperature of the reaction mixture for 30 minutes to 24 hours, with optional use of a solvent (e.g., benzene, toluene, diethyl ether, tert-butyl methyl ether, tetrahydrofuran, 1,4-dioxane, N,N-dimethylformamide, N,N-dimethylacetamide, acetonitrile, dimethyl sulfoxide, sulfolane, triamide hexamethylphosphate, water, or a mixture containing two or more of these in any proportions), and optionally in the presence of a base (e.g., sodium hydroxide, potassium hydroxide, lithium hydroxide, calcium hydroxide, sodium carbonate, potassium carbonate, cesium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, sodium hydride, potassium hydride, potassium tert-butoxide, lithium diisopropylamide, sodium bis(trimethylsilyl)amide, or lithium bis(trimethylsilyl)amide) in an amount of 1 to 3 equivalents by mole relative to compound (1-1).

Some of compounds (7) used herein are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds.

Production Method E

A compound of Formula (1b) [wherein G, X, R¹, R², R³, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1b)”], which is a type of compound (1) wherein W¹ is a sulfur atom, can be produced by reacting a compound of Formula (1a) [wherein G, X, R¹, R², R³, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1a)”], which is a type of compound (1) wherein W¹ is an oxygen atom, with diphosphorus pentasulfide or Lawesson's reagent: 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide] in an amount of 1 to 10 equivalents by mole relative to compound (1a) at a temperature ranging from room temperature to the reflux temperature of the reaction mixture for 30 minutes to 24 hours, with optional use of a solvent (e.g., benzene, toluene, xylene, pyridine, piperidine, diethyl ether, tert-butyl methyl ether, tetrahydrofuran, 1,4-dioxane, methanol, ethanol, water, or a mixture containing two or more of these in any proportions).

Compound (1-1a) can be produced by the method described below.

Production Method F

A compound of Formula (1-1a) [wherein X, R¹, R², R³, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-1a)”], which is a type of compound (1-1) wherein W¹ is an oxygen atom, can be produced by reacting a compound of Formula (8) [wherein X, R¹, R², R³, Z¹, and n have the same meanings as defined above, and R^(x) is C₁₋₆ alkyl] [hereinafter the compound will be referred to as “compound (8)”] at a temperature ranging from room temperature to the reflux temperature of the reaction mixture for 30 minutes to 24 hours, with optional use of a solvent (e.g., hexane, heptane, benzene, toluene, diethyl ether, diisopropyl ether, tetrahydrofuran, 1,4-dioxane, dichloromethane, chloroform, 1,2-dichloroethane, N,N-dimethylformamide, N,N-dimethylacetamide, dimethyl sulfoxide, acetonitrile, acetone, methyl ethyl ketone, acetonitrile, water, or a mixture containing two or more of these in any proportions), and optionally in the presence of a base (e.g., triethylamine, tributylamine, diisopropylethylamine, pyridine, 4-(dimethylamino)pyridine, 1,8-diazabicyclo[5,4,0]-7-undecene, 1,4-diazabicyclo[2,2,2]octane, sodium hydroxide, potassium hydroxide, calcium hydroxide, sodium carbonate, potassium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, sodium hydride, or potassium tert-butoxide) in an amount of 1 to 5 equivalents by mole relative to compound (8).

Production Method G

Compound (1-1) can be produced by reacting compound (1-2) with morpholine in an amount of 1 to 20 equivalents by mole relative to compound (1-2) at a temperature ranging from 0° C. to the reflux temperature of the reaction mixture for one hour to 48 hours, with optional use of a solvent (e.g., benzene, toluene, xylene, N,N-dimethylformamide, N,N-dimethylacetamide, N-methyl-2-pyrrolidone, dimethyl sulfoxide, sulfolane, acetonitrile, water, or a mixture containing two or more of these in any proportions); or reacting compound (1-2) with a protonic acid (e.g., sulfuric acid or hydrochloric acid) or a Lewis acid (e.g., boron bromide, aluminum chloride, or zinc chloride) in an amount of 1 to 100 equivalents by mole relative to compound (1-2) at a temperature ranging from −78° C. to the reflux temperature of the reaction mixture for one hour to 48 hours, with optional use of a solvent (e.g., dichloromethane, chloroform, 1,2-dichloroethane, carbon tetrachloride, or a mixture containing two or more of these in any proportions); or reacting compound (1-2) with a base (e.g., sodium hydroxide, potassium hydroxide, or lithium hydroxide) in an amount of 1 to 20 equivalents by mole relative to compound (1-2) at a temperature ranging from 0° C. to the reflux temperature of the reaction mixture for one hour to 48 hours, with optional use of a solvent (e.g., methanol, ethanol, normal propanol, isopropanol, normal butanol, 1,4-dioxane, 1,2-dimethoxyethane, tetrahydrofuran, water, or a mixture containing two or more of these in any proportions).

Production Method H

Compound (1-1) can be produced by reacting compound (1-3) with sodium hydroxide, potassium hydroxide, lithium hydroxide, sodium methoxide, or sodium ethoxide in an amount of 1 to 5 equivalents by mole relative to compound (1-3) at a temperature ranging from 0° C. to the reflux temperature of the reaction mixture for one hour to 48 hours, with optional use of a solvent (e.g., methanol, ethanol, benzene, toluene, tetrahydrofuran, 1,4-dioxane, acetonitrile, acetone, water, or a mixture containing two or more of these in any proportions).

Production Method I

A compound of Formula (1-5) [wherein W¹, X, G, R¹, R³, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-5)”], which is a type of compound (1) wherein R² is a hydrogen atom, can be produced by reacting a compound of Formula (1-6) [wherein W¹, X, G, R¹, R³, J¹, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-6)”], which is a type of compound (1) wherein R² is J¹⁻, in a hydrogen atmosphere at a temperature ranging from 0° C. to the reflux temperature of the reaction mixture for 30 minutes to 50 hours in the presence of a palladium carbon catalyst in an amount of 0.1 to 3 parts by mass relative to compound (1-6), with use of a solvent (e.g., methanol, ethanol, benzene, toluene, 1,4-dioxane, tetrahydrofuran, dimethoxyethane, ethyl acetate, acetonitrile, N,N-dimethylformamide, acetic acid, water, or a mixture containing two or more of these in any proportions), and with optional use of an acid (e.g., hydrochloric acid, sulfuric acid, or methanesulfonic acid) or a base (e.g., triethylamine, N,N-diisopropylethylamine, or pyridine).

Production Method J

A compound of Formula (1-6) [wherein X, G, R¹, R³, Z¹, n, and J¹ have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-6)”], which is a type of compound (1) wherein R² is J¹, can be produced by reacting a compound of Formula (1-7) [wherein W¹, X, G, R¹, R³, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-7)”], which is a type of compound (1) wherein R² is —NH₂, with sodium nitrite (9) or a compound of Formula (10) [wherein J⁵ is C₃₋₆ alkyl] [hereinafter the compound will be referred to as “compound (10)”] in an amount of 0.5 to 5 equivalents by mole relative to compound (1-7) and a compound of Formula (11) [wherein J¹ has the same meaning as defined above] [hereinafter the compound will be referred to as “compound (11)”] at a temperature ranging from 0° C. to the reflux temperature of the reaction mixture for 30 minutes to 24 hours, with optional use of, for example, copper chloride, copper bromide, copper iodide, or potassium iodide, and with use of a solvent (e.g., methanol, ethanol, 1,4-dioxane, tetrahydrofuran, acetonitrile, dichloromethane, N,N-dimethylformamide, water, or a mixture containing two or more of these in any proportions).

Compounds (9), (10), and (11) used herein are known compounds and some of them are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds.

Production Method K

Compound (1-7) can be produced by reacting a compound of Formula (1-8) [wherein X, G, R¹, R³, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-8)”], which is a type of compound (1) wherein R² is —N(Bn)₂, in a hydrogen atmosphere at a temperature ranging from 0° C. to the reflux temperature of the reaction mixture for 30 minutes to 100 hours in the presence of a palladium carbon catalyst in an amount of 0.1 to 3 parts by mass relative to compound (1-8), with use of a solvent (e.g., methanol, ethanol, benzene, toluene, 1,4-dioxane, tetrahydrofuran, dimethoxyethane, ethyl acetate, acetonitrile, N,N-dimethylformamide, acetic acid, water, or a mixture containing two or more of these in any proportions), and with optional addition of an acid catalyst (e.g., hydrochloric acid, sulfuric acid, or methanesulfonic acid).

Production Method L

A compound of Formula (1-10) [wherein W¹, G, X, R¹, R², and R³ have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-10)”], which is a type of compound (1) wherein Z¹ is a hydroxy group, can be produced by reacting a compound of Formula (1-9) [wherein W¹, G, X, R¹, R², and R³ have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-9)”], which is a type of compound (1) wherein at least one Z¹ is —OBn, in a hydrogen atmosphere at a temperature ranging from 0° C. to the reflux temperature of the reaction mixture for 30 minutes to 50 hours in the presence of a palladium carbon catalyst in an amount of 0.1 to 3 parts by mass relative to compound (1-9), with use of a solvent (e.g., methanol, ethanol, benzene, toluene, 1,4-dioxane, tetrahydrofuran, dimethoxyethane, ethyl acetate, acetonitrile, N,N-dimethylformamide, acetic acid, water, or a mixture containing two or more of these in any proportions), and with optional use of an acid (e.g., hydrochloric acid, sulfuric acid, or methanesulfonic acid) or a base (e.g., triethylamine, N,N-diisopropylethylamine, or pyridine). Subsequently, a compound of Formula (1-11) [wherein G, X, R¹, R², R³, and R^(35a) have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-11)”] can be produced by reacting compound (1-10) with a compound of Formula (12) [wherein J⁴ has the same meaning as defined above, and R^(35a) corresponds to substituents represented by R³⁵ (except for a hydrogen atom)] [hereinafter the compound will be referred to as “compound (12)”] at a temperature ranging from room temperature to the reflux temperature of the reaction mixture for 30 minutes to 24 hours, with use of a solvent (e.g., tetrahydrofuran, 1,4-dioxane, dichloromethane, chloroform, 1,2-dichloroethane, N,N-dimethylformamide, N,N-dimethylacetamide, dimethyl sulfoxide, acetonitrile, acetone, methyl ethyl ketone, acetonitrile, water, or a mixture containing two or more of these in any proportions), and in the presence of a base (e.g., sodium hydroxide, potassium carbonate, cesium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, sodium hydride, potassium hydride, potassium tert-butoxide, triethylamine, tributylamine, diisopropylethylamine, pyridine, 4-(dimethylamino)pyridine, or 1,8-diazabicyclo[5,4,0]-7-undecene) in an amount of 1 to 5 equivalents by mole relative to compound (1-10).

Some of compounds (12) used herein are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds.

Production Method M

A compound of Formula (1-13) [wherein W¹, Z¹, X, G, n, R¹, R², and R³ have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-13)”], which is a type of compound (1) wherein at least one Y¹ is a hydroxy group, can be produced by reacting a compound of Formula (1-12) [wherein W¹, Z¹, X, G, n, R¹, R², and R³ have the same meanings as defined above; note: BnO—, HO—, and R^(11a)O— are originally included in R³, but are shown in the Formulae separately from R³ for the sake of convenience and clarity] [hereinafter the compound will be referred to as “compound (1-12)”], which is a type of compound (1) wherein at least one Y¹ in R³ is —OBn, under the same conditions as in production method L. Subsequently, a compound of Formula (1-14) [wherein W¹, Z¹, X, G, n, R¹, R², R³, and R^(11a) have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-14)”], which is a type of compound (1) wherein at least one Y¹ is —OR^(11a) can be produced by reacting compound (1-13) with a compound of Formula (13) [wherein J⁴ has the same meaning as defined above, and R^(11a) corresponds to substituents represented by (except for a hydrogen atom)] [hereinafter the compound will be referred to as “compound (13)”] in the same manner as in production method L.

Some of compounds (13) used herein are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds.

Production Method N

A compound of Formula (1-16) [wherein W¹, G, X, R¹, R², and R³ have the same meanings as defined above, and Z^(1b) is —NR¹⁵R¹⁶ or —N═C(C₆H₅)₂] [hereinafter the compound will be referred to as “compound (1-16)”], which is a type of compound (1) wherein at least one Z¹ is —NR¹⁵R¹⁶ or —N═C(C₆H₅)₂, can be produced by reacting a compound of Formula (1-15) [wherein W¹, X, G, R¹, R², and R³ have the same meanings as defined above, and Z^(1a) is a chlorine atom, a bromine atom, an iodine atom, C₁₋₆ alkylsulfonyloxy or C₁₋₆ haloalkylsulfonyloxy] [hereinafter the compound will be referred to as “compound (1-15)”], which is a type of compound (1) wherein at least one Z¹ is Z^(1a), with a compound of Formula (14) [wherein R¹⁵ and R¹⁶ have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (14)”] or benzophenoneimine (15) through a method described in, for example, International Publication WO 2013/033228 or WO 2016/102420 in the presence of a palladium catalyst.

Some of compounds (14) and (15) used herein are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds.

Production Method 0

A compound of Formula (1-17) [wherein W¹, X, G, R¹, R², R³, and Z^(1c) have the same meanings as defined above], which is a type of compound (1) wherein at least one Z¹ is Z^(1c), can be produced by reacting compound (1-15) with a compound of Formula (16) [wherein Z^(1c) is phenyl, phenyl substituted with (Z⁴)_(p5c), Q-2, Q-3, Q-⁴, Q-5, or C₃₋₆ cycloalkyl] or a compound of Formula (17) [wherein Z^(1c) has the same meaning as defined above] through a method described in, for example, International Publication WO 2019/178129 or Angewandte Chemie, International Edition, 2018, Vol. 57, page 14198 in the presence of a palladium catalyst.

Some of compounds (16) and (17) used herein are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds.

Production Method P

A compound of Formula (1-18) [wherein W¹, X, G, R¹, R², R³, and R^(a) have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-18)”] can be produced by reacting compound (1-15) with a compound of Formula (18) [wherein R^(a) is C₁₋₄ alkyl, C₃₋₆ cycloalkyl, or tri(C₁₋₆ alkyl)silyl] [hereinafter the compound will be referred to as “compound (18)”] through a method described in, for example, The Journal of Organic Chemistry, 2007, Vol. 72, page 6672.

Some of compounds (18) used herein are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds.

Production Method Q

A compound of Formula (1-19) [wherein W¹, X, G, R¹, R², R³, and R^(36a) have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-19)”], which is a type of compound (1) wherein at least one Z¹ is —SR^(36a), can be produced by reacting compound (1-15) with a compound of Formula (19) [wherein R^(36a) is C₁₋₆ haloalkyl] [hereinafter the compound will be referred to as “compound (19)”] through a method described in, for example, U.S. Patent Application Publication No. 6215021.

Some of compounds (19) used herein are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds.

Production Method R

A compound of Formula (1-20) [wherein W¹, X, G, R¹, R², R³, and R^(y) have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-20)”] is prepared by reacting compound (1-15) with a compound of Formula (20) [wherein R^(y) is C₁₋₁₀ alkyl] [hereinafter the compound will be referred to as “compound (20)”] through a method described in, for example, International Publication WO 2016/044770 in the presence of a palladium catalyst. Subsequently, a compound of Formula (1-21) [wherein X, G, R¹, R², R³, and R³⁶ have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (1-21)”], which is a type of compound (1) wherein at least one Z¹ is —SR³⁶, can be produced by reacting compound (1-20) with a compound of Formula (20) [wherein R³⁶ and J⁴ have the same meanings defined above] [hereinafter the compound will be referred to as “compound (20)”] in the presence of a base (e.g., sodium methoxide, sodium ethoxide, or potassium tert-butoxide) in an amount of 1 to 20 equivalents by mole relative to compound (1-20).

Some of compounds (20) and (21) used herein are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds.

In production methods A to R, the reaction mixture after completion of the reaction can be subjected to a common post-treatment (e.g., direct concentration; or dissolution in an organic solvent, washing with water, and subsequent concentration; or addition into ice water, extraction with an organic solvent, and subsequent concentration), to thereby yield a pyridazinone compound of interest. When purification is required, the reaction mixture can be purified through separation of impurities by any purification technique, such as recrystallization, column chromatography, thin-layer chromatography, or preparative liquid chromatography.

Compound (2) used in production method A can be synthesized as shown in, for example, reaction scheme 1.

Compound (2) can be produced by reacting a compound of Formula (21) [wherein W¹, G, R¹, R², Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (21)”] with a compound of Formula (22) [wherein J¹ has the same meaning as defined above] [hereinafter the compound will be referred to as “compound (22)”] or a compound of Formula (23) [wherein J¹ has the same meaning as defined above] [hereinafter the compound will be referred to as “compound (23)”] through a method described in, for example, Chemistry of Heterocyclic Compounds, 2017, Vol. 53, page 1156.

Some of compounds (21) used in reaction scheme 1 are known compounds and can be synthesized by a method described in literature, for example, a method described in International Publication WO 2015/168010 or WO 2017/074992.

Compound (22) or (23) used in reaction scheme 1 is also a known compound and is available as a commercial product.

Compound (8) used in production method F can be synthesized as shown in reaction scheme 2 or 3, and compound (8-1a), which is a type of compound (8) wherein R¹ is R^(1a), can be synthesized as shown in reaction scheme 4.

A compound of Formula (26) [wherein X, R³, Z¹, n, and J⁶ have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (26)”] is prepared by reacting a compound of Formula (24) [wherein X, R³, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (24)”] with a compound of Formula (25) [wherein J⁶ is pentafluorophenyl or 2,4,6-trichlorophenyl] [hereinafter the compound will be referred to as “compound (25)”] through a method described in, for example, International Publication WO 2017/074992 with use of a condensing agent such as N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride. Subsequently, a compound of Formula (28) [wherein X, R¹, R³, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (28)”] can be produced by reacting compound (26) with a hydrazine derivative of Formula (27) [wherein R¹ has the same meaning as defined above] or a salt thereof [e.g., hydrochloride, bromate, or sulfate, hereinafter referred to as “compound (27)”]. Subsequently, compound (8) can be produced by reacting compound (28) with a compound of Formula (29) [wherein R² and R^(x) have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (29)”].

Some of compounds (25), (27), and (29) used in reaction scheme 2 are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds.

A compound of Formula (32) [wherein X, R³, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (32)”] is prepared by reacting compound (24) with oxalyl chloride (30) or thionyl chloride (31) in an amount of 1 to 20 equivalents by mole relative to compound (24) at 0° C. to the reflux temperature of the reaction mixture for 30 minutes to 24 hours, with optional use of a solvent (e.g., dichloromethane, chloroform, 1,2-dichloroethane, toluene, xylene, or a mixture containing two or more of these in any proportions), and with optional addition of N,N-dimethylformamide. Subsequently, compound (8) can be produced by reacting compound (32) with a compound of Formula (33) [wherein R¹, R², and R^(x) have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (33)”] at 0° C. to the reflux temperature of the reaction mixture for 30 minutes to 24 hours, with use of a solvent (e.g., dichloromethane, chloroform, 1,2-dichloroethane, pyridine, toluene, xylene, ethyl acetate, butyl acetate, heptane, 2-butanone, water, or a mixture containing two or more of these in any proportions), and optionally in the presence of a base (e.g., triethylamine, diisopropylethylamine, pyridine, 4-dimethylaminopyridine, sodium carbonate, sodium hydrogen carbonate, potassium carbonate, potassium hydrogen carbonate, cesium carbonate, sodium hydroxide, or potassium hydroxide).

Some of compounds (33) used herein are known compounds, and the other compounds can also be synthesized by synthesis methods for known compounds; for example, a method described in Nature Communications, 2017, Vol. 8, page 1 or International Publication WO 2012/091156.

A compound of Formula (8-1a) [hereinafter the compound will be referred to as “compound (8-1a)”], which is a type of compound (8) wherein R¹ is R^(1a), can be synthesized by reacting a compound of Formula (8-1) [hereinafter the compound will be referred to as “compound (8-1)”], which is a type of compound (8) wherein R¹ is a hydrogen atom, with a compound of Formula (34) [wherein R^(1a) is C₁₋₆ alkyl, C₁₋₆ alkenyl, C₁₋₆ alkynyl, or C₁₋₆ alkyl substituted with R³⁴, and R³⁴ and J⁴ have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (34)”] through a method described in, for example, Advanced Synthesis & Catalysis, 2016, Vol. 358, page 276.

Compound (8-1) used herein can be synthesized by the method shown in reaction scheme 2 or 3. Some of compounds (34) are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds.

Some of compounds (24) used in reaction schemes 2 and 3 are known compounds and are available as commercial products. The other compounds can be synthesized by a method shown in, for example, reaction scheme 5, 6, or 7.

A compound of Formula (36) [wherein X, R^(x), Z¹, J¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (36)”] can be produced by reacting a compound of Formula (35) [wherein X, R^(x), Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (35)”] with compound (22) or compound (23) in the same manner as shown in reaction scheme 1. Subsequently, a compound of Formula (37) [wherein X, R³, R^(x), Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (37)”] can be produced by reacting with compound (36) with compound (3) or compound (4) in the same manner as in production method A. Subsequently, compound (24) can be produced by reacting compound (37) with an aqueous solution of an alkali metal (e.g., sodium hydroxide, potassium hydroxide, or lithium hydroxide) through a method described in, for example, International Publication WO 2013/009259.

Some of compounds (35) used in reaction scheme 5 are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds. The synthesis method for known compounds is described in, for example, Der Pharma Chemica, 2017, Vol. 9, page 85 and Organic Letters, 2008, Vol. 10, page 573.

A compound of Formula (37-1) [wherein X, Z¹, R³, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (37-1)”], which is a type of compound (37) wherein R^(x) is methyl, can be produced by reacting a compound of Formula (38) [wherein X, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (38)”] with a compound of Formula (39) [wherein R³ and J¹ have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (39)”] in the presence of a palladium catalyst, and by treating the reaction mixture with methyl iodide and potassium carbonate through a synthesis method for a known compound; for example, a method described in Chemistry Letters, 2011, Vol. 40, page 1015. Subsequently, compound (24) can be produced through hydrolysis of compound (37-1) in the same manner as shown in reaction scheme 5.

Some of compounds (38) used in reaction scheme 6 are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds. The synthesis method for known compounds is described in, for example, Heterocycles, 1995, Vol. 41, page 647.

Some of compounds (39) are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds.

A compound of Formula (42) [wherein X, R³, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (42)”] can be produced by reacting a compound of Formula (40) [wherein Z¹ and n have the same meanings as defined above, and J⁷ is a fluorine atom, a chlorine atom, a bromine atom, or an iodine atom] [hereinafter the compound will be referred to as “compound (40)”] with a compound of Formula (41) [wherein X and R³ have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (41)”] in the presence of a base (e.g., sodium hydroxide, potassium hydroxide, sodium carbonate, or potassium carbonate) through a synthesis method for a known compound; for example, a method described in Tetrahedron Letters, 2003, Vol. 44, page 6665. Subsequently, a compound of Formula (46) [wherein X, R³, J¹, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (46)”] can be produced by reacting compound (42) with a formaldehyde equivalent such as 1,3,5-trioxane (43), paraformaldehyde (44), or with formaldehyde (45) in the presence of compound (11) through a method described in, for example, Journal of the American Chemical Society, 1948, Vol. 70, page 3768. Subsequently, a compound of Formula (49) [wherein X, R³, Z¹, and n have the same meanings as defined above] [hereinafter the compound will be referred to as “compound (49)”] can be produced by reacting compound (46) with a compound of Formula (47) [wherein J⁸ is methyl or ethyl] [hereinafter the compound will be referred to as “compound (47)”] or a compound of Formula (48) [wherein M is an alkali metal such as sodium or potassium] [hereinafter the compound will be referred to as “compound (48)”] through a method described in, for example, Journal of Heterocyclic Chemistry, 1965, Vol. 2, page 231. Subsequently, compound (24) can be produced by reacting compound (49) with an aqueous solution of an alkali metal (e.g., sodium hydroxide, potassium hydroxide, or lithium hydroxide) or an acidic compound (e.g., hydrochloric acid, sulfuric acid, or acetic acid) through a method described in, for example, International Publication WO 2002/016353.

Some of compounds (40), (41), (47), and (48) used in reaction scheme 7 are known compounds and are available as commercial products. The other compounds can also be synthesized by synthesis methods for known compounds.

A production intermediate serving as a raw material compound for each of reaction schemes 1 to 7 can be produced by performing a common post-treatment after completion of the aforementioned reaction.

Each of the production intermediates produced by such a method can be used for the reaction in the subsequent step without isolation or purification.

Examples of the pyridazinone compound of Formula (1) of the present invention, which can be produced by any of the aforementioned methods, include compounds shown in Table 1. However, Table 1 is merely provided for illustration, and the pyridazinone compound of the present invention is not limited to examples shown in Table 1.

In Table 1, Me denotes methyl; Et, ethyl; n-Pr or Pr-n, normal propyl; i-Pr or Pr-i, isopropyl; c-Pr or Pr-c, cyclopropyl; n-Bu or Bu-n, normal butyl; i-Bu or Bu-i, isobutyl; sec-Bu or Bu-sec, secondary butyl; tert-Bu or Bu-tert, tertiary butyl; c-Bu or Bu-c, cyclobutyl; c-Pen or Pen-c, cyclopentyl; and c-Hex or Hex-c, cyclohexyl.

In Table 1, D-1 to D-56 correspond to the following structures.

In Table 1, U-1a to U-32a, T-1-1 to T-1-5, and Q-1-1 to Q-35-1 correspond to the following structures.

The expression “(Y¹)” in Table 1 refers to (Y¹)_(p7), (Y¹)_(p6), (Y¹)_(p5), (Y¹)_(P4), (Y¹)_(P3), or (Y¹)_(P2) corresponding to each of the aforementioned structures of D-1 to D-56 specified in the column of R³. The substitution position number corresponds to the numbered position in each of the aforementioned structural formulae. The expression “-” in the column of (Z¹)_(n) and “(Y¹)” refers to no substitution.

R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is-(no substitution). R³ [(Y¹)] R³ [(Y¹)] D-1 [—] D-1 [2-F] D-1 [3-F] D-1 [4-F] D-1 [2-Cl] D-1 [3-Cl] D-1 [4-Cl] D-1 [2-Me] D-1 [3-Me] D-1 [4-Me] D-1 [2-OMe] D-1 [3-OMe] D-1 [4-OMe] D-1 [2,4-F₂] D-1 [2-F-4-Me] D-1 [2-F-4-OMe] D-1 [2-Cl-4-F] D-1 [2,4-Cl₂] D-1 [2-Cl-4-Me] D-1 [2-Cl-4-OMe] D-2 [3-Cl] D-2 [4-Cl] D-2 [5-Cl] D-2 [6-Cl] D-2 [3-OMe] D-2 [4-OMe] D-2 [5-OMe] D-2 [6-OMe] D-3 [2-Cl] D-3 [4-Cl] D-3 [5-Cl] D-3 [6-Cl] D-3 [2-OMe] D-3 [4-OMe] D-3 [5-OMe] D-3 [6-OMe] D-4 [2-Cl] D-4 [3-Cl] D-4 [2-OMe] D-4 [3-OMe] D-1 [2-Et] D-1 [2-Pr-n] D-1 [3-Et] D-1 [3-Pr-n] D-1 [4-Et] D-1 [4-Pr-n] D-1 [2-Pr-i] D-1 [2-Bu-n] D-1 [3-Pr-i] D-1 [3-Bu-n] D-1 [4-Pr-i] D-1 [4-Bu-n] D-1 [4-CH₂F] D-1 [2-CHF₂] D-1 [4-CH₂Cl] D-1 [3-CHF₂] D-1 [4-CH₂Br] D-1 [4-CHF₂] D-1 [2-CF₃] D-1 [2-CH═CH₂] D-1 [3-CF₃] D-1 [3-CH═CH₂] D-1 [4-CF₃] D-1 [4-CH═CH₂] D-1 [2-CH₂CH═CH₂] D-1 [2-CH═CF₂] D-1 [3-CH₂CH═CH₂] D-1 [3-CH═CF₂] D-1 [4-CH₂CH═CH₂] D-1 [4-CH═CF₂] D-1 [2-CH═CCl₂] D-1 [2-CH═CF₂] D-1 [3-CH═CCl₂] D-1 [3-CH═CF₂] D-1 [4-CH═CCl₂] D-1 [4-CH═CF₂] D-1 [4-C≡CH] D-1 [4-C≡CMe] D-1 [4-C≡CBu-tert] D-1 [4-C≡CCl] D-1 [4-Pr-c] D-1 [4-(T-1-1)] D-1 [T-1-2] D-1 [4-(T-1-3)] D-1 [T-1-4] D-1 [4-(T-1-5)] D-1 [2-CH₂OH] D-1 [3-CH₂OH] D-1 [4-CH₂OH] D-1 [2-CH₂OMe] D-1 [3-CH₂OMe] D-1 [4-CH₂OMe] D-1 [4-CH₂OEt] D-1 [4-CH₂OPr-n] D-1 [4-CH₂OPr-i] D-1 [4-CH₂OBu-n] D-1 [4-CH₂OBu-i] D-1 [4-CH₂OBu-sec] D-1 [4-CH₂CH₂CH═CH₂] D-1 [4-CH₂OCH₂C(Me)═CH₂] D-1 [4-CH₂CH₂CH═CHMe] D-1 [4-CH₂OCH(Me)CH═CH₂] D-1 [4-CH₂OCH₂CH═C(Me)₂] D-1 [4-CH₂OC(Me)₂CH═CH₂] D-1 [4-CH₂OCH₂C≡CH] D-1 [4-CH₂OCH(Me)C≡CH] D-1 [4-CH₂OCH₂C≡CMe] D-1 [4-CH₂OC(Me)₂C≡CH] D-1 [4-CH₂OCH₂CH₂C≡CH] D-1 [4-CH₂OC(Me)(Et)C≡CH] D-1 [2-CH₂OCHF₂] D-1 [3-CH₂OCHF₂] D-1 [4-CH₂OCHF₂] D-1 [4-CH₂OCH₂CH₂F] D-1 [4-CH₂OCH₂CHF₂] D-1 [4-CH₂OCH₂CF₃] D-1 [4-CH₂OCH₂CH₂Cl] D-1 [4-CH₂OCH₂CHF₂] D-1 [4-CH₂OCH₂CH₂Br] D-1 [4-CH₂OCH₂CF₂CF₃] D-1 [4-CH₂OCH₂CH═CF₂] D-1 [4-CH₂OCH₂C(Br)═CH₂] D-1 [4-CH₂OCH₂CH═CHCl] D-1 [4-CH₂OCH₂CH₂CH═CF₂] D-1 [4-CH₂OCH₂CH═CCl₂] D-1 [4-CH₂OCH₂CH₂CF═CF₂] D-1 [4-CH₂OCH₂C≡CCl] D-1 [4-CH₂OCH₂CH₂C≡CCl] D-1 [4-CH₂OCH₂C≡CBr] D-1 [4-CH₂OCH₂CH₂C≡CBr] D-1 [4-CH₂OCH₂C≡CCl] D-1 [4-CH₂OCH₂CH₂C≡Cl] D-1 [4-CH₂OPen-c] D-1 [2-CH₂OHex-c] D-1 [4-CH₂OCH₂CH₂OMe] D-1 [4-CH₂OCH(Me)CH₂OMe] D-1 [4-CH₂OCH₂CH₂OEt] D-1 [4-CH₂OCH₂CH(Me)OMe] D-1 [4-CH₂OCH₂CH₂SMe] D-1 [4-CH₂OCH(Me)CH₂SMe] D-1 [4-CH₂OCH₂CH₂SEt] D-1 [4-CH₂OCH₂CH(Me)SMe] D-1 [4-CH₂OCH₂CN] D-1 [4-CH₂OCH₂CH₂OCH₂CH₂F] D-1 [4-CH₂OCH₂CH₂CN] D-1 [4-CH₂OCH₂CH₂OCH₂CHF₂] D-1 [4-CH₂OCH(Me)CN] D-1 [4-CH₂OCH₂CH₂OCH₂CF₃] D-1 [4-CH₂OCH₂(U-1a)] D-1 [4-CH₂OCH₂CH₂OCH₂CH₂Cl] D-1 [4-CH₂OCH₂CH₂(U-1a)] D-1 [4-CH₂OCH₂CH₂OCH₂CHCl₂] D-1 [4-CH₂OCH₂(U-3a)] D-1 [4-CH₂OCH₂CH₂OCH₂CHCl₃] D-1 [4-CH₂OCH₂CH₂(U-3a)] D-1 [4-CH₂OCH₂CH(Me)S(O)Me] D-1 [4-CH₂OCH₂(U-9a)] D-1 [4-CH₂OCH₂CH(Me)S(O)₂Me] D-1 [4-CH₂OCH₂CH₂(U-9a)] D-1 [4-CH₂OCH(Me)CH₂S(O)Me] D-1 [4-CH₂OCH₂Pr-c] D-1 [4-CH₂OCH(Me)CH₂S(O)₂Me] D-1 [4-CH₂OCH₂Bu-c] D-1 [4-CH₂OCH₂CH₂S(O)Me] D-1 [4-CH₂OCH₂Pen-c] D-1 [4-CH₂OCH₂CH₂S(O)₂Me] D-1 [4-CH₂OCH₂Hex-c] D-1 [4-CH₂OCH₂CH₂SCH₂CH₂F] D-1 [4-CH₂OCH₂(T-1-1)] D-1 [4-CH₂OCH₂CH₂SCH₂CHF₂] D-1 [4-CH₂OCH₂(T-1-2)] D-1 [4-CH₂OCH₂CH₂SCH₂CF₃] D-1 [4-CH₂OCH₂(T-1-3)] D-1 [4-CH₂OCH₂CH₂SCH₂CH₂Cl] D-1 [4-CH₂OCH₂(T-1-4)] D-1 [4-CH₂OCH₂CH₂SCH₂CHCl₂] D-1 [4-CH₂OCH₂(T-1-5)] D-1 [4-CH₂OCH₂CH₂SCH₂CCl₃] D-1 [4-CH₂SH] D-1 [4-CH₂OCH₂CH₂S(O)CH₂CH₂F] D-1 [4-CH₂SMe)] D-1 [4-CH₂OCH₂CH₂S(O)CH₂CHF₂] D-1 [4-CH₂SEt] D-1 [4-CH₂OCH₂CH₂S(O)CH₂CF₃] D-1 [4-CH₂SPr-n] D-1 [4-CH₂OCH₂CH₂S(O)₂CH₂CH₂F] D-1 [4-CH₂SPr-i] D-1 [4-CH₂OCH₂CH₂S(O)₂CH₂CHF₂] D-1 [4-CH₂S(O)Me] D-1 [4-CH₂OCH₂CH₂S(O)₂CH₂CF₃] D-1 [4-CH₂S(O)Et] D-1 [4-CH₂SCH₂CH═CH₂] D-1 [4-CH₂S(O)Pr-n] D-1 [4-CH₂S(O)CH₂CH═CH₂] D-1 [4-CH₂S(O)Pr-i] D-1 [4-CH₂S(O)₂CH₂CH═CH₂] D-1 [4-CH₂S(O)₂Me] D-1 [4-CH₂SCH₂CH═CCl₂] D-1 [4-CH₂S(O)₂Et] D-1 [4-CH₂S(O)CH₂CH═CCl₂] D-1 [4-CH₂S(O)₂Pr-n] D-1 [4-CH₂S(O)₂CH₂CH═CCl₂] D-1 [4-CH₂S(O)₂Pr-i] D-1 [4-CH₂SCH₂C(Br)═CH₂] D-1 [4-SCH₂SCH₂C≡CH] D-1 [4-CH₂S(O)CH₂C(Br)═CH₂] D-1 [4-SCH₂S(O)CH₂C≡CH] D-1 [4-CH₂S(O)₂CH₂C(Br)═CH₂] D-1 [4-SCH₂SPen-c] D-1 [4-CH₂S(O)CH₂C≡CH] D-1 [4-SCH₂S(O)Pen-c] D-1 [4-CH₂S(O)₂CH₂C≡CH] D-1 [4-SCH₂S(O)₂Pen-c] D-1 [4-CH₂SCH₂C≡CCl] D-1 [4-SCH₂SHex-c] D-1 [4-CH₂S(O)CH₂C≡CCl] D-1 [4-SCH₂S(O)Hex-c] D-1 [4-CH₂S(O)₂CH₂C≡CCl] D-1 [4-SCH₂S(O)₂Hex-c] D-1 [4-CH₂S(T-1-5)] D-1 [4-SCH₂S(O)(T-1-5)] D-1 [4-CH₂S(O)₂(T-1-5)] D-1 [4-CH₂SCH₂CH₂OMe] D-1 [4-CH₂S(O)₂CH₂CH₂OMe] D-1 [4-CH₂SCH₂CH₂OEt] D-1 [4-CH₂S(O)₂CH₂CH₂OEt] D-1 [4-CH₂S(O)CH₂CH₂OMe] D-1 [4-CH₂S(O)CH(Me)CH₂OMe] D-1 [4-CH₂S(O)CH₂CH₂OEt] D-1 [4-CH₂S(O)₂CH(Me)CH₂OMe] D-1 [4-CH₂SCH(Me)CH₂OMe] D-1 [4-CH₂S(O)CH₂CH(Me)OMe] D-1 [4-CH₂SCH₂CH(Me)OMe] D-1 [4-CH₂S(O)₂CH₂CH(Me)OMe] D-1 [4-CH₂SCH₂CH₂SMe] D-1 [4-CH₂S(O)₂CH₂CH₂SMe] D-1 [4-CH₂S(O)CH₂CH₂SMe] D-1 [4-CH₂SCH₂CH₂S(O)₂Me] D-1 [4-CH₂SCH₂CH₂S(O)Me] D-1 [4-CH₂S(O)₂CH₂CH₂S(O)₂Me] D-1 [4-CH₂SCH₂(U-1a)] D-1 [4-CH₂SCH₂CH₂SCH₂CF₃] D-1 [4-CH₂S(O)CH₂(U-1a)] D-1 [4-CH₂SCH₂CH₂S(O)CH₂CF₃] D-1 [4-CH₂S(O)₂CH₂(U-1a)] D-1 [4-CH₂SCH₂CH₂S(O)₂CH₂CF₃] D-1 [4-CH₂SCH₂(U-3a)] D-1 [4-CH₂S(O)CH₂CH₂SCH₂CF₃] D-1 [4-CH₂S(O)CH₂(U-3a)] D-1 [4-CH₂S(O)CH₂CH₂S(O)CH₂CF₃] D-1 [4-CH₂S(O)₂CH₂(U-3a)] D-1 [4-CH₂S(O)CH₂CH₂S(O)₂CH₂CF₃] D-1 [4-CH₂SCH₂(U-9a)] D-1 [4-CH₂S(O)₂CH₂CH₂SCH₂CF₃] D-1 [4-CH₂S(O)CH₂(U-9a)] D-1 [4-CH₂S(O)₂CH₂CH₂S(O)CH₂CF₃] D-1 [4-CH₂S(O)₂CH₂(U-9a)] D-1 [4-CH₂S(O)₂CH₂CH₂S(O)₂CH₂CF₃] D-1 [4-CH₂SCH₂Pr-c] D-1 [4-CH₂SCH₂CN] D-1 [4-CH₂S(O)CH₂Pr-c] D-1 [4-CH₂S(O)CH₂CN] D-1 [4-CH₂S(O)₂CH₂Pr-c] D-1 [4-CH₂S(O)₂CH₂CN] D-1 [4-CH₂SCH₂Bu-c] D-1 [4-CH₂SCH₂CH₂CN] D-1 [4-CH₂S(O)CH₂Bu-c] D-1 [4-CH₂S(O)(CH₂CH₂CN] D-1 [4-CH₂S(O)₂CH₂Bu-c] D-1 [4-CH₂S(O)₂CH₂CH₂CN] D-1 [4-CH₂SCH₂Pen-c] D-1 [4-CH₂SCH₂(T-1-1)] D-1 [4-CH₂S(O)CH₂Pen-c] D-1 [4-CH₂(O)CH₂(T-1-1)] D-1 [4-CH₂S(O)₂CH₂Pen-c] D-1 [P-CH₂S(O)₂CH₂(T-1-1)] D-1 [4-CH₂SCH₂Hex-c] D-1 [4-CH₂SCH₂(T-1-2)] D-1 [4-CH₂S(O)CH₂Hex-c] D-1 [P-CH₂S(O)CH₂(T-1-2)] D-1 [4-CH₂S(O)₂CH₂Hex-c] D-1 [4-CH₂S(O)₂CH₂(T-1-2)] D-1 [2-OH] D-1 [2-OEt] D-1 [3-OH] D-1 [3-OEt] D-1 [4-OH] D-1 [4-OEt] D-1 [2-OPr-n] D-1 [2-OPr-i] D-1 [3-OPr-n] D-1 [3-OPr-i] D-1 [4-OPr-n] D-1 [4-OPr-i] D-1 [2-OBu-n] D-1 [2-OBu-i] D-1 [3-OBu-n] D-1 [3-OBu-i] D-1 [4-OBu-n] D-1 [4-OBu-i] D-1 [2-OBu-sec] D-1 [2-OPen-n] D-1 [3-OBu-sec] D-1 [3-OPen-n] D-1 [4-OBu-sec] D-1 [4-OPen-n] D-1 [2-OHex-n] D-1 [4-OCH₂Bu-tert] D-1 [3-OHex-n] D-1 [4-OCH(Et)₂] D-1 [4-OHex-n] D-1 [4-OCH(Me)Pr-i] D-1 [4-OCH(Me)Bu-tert] D-1 [4-OBu-tert] D-1 [2-OCHF₂] D-1 [2-OCF₃] D-1 [3-OCHF₂] D-1 [3-OCF₃] D-1 [4-OCHF₂] D-1 [4-OCF₃] D-1 [2-OCF₂Br] D-1 [4-OCH₂CH₂F] D-1 [3-OCF₂Br] D-1 [4-OCH₂CH₂Cl] D-1 [4-OCF₂Br] D-1 [4-OCH₂CH₂Br] D-1 [4-OCH₂CHF₂] D-1 [4-OCH₂CH₂CHF] D-1 [4-OCH₂CHCl₂] D-1 [4-OCH₂CH₂CHCl] D-1 [4-OCH₂CF₃] D-1 [4-OCH₂CH₂CH₂Br] D-1 [4-OCH₂CF₂CHF₂] D-1 [4-OCH₂HCF₂CF₃] D-1 [4-OCH₂CH═CH₂] D-1 [4-OCH₂C(Me)═CH₂] D-1 [4-OCH₂CH═C(Me)₂] D-1 [4-OCH₂CH₂CH═CH₂] D-1 [4-OCH(Me)CH═CH₂] D-1 [4-OC(Me)₂CH═CH₂] D-1 [4-OCH₂CH═CF₂] D-1 [4-OCH₂C(Br)═CH₂] D-1 [4-OCH₂CH═CCl₂] D-1 [4-OCH₂CCl═CHCl] D-1 [4-OCH₂CH₂CH═CF₂] D-1 [4-OCH₂CH₂CF═CF₂] D-1 [4-OCH₂C≡CH] D-1 [4-OCH₂C≡CMe] D-1 [4-OCH(Me)C≡CH] D-1 [4-OC(Me)₂C≡CH] D-1 [4-OCH₂CH₂C≡CH] D-1 [4-OCH₂C≡CEt] D-1 [4-OCH₂CH₂C≡CMe] D-1 [4-OCH₂C≡CPr-n] D-1 [4-OCH₂C≡CCl] D-1 [4-OCH₂C≡CBr] D-1 [4-OCH₂Pr-c] D-1 [4-OCH₂CBu-c] D-1 [4-OCH₂Pec-c] D-1 [4-OCH₂CHex-c] D-1 [2-OCH₂(T-1-1)] D-1 [2-OCH₂(T-1-2)] D-1 [3-OCH₂(T-1-1)] D-1 [3-OCH₂(T-1-2)] D-1 [4-OCH₂(T-1-1)] D-1 [4-OCH₂(T-1-2)] D-1 [2-OCH₂(T-1-3)] D-1 [2-OCH₂(T-1-4)] D-1 [3-OCH₂(T-1-3)] D-1 [3-OCH₂(T-1-4)] D-1 [4-OCH₂(T-1-3)] D-1 [4-OCH₂(T-1-4)] D-1 [4-OCH₂OMe] D-1 [4-OCH₂OEt] D-1 [4-OCH₂OPr-n] D-1 [2-OCH₂CH₂OH] D-1 [3-OCH₂CH₂OH] D-1 [4-OCH₂CH₂OH] D-1 [4-OCH₂CH₂OMe] D-1 [4-OCH₂CH(OMe)₂] D-1 [4-OCH₂CH₂OEt] D-1 [4-OCH(Me)CH₂OMe] D-1 [4-OCH₂CH₂OPr-n] D-1 [4-OCH₂CH(Me)OMe] D-1 [4-OCH₂OCH₂CH₂F] D-1 [4-OCH₂OCH₂CH₂Cl] D-1 [4-OCH₂CH₂OCH₂CH₂F] D-1 [4-OCH₂CH₂CH₂OCH₂CH₂Cl] D-1 [4-OCH₂CH₂OCH₂CHF₂] D-1 [4-OCH₂CH₂CH₂OCH₂CHCl₂] D-1 [4-OCH₂CH₂OCH₂CF₃] D-1 [4-OCH₂CH₂CH₂OCH₂CCl₃] D-1 [4-OCH₂CH₂OCH₂CH═CH₂] D-1 [4-OCH₂CH₂OCH₂CH₂CH═CH₂] D-1 [4-OCH₂CH₂OCH₂CH═CF₂] D-1 [4-OCH₂CH₂OCH₂CH═C(Me)₂] D-1 [4-OCH₂CH₂OCH₂CH═CCl₂] D-1 [4-OCH₂CH₂OCH(Me)CH═CH₂] D-1 [4-OCH₂CH₂OCH₂CF═CF₂] D-1 [4-OCH₂CH₂OC(Me)₂CH═CH₂] D-1 [4-OCH₂CH₂OCH₂C≡CH] D-1 [4-OCH₂CH₂OCH₂C≡CMe] D-1 [4-OCH₂CH₂OCH₂C≡CCl] D-1 [4-OCH₂CH₂OCH₂C≡CBr] D-1 [4-OCH₂CH₂OPen-c] D-1 [4-OCH₂CH₂OHex-c] D-1 [4-OCH₂CH₂OC(O)Me D-1 [4-OCH₂CH₂OC(O)Et] D-1 [4-OCH₂CH₂OC(O)Pr-i D-1 [4-OCH₂CH₂OC(O)Bu-tert] D-1 [4-OCH₂CH₂OC(O)OMe D-1 [4-OCH₂CH₂OC(O)OEt] D-1 [4-OCH₂CH₂OC(O)OPr-i D-1 [4-OCH₂CH₂OC(O)OBu-tert] D-1 [4-OCH₂CH₂OC(O)N(Me)₂ D-1 [4-OCH₂CH₂OS(O)₂Me] D-1 [4-OCH₂CH₂OS(O)₂Et D-1 [4-OCH₂CH₂OS(O)₂CH₂Cl] D-1 [4-OCH₂CH₂OS(O)₂CF₃ D-1 [4-OCH₂CH₂OS(O)₂N(Me)₂] D-1 [4-OCH₂SMe] D-1 [4-OCH₂SEt] D-1 [4-OCH₂CH₂SMe] D-1 [4-OCH(Me)CH₂SMe] D-1 [4-OCH₂CH₂S(O)Me] D-1 [4-OCH(Me)CH₂S(O)Me] D-1 [4-OCH₂CH₂S(O)₂Me] D-1 [4-OCH(Me)CH₂S(O)₂Me] D-1 [4-OCH₂CH(Me)SMe] D-1 [4-OCH(Me)CH₂SMe] D-1 [4-OCH₂CH(Me)S(O)Me] D-1 [4-OCH(Me)CH₂S(O)Me] D-1 [4-OCH₂CH₂SCH₂CF₃] D-1 [4-OCH₂CH₂SCH₂CHF₂] D-1 [4-OCH₂CH₂S(O)CH₂CF₃] D-1 [4-OCH₂CH₂S(O)CH₂CHF₂] D-1 [4-OCH₂CH₂S(O)₂CH₂CF₃] D-1 [4-OCH₂CH₂S(O)₂CH₂CHF₂] D-1 [4-OCH₂CH₂SCH₂CH═CH₂] D-1 [4-OCH₂CH₂S(O)CH₂CH═CH₂] D-1 [4-OCH₂CH₂sCH₂CH═C(Me)₂] D-1 [4-OCH₂CH₂S(O)₂CH₂CH═CH₂] D-1 [4-OCH₂CH₂SCH₂CH═CCl₂] D-1 [4-OCH₂CH₂S(O)CH₂CH═CCl₂] D-1 [4-OCH₂CH₂SCH₂C≡CH] D-1 [4-OCH₂CH₂S(O)CH₂C≡CH] D-1 [4-OCH₂CH₂SCH₂C≡CMe] D-1 [4-OCH₂CH₂S(O)₂CH₂C≡CH] D-1 [4-OCH₂CH₂SCH₂C≡CCl] D-1 [4-OCH₂CH₂S(O)CH₂C≡CMe] D-1 [4-OCH₂CH₂SCH₂C≡CBr] D-1 [4-OCH₂CH₂S(O)₂CH₂C≡CMe] D-1 [4-OCH₂CH₂SPen-c] D-1 [4-OCH₂CH₂S(O)CH₂C≡CCl] D-1 [4-OCH₂CH₂S(O)Pen-c] D-1 [4-OCH₂CH₂S(O)₂CH₂C≡CCl] D-1 [4-OCH₂CH₂S(O)₂Pen-c] D-1 [4-OCH₂CH₂S(O)CH₂C≡CBr] D-1 [4-OCH₂CH₂SHex-c] D-1 [4-OCH₂CH₂S(O)₂CH₂C≡CBr] D-1 [4-OCH₂CH₂S(O)Hex-c] D-1 [4-OCH₂CH₂S(O)₂Hex-c] D-1 [2-OCH₂Ph] D-1 [2-OCH₂CN] D-1 [3-OCH₂Ph] D-1 [3-OCH₂CCN] D-1 [4-OCH₂Ph] D-1 [4-OCH₂CN] D-1 [2-OCH(Me)CN] D-1 [2-OCH₂CH₂CN] D-1 [3-OCH(Me)CN] D-1 [3-OCH₂CH₂CN] D-1 [4-OCH(Me)CN] D-1 [4-OCH₂CH₂CN] D-1 [2-OCH₂Ph(2-F)] D-1 [4-OCH₂Ph(2-F)] D-1 [2-OCH₂Ph(3-F)] D-1 [4-OCH₂Ph(3-F)] D-1 [2-OCH₂Ph(4-F)] D-1 [4-OCH₂Ph(4-F)] D-1 [2-OCH₂Ph(2-Cl)] D-1 [4-OCH₂Ph(2-Cl)] D-1 [2-OCH₂Ph(3-Cl)] D-1 [4-OCH₂Ph(3-Cl)] D-1 [2-OCH₂Ph(4-Cl)] D-1 [4-OCH₂Ph(4-Cl)] D-1 [2-OCH₂Ph(2-Me)] D-1 [4-OCH₂Ph(2-Me)] D-1 [2-OCH₂Ph(3-Me)] D-1 [4-OCH₂Ph(3-Me)] D-1 [2-OCH₂Ph(4-Me)] D-1 [4-OCH₂Ph(4-Me)] D-1 [2-OCH₂Ph(2-OMe)] D-1 [4-OCH₂Ph(2-OMe)] D-1 [2-OCH₂Ph(3-OMe)] D-1 [4-OCH₂Ph(3-OMe)] D-1 [2-OCH₂Ph(4-OMe)] D-1 [4-OCH₂Ph(4-OMe)] D-1 [4-OCH₂C(═NOH)H] D-1 [4-OCH₂C(═NOCH₂CH═CH₂)Me] D-1 [4-OCH₂CH₂C(═NOH)Me] D-1 [4-OCH₂C(═NOCH₂C≡CH)Me] D-1 [4-OCH₂C(═NOMe)H] D-1 [4-OCH₂C(═NOCH₂CH₂F)Me] D-1 [4-OCH₂CH₂C(═NOMe)Me] D-1 [4-OCH₂C(═NOCH₂CH₂Cl)Me] D-1 [4-OCH₂C(═NOMe)OMe] D-1 [4-OCH₂C(═NOCH₂CHF₂)Me] D-1 [4-OCH₂C(═NOEt)OMe] D-1 [4-OCH₂C(═NOCH₂CHCl₂)Me] D-1 [4-OCH₂C(═NOPr-n)Me] D-1 [4-OCH₂C(═NOCH₂CF₃)Me] D-1 [4-OCH₂C(═NOPr-i)Me] D-1 [4-OCH₂C(═NOCH₂CH₂CH₂Cl)Me] D-1 [4-OCH₂C(═NOH)Me] D-1 [4-OCH₂C(═NOCH₂CH₂OMe)Me] D-1 [4-OCH₂C(═NOF)NH₂ D-1 [4-OCH₂C(═NOCH₂CH₂SMe)Me] D-1 [4-OCH₂C(═NOMe)Me] D-1 [4-OCH₂C(═NOCH₂Pr-c)Me] D-1 [4-OCH₂C(═NOMe)NH₂] D-1 [4-OCH₂C(═NOCH₂(Ph-2-F))Me] D-1 [4-OCH₂C(═NOMe)SMe] D-1 [4-OCH₂C(═NOCH₂(Ph-3-F))Me] D-1 [4-OCH₂C(═NOMe)OMe] D-1 [4-OCH₂C(═NOCH₂(Ph-4-F))Me] D-1 [4-OCH₂CH₂C(═NOH)Me] D-1 [4-OCH₂C(═NOCH₂(Ph-2-OMe))Me] D-1 [4-OCH₂CH₂C(═NOMe)Me] D-1 [4-OCH₂C(═NOCH₂(Ph-3-OMe))Me] D-1 [4-OCH₂CH₂C(═NOEt)Me] D-1 [4-OCH₂C(═NOCH₂(Ph-4-OMe))Me] D-1 [4-OCH₂(U-1a)] D-1 [4-OCH₂C(═NOCH₂(Ph-2-Cl))Me] D-1 [4-OCH₂(U-2a)] D-1 [4-OCH₂C(═NOCH₂(Ph-3-Cl))Me] D-1 [4-OCH₂(U-3a)] D-1 [4-OCH₂C(═NOCH₂(Ph-4-Cl))Me] D-1 [4-OCH₂(U-4a)] D-1 [4-OCH₂C(═NOCH₂(Ph-2-Me))Me] D-1 [4-OCH₂(U-5a)] D-1 [4-OCH₂C(═NOCH₂(Ph-3-Me))Me] D-1 [4-OCH₂(U-9a)] D-1 [4-OCH₂C(═NOCH₂(Ph-4-Me))Me] D-1 [4-OCH₂(U-10a)] D-1 [4-OCH₂(U-11a)] D-1 [4-OCH₂(U-12a)] D-1 [4-OCH₂(U-13a)] D-1 [4-OCH₂(U-14a)] D-1 [4-OCH₂(U-15a)] D-1 [4-OCH₂(U-16a)] D-1 [4-OCH₂(U-17a)] D-1 [4-OCH₂(U-20a)] D-1 [4-OCH₂(U-31a)] D-1 [4-OCH₂(U-32a)] D-1 [4-OCH₂(Q-1-1)] D-1 [4-OCH₂(Q-2)] D-1 [4-OCH₂(Q-3)] D-1 [4-OCH₂(Q-4)] D-1 [4-OCH₂(Q-5)] D-1 [4-OCH₂(Q-8-1)] D-1 [4-OCH₂(Q-9-1)] D-1 [4OCH₂(Q-14-1)] D-1 [4-OCH₂(Q-15-1)] D-1 [4-OCH₂(Q-16-1)] D-1 [4-OCH₂(Q-17)] D-1 [4-OCH₂(Q-18)] D-1 [4-OCH₂(Q-18-1)] D-1 [4-OCH₂(Q-19)] D-1 [4-OCH₂(Q-20)] D-1 [4-OCH₂(Q-35-1)] D-1 [4-OCH₂ON═C(Me)H] D-1 [4-OCH₂ON═C(Me)₂] D-1 [4-OCH₂ON═C(Me)Et] D-1 [4-OCH₂ON═C(CH₂)₄] D-1 [4-OCH₂ON═C(CH₂)₅] D-1 [4-OPr-c] D-1 [4-OBu-c)] D-1 [4-OPen-c] D-1 [4-OHex-c)] D-1 [2-O(T-1-5)] D-1 [4-O(T-1-5)] D-1 [2-OPh] D-1 [4-O(Ph)] D-1 [4-O(Ph-2-F)] D-1 [4-O(Ph-3-F)] D-1 [4-O(Ph-4-F)] D-1 [4-O(Ph-2-Cl)] D-1 [4-O(Ph-3-Cl)] D-1 [4-O(Ph-4-Cl)] D-1 [4-O(Ph-2-Me)] D-1 [4-O(Ph-3-Me)] D-1 [4-O(Ph-4-Me)] D-1 [4-O(Ph-2-OMe)] D-1 [4-O(Ph-3-OMe)] D-1 [4-O(Ph-4-OMe)] D-1 [4-O(Ph-2-CF₃)] D-1 [4-O(Ph-3-CF₃)] D-1 [4-O(Ph-4-CF₃)] D-1 [4-O(Ph-2-SMe)] D-1 [4-O(Ph-3-SMe)] D-1 [4-O(Ph-4-SMe)] D-1 [4-O(Ph-4-CN)] D-1 [4-O(Ph-4-NO₂)] D-1 [4-O(Ph-2-Cl-4-CF₃)] D-1 [4-O(Ph-2,4-Cl₂)] D-1 [4-OC(O)Me] D-1 [4-OC(O)Et] D-1 [4-OC(O)Pr-n] D-1 [4-OC(O)Pr-i] D-1 [4-OC(O)Bu-tert] D-1 [4-OC(O)OMe] D-1 [4-OC(O)OEt] D-1 [4-OC(O)OBu-tert] D-1 [4-OS(O)₂Me] D-1 [4-OS(O)₂Et] D-1 [4-OS(O)₂CH₂Cl] D-1 [4-OS(O)₂CF₃] D-1 [4-O(U-1a)] D-1 [4-O(U-2a)] D-1 [4-O(U-3a)] D-1 [4-O(U-4a)] D-1 [4-O(U-5a)] D-1 [4-O(U-12a)] D-1 [4-O(U-14a)] D-1 [4-O(U-15a)] D-1 [4-O(U-16a)] D-1 [4-O(Q-17-1)] D-1 [4-O(Q-17-2)] D-1 [4-O(Q-17-3)] D-1 [4-O(Q-17b)] D-1 [4-O(Q-18)] D-1 [4-O(Q-19)] D-1 [4-O(Q-20)] D-1 [2-SMe] D-1 [2-S(O)Me] D-1 [3-SMe] D-1 [3-S(O)Me] D-1 [4-SMe] D-1 [4-S(O)Me] D-1 [2-S(O)₂Me] D-1 [2-SEt] D-1 [3-S(O)₂Me] D-1 [3-SEt] D-1 [4-S(O)₂Me] D-1 [4-SEt] D-1 [2-S(O)Et] D-1 [2-S(O)₂Et] D-1 [3-S(O)Et] D-1 [3-S(O)₂Et] D-1 [4-S(O)Et] D-1 [4-S(O)₂Et] D-1 [2-SPr-n] D-1 [2-S(O)Pr-n] D-1 [3-SPr-n] D-1 [3-S(O)Pr-n] D-1 [4-SPr-n] D-1 [4-S(O)Pr-n] D-1 [2-S(O)₂Pr-n] D-1 [2-SPr-i] D-1 [3-S(O)₂Pr-n] D-1 [3-SPr-i] D-1 [4-S(O)₂Pr-n] D-1 [4-SPr-i] D-1 [2-S(O)Pr-i] D-1 [2-S(O)₂Pr-i] D-1 [3-S(O)Pr-i] D-1 [3-S(O)₂Pr-i] D-1 [4-S(O)Pr-i] D-1 [4-S(O)₂Pr-i] D-1 [2-SBu-n] D-1 [2-S(O)Bu-n] D-1 [3-SBu-n] D-1 [3-S(O)Bu-n] D-1 [4-SBu-n] D-1 [4-S(O)Bu-n] D-1 [2-S(O)₂Bu-n] D-1 [2-SBu-i] D-1 [3-S(O)₂Bu-n] D-1 [3-SBu-i] D-1 [4-S(O)₂Bu-n] D-1 [4-SBu-i] D-1 [2-S(O)Bu-i] D-1 [2-S(O)₂Bu-i] D-1 [3-S(O)Bu-i] D-1 [3-S(O)₂Bu-i] D-1 [4-S(O)Bu-i] D-1 [4-S(O)₂Bu-i] D-1 [2-SBu-sec] D-1 [2-S(O)Bu-sec] D-1 [3-SBu-sec] D-1 [3-S(O)Bu-sec] D-1 [4-SBu-sec] D-1 [4-S(O)Bu-sec] D-1 [2-S(O)₂Bu-sec] D-1 [2-SBu-tert] D-1 [3-S(O)₂Bu-sec] D-1 [3-SBu-tert] D-1 [4-S(O)₂Bu-sec] D-1 [4-SBu-tert] D-1 [2-S(O)Bu-tert] D-1 [2-S(O)₂Bu-tert] D-1 [3-S(O)Bu-tert] D-1 [3-S(O)₂Bu-tert] D-1 [4-S(O)Bu-tert] D-1 [4-S(O)₂Bu-tert] D-1 [2-SPen-n] D-1 [2-S(O)Pen-n] D-1 [3-SPen-n] D-1 [3-S(O)Pen-n] D-1 [4-SPen-n] D-1 [4-S(O)Pen-n] D-1 [2-S(O)₂Pen-n] D-1 [2-SHex-n] D-1 [3-S(O)₂Pen-n] D-1 [3-SHex-n] D-1 [4-S(O)₂Pen-n] D-1 [4-SHex-n] D-1 [2-S(O)Hex-n] D-1 [2-S(O)₂Hex-n] D-1 [3-S(O)Hex-n] D-1 [3-S(O)₂Hex-n] D-1 [4-S(O)Hex-n] D-1 [4-S(O)₂Hex-n] D-1 [4-SCH₂Bu-tert] D-1 [4-SCH(Et)₂] D-1 [4-S(O)CH₂Bu-tert] D-1 [4-S(O)CH(Et)₂] D-1 [4-S(O)₂CH₂Bu-tert] D-1 [4-S(O)₂CH(Et)₂] D-1 [4-SCH(Me)Pr-i] D-1 [4-SCH(Me)Bu-tert] D-1 [4-S(O)CH(Me)Pr-i] D-1 [4-S(O)CH(Me)Bu-tert] D-1 [4-S(O)₂CH(Me)Pr-i] D-1 [4-S(O)₂CH(Me)Bu-tert] D-1 [4-SCH₂CH═CH₂] D-1 [4-SCH₂C(Me)═CH₂] D-1 [4-S(O)CH₂CH═CH₂] D-1 [4-S(O)CH₂C(Me)═CH₂] D-1 [4-S(O)₂CH₂CH═CH₂] D-1 [4-S(O)₂CH₂C(Me)═CH₂] D-1 [4-SCH₂CH═C(Me)₂] D-1 [4-SCH₂CH₂CH═CH₂] D-1 [4-S(O)CH₂CH═C(Me)₂] D-1 [4-S(O)CH₂CH₂CH═CH₂] D-1 [4-S(O)₂CH₂CH═C(Me)₂] D-1 [4-S(O)₂CH₂CH₂CH═CH₂] D-1 [4-SCH(Me)CH═CH₂] D-1 [4-SC(Me)₂CH═CH₂] D-1 [4-S(O)CH(Me)CH═CH₂] D-1 [4-S(O)C(Me)₂CH═CH₂] D-1 [4-S(O)₂CH(Me)CH═CH₂] D-1 [4-S(O)₂C(Me)₂CH═CH₂] D-1 [2-SCHF₂] D-1 [2-SCF₃] D-1 [3-SCHF₂] D-1 [3-SCF₃] D-1 [4-SCHF₂] D-1 [4-SCF₃] D-1 [2-S(O)CHF₂] D-1 [2-S(O)CF₃] D-1 [3-S(O)CHF₂] D-1 [3-S(O)CF₃] D-1 [4-S(O)CHF₂] D-1 [4-S(O)CF₃] D-1 [2-S(O)₂CHF₂] D-1 [2-S(O)₂CF₃] D-1 [3-S(O)₂CHF₂] D-1 [3-S(O)₂CF₃] D-1 [4-S(O)₂CHF₂] D-1 [4-S(O)₂CF₃] D-1 [2-SCF₂Br] D-1 [4-SCH₂CH₂F] D-1 [3-SCF₂Br] D-1 [4-SCH₂CH₂Cl] D-1 [4-SCF₂Br] D-1 [4-SCH₂CH₂Br] D-1 [2-S(O)CF₂Br] D-1 [4-S(O)CH₂CH₂F] D-1 [3-S(O)CF₂Br] D-1 [4-S(O)CH₂CH₂Cl] D-1 [4-S(O)CF₂Br] D-1 [4-S(O)CH₂CH₂Br] D-1 [2-S(O)₂CF₂Br] D-1 [4-S(O)₂CH₂CH₂F] D-1 [3-S(O)₂CF₂Br] D-1 [4-S(O)₂CH₂CH₂Cl] D-1 [4-S(O)₂CF₂Br] D-1 [4-S(O)₂CH₂CH₂Br] D-1 [4-SCH₂CHF₂] D-1 [4-SCH₂CH₂CHF] D-1 [4-SCH₂CHCl₂] D-1 [4-SCH₂CH₂CHCl] D-1 [4-SCH₂CF₃] D-1 [4-SCH₂CH₂CH₂Br] D-1 [4-SCH₂CF₂CHF₂] D-1 [4-SCH₂HCF₂CF₃] D-1 [4-S(O)CH₂CHF₂] D-1 [4-S(O)CH₂CH₂CHF] D-1 [4-S(O)CH₂CHCl₂] D-1 [4-S(O)CH₂CH₂CHCl] D-1 [4-S(O)CH₂CF₃] D-1 [4-S(O)CH₂CH₂CH₂Br] D-1 [4-S(O)CH₂CF₂CHF₂] D-1 [4-S(O)CH₂HCF₂CF₃] D-1 [4-S(O)₂CH₂CHF₂] D-1 [4-S(O)₂CH₂CH₂CHF] D-1 [4-S(O)₂CH₂CHCl₂] D-1 [4-S(O)₂CH₂CH₂CHCl] D-1 [4-S(O)₂CH₂CF₃] D-1 [4-S(O)₂CH₂CH₂CH₂Br] D-1 [4-S(O)₂CH₂CF₂CHF₂] D-1 [4-S(O)₂CH₂HCF₂CF₃] D-1 [4-SCH₂CH═CF₂] D-1 [4-SCH₂C(Br)═CH₂] D-1 [4-SCH₂CH═CCl₂] D-1 [4-SCH₂CCl═CHCl] D-1 [4-SCH₂CH₂CH═CF₂] D-1 [4-SCH₂CH₂CF═CF₂] D-1 [4-S(O)CH₂CH═CF₂] D-1 [4-S(O)CH₂C(Br)═CH₂] D-1 [4-S(O)CH₂CH═CCl₂] D-1 [4-S(O)CH₂CCl═CHCl] D-1 [4-S(O)CH₂CH₂CH═CF₂] D-1 [4-S(O)CH₂CH₂CF═CF₂] D-1 [4-S(O)₂CH₂CH═CF₂] D-1 [4-S(O)₂CH₂C(Br)═CH₂] D-1 [4-S(O)₂CH₂CH═CCl₂] D-1 [4-S(O)₂CH₂CCl═CHCl] D-1 [4-S(O)₂CH₂CH₂CH═CF₂] D-1 [4-S(O)₂CH₂CH₂CF═CF₂] D-1 [4-SCH₂C≡CH] D-1 [4-SCH₂C≡CMe] D-1 [4-SCH(Me)C≡CH] D-1 [4-SC(Me)₂C≡CH] D-1 [4-SCH₂CH₂C≡CH] D-1 [4-SCH₂C≡CEt] D-1 [4-SCH₂CH₂C≡CMe] D-1 [4-SCH₂C≡CPr-n] D-1 [4-S(O)CH₂C≡CH] D-1 [4-S(O)CH₂C≡CMe] D-1 [4-S(O)CH(Me)C≡CH] D-1 [4-S(O)C(Me)₂C≡CH] D-1 [4-S(O)CH₂CH₂C≡CH] D-1 [4-S(O)CH₂C≡CEt] D-1 [4-S(O)CH₂CH₂C≡CMe] D-1 [4-S(O)CH₂C≡CPr-n] D-1 [4-S(O)₂CH₂C≡CH] D-1 [4-S(O)₂CH₂C≡CMe] D-1 [4-S(O)₂CH(Me)C≡CH] D-1 [4-S(O)₂C(Me)₂C≡CH] D-1 [4-S(O)₂CH₂CH₂C≡CH] D-1 [4-S(O)₂CH₂C≡CEt] D-1 [4-S(O)₂CH₂CH₂C≡CMe] D-1 [4-S(O)₂CH₂C≡CPr-n] D-1 [4-SCH₂C≡CCl] D-1 [4-SCH₂C≡CBr] D-1 [4-S(O)CH₂C≡CCl] D-1 [4-S(O)CH₂C≡CBr] D-1 [4-S(O)₂CH₂C≡CCl] D-1 [4-S(O)₂CH₂C≡CBr] D-1 [4-SCH₂Pr-c] D-1 [4-SCH₂CBu-c] D-1 [4-SCH₂Pen-c] D-1 [4-SCH₂CHex-c] D-1 [4-S(O)CH₂Pr-c] D-1 [4-S(O)CH₂CBu-c] D-1 [4-S(O)CH₂Pen-c] D-1 [4-S(O)CH₂CHex-c] D-1 [4-S(O)₂CH₂Pr-c] D-1 [4-S(O)₂CH₂CBu-c] D-1 [4-S(O)₂CH₂Pen-c] D-1 [4-S(O)₂CH₂CHex-c] D-1 [2-SCH₂(T-1-1)] D-1 [2-SCH₂(T-1-2)] D-1 [3-SCH₂(T-1-1)] D-1 [3-SCH₂(T-1-2)] D-1 [4-SCH₂(T-1-1)] D-1 [4-SCH₂(T-1-2)] D-1 [2-SCH₂(T-1-3)] D-1 [2-SCH₂(T-1-4)] D-1 [3-SCH₂(T-1-3)] D-1 [3-SCH₂(T-1-4)] D-1 [4-SCH₂(T-1-3)] D-1 [4-SCH₂(T-1-4)] D-1 [2-S(O)CHAT-1-1)] D-1 [2-S(O)CH₂(T-1-2)] D-1 [3-S(O)CH₂(T-1-1)] D-1 [3-S(O)CH₂(T-1-2)] D-1 [4-S(O)CH₂(T-1-1)] D-1 [4-S(O)CH₂(T-1-2)] D-1 [2-S(O)CH₂(T-1-3)] D-1 [2-S(O)CH₂(T-1-4)] D-1 [3-S(O)CH₂(T-1-3)] D-1 [3-S(O)CH₂(T-1-4)] D-1 [4-S(O)CH₂(T-1-3)] D-1 [4-S(O)CH₂(T-1-4)] D-1 [2-S(O)₂CH₂(T-1-1)] D-1 [2-S(O)₂CH₂(T-1-2)] D-1 [3-S(O)₂CH₂(T-1-1)] D-1 [3-S(O)₂CH₂(T-1-2)] D-1 [4-S(O)₂CH₂(T-1-1)] D-1 [4-S(O)₂CH₂(T-1-2)] D-1 [2-S(O)₂CH₂(T-1-3)] D-1 [2-S(O)₂CH₂(T-1-4)] D-1 [3-S(O)₂CH₂(T-1-3)] D-1 [3-S(O)₂CH₂(T-1-4)] D-1 [4-S(O)₂CH₂(T-1-3)] D-1 [4-S(O)₂CH₂(T-1-4)] D-1 [4-SCH₂OMe] D-1 [4-SCH₂OEt] D-1 [4-SCH₂OPr-n] D-1 [2-SCH₂CH₂OH] D-1 [3-SCH₂CH₂OH] D-1 [4-SCH₂CH₂OH] D-1 [4-SCH₂CH₂OMe] D-1 [4-SCH₂CH(OMe)₂] D-1 [4-SCH₂CH₂OEt] D-1 [4-SCH(Me)CH₂OMe] D-1 [4-SCH₂CH₂OPr-n] D-1 [4-SCH₂CH(Me)OMe] D-1 [4-S(O)CH₂OMe] D-1 [4-S(O)CH₂OEt] D-1 [4-S(O)CH₂OPr-n] D-1 [2-S(O)CH₂CH₂OH] D-1 [3-S(O)CH₂CH₂OH] D-1 [4-S(O)CH₂CH₂OH] D-1 [4-S(O)CH₂CH₂OMe] D-1 [4-S(O)CH₂CH(OMe)₂] D-1 [4-S(O)CH₂CH₂OEt] D-1 [4-S(O)CH(Me)CH₂OMe] D-1 [4-S(O)CH₂CH₂OPr-n] D-1 [4-S(O)CH₂CH(Me)OMe] D-1 [4-S(O)₂CH₂OMe] D-1 [4-S(O)₂CH₂OEt] D-1 [4-S(O)₂CH₂OPr-n] D-1 [2-S(O)₂CH₂CH₂OH] D-1 [3-S(O)₂CH₂CH₂OH] D-1 [4-S(O)₂CH₂CH₂OH] D-1 [4-S(O)₂CH₂CH₂OMe] D-1 [4-S(O)₂CH₂CH(OMe)₂] D-1 [4-S(O)₂CH₂CH₂OEt] D-1 [4-S(O)₂CH(Me)CH₂OMe] D-1 [4-S(O)₂CH₂CH₂OPr-n] D-1 [4-S(O)₂CH₂CH(Me)OMe] D-1 [4-SCH₂OCH₂CH₂F] D-1 [4-SCH₂OCH₂CH₂Cl] D-1 [4-SCH₂CH₂OCH₂CH₂F] D-1 [4-SCH₂CH₂CH₂OCH₂CH₂Cl] D-1 [4-SCH₂CH₂OCH₂CHF₂] D-1 [4-SCH₂CH₂CH₂OCH₂CHCl₂] D-1 [4-SCH₂CH₂OCH₂CF₃] D-1 [4-SCH₂CH₂CH₂OCH₂CCl₃] D-1 [4-S(O)CH₂OCH₂CH₂F] D-1 [4-S(O)CH₂OCH₂CH₂Cl] D-1 [4-S(O)CH₂CH₂OCH₂CH₂F] D-1 [4-S(O)CH₂CH₂CH₂OCH₂CH₂Cl] D-1 [4-S(O)CH₂CH₂OCH₂CHF₂] D-1 [4-S(O)CH₂CH₂CH₂OCH₂CHCl₂] D-1 [4-S(O)CH₂CH₂OCH₂CF₃] D-1 [4-S(O)CH₂CH₂CH₂OCH₂CCl₃] D-1 [4-S(O)₂CH₂OCH₂CH₂F] D-1 [4-S(O)₂CH₂OCH₂CH₂Cl] D-1 [4-S(O)₂CH₂CH₂OCH₂CH₂F] D-1 [4-S(O)₂CH₂CH₂CH₂OCH₂CH₂Cl] D-1 [4-S(O)₂CH₂CH₂OCH₂CHF₂] D-1 [4-S(O)₂CH₂CH₂CH₂OCH₂CHCl₂] D-1 [4-S(O)₂CH₂CH₂OCH₂CF₃] D-1 [4-S(O)₂CH₂CH₂CH₂OCH₂CCl₃] D-1 [4-SCH₂CH₂OCH₂CH═CH₂] D-1 [4-SCH₂CH₂OCH₂CH₂CH═CH₂] D-1 [4-SCH₂CH₂OCH₂CH═CF₂] D-1 [4-SCH₂CH₂OCH₂CH═C(Me)₂] D-1 [4-S(O)CH₂CH₂OCH₂CH═CH₂] D-1 [4-S(O)CH₂CH₂OCH₂CH₂CH═CH₂] D-1 [4-S(O)CH₂CH₂OCH₂CH═CF₂] D-1 [4-S(O)CH₂CH₂OCH₂CH═C(Me)₂] D-1 [4-S(O)₂CH₂CH₂OCH₂CH═CH₂] D-1 [4-S(O)₂CH₂CH₂OCH₂CH₂CH═CH₂] D-1 [4-S(O)₂CH₂CH₂OCH₂CH═CF₂] D-1 [4-S(O)₂CH₂CH₂OCH₂CH═C(Me)₂] D-1 [4-SCH₂CH₂OCH₂CH═CCl₂] D-1 [4-SCH₂CH₂OCH(Me)CH═CH₂] D-1 [4-SCH₂CH₂OCH₂CF═CF₂] D-1 [4-SCH₂CH₂OC(Me)₂CH═CH₂] D-1 [4-S(O)CH₂CH₂OCH₂CH═CCl₂] D-1 [4-S(O)CH₂CH₂OCH(Me)CH═CH₂] D-1 [4-S(O)CH₂CH₂OCH₂CF═CF₂] D-1 [4-S(O)CH₂CH₂OC(Me)₂CH═CH₂] D-1 [4-S(O)₂CH₂CH₂OCH₂CH═CCl₂] D-1 [4-S(O)₂CH₂CH₂OCH(Me)CH═CH₂] D-1 [4-S(O)₂CH₂CH₂OCH₂CF═CF₂] D-1 [4-S(O)₂CH₂CH₂OC(Me)₂CH═CH₂] D-1 [4-SCH₂CH₂OCH₂C≡CH] D-1 [4-SCH₂CH₂OCH₂C≡CMe] D-1 [4-SCH₂CH₂OCH₂C≡CCl] D-1 [4-SCH₂CH₂OCH₂C≡CBr] D-1 [4-S(O)CH₂CH₂OCH₂C≡CH] D-1 [4-S(O)CH₂CH₂OCH₂C≡CMe] D-1 [4-S(O)CH₂CH₂OCH₂C≡CCl] D-1 [4-S(O)CH₂CH₂OCH₂C≡CBr] D-1 [4-S(O)₂CH₂CH₂OCH₂C≡CH] D-1 [4-S(O)₂CH₂CH₂OCH₂C≡CMe] D-1 [4-S(O)₂CH₂CH₂OCH₂C≡CCl] D-1 [4-S(O)₂CH₂CH₂OCH₂C≡CBr] D-1 [4-SCH₂SMe] D-1 [4-SCH₂SEt] D-1 [4-SCH₂CH₂SMe] D-1 [4-SCH(Me)CH₂SMe] D-1 [4-SCH₂CH₂S(O)Me] D-1 [4-SCH(Me)CH₂S(O)Me] D-1 [4-SCH₂CH₂S(O)₂Me] D-1 [4-SCH(Me)CH₂S(O)₂Me] D-1 [4-SCH₂CH(Me)SMe] D-1 [4-SCH(Me)CH₂SMe] D-1 [4-SCH₂CH(Me)S(O)Me] D-1 [4-SCH(Me)CH₂S(O)Me] D-1 [4-SCH₂CH(Me)S(O)₂Me] D-1 [4-SCH(Me)CH₂S(O)₂Me] D-1 [4-S(O)CH₂SMe] D-1 [4-S(O)CH₂SEt] D-1 [4-S(O)CH₂CH₂SMe] D-1 [4-S(O)CH(Me)CH₂SMe] D-1 [4-S(O)CH₂CH₂S(O)Me] D-1 [4-S(O)CH(Me)CH₂S(O)Me] D-1 [4-S(O)CH₂CH₂S(O)₂Me] D-1 [4-S(O)CH(Me)CH₂S(O)₂Me] D-1 [4-S(O)CH₂CH(Me)SMe] D-1 [4-S(O)CH(Me)CH₂SMe] D-1 [4-S(O)CH₂CH(Me)S(O)Me] D-1 [4-S(O)CH(Me)CH₂S(O)Me] D-1 [4-S(O)CH₂CH(Me)S(O)₂Me] D-1 [4-S(O)CH(Me)CH₂S(O)₂Me] D-1 [4-S(O)₂CH₂SMe] D-1 [4-S(O)₂CH₂SEt] D-1 [4-S(O)₂CH₂CH₂SMe] D-1 [4-S(O)₂CH(Me)CH₂SMe] D-1 [4-S(O)₂CH₂CH₂S(O)Me] D-1 [4-S(O)₂CH(Me)CH₂S(O)Me] D-1 [4-S(O)₂CH₂CH₂S(O)₂Me] D-1 [4-S(O)₂CH(Me)CH₂S(O)₂Me] D-1 [4-S(O)₂CH₂CH(Me)SMe] D-1 [4-S(O)₂CH(Me)CH₂SMe] D-1 [4-S(O)₂CH₂CH(Me)S(O)Me] D-1 [4-S(O)₂CH(Me)CH₂S(O)Me] D-1 [4-S(O)₂CH₂CH(Me)S(O)₂Me] D-1 [4-S(O)₂CH(Me)CH₂S(O)₂Me] D-1 [4-SCH₂CH₂SCH₂CF₃] D-1 [4-SCH₂CH₂SCH₂CHF₂] D-1 [4-SCH₂CH₂S(O)CH₂CF₃] D-1 [4-SCH₂CH₂S(O)CH₂CHF₂] D-1 [4-SCH₂CH₂S(O)₂CH₂CF₃] D-1 [4-SCH₂CH₂S(O)₂CH₂CHF₂] D-1 [4-S(O)CH₂CH₂SCH₂CF₃] D-1 [4-S(O)CH₂CH₂SCH₂CHF₂] D-1 [4-S(O)CH₂CH₂S(O)CH₂CF₃] D-1 [4-S(O)CH₂CH₂S(O)CH₂CHF₂] D-1 [4-S(O)CH₂CH₂S(O)₂CH₂CF₃] D-1 [4-S(O)CH₂CH₂S(O)₂CH₂CHF₂] D-1 [4-S(O)₂CH₂CH₂SCH₂CF₃] D-1 [4-S(O)₂CH₂CH₂SCH₂CHF₂] D-1 [4-S(O)₂(O)₂CH₂CH₂S(O)CH₂CF₃] D-1 [4-S(O)₂CH₂CH₂S(O)CH₂CHF₂] D-1 [4-S(O)₂CH₂CH₂S(O)₂CH₂CF₃] D-1 [4-S(O)₂CH₂CH₂S(O)₂CH₂CHF₂] D-1 [4-SCH₂CH₂SCH₂CH═CH₂] D-1 [4-SCH₂CH₂S(O)CH₂CH═CH₂] D-1 [4-SCH₂CH₂SCH₂CH═C(Me)₂] D-1 [4-SCH₂CH₂S(O)₂CH₂CH═CH₂] D-1 [4-SCH₂CH₂SCH₂CH═CCl₂] D-1 [4-SCH₂CH₂S(O)CH₂CH═CCl₂] D-1 [4-S(O)CH₂CH₂SCH₂CH═CH₂] D-1 [4-S(O)CH₂CH₂S(O)CH₂CH═CH₂] D-1 [4-S(O)CH₂CH₂SCH₂CH═C(Me)₂] D-1 [4-S(O)CH₂CH₂S(O)₂CH₂CH═CH₂] D-1 [4-S(O)CH₂CH₂SCH₂CH═CCl₂] D-1 [4-S(O)CH₂CH₂S(O)CH₂CH═CCl₂] D-1 [4-S(O)₂CH₂CH₂SCH₂CH═CH₂] D-1 [4-S(O)₂CH₂CH₂S(O)CH₂CH═CH₂] D-1 [4-S(O)₂CH₂CH₂SCH₂CH═C(Me)₂] D-1 [4-S(O)₂CH₂CH₂S(O)₂CH₂CH═CH₂] D-1 [4-S(O)₂CH₂CH₂SCH₂CH═CCl₂] D-1 [4-S(O)₂CH₂CH₂S(O)CH₂CH═CCl₂] D-1 [4-SCH₂CH₂SCH₂C≡CH] D-1 [4-SCH₂CH₂SCH₂C≡CMe] D-1 [4-SCH₂CH₂S(O)CH₂C≡CH] D-1 [4-SCH₂CH₂S(O)CH₂C≡CMe] D-1 [4-SCH₂CH₂S(O)₂CH₂C≡CH] D-1 [4-SCH₂CH₂S(O)₂CH₂C≡CMe] D-1 [4-SCH₂CH₂SCH₂C≡CCl] D-1 [4-SCH₂CH₂SCH₂C≡CBr] D-1 [4-SCH₂CH₂S(O)CH₂C≡CCl] D-1 [4-SCH₂CH₂S(O)CH₂C≡CBr] D-1 [4-SCH₂CH₂SC(O)₂CH₂C≡CCl] D-1 [4-SCH₂CH₂S(O)₂CH₂C≡CBr] D-1 [4-S(O)CH₂CH₂SCH₂C≡CH] D-1 [4-S(O)CH₂CH₂SCH₂C≡CMe] D-1 [4-S(O)CH₂CH₂S(O)CH₂C≡CH] D-1 [4-S(O)CH₂CH₂S(O)CH₂C≡CMe] D-1 [4-S(O)CH₂CH₂S(O)₂CH₂C≡CH] D-1 [4-S(O)CH₂CH₂S(O)₂CH₂C≡CMe] D-1 [4-SCH₂CH₂SPen-c] D-1 [4-S(O)CH₂CH₂SCH₂C≡CBr] D-1 [4-SCH₂CH₂S(O)Pen-c] D-1 [4-S(O)CH₂CH₂S(O)CH₂C≡CBr] D-1 [4-SCH₂CH₂S(O)₂Pen-c] D-1 [4-S(O)CH₂CH₂S(O)₂CH₂C≡CBr] D-1 [4-S(O)CH₂CH₂SPen-c] D-1 [4-S(O)₂CH₂CH₂SCH₂C≡CMe] D-1 [4-S(O)CH₂CH₂S(O)Pen-c] D-1 [4-S(O)₂CH₂CH₂S(O)CH₂C≡CMe] D-1 [4-S(O)SCH₂CH₂S(O)₂Pen-c] D-1 [4-S(O)₂CH₂CH₂S(O)₂CH₂C≡CMe] D-1 [4-S(O)₂CH₂CH₂SPen-c] D-1 [4-S(O)₂CH₂CH₂SCH₂C≡CBr] D-1 [4-S(O)₂CH₂CH₂S(O)Pen-c] D-1 [4-S(O)₂CH₂CH₂S(O)CH₂C≡CBr] D-1 [4-S(O)₂SCH₂CH₂S(O)₂Pen-c] D-1 [4-S(O)₂CH₂CH₂S(O)₂CH₂C≡CBr] D-1 [4-SCH₂CH₂SHex-c ] D-1 [4-S(O)₂CH₂CH₂SCH₂C≡CH] D-1 [4-SCH₂CH₂S(O)Hex-c] D-1 [S(O)₂CH₂CH₂S(O)CH₂C≡CH] D-1 [4-SCH₂CH₂S(O)Hex-c] D-1 [S(O)₂CH₂CH₂S(O)CH₂C≡CH] D-1 [4-S(O)CH₂CH₂SHex-c] D-1 [4-S(O)CH₂CH₂SCH₂C≡CCl] D-1 [4-S(O)CH₂CH₂S(O)Hex-c] D-1 [4-S(O)CH₂CH₂S(O)CH₂C≡CCl] D-1 [4-S(O)₂CH₂CH₂S(O)₂Hex-c] D-1 [4-S(O)CH₂CH₂SC(O)₂CH₂C≡CCl] D-1 [4-S(O)₂CH₂CH₂SHex-c] D-1 [4-S(O)₂CH₂CH₂SCH₂C≡CCl] D-1 [4-S(O)₂CH₂CH₂S(O)Hex-c] D-1 [4-S(O)₂CH₂CH₂S(O)CH₂C≡CCl] D-1 [4-S(O)₂CH₂CH₂S(O)₂Hex-c] D-1 [4-S(O)₂CH₂CH₂SC(O)₂CH₂C≡CCl] D-1 [2-SCH₂Ph] D-1 [2-SCH₂CN] D-1 [3-SCH₂Ph] D-1 [3-SCH₂CN] D-1 [4-SCH₂Ph] D-1 [4-SCH₂CN] D-1 [2-SCH(Me)CN] D-1 [2-SCH₂CH₂CN] D-1 [3-SCH(Me)CN] D-1 [3-SCH₂CH₂CN] D-1 [4-SCH(Me)CN] D-1 [4-SCH₂CH₂CN] D-1 [2-S(O)CH₂Ph] D-1 [2-S(O)CH₂CN] D-1 [3-S(O)CH₂Ph] D-1 [3-S(O)CH₂CN] D-1 [4-S(O)CH₂Ph] D-1 [4-S(O)CH₂CN] D-1 [2-S(O)CH(Me)CN] D-1 [2-S(O)CH₂CH₂CN] D-1 [3-S(O)CH(Me)CN] D-1 [3-S(O)CH₂CH₂CN] D-1 [4-S(O)CH(Me)CN] D-1 [4-S(O)CH₂CH₂CN] D-1 [2-S(O)₂CH₂Ph] D-1 [2-S(O)₂CH₂CN] D-1 [3-S(O)₂CH₂Ph] D-1 [3-S(O)₂CH₂CN] D-1 [4-S(O)₂CH₂Ph] D-1 [4-S(O)₂CH₂CN] D-1 [2-S(O)₂CH(Me)CN] D-1 [2-S(O)₂CH₂CH₂CN] D-1 [3-S(O)₂CH(Me)CN] D-1 [3-S(O)₂CH₂CH₂CN] D-1 [4-S(O)₂CH(Me)CN] D-1 [4-S(O)₂CH₂CH₂CN] D-1 [2-SCH₂Ph(2-F)] D-1 [4-SCH₂Ph(2-F)] D-1 [2-SCH₂Ph(3-F)] D-1 [4-SCH₂Ph(3-F)] D-1 [2-SCH₂Ph(4-F)] D-1 [4-SCH₂Ph(4-F)] D-1 [2-SCH₂Ph(2-Cl)] D-1 [4-SCH₂Ph(2-Cl)] D-1 [2-SCH₂Ph(3-Cl)] D-1 [4-SCH₂Ph(3-Cl)] D-1 [2-SCH₂Ph(4-Cl)] D-1 [4-SCH₂Ph(4-Cl)] D-1 [2-SCH₂Ph(2-Me)] D-1 [4-SCH₂Ph(2-Me)] D-1 [2-SCH₂Ph(3-Me)] D-1 [4-SCH₂Ph(3-Me)] D-1 [2-SCH₂Ph(4-Me)] D-1 [4-SCH₂Ph(4-Me)] D-1 [2-SCH₂Ph(2-OMe)] D-1 [4-SCH₂Ph(2-OMe)] D-1 [2-SCH₂Ph(3-OMe)] D-1 [4-SCH₂Ph(3-OMe)] D-1 [2-SCH₂Ph(4-OMe)] D-1 [4-SCH₂Ph(4-OMe)] D-1 [2-S(O)CH₂Ph(2-F)] D-1 [4-S(O)CH₂Ph(2-F)] D-1 [2-S(O)CH₂Ph(3-F)] D-1 [4-S(O)CH₂Ph(3-F)] D-1 [2-S(O)CH₂Ph(4-F)] D-1 [4-S(O)CH₂Ph(4-F)] D-1 [2-S(O)CH₂Ph(2-Cl)] D-1 [4-S(O)CH₂Ph(2-Cl)] D-1 [2-S(O)CH₂Ph(3-Cl)] D-1 [4-S(O)CH₂Ph(3-Cl)] D-1 [2-S(O)CH₂Ph(4-Cl)] D-1 [4-S(O)CH₂Ph(4-Cl)] D-1 [2-S(O)CH₂Ph(2-Me)] D-1 [4-S(O)CH₂Ph(2-Me)] D-1 [2-S(O)CH₂Ph(3-Me)] D-1 [4-S(O)CH₂Ph(3-Me)] D-1 [2-S(O)CH₂Ph(4-Me)] D-1 [4-S(O)CH₂Ph(4-Me)] D-1 [2-S(O)CH₂Ph(2-OMe)] D-1 [4-S(O)CH₂Ph(2-OMe)] D-1 [2-S(O)CH₂Ph(3-OMe)] D-1 [4-S(O)CH₂Ph(3-OMe)] D-1 [2-S(O)CH₂Ph(4-OMe)] D-1 [4-S(O)CH₂Ph(4-OMe)] D-1 [2-S(O)₂CH₂Ph(2-F)] D-1 [4-S(O)₂CH₂Ph(2-F)] D-1 [2-S(O)₂CH₂Ph(3-F)] D-1 [4-S(O)₂CH₂Ph(3-F)] D-1 [2-S(O)₂CH₂Ph(4-F)] D-1 [4-S(O)₂CH₂Ph(4-F)] D-1 [2-S(O)₂CH₂Ph(2-Cl)] D-1 [4-S(O)₂CH₂Ph(2-Cl)] D-1 [2-S(O)₂CH₂Ph(3-Cl)] D-1 [4-S(O)₂CH₂Ph(3-Cl)] D-1 [2-S(O)₂CH₂Ph(4-Cl)] D-1 [4-S(O)₂CH₂Ph(4-Cl)] D-1 [2-S(O)₂CH₂Ph(2-Me)] D-1 [4-S(O)₂CH₂Ph(2-Me)] D-1 [2-S(O)₂CH₂Ph(3-Me)] D-1 [4-S(O)₂CH₂Ph(3-Me)] D-1 [2-S(O)₂CH₂Ph(4-Me)] D-1 [4-S(O)₂CH₂Ph(4-Me)] D-1 [2-S(O)₂CH₂Ph(2-OMe)] D-1 [4-S(O)₂CH₂Ph(2-OMe)] D-1 [2-S(O)₂CH₂Ph(3-OMe)] D-1 [4-S(O)₂CH₂Ph(3-OMe)] D-1 [2-S(O)₂CH₂Ph(4-OMe)] D-1 [4-S(O)₂CH₂Ph(4-OMe)] D-1 [4-SCH₂C(═NOH)H] D-1 [4-SCH₂C(═NOCH₂CH═CH₂)Me] D-1 [4-SCH₂CH₂C(═NOH)Me] D-1 [4-SCH₂C(═NOCH₂C≡CH)Me] D-1 [4-SCH₂C(═NOMe)H] D-1 [4-SCH₂C(═NOCH₂CH₂F)Me] D-1 [4-SCH₂CH₂C(═NOMe)Me] D-1 [4-SCH₂C(═NOCH₂CH₂Cl)Me] D-1 [4-SCH₂C(═NOMe)OMe] D-1 [4-SCH₂C(═NOCH₂CHF₂)Me] D-1 [4-SCH₂C(═NOEt)Me] D-1 [4-SCH₂C(═NOCH₂CHCl₂)Me] D-1 [4-SCH₂C(═NOPr-n)Me] D-1 [4-SCH₂C(═NOCH₂CF₃)Me] D-1 [4-SCH₂C(═NOPr-i)Me] D-1 [4-SCH₂C(═NOCH₂CH₂CH₂Cl)Me] D-1 [4-SCH₂C(═NOH)Me] D-1 [4-SCH₂C(═NOCH₂CH₂OMe)Me] D-1 [4-SCH₂C(═NOH)NH₂] D-1 [4-SCH₂C(═NOCH₂CH₂SMe)Me] D-1 [4-SCH₂C(═NOMe)Me] D-1 [4-SCH₂C(═NOCH₂Pr-c)Me] D-1 [4-SCH₂C(═NOMe)NH₂] D-1 [4-SCH₂C(═NOCH₂(Ph-2-F))Me] D-1 [4-SCH₂C(═NOMe)SMe] D-1 [4-SCH₂C(═NOCH₂(Ph-3-F))Me] D-1 [4-SCH₂C(═NOMe)OMe] D-1 [4-SCH₂C(═NOCH₂(Ph-4-F))Me] D-1 [4-SCH₂CH₂C(═NOH)Me] D-1 [4-SCH₂C(═NOCH₂(Ph-2-OMe))Me] D-1 [4-SCH₂CH₂C(═NOMe)Me] D-1 [4-SCH₂C(═NOCH₂(Ph-3-OMe))Me] D-1 [4-SCH₂CH₂C(═NOEt)Me] D-1 [4-SCH₂C(═NOCH₂(Ph-4-OMe))Me] D-1 [4-SCH₂C(═NOCH₂(Ph-2-Cl))Me] D-1 [4-SCH₂C(═NOCH₂(Ph-2-Me))Me] D-1 [4-SCH₂C(═NOCH₂(Ph-3-Cl))Me] D-1 [4-SCH₂C(═NOCH₂(Ph-3-Me))Me] D-1 [4-SCH₂C(═NOCH₂(Ph-4-Cl))Me] D-1 [4-SCH₂C(═NOCH₂(Ph-4-Me))Me] D-1 [4-S(O)CH₂C(═NOH)H] D-1 [4-S(O)CH₂C(═NOCH₂CH═CH₂)Me] D-1 [4-S(O)CH₂CH₂C(═NOH)Me] D-1 [4-S(O)CH₂C(═NOCH₂C≡CH)Me] D-1 [4-S(O)CH₂C(═NOMe)H] D-1 [4-S(O)CH₂C(═NOCH₂CH₂F)Me] D-1 [4-S(O)CH₂CH₂C(═NOMe)Me] D-1 [4-S(O)CH₂C(═NOCH₂CH₂Cl)Me] D-1 [4-S(O)CH₂C(═NOMe)OMe] D-1 [4-S(O)CH₂C(═NOCH₂CHF₂)Me] D-1 [4-S(O)CH₂C(═NOEt)Me] D-1 [4-S(O)CH₂C(═NOCH₂CHCl₂)Me] D-1 [4-S(O)CH₂C(═NOPr-n)Me] D-1 [4-S(O)CH₂C(═NOCH₂CF₃)Me] D-1 [4-S(O)CH₂C(═NOPr-i)Me] D-1 [4-S(O)CH₂C(═NOCH₂CH₂CH₂Cl)Me] D-1 [4-S(O)CH₂C(═NOMe)NH₂] D-1 [4-S(O)CH₂C(═NOCH₂(Ph-2-F))Me] D-1 [4-S(O)CH₂C(═NOMe)SMe] D-1 [4-S(O)CH₂C(═NOCH₂(Ph-3-F))Me] D-1 [4-S(O)CH₂C(═NOMe)OMe] D-1 [4-S(O)CH₂C(═NOCH₂(Ph-4-F))Me] D-1 [4-S(O)CH₂CH₂C(═NOH)Me] D-1 [4-S(O)CH₂C(═NOCH₂(Ph-2-OMe))Me] D-1 [4-S(O)CH₂CH₂C(═NOMe)Me] D-1 [4-S(O)CH₂C(═NOCH₂(Ph-3-OMe))Me] D-1 [4-S(O)CH₂CH₂C(═NOEt)Me] D-1 [4-S(O)CH₂C(═NOCH₂(Ph-4-OMe))Me] D-1 [4-S(O)CH₂C(═NOH)Me] D-1 [4-S(O)CH₂C(═NOCH₂(Ph-2-Cl))Me] D-1 [4-S(O)CH₂C(═NOCH₂CH₂OMe)Me] D-1 [4-S(O)CH₂C(═NOCH₂(Ph-3-Cl))Me] D-1 [4-S(O)CH₂C(═NOH)NH₂] D-1 [4-S(O)CH₂C(═NOCH₂(Ph-4-Cl))Me] D-1 [4-S(O)CH₂C(═NOCH₂CH₂SMe)Me] D-1 [4-S(O)CH₂C(═NOCH₂(Ph-2-Me))Me] D-1 [4-S(O)CH₂C(═NOMe)Me] D-1 [4-S(O)CH₂C(═NOCH₂(Ph-2-Me))Me] D-1 [4-S(O)CH₂C(═NOCH₂Pr-c)Me] D-1 [4-S(O)CH₂C(═NOCH₂(Ph-4-Me))Me] D-1 [4-S(O)₂CH₂C(═NOH)H] D-1 [4-S(O)₂CH₂C(═NOCH₂CH═CH₂)Me] D-1 [4-S(O)₂CH₂CH₂C(═NOH)Me] D-1 [4-S(O)₂CH₂C(═NOCH₂C≡CH)Me] D-1 [4-S(O)₂CH₂C(═NOMe)H] D-1 [4-S(O)₂CH₂C(═NOCH₂CH₂F)Me] D-1 [4-S(O)₂CH₂CH₂C(═NOMe)Me] D-1 [4-S(O)₂CH₂C(═NOCH₂CH₂Cl)Me] D-1 [4-S(O)₂CH₂C(═NOMe)OMe] D-1 [4-S(O)₂CH₂C(═NOCH₂CHF₂)Me] D-1 [4-S(O)₂CH₂C(═NOEt)Me] D-1 [4-S(O)₂CH₂C(═NOCH₂CHCl₂)Me] D-1 [4-S(O)₂CH₂C(═NOPr-n)Me] D-1 [4-S(O)₂CH₂C(═NOCH₂CF₃)Me] D-1 [4-S(O)₂CH₂C(═NOPr-i)Me] D-1 [4-S(O)₂CH₂C(═NOCH₂CH₂CH₂Cl)Me] D-1 [4-S(O)₂CH₂C(═NOH)Me] D-1 [4-S(O)₂CH₂C(═NOCH₂CH₂OMe)Me] D-1 [4-S(O)₂CH₂C(═NOH)NH₂] D-1 [4-S(O)₂CH₂C(═NOCH₂CH₂SMe)Me] D-1 [4-S(O)₂CH₂C(═NOMe)Me] D-1 [4-S(O)₂CH₂C(═NOCH₂Pr-c)Me] D-1 [4-S(O)₂CH₂C(═NOMe)NH₂] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-2-F))Me] D-1 [4-S(O)₂CH₂C(═NOMe)SMe] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-3-F))Me] D-1 [4-S(O)₂CH₂C(═NOMe)OMe] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-4-F))Me] D-1 [4-S(O)₂CH₂CH₂C(═NOH)Me] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-2-OMe))Me] D-1 [4-S(O)₂CH₂CH₂C(═NOMe)Me] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-3-OMe))Me] D-1 [4-S(O)₂CH₂CH₂C(═NOEt)Me] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-4-OMe))Me] D-1 [4-SCH₂(U-1a)] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-2-Me))Me] D-1 [4-SCH₂(U-2a)] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-3-Me))Me] D-1 [4-SCH₂(U-3a)] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-4-Me))Me] D-1 [4-SCH₂(U-4a)] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-2-Cl))Me] D-1 [4-SCH₂(U-5a) ] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-3-Cl))Me] D-1 [4-SCH₂(U-9a)] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-4-Cl))Me] D-1 [4-SCH₂(U-1a)] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-2-Me))Me] D-1 [4-SCH₂(U-2a)] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-3-Me))Me] D-1 [4-SCH₂(U-3a)] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-4-Me))Me] D-1 [4-SCH₂(U-4a)] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-2-Cl))Me] D-1 [4-SCH₂(U-5a) ] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-3-Cl))Me] D-1 [4-SCH₂(U-9a)] D-1 [4-S(O)₂CH₂C(═NOCH₂(Ph-4-Cl))Me] D-1 [4-SCH₂(U-11a)] D-1 [4-SCH₂(U-12a)] D-1 [4-SCH₂(U-13a)] D-1 [4-SCH₂(U-14a)] D-1 [4-SCH₂(U-15a)] D-1 [4-SCH₂(U-16a)] D-1 [4-SCH₂(U-17a)] D-1 [4-SCH₂(U-20a)] D-1 [4-SCH₂(U-31a)] D-1 [4-SCH₂(U-32a)] D-1 [4-S(O)CH₂(U-1a)] D-1 [4-S(O)CH₂(U-2a)] D-1 [4-S(O)CH₂(U-3a)] D-1 [4-S(O)CH₂(U-4a)] D-1 [4-S(O)CH₂(U-5a)] D-1 [4-S(O)CH₂(U-9a)] D-1 [4-S(O)CH₂(U-11a)] D-1 [4-S(O)CH₂(U-12a)] D-1 [4-S(O)CH₂(U-13a)] D-1 [4-S(O)CH₂(U-14a)] D-1 [4-S(O)CH₂(U-15a)] D-1 [4-S(O)CH₂(U-16a)] D-1 [4-S(O)CH₂(U-17a)] D-1 [4-S(O)CH₂(U-20a)] D-1 [4-S(O)CH₂(U-31a)] D-1 [4-S(O)CH₂(U-32a)] D-1 [4-S(O)₂CH₂(U-1a)] D-1 [4-S(O)₂CH₂(U-2a)] D-1 [4-S(O)₂CH₂(U-3a)] D-1 [4-S(O)₂CH₂(U-4a)] D-1 [4-S(O)₂CH₂(U-5a)] D-1 [4-S(O)₂CH₂(U-9a)] D-1 [4-S(O)₂CH₂(U-11a)] D-1 [4-S(O)₂CH₂(U-12a)] D-1 [4-S(O)₂CH₂(U-13a)] D-1 [4-S(O)₂CH₂(U-14a)] D-1 [4-S(O)₂CH₂(U-15a)] D-1 [4-S(O)₂CH₂(U-16a)] D-1 [4-S(O)₂CH₂(U-17a)] D-1 [4-S(O)₂CH₂(U-20a)] D-1 [4-S(O)₂CH₂(U-31a)] D-1 [4-S(O)₂CH₂(U-32a)] D-1 [4-SCH₂(Q-1-1)] D-1 [4-SCH₂(Q-2)] D-1 [4-SCH₂(Q-3)] D-1 [4-SCH₂(Q-4)] D-1 [4-SCH₂(Q-5)] D-1 [4-SCH₂(Q-8-1)] D-1 [4-SCH₂(Q-9-1)] D-1 [4-SCH₂(Q-14-1)] D-1 [4-SCH₂(Q-15-1)] D-1 [4-SCH₂(Q-16-1)] D-1 [4-SCH₂(Q-17)] D-1 [4-SCH₂(Q-18)] D-1 [4-SCH₂(Q-18-1)] D-1 [4-SCH₂(Q-19)] D-1 [4-SCH₂(Q-20)] D-1 [4-SCH₂ON═C(Me)H] D-1 [4-SCH₂ON═C(Me)₂] D-1 [4-SCH₂ON═C(Me)Et] D-1 [4-SCH₂ON═C(CH₂)₄] D-1 [4-SCH₂ON═C(CH₂)₅] D-1 [2-S(T-1-5)] D-1 [4-S(T-1-5)] D-1 [4-SPr-c] D-1 [4-SBu-c)] D-1 [4-SPen-c] D-1 [4-SHex-c)] D-1 [4-S(U-1a)] D-1 [4-S(U-2a)] D-1 [4-S(U-4a)] D-1 [4-S(U-5a)] D-1 [4-S(U-12a)] D-1 [4-S(U-14a)] D-1 [4-S(U-15a)] D-1 [4-S(U-16a)] D-1 [4-S(O)CH₂(Q-1-1)] D-1 [4-S(O)CH₂(Q-2)] D-1 [4-S(O)CH₂(Q-3)] D-1 [4-S(O)CH₂(Q-4)] D-1 [4-S(O)CH₂(Q-5)] D-1 [4-S(O)CH₂(Q-8-1)] D-1 [4-S(O)CH₂(Q-9-1)] D-1 [4-S(O)CH₂(Q-14-1)] D-1 [4-S(O)CH₂(Q-15-1)] D-1 [4-S(O)CH₂(Q-16-1)] D-1 [4-S(O)CH₂(Q-17)] D-1 [4-S(O)CH₂(Q-18)] D-1 [4-S(O)CH₂(Q-18-1)] D-1 [4-S(O)CH₂(Q-19)] D-1 [4-S(O)CH₂(Q-20)] D-1 [4-S(O)CH₂ON═C(Me)H] D-1 [4-S(O)CH₂ON═C(Me)₂] D-1 [4-S(O)CH₂ON═C(Me)Et] D-1 [4-S(O)CH₂ON═C(CH₂)₄] D-1 [4-S(O)CH₂ON═C(CH₂)₅] D-1 [2-S(O)(T-1-5)] D-1 [4-S(O)(T-1-5)] D-1 [4-S(O)Pr-c] D-1 [4-S(O)Bu-c] D-1 [4-S(O)Pen-c] D-1 [4-S(O)Hex-c] D-1 [4-S(O)(U-1a)] D-1 [4-S(O)(U-2a)] D-1 [4-S(O)(U-4a)] D-1 [4-S(O)(U-5a)] D-1 [4-S(O)(U-12a)] D-1 [4-S(O)(U-14a)] D-1 [4-S(O)(U-15a)] D-1 [4-S(O)(U-16a)] D-1 [4-S(O)₂CH₂(Q-1-1)] D-1 [4-S(O)₂CH₂(Q-2)] D-1 [4-S(O)₂CH₂(Q-3)] D-1 [4-S(O)₂CH₂(Q-4)] D-1 [4-S(O)₂CH₂(Q-5)] D-1 [4-S(O)₂CH₂(Q-8-1)] D-1 [4-S(O)₂CH₂(Q-9-1)] D-1 [4-S(O)₂CH₂(Q-14-1)] D-1 [4-S(O)₂CH₂(Q-15-1)] D-1 [4-S(O)₂CH₂(Q-16-1)] D-1 [4-S(O)₂CH₂(Q-17)] D-1 [4-S(O)₂CH₂(Q-18)] D-1 [4-S(O)₂CH₂(Q-18-1)] D-1 [4-S(O)₂CH₂(Q-19)] D-1 [4-S(O)₂CH₂(Q-20)] D-1 [4-S(O)₂CH₂ON═C(Me)H] D-1 [4-S(O)₂CH₂ON═C(Me)₂] D-1 [4-S(O)₂CH₂ON═C(Me)Et] D-1 [4-S(O)₂CH₂ON═C(CH₂)₄] D-1 [4-S(O)₂CH₂ON═C(CH₂)₅] D-1 [2-S(O)₂(T-1-5)] D-1 [4-S(O)₂ (T-1-5)] D-1 [4-S(O)₂Pr-c] D-1 [4-S(O)₂Bu-c] D-1 [4-S(O)₂Pen-c] D-1 [4-S(O)₂Hex-c] D-1 [4-S(O)₂(U-1a)] D-1 [4-S(O)₂(U-2a)] D-1 [4-S(O)₂(U-4a)] D-1 [4-S(O)₂(U-5a)] D-1 [4-S(O)₂W-12a)] D-1 [4-S(O)₂W-14a)] D-1 [4-S(O)₂(U-15a)] D-1 [4-S(O)₂(U-16a)] D-1 [4-NH₂] D-1 [4-NHMe] D-1 [4-NHEt] D-1 [4-NHPr-n] D-1 [4-NHPr-i] D-1 [4-NHBu-tert] D-1 [4-N(Me)Me] D-1 [4-N(Me)Et] D-1 [4-N(Me)Pr-n] D-1 [4-N(Me)Pr-i] D-1 [4-N(Me)Bu-tert] D-1 [4-N(Et)Et] D-1 [2-CN] D-1 [3-CN] D-1 [4-CN] D-1 [2-NO₂] D-1 [3-NO₂] D-1 [4-NO₂] D-1 [2-C(O)OH] D-1 [2-C(O)H] D-1 [3-C(O)OH] D-1 [3-C(O)H] D-1 [4-C(O)OH] D-1 [4-C(O)H] D-1 [2-C(O)Me] D-1 [2-C(O)Et] D-1 [3-C(O)Me] D-1 [3-C(O)Et] D-1 [4-C(O)Me] D-1 [4-C(O)Et] D-1 [2-C(O)NH₂] D-1 [2-C(O)NHMe] D-1 [3-C(O)NH₂] D-1 [3-C(O)NHMe] D-1 [4-C(O)NH₂] D-1 [4-C(O)NHMe] D-1 [2-C(O)N(Me)₂] D-1 [2-C(O)NHEt] D-1 [3-C(O)N(Me)₂] D-1 [3-C(O)NHEt] D-1 [4-C(O)N(Me)₂] D-1 [4-C(O)NHEt] D-1 [2-C(O)N(Me)Et] D-1 [2-C(O)NHPr-n] D-1 [3-C(O)N(Me)Et] D-1 [3-C(O)NHPr-n] D-1 [4-C(O)N(Me)Et] D-1 [4-C(O)NHPr-n] D-1 [2-C(O)N(Et)₂] D-1 [2-C(O)NHPr-i] D-1 [3-C(O)N(Et)₂] D-1 [3-C(O)NHPr-i] D-1 [4-C(O)N(Et)₂] D-1 [4-C(O)NHPr-i] D-1 [2-C(O)NHCH₂CF₃] D-1 [2-C(O)N(Me)CH₂CF₃] D-1 [3-C(O)NHCH₂CF₃] D-1 [3-C(O)N(Me)CH₂CF₃] D-1 [4-C(O)NHCH₂CF₃] D-1 [4-C(O)N(Me)CH₂CF₃] D-1 [4-C(═NOH)H] D-1 [4-C(═NOCH₂CH═CH₂)Me] D-1 [4-C(═NOH)Me] D-1 [4-C(═NOCH₂C≡CH)Me] D-1 [4-C(═NOMe)H] D-1 [4-C(═NOCH₂CH₂F)Me] D-1 [4-C(═NOMe)Me] D-1 [4-C(═NOCH₂CH₂Cl)Me] D-1 [4-OCH₂C(═NOMe)OMe] D-1 [4-C(═NOCH₂CHF₂)Me] D-1 [4-OCH₂C(═NOEt)OMe] D-1 [4-C(═NOCH₂CHCl₂)Me] D-1 [4-OCH₂C(═NOPr-n)Me] D-1 [4-C(═NOCH₂CF₃)Me] D-1 [4-OCH₂C(═NOPr-i)Me] D-1 [4-C(═NOCH₂CH₂CH₂Cl)Me] D-1 [4-OCH₂C(═NOH)Me] D-1 [4-C(═NOCH₂CH₂OMe)Me] D-1 [4-OCH₂C(═NOF)NH₂] D-1 [4-C(═NOCH₂CH₂SMe)Me] D-1 [4-OCH₂C(═NOMe)Me] D-1 [4-C(═NOCH₂Pr-c)Me] D-1 [4-OCH₂C(═NOMe)NH₂] D-1 [4-C(═NOCH₂(Ph-2-F))Me] D-1 [4-OCH₂C(═NOMe)SMe] D-1 [4-C(═NOCH₂(Ph-3-F))Me] D-1 [4-OCH₂C(═NOMe)OMe] D-1 [4-C(═NOCH₂(Ph-4-F))Me] D-1 [4-OCH₂CH₂C(═NOH)Me] D-1 [4-C(═NOCH₂(Ph-2-OMe))Me] D-1 [4-OCH₂CH₂C(═NOMe)Me] D-1 [4-C(═NOCH₂(Ph-3-OMe))Me] D-1 [4-OCH₂CH₂C(═NOEt)Me] D-1 [4-C(═NOCH₂(Ph-4-OMe))Me] D-1 [4-C(═NOCH₂(Ph-2-Cl))Me ] D-1 [4-C(═NOCH₂(Ph-2-Me))Me] D-1 [4-C(═NOCH₂(Ph-3-Cl))Me] D-1 [4-C(═NOCH₂(Ph-3-Me))Me] D-1 [4-C(═NOCH₂(Ph-4-Cl))Me] D-1 [4-C(═NOCH₂(Ph-4-Me))Me] D-1 [3-Ph] D-1 [4-Ph] D-1 [4-Ph(2-F)] D-1 [4-Ph(3-F)] D-1 [4-Ph(4-F)] D-1 [4-Ph(2-Cl)] D-1 [4-Ph(3-Cl)] D-1 [4-Ph(4-Cl)] D-1 [4-Ph(2-Me)] D-1 [4-Ph(3-Me)] D-1 [4-Ph(4-Me)] D-1 [4-Ph(2-OMe)] D-1 [4-Ph(3-OMe)] D-1 [4-Ph(4-OMe)] D-1 [2-Br] D-1 [4-I] D-1 [3-Br] D-1 [4-I] D-1 [4-Br] D-1 [4-I] D-1 [2,3-F₂] D-1 [2,5-F₂] D-1 [2,6-F₂] D-1 [3,4-F₂] D-1 [3,5-F₂] D-1 [2,3-Cl₂] D-1 [2,5-Cl₂] D-1 [2,6-Cl₂] D-1 [3,4-Cl₂] D-1 [3,5-Cl₂] D-1 [2,3-(Me)₂] D-1 [2,5-(Me)₂] D-1 [2,6-(Me)₂] D-1 [3,4-(Me)₂] D-1 [3,5-(Me)₂] D-1 [2,4-(Me)₂] D-1 [2,3-(OMe₂] D-1 [2,4-(OMe)₂] D-1 [2,5-(OMe)₂] D-1 [2,6-(OMe)₂] D-1 [3,4-(OMe)₂] D-1 [3,5-(OMe)₂] D-1 [2-F-3-Cl] D-1 [2-F-4-Cl] D-1 [2-F-5-Cl] D-1 [2-F-6-Cl] D-1 [2-F-3-Me] D-1 [2-F-5-Me] D-1 [2-F-6-Me] D-1 [2-F-3-OMe] D-1 [2-F-5-OMe] D-1 [2-F-6-OMe] D-1 [2-Cl-3-Me] D-1 [2-Cl-5-Me] D-1 [2-Cl-6-Me] D-1 [2-Cl-3-OMe] D-1 [2-Cl-5-OMe] D-1 [2-Cl-6-OMe] D-1 [2-Me-3-F] D-1 [2-Me-4-F] D-1 [2-Me-5-F] D-1 [2-Me-3-Cl] D-1 [2-Me-4-Cl] D-1 [2-Me-5-Cl] D-1 [3-F-5-Cl] D-1 [3-F-5-Me] D-1 [3-F-5-OMe] D-1 [3-F-5-CF₃] D-1 [3-F-5-OCF₃] D-1 [3-F-5-SMe] D-1 [3-Cl-5-Me] D-1 [3-Cl-5-OMe] D-1 [3-Cl-5-CF₃] D-1 [3-Cl-5-OCF₃] D-1 [3-Cl-5-SMe] D-1 [3-Cl-5-S(O)Me] D-1 [2,4,6-F₃] D-1 [2,4,5-F₃] D-1 [3,4,5-F₃] D-1 [2,4,6-(Me)₃] D-1 [3,5-F2-4-OMe] D-1 [2-F-4-OEt] D-1 [2-F-4-OPr-n] D-1 [2-F-4-OPr-i] D-1 [2-F-4-OPr-c] D-1 [2-F-4-OBu-n] D-1 [2-F-4-OBu-i] D-1 [2-F-4-OBu-sec] D-1 [2-F-4-OBu-tert] D-1 [2-F-4-OBu-c] D-1 [2-F-4-OPen-c] D-1 [2-F-4-OHex-c] D-1 [2-F-4-OCH₂CH═CH₂] D-1 [2-F-4-OCH₂C≡CH] D-1 [2-F-4-OCH₂CH═C(Me)₂] D-1 [2-F-4-OCH₂C≡CMe] D-1 [2-F-4-OCHF₂] D-1 [2-F-4-OCF₃] D-1 [2-F-4-OCH₂CH₂F] D-1 [2-F-4-OCH₂CH₂Cl] D-1 [2-F-4-OCH₂CHF₂] D-1 [2-F-4-OCH₂CH₂CF₃] D-1 [2-F-4-OCH₂CF₂CHF₂] D-1 [2-F-4-OCH₂CF₂CF₃] D-1 [2-F-4-OCH₂CH═CF₂] D-1 [2-F-4-OCH₂CH═CCl₂] D-1 [2-F-4-OCH₂CH₂CF═CF₂] D-1 [2-F-4-OCH₂CH₂CH═CF₂] D-1 [2-F-4-OCH₂C≡CCl] D-1 [2-F-4-OCH₂C≡CBr] D-1 [2-F-4-OCH₂CH₂OMe] D-1 [2-F-4-OCH₂CH₂SMe] D-1 [3-F-4-OMe] D-1 [3-F-4-OEt] D-1 [3-F-4-OPr-n] D-1 [3-F-4-OPr-i] D-1 [3-F-4-OPr-c] D-1 [3-F-4-OBu-n] D-1 [3-F-4-OBu-i] D-1 [3-F-4-OBu-sec] D-1 [3-F-4-OBu-tert] D-1 [3-F-4-OBu-c] D-1 [3-F-4-OPen-c] D-1 [3-F-4-OHex-c] D-1 [3-F-4-OCH₂CH═CH₂] D-1 [3-F-4-OCH₂C≡CH] D-1 [3-F-4-OCH₂CH═C(Me)₂] D-1 [3-F-4-OCH₂C≡CMe] D-1 [3-F-4-OCHF₂] D-1 [3-F-4-OCF₃] D-1 [3-F-4-OCH₂CH₂F] D-1 [3-F-4-OCH₂CH₂Cl] D-1 [3-F-4-OCH₂CHF₂] D-1 [3-F-4-OCH₂CH₂CF₃] D-1 [3-F-4-OCH₂CF₂CHF₂] D-1 [3-F-4-OCH₂CF₂CF₃] D-1 [3-F-4-OCH₂CH═CF₂] D-1 [3-F-4-OCH₂CH═CCl₂] D-1 [3-F-4-OCH₂CH₂CF═CF₂] D-1 [3-F-4-OCH₂CH₂CH═CF₂] D-1 [3-F-4-OCH₂C≡CCl] D-1 [3-F-4-OCH₂C≡CBr] D-1 [3-F-4-OCH₂CH₂OMe] D-1 [3-F-4-OCH₂CH₂SMe] D-1 [3,5-Cl₂-4-OMe] D-1 [2-Cl-4-OEt] D-1 [2-Cl-4-OPr-n] D-1 [2-Cl-4-OPr-i] D-1 [2-Cl-4-OPr-c] D-1 [2-Cl-4-OBu-n] D-1 [2-Cl-4-OBu-i] D-1 [2-Cl-4-OBu-sec] D-1 [2-Cl-4-OBu-tert] D-1 [2-Cl-4-OBu-c] D-1 [2-Cl-4-OPen-c] D-1 [2-Cl-4-OHex-c] D-1 [2-Cl-4-OCH₂CH═CH₂] D-1 [2-Cl-4-OCH₂C≡CH] D-1 [2-Cl-4-OCH₂CH═C(Me)₂] D-1 [2-Cl-4-OCH₂C≡CMe] D-1 [2-Cl-4-OCHF₂] D-1 [2-Cl-4-OCF₃] D-1 [2-Cl-4-OCH₂CH₂F] D-1 [2-Cl-4-OCH₂CH₂Cl] D-1 [2-Cl-4-OCH₂CHF₂] D-1 [2-Cl-4-OCH₂CH₂CF₃] D-1 [2-Cl-4-OCH₂CF₂CHF₂] D-1 [2-Cl-4-OCH₂CF₂CF₃] D-1 [2-Cl-4-OCH₂CH═CF₂] D-1 [2-Cl-4-OCH₂CH═CCl₂] D-1 [2-Cl-4-OCH₂CH₂CF═CF₂] D-1 [2-Cl-4-OCH₂CH₂CH═CF₂] D-1 [2-Cl-4-OCH₂C≡CCl] D-1 [2-Cl-4-OCH₂C≡CBr] D-1 [2-Cl-4-OCH₂CH₂OMe] D-1 [2-Cl-4-OCH₂CH₂SMe] D-1 [3-Cl-4-OMe] D-1 [3-Cl-4-OEt] D-1 [3-Cl-4-OPr-n] D-1 [3-Cl-4-OPr-i] D-1 [3-Cl-4-OPr-c] D-1 [3-Cl-4-OBu-n] D-1 [3-Cl-4-OBu-i] D-1 [3-Cl-4-OBu-sec] D-1 [3-Cl-4-OBu-tert] D-1 [3-Cl-4-OBu-c] D-1 [3-Cl-4-OPen-c] D-1 [3-Cl-4-OHex-c] D-1 [3-Cl-4-OCH₂CH═CH₂] D-1 [3-Cl-4-OCH₂C≡CH] D-1 [3-Cl-4-OCH₂CH═C(Me)₂] D-1 [3-Cl-4-OCH₂C≡CMe] D-1 [3-Cl-4-OCHF₂] D-1 [3-Cl-4-OCF₃] D-1 [3-Cl-4-OCH₂CH₂F] D-1 [3-Cl-4-OCH₂CH₂Cl] D-1 [3-Cl-4-OCH₂CHF₂] D-1 [3-Cl-4-OCH₂CH₂CF₃] D-1 [3-Cl-4-OCH₂CF₂CHF₂] D-1 [3-Cl-4-OCH₂CF₂CF₃] D-1 [3-Cl-4-OCH₂CH═CF₂] D-1 [3-Cl-4-OCH₂CH═CCl₂] D-1 [3-Cl-4-OCH₂CH₂CF═CF₂] D-1 [3-Cl-4-OCH₂CH₂CH═CF₂] D-1 [3-Cl-4-OCH₂C≡CCl] D-1 [3-Cl-4-OCH₂C≡CBr] D-1 [3-Cl-4-OCH₂CH₂OMe] D-1 [3-Cl-4-OCH₂CH₂SMe] D-1 [2-F-4-SMe] D-1 [2-F-4-SEt] D-1 [2-F-4-SPr-n] D-1 [2-F-4-SPr-i] D-1 [2-F-4-SPr-c] D-1 [2-F-4-SBu-n] D-1 [2-F-4-SBu-i] D-1 [2-F-4-SBu-sec] D-1 [2-F-4-SBu-tert] D-1 [2-F-4-SBu-c] D-1 [2-F-4-SPen-c] D-1 [2-F-4-SHex-c] D-1 [2-F-4-SCH₂CH═CH₂] D-1 [2-F-4-SCH₂C≡CH] D-1 [2-F-4-SCH₂CH═C(Me)₂] D-1 [2-F-4-SCH₂C≡CMe] D-1 [2-F-4-SCHF₂] D-1 [2-F-4-SCF₃] D-1 [2-F-4-SCH₂CH₂F] D-1 [2-F-4-SCH₂CH₂Cl] D-1 [2-F-4-SCH₂CHF₂] D-1 [2-F-4-SCH₂CH₂CF₃] D-1 [2-F-4-SCH₂CF₂CHF₂] D-1 [2-F-4-SCH₂CF₂CF₃] D-1 [2-F-4-SCH₂CH═CF₂] D-1 [2-F-4-SCH₂CH═CCl₂] D-1 [2-F-4-SCH₂CH₂CF═CF₂] D-1 [2-F-4-SCH₂CH₂CH═CF₂] D-1 [2-F-4-SCH₂C≡CCl] D-1 [2-F-4-SCH₂C≡CBr] D-1 [2-F-4-SCH₂CH₂OMe] D-1 [2-F-4-SCH₂CH₂SMe] D-1 [3-F-4-SMe] D-1 [3-F-4-SEt] D-1 [3-F-4-SPr-n] D-1 [3-F-4-SPr-i] D-1 [3-F-4-SPr-c] D-1 [3-F-4-SBu-n] D-1 [3-F-4-SBu-i] D-1 [3-F-4-SBu-sec] D-1 [3-F-4-SBu-tert] D-1 [3-F-4-SBu-c] D-1 [3-F-4-SPen-c] D-1 [3-F-4-SHex-c] D-1 [3-F-4-SCH₂CH═CH₂] D-1 [3-F-4-SCH₂C≡CH] D-1 [3-F-4-SCH₂CH═C(Me)₂] D-1 [3-F-4-SCH₂C≡CMe] D-1 [3-F-4-SCHF₂] D-1 [3-F-4-SCF₃] D-1 [3-F-4-SCH₂CH₂F] D-1 [3-F-4-SCH₂CH₂Cl] D-1 [3-F-4-SCH₂CHF₂] D-1 [3-F-4-SCH₂CH₂CF₃] D-1 [3-F-4-SCH₂CF₂CHF₂] D-1 [3-F-4-SCH₂CF₂CF₃] D-1 [3-F-4-SCH₂CH═CF₂] D-1 [3-F-4-SCH₂CH═CCl₂] D-1 [3-F-4-SCH₂CH₂CF═CF₂] D-1 [3-F-4-SCH₂CH₂CH═CF₂] D-1 [3-F-4-SCH₂C≡CCl] D-1 [3-F-4-SCH₂C≡CBr] D-1 [3-F-4-SCH₂CH₂OMe] D-1 [3-F-4-SCH₂CH₂SMe] D-1 [2-Cl-4-SMe] D-1 [2-Cl-4-SEt] D-1 [2-Cl-4-SPr-n] D-1 [2-Cl-4-SPr-i] D-1 [2-Cl-4-SPr-c] D-1 [2-Cl-4-SBu-n] D-1 [2-Cl-4-SBu-i] D-1 [2-Cl-4-SBu-sec] D-1 [2-Cl-4-SBu-tert] D-1 [2-Cl-4-SBu-c] D-1 [2-Cl-4-SPen-c] D-1 [2-Cl-4-SHex-c] D-1 [2-Cl-4-SCH₂CH═CH₂] D-1 [2-Cl-4-SCH₂C≡CH] D-1 [2-Cl-4-SCH₂CH═C(Me)₂] D-1 [2-Cl-4-SCH₂C≡CMe] D-1 [2-Cl-4-SCHF₂] D-1 [2-Cl-4-SCF₃] D-1 [2-Cl-4-SCH₂CH₂F] D-1 [2-Cl-4-SCH₂CH₂Cl] D-1 [2-Cl-4-SCH₂CHF₂] D-1 [2-Cl-4-SCH₂CH₂CF₃] D-1 [2-Cl-4-SCH₂CF₂CHF₂] D-1 [2-Cl-4-SCH₂CF₂CF₃] D-1 [2-Cl-4-SCH₂CH═CF₂] D-1 [2-Cl-4-SCH₂CH═CCl₂] D-1 [2-Cl-4-SCH₂CH₂CF═CF₂] D-1 [2-Cl-4-SCH₂CH₂CH═CF₂] D-1 [2-Cl-4-SCH₂C≡CCl] D-1 [2-Cl-4-SCH₂C≡CBr] D-1 [2-Cl-4-SCH₂CH₂OMe] D-1 [2-Cl-4-SCH₂CH₂SMe] D-1 [3-Cl-4-SMe] D-1 [3-Cl-4-SEt] D-1 [3-Cl-4-SPr-n] D-1 [3-Cl-4-SPr-i] D-1 [3-Cl-4-SPr-c] D-1 [3-Cl-4-SBu-n] D-1 [3-Cl-4-SBu-i] D-1 [3-Cl-4-SBu-sec] D-1 [3-Cl-4-SBu-tert] D-1 [3-Cl-4-SBu-c] D-1 [3-Cl-4-SPen-c] D-1 [3-Cl-4-SHex-c] D-1 [3-Cl-4-SCH₂CH═CH₂] D-1 [3-Cl-4-SCH₂C≡CH] D-1 [3-Cl-4-SCH₂CH═C(Me)₂] D-1 [3-Cl-4-SCH₂C≡CMe] D-1 [3-Cl-4-SCHF₂] D-1 [3-Cl-4-SCF₃] D-1 [3-Cl-4-SCH₂CH₂F] D-1 [3-Cl-4-SCH₂CH₂Cl] D-1 [3-Cl-4-SCH₂CHF₂] D-1 [3-Cl-4-SCH₂CH₂CF₃] D-1 [3-Cl-4-SCH₂CF₂CHF₂] D-1 [3-Cl-4-SCH₂CF₂CF₃] D-1 [3-Cl-4-SCH₂CH═CF₂] D-1 [3-Cl-4-SCH₂CH═CCl₂] D-1 [3-Cl-4-SCH₂CH₂CF═CF₂] D-1 [3-Cl-4-SCH₂CH₂CH═CF₂] D-1 [3-Cl-4-SCH₂C≡CCl] D-1 [3-Cl-4-SCH₂C≡CBr] D-1 [3-Cl-4-SCH₂CH₂OMe] D-1 [3-Cl-4-SCH₂CH₂SMe] D-1 [2-F-4-S(O)Me] D-1 [2-F-4-S(O)Et] D-1 [2-F-4-S(O)Pr-n] D-1 [2-F-4-S(O)Pr-i] D-1 [2-F-4-S(O)Pr-c] D-1 [2-F-4-S(O)Bu-n] D-1 [2-F-4-S(O)Bu-i] D-1 [2-F-4-S(O)Bu-sec] D-1 [2-F-4-S(O)Bu-tert] D-1 [2-F-4-S(O)Bu-c] D-1 [2-F-4-S(O)Pen-c] D-1 [2-F-4-S(O)Hex-c] D-1 [2-F-4-S(O)CH₂CH═CH₂] D-1 [2-F-4-S(O)CH₂C≡CH] D-1 [2-F-4-S(O)CH₂CH═C(Me)₂] D-1 [2-F-4-S(O)CH₂C≡CMe] D-1 [2-F-4-S(O)CHF₂] D-1 [2-F-4-S(O)CF₃] D-1 [2-F-4-S(O)CH₂CH₂F] D-1 [2-F-4-S(O)CH₂CH₂Cl] D-1 [2-F-4-S(O)CH₂CHF₂] D-1 [2-F-4-S(O)CH₂CH₂CF₃] D-1 [2-F-4-S(O)CH₂CF₂CHF₂] D-1 [2-F-4-S(O)CH₂CF₂CF₃] D-1 [2-F-4-S(O)CH₂CH═CF₂] D-1 [2-F-4-S(O)CH₂CH═CCl₂] D-1 [2-F-4-S(O)CH₂CH₂CF═CF₂] D-1 [2-F-4-S(O)CH₂CH₂CH═CF₂] D-1 [2-F-4-S(O)CH₂C≡CCl] D-1 [2-F-4-S(O)CH₂C≡CBr] D-1 [2-F-4-S(O)CH₂CH₂OMe] D-1 [2-F-4-S(O)CH₂CH₂SMe] D-1 [3-F-4-S(O)Me] D-1 [3-F-4-S(O)Et] D-1 [3-F-4-S(O)Pr-n] D-1 [3-F-4-S(O)Pr-i] D-1 [3-F-4-S(O)Pr-c] D-1 [3-F-4-S(O)Bu-n] D-1 [3-F-4-S(O)Bu-i] D-1 [3-F-4-S(O)Bu-sec] D-1 [3-F-4-S(O)Bu-tert] D-1 [3-F-4-S(O)Bu-c] D-1 [3-F-4-S(O)Pen-c] D-1 [3-F-4-S(O)Hex-c] D-1 [3-F-4-S(O)CH₂CH═CH₂] D-1 [3-F-4-S(O)CH₂C≡CH] D-1 [3-F-4-S(O)CH₂CH═C(Me)₂] D-1 [3-F-4-S(O)CH₂C≡CMe] D-1 [3-F-4-S(O)CHF₂] D-1 [3-F-4-S(O)CF₃] D-1 [3-F-4-S(O)CH₂CH₂F] D-1 [3-F-4-S(O)CH₂CH₂Cl] D-1 [3-F-4-S(O)CH₂CHF₂] D-1 [3-F-4-S(O)CH₂CH₂CF₃] D-1 [3-F-4-S(O)CH₂CF₂CHF₂] D-1 [3-F-4-S(O)CH₂CF₂CF₃] D-1 [3-F-4-S(O)CH₂CH═CF₂] D-1 [3-F-4-S(O)CH₂CH═CCl₂] D-1 [3-F-4-S(O)CH₂CH₂CF═CF₂] D-1 [3-F-4-S(O)CH₂CH₂CH═CF₂] D-1 [3-F-4-S(O)CH₂C═CCl] D-1 [3-F-4-S(O)CH₂C═CBr] D-1 [3-F-4-S(O)CH₂CH₂OMe] D-1 [3-F-4-S(O)CH₂CH₂SMe] D-1 [2-Cl-4-S(O)Me] D-1 [2-Cl-4-S(O)Et] D-1 [2-Cl-4-S(O)Pr-n] D-1 [2-Cl-4-S(O)Pr-i] D-1 [2-Cl-4-S(O)Pr-c] D-1 [2-Cl-4-S(O)Bu-n] D-1 [2-Cl-4-S(O)Bu-i] D-1 [2-Cl-4-S(O)Bu-sec] D-1 [2-Cl-4-S(O)Bu-tert] D-1 [2-Cl-4-S(O)Bu-c] D-1 [2-Cl-4-S(O)Pen-c] D-1 [2-Cl-4-S(O)Hex-c] D-1 [2-Cl-4-S(O)CH₂CH═CH₂] D-1 [2-Cl-4-S(O)CH₂C≡CH] D-1 [2-Cl-4-S(O)CH₂CH═C(Me)₂] D-1 [2-Cl-4-S(O)CH₂C≡CMe] D-1 [2-Cl-4-S(O)CHF₂] D-1 [2-Cl-4-S(O)CF₃] D-1 [2-Cl-4-S(O)CH₂CH₂F] D-1 [2-Cl-4-S(O)CH₂CH₂Cl] D-1 [2-Cl-4-S(O)CH₂CHF₂] D-1 [2-Cl-4-S(O)CH₂CH₂CF₃] D-1 [2-Cl-4-S(O)CH₂CF₂CHF₂] D-1 [2-Cl-4-S(O)CH₂CF₂CF₃] D-1 [2-Cl-4-S(O)CH₂CH═CF₂] D-1 [2-Cl-4-S(O)CH₂CH═CCl₂] D-1 [2-Cl-4-S(O)CH₂CH₂CF═CF₂] D-1 [2-Cl-4-S(O)CH₂CH₂CH═CF₂] D-1 [2-Cl-4-S(O)CH₂C≡CCl] D-1 [2-Cl-4-S(O)CH₂C≡CBr] D-1 [2-Cl-4-S(O)CH₂CH₂OMe] D-1 [2-Cl-4-S(O)CH₂CH₂SMe] D-1 [3-Cl-4-S(O)Me] D-1 [3-Cl-4-S(O)Et] D-1 [3-Cl-4-S(O)Pr-n] D-1 [3-Cl-4-S(O)Pr-i] D-1 [3-Cl-4-S(O)Pr-c] D-1 [3-Cl-4-S(O)Bu-n] D-1 [3-Cl-4-S(O)Bu-i] D-1 [3-Cl-4-S(O)Bu-sec] D-1 [3-Cl-4-S(O)Bu-tert] D-1 [3-Cl-4-S(O)Bu-c] D-1 [3-Cl-4-S(O)Pen-c] D-1 [3-Cl-4-S(O)Hex-c] D-1 [3-Cl-4-S(O)CH₂CH═CH₂] D-1 [3-Cl-4-S(O)CH₂C≡CH] D-1 [3-Cl-4-S(O)CH₂CH═C(Me)₂] D-1 [3-Cl-4-S(O)CH₂C≡CMe] D-1 [3-Cl-4-S(O)CHF₂] D-1 [3-Cl-4-S(O)CF₃] D-1 [3-Cl-4-S(O)CH₂CH₂F] D-1 [3-Cl-4-S(O)CH₂CH₂Cl] D-1 [3-Cl-4-S(O)CH₂CHF₂] D-1 [3-Cl-4-S(O)CH₂CH₂CF₃] D-1 [3-Cl-4-S(O)CH₂CF₂CHF₂] D-1 [3-Cl-4-S(O)CH₂CF₂CF₃] D-1 [3-Cl-4-S(O)CH₂CH═CF₂] D-1 [3-Cl-4-S(O)CH₂CH═CCl₂] D-1 [3-Cl-4-S(O)CH₂CH₂CF═CF₂] D-1 [3-Cl-4-S(O)CH₂CH₂CH═CF₂] D-1 [3-Cl-4-S(O)CH₂C≡CCl] D-1 [3-Cl-4-S(O)CH₂C≡CBr] D-1 [3-Cl-4-S(O)CH₂CH₂OMe] D-1 [3-Cl-4-S(O)CH₂CH₂SMe] D-1 [2-F-4-S(O)₂Me] D-1 [2-F-4-S(O)₂Et] D-1 [2-F-4-S(O)₂Pr-n] D-1 [2-F-4-S(O)₂Pr-i] D-1 [2-F-4-S(O)₂Pr-c] D-1 [2-F-4-S(O)₂Bu-n] D-1 [2-F-4-S(O)₂Bu-i] D-1 [2-F-4-S(O)₂Bu-sec] D-1 [2-F-4-S(O)₂Bu-tert] D-1 [2-F-4-S(O)₂Bu-c] D-1 [2-F-4-S(O)₂Pen-c] D-1 [2-F-4-S(O)₂Hex-c] D-1 [2-F-4-S(O)₂CH₂CH═CH₂] D-1 [2-F-4-S(O)₂CH₂C≡CH] D-1 [2-F-4-S(O)₂CH₂CH═C(Me)₂] D-1 [2-F-4-S(O)₂CH₂C≡CMe] D-1 [2-F-4-S(O)₂CHF₂] D-1 [2-F-4-S(O)₂CF₃] D-1 [2-F-4-S(O)₂CH₂CH₂F] D-1 [2-F-4-S(O)₂CH₂CH₂Cl] D-1 [2-F-4-S(O)₂CH₂CHF₂] D-1 [2-F-4-S(O)₂CH₂CH₂CF₃] D-1 [2-F-4-S(O)₂CH₂CF₂CHF₂] D-1 [2-F-4-S(O)₂CH₂CF₂CF₃] D-1 [2-F-4-S(O)₂CH₂CH═CF₂] D-1 [2-F-4-S(O)₂CH₂CH═CCl₂] D-1 [2-F-4-S(O)₂CH₂CH₂CF═CF₂] D-1 [2-F-4-S(O)₂CH₂CH₂CH═CF₂] D-1 [2-F-4-S(O)₂CH₂C≡CCl] D-1 [2-F-4-S(O)₂CH₂C≡CBr] D-1 [2-F-4-S(O)₂CH₂CH₂OMe] D-1 [2-F-4-S(O)₂CH₂CH₂SMe] D-1 [3-F-4-S(O)₂Me] D-1 [3-F-4-S(O)₂Et] D-1 [3-F-4-S(O)₂Pr-n] D-1 [3-F-4-S(O)₂Pr-i] D-1 [3-F-4-S(O)₂Pr-c] D-1 [3-F-4-S(O)₂Bu-n] D-1 [3-F-4-S(O)₂Bu-i] D-1 [3-F-4-S(O)₂Bu-sec] D-1 [3-F-4-S(O)₂Bu-tert] D-1 [3-F-4-S(O)₂Bu-c] D-1 [3-F-4-S(O)₂Pen-c] D-1 [3-F-4-S(O)₂Hex-c] D-1 [3-F-4-S(O)₂CH₂CH═CH₂] D-1 [3-F-4-S(O)₂CH₂C≡CH] D-1 [3-F-4-S(O)₂CH₂CH═C(Me)₂] D-1 [3-F-4-S(O)₂CH₂C≡CMe] D-1 [3-F-4-S(O)₂CHF₂] D-1 [3-F-4-S(O)₂CF₃] D-1 [3-F-4-S(O)₂CH₂CH₂F] D-1 [3-F-4-S(O)₂CH₂CH₂Cl] D-1 [3-F-4-S(O)₂CH₂CHF₂] D-1 [3-F-4-S(O)₂CH₂CH₂CF₃] D-1 [3-F-4-S(O)₂CH₂CF₂CHF₂] D-1 [3-F-4-S(O)₂CH₂CF₂CF₃] D-1 [3-F-4-S(O)₂CH₂CH═CF₂] D-1 [3-F-4-S(O)₂CH₂CH═CCl₂] D-1 [3-F-4-S(O)₂CH₂CH₂CF═CF₂] D-1 [3-F-4-S(O)₂CH₂CH₂CH═CF₂] D-1 [3-F-4-S(O)₂CH₂C≡CCl] D-1 [3-F-4-S(O)₂CH₂C≡CBr] D-1 [3-F-4-S(O)₂CH₂CH₂OMe] D-1 [3-F-4-S(O)₂CH₂CH₂SMe] D-1 [2-Cl-4-S(O)₂Me] D-1 [2-Cl-4-S(O)₂Et] D-1 [2-Cl-4-S(O)₂Pr-n] D-1 [2-Cl-4-S(O)₂Pr-i] D-1 [2-Cl-4-S(O)₂Pr-c] D-1 [2-Cl-4-S(O)₂Bu-n] D-1 [2-Cl-4-S(O)₂Bu-i] D-1 [2-Cl-4-S(O)₂Bu-sec] D-1 [2-Cl-4-S(O)₂Bu-tert] D-1 [2-Cl-4-S(O)₂Bu-c] D-1 [2-Cl-4-S(O)₂Pen-c] D-1 [2-Cl-4-S(O)₂Hex-c] D-1 [2-Cl-4-S(O)₂CH₂CH═CH₂] D-1 [2-Cl-4-S(O)₂CH₂C≡CH] D-1 [2-Cl-4-S(O)₂CH₂CH═C(Me)₂] D-1 [2-Cl-4-S(O)₂CH₂C≡CMe] D-1 [2-Cl-4-S(O)₂CHF₂] D-1 [2-Cl-4-S(O)₂CF₃] D-1 [2-Cl-4-S(O)₂CH₂CH₂F] D-1 [2-Cl-4-S(O)₂CH₂CH₂Cl] D-1 [2-Cl-4-S(O)₂CH₂CHF₂] D-1 [2-Cl-4-S(O)₂CH₂CH₂CF₃] D-1 [2-Cl-4-S(O)₂CH₂CF₂CHF₂] D-1 [2-Cl-4-S(O)₂CH₂CF₂CF₃] D-1 [2-Cl-4-S(O)₂CH₂CH═CF₂] D-1 [2-Cl-4-S(O)₂CH₂CH═CCl₂] D-1 [2-Cl-4-S(O)₂CH₂CH₂CF═CF₂] D-1 [2-Cl-4-S(O)₂CH₂CH₂CH═CF₂] D-1 [2-Cl-4-S(O)₂CH₂C≡CCl] D-1 [2-Cl-4-S(O)₂CH₂C≡CBr] D-1 [2-Cl-4-S(O)₂CH₂CH₂OMe] D-1 [2-Cl-4-S(O)₂CH₂CH₂SMe] D-1 [3-Cl-4-S(O)₂Me] D-1 [3-Cl-4-S(O)₂Et] D-1 [3-Cl-4-S(O)₂Pr-n] D-1 [3-Cl-4-S(O)₂Pr-i] D-1 [3-Cl-4-S(O)₂Pr-c] D-1 [3-Cl-4-S(O)₂Bu-n] D-1 [3-Cl-4-S(O)₂Bu-i] D-1 [3-Cl-4-S(O)₂Bu-sec] D-1 [3-Cl-4-S(O)₂Bu-tert] D-1 [3-Cl-4-S(O)₂Bu-c] D-1 [3-Cl-4-S(O)₂Pen-c] D-1 [3-Cl-4-S(O)₂Hex-c] D-1 [3-Cl-4-S(O)₂CH₂CH═CH₂] D-1 [3-Cl-4-S(O)₂CH₂C≡CH] D-1 [3-Cl-4-S(O)₂CH₂CH═C(Me)₂] D-1 [3-Cl-4-S(O)₂CH₂C≡CMe] D-1 [3-Cl-4-S(O)₂CHF₂] D-1 [3-Cl-4-S(O)₂CF₃] D-1 [3-Cl-4-S(O)₂CH₂CH₂F] D-1 [3-Cl-4-S(O)₂CH₂CH₂Cl] D-1 [3-Cl-4-S(O)₂CH₂CHF₂] D-1 [3-Cl-4-S(O)₂CH₂CH₂CF₃] D-1 [3-Cl-4-S(O)₂CH₂CF₂CHF₂] D-1 [3-Cl-4-S(O)₂CH₂CF₂CF₃] D-1 [3-Cl-4-S(O)₂CH₂CH═CF₂] D-1 [3-Cl-4-S(O)₂CH₂CH═CCl₂] D-1 [3-Cl-4-S(O)₂CH₂CH₂CF═CF₂] D-1 [3-Cl-4-S(O)₂CH₂CH₂CH═CF₂] D-1 [3-Cl-4-S(O)₂CH₂C≡CCl] D-1 [3-Cl-4-S(O)₂CH₂C≡CBr] D-1 [3-Cl-4-S(O)₂CH₂CH₂OMe] D-1 [3-Cl-4-S(O)₂CH₂CH₂SMe] D-1 [2-OMe-3-F] D-1 [2-OMe-4-F] D-1 [2-OMe-5-F] D-1 [2-OMe-3-Cl] D-1 [2-OMe-4-Cl] D-1 [2-OMe-5-Cl] D-1 [2-OMe-3-Me] D-1 [2-OMe-4-Me] D-1 [2-OMe-5-Me] D-1 [2-OMe-6-Me] D-1 [2-OMe-3-CF₃] D-1 [2-OMe-4-CF₃] D-1 [2-OMe-5-CF₃] D-1 [2-OMe-6-CF₃] D-1 [2-OMe-3-OCHF₂] D-1 [2-OMe-4-OCHF₂] D-1 [2-OMe-5-OCHF₂] D-1 [2-OMe-6-OCHF₂] D-1 [2-OMe-3-OCF₃] D-1 [2-OMe-4-OCF₃] D-1 [2-OMe-5-OCF₃] D-1 [2-OMe-6-OCF₃] D-1 [2-OMe-3-CN] D-1 [2-OMe-4-CN] D-1 [2-OMe-5-CN] D-1 [2-OMe-6-CN] D-1 [2-OMe-3-NO₂] D-1 [2-OMe-4-NO₂] D-1 [2-OMe-5-NO₂] D-1 [2-OMe-6-NO₂] D-1 [2-OMe-3-C(O)Me] D-1 [2-OMe-4-C(O)Me] D-1 [2-OMe-5-C(O)Me] D-1 [2-OMe-6-C(O)Me] D-1 [2-OMe-3-C(═NOMe)Me] D-1 [2-OMe-4-C(═NOMe)Me] D-1 [2-OMe-5-C(═NOMe)Me] D-1 [2-OMe-6-C(═NOMe)Me] D-1 [2-OEt-3-F] D-1 [2-OEt-4-F] D-1 [2-OEt-5-F] D-1 [2-OEt-4-F] D-1 [2-OEt-3-Cl] D-1 [2-OEt-4-Cl] D-1 [2-OEt-5-Cl] D-1 [2-OEt-4-Cl] D-1 [2-OEt-3-Me] D-1 [2-OEt-4-Me] D-1 [2-OEt-5-Me] D-1 [2-OEt-6-Me] D-1 [2-OEt-3-CF₃] D-1 [2-OEt-4-CF₃] D-1 [2-OEt-5-CF₃] D-1 [2-OEt-6-CF₃] D-1 [2-OEt-3-OCHF₂] D-1 [2-OEt-4-OCHF₂] D-1 [2-OEt-5-OCHF₂] D-1 [2-OEt-6-OCHF₂] D-1 [2-OEt-3-OCF₃] D-1 [2-OEt-4-OCF₃] D-1 [2-OEt-5-OCF₃] D-1 [2-OEt-6-OCF₃] D-1 [2-OEt-3-CN] D-1 [2-OEt-4-CN] D-1 [2-OEt-5-CN] D-1 [2-OEt-6-CN] D-1 [2-OEt-3-NO₂] D-1 [2-OEt-4-NO₂] D-1 [2-OEt-5-NO₂] D-1 [2-OEt-6-NO₂] D-1 [2-OEt-3-C(O)Me] D-1 [2-OEt-4-C(O)Me] D-1 [2-OEt-5-C(O)Me] D-1 [2-OEt-6-C(O)Me] D-1 [2-OEt-3-C(═NOMe)Me] D-1 [2-OEt-4-C(═NOMe)Me] D-1 [2-OEt-5-C(═NOMe)Me] D-1 [2-OEt-6-C(═NOMe)Me] D-1 [2-OPr-n-3-F] D-1 [2-OPr-n-4-F] D-1 [2-OPr-n-5-F] D-1 [2-OPr-n-3-Cl] D-1 [2-OPr-n-4-Cl] D-1 [2-OPr-n-5-Cl] D-1 [2-OPr-n-3-Me] D-1 [2-OPr-n-4-Me] D-1 [2-OPr-n-5-Me] D-1 [2-OPr-n-6-Me] D-1 [2-OPr-n-3-CF₃] D-1 [2-OPr-n-4-CF₃] D-1 [2-OPr-n-5-CF₃] D-1 [2-OPr-n-6-CF₃] D-1 [2-OPr-n-3-OCHF₂] D-1 [2-OPr-n-4-OCHF₂] D-1 [2-OPr-n-5-OCHF₂] D-1 [2-OPr-n-6-OCHF₂] D-1 [2-OPr-n-3-OCF₃] D-1 [2-OPr-n-4-OCF₃] D-1 [2-OPr-n-5-OCF₃] D-1 [2-OPr-n-6-OCF₃] D-1 [2-OPr-n-3-CN] D-1 [2-OPr-n-4-CN] D-1 [2-OPr-n-5-CN] D-1 [2-OPr-n-6-CN] D-1 [2-OPr-n-3-NO₂] D-1 [2-OPr-n-4-NO₂] D-1 [2-OPr-n-5-NO₂] D-1 [2-OPr-n-6-NO₂] D-1 [2-OPr-n-3-C(O)Me] D-1 [2-OPr-n-4-C(O)Me] D-1 [2-OPr-n-5-C(O)Me] D-1 [2-OPr-n-6-C(O)Me] D-1 [2-OPr-n-3-C(═NOMe)Me] D-1 [2-OPr-n-4-C(═NOMe)Me] D-1 [2-OPr-n-5-C(═NOMe]Me] D-1 [2-OPr-n-6-C(═NOMe)Me] D-1 [2-OPr-i-3-F] D-1 [2-OPr-i-4-F] D-1 [2-OPr-i-5-F] D-1 [2-OPr-i-3-Cl] D-1 [2-OPr-i-4-Cl] D-1 [2-OPr-i-5-Cl] D-1 [2-OPr-i-3-Me] D-1 [2-OPr-i-4-Me] D-1 [2-OPr-i-5-Me] D-1 [2-OPr-i-6-Me] D-1 [2-OPr-i-3-CF₃] D-1 [2-OPr-i-4-CF₃] D-1 [2-OPr-i-5-CF₃] D-1 [2-OPr-i-6-CF₃] D-1 [2-OPr-i-3-OCHF₂] D-1 [2-OPr-i-4-OCHF₂] D-1 [2-OPr-i-5-OCHF₂] D-1 [2-OPr-i-6-OCHF₂] D-1 [2-OPr-i-3-OCF₃] D-1 [2-OPr-i-4-OCF₃] D-1 [2-OPr-i-5-OCF₃] D-1 [2-OPr-i-6-OCF₃] D-1 [2-OPr-i-3-CN] D-1 [2-OPr-i-4-CN] D-1 [2-OPr-i-5-CN] D-1 [2-OPr-i-6-CN] D-1 [2-OPr-i-3-NO₂] D-1 [2-OPr-i-4-NO₂] D-1 [2-OPr-i-5-NO₂] D-1 [2-OPr-i-6-NO₂] D-1 [2-OPr-i-3-C(O)Me] D-1 [2-OPr-i-4-C(O)Me] D-1 [2-OPr-i-5-C(O)Me] D-1 [2-OPr-i-6-C(O)Me] D-1 [2-OPr-i-3-C(═NOMe)Me] D-1 [2-OPr-i-4-C(═NOMe)Me] D-1 [2-OPr-i-5-C(═NOMe)Me] D-1 [2-OPr-i-6-C(═NOMe)Me] D-1 [2-OBu-n-3-F] D-1 [2-OBu-n-4-F] D-1 [2-OBu-n-5-F] D-1 [2-OBu-n-3-Cl] D-1 [2-OBu-n-4-Cl] D-1 [2-OBu-n-5-Cl] D-1 [2-OBu-n-3-Me] D-1 [2-OBu-n-4-Me] D-1 [2-OBu-n-5-Me] D-1 [2-OBu-n-6-Me] D-1 [2-OBu-n-3-CF₃] D-1 [2-OBu-n-4-CF₃] D-1 [2-OBu-n-5-CF₃] D-1 [2-OBu-n-6-CF₃] D-1 [2-OBu-n-3-OCHF₂] D-1 [2-OBu-n-4-OCHF₂] D-1 [2-OBu-n-5-OCHF₂] D-1 [2-OBu-n-6-OCHF₂] D-1 [2-OBu-n-3-OCF₃] D-1 [2-OBu-n-4-OCF₃] D-1 [2-OBu-n-5-OCF₃] D-1 [2-OBu-n-6-OCF₃] D-1 [2-OBu-n-3-CN] D-1 [2-OBu-n-4-CN] D-1 [2-OBu-n-5-CN] D-1 [2-OBu-n-6-CN] D-1 [2-OBu-n-3-NO₂] D-1 [2-OBu-n-4-NO₂] D-1 [2-OBu-n-5-NO₂] D-1 [2-OBu-n-6-NO₂] D-1 [2-OBu-n-3-C(O)Me] D-1 [2-OBu-n-4-C(O)Me] D-1 [2-OBu-n-5-C(O)Me] D-1 [2-OBu-n-6-C(O)Me] D-1 [2-OBu-n-3-C(═NOMe)Me] D-1 [2-OBu-n-4-C(═NOMe)Me] D-1 [2-OBu-n-5-C(═NOMe)Me] D-1 [2-OBu-n-6-C(═NOMe)Me] D-1 [2-OBu-i-3-F] D-1 [2-OBu-i-4-F] D-1 [2-OBu-i-5-F] D-1 [2-OBu-i-3-Cl] D-1 [2-OBu-i-4-Cl] D-1 [2-OBu-i-5-Cl] D-1 [2-OBu-i-3-Me] D-1 [2-OBu-i-4-Me] D-1 [2-OBu-i-5-Me] D-1 [2-OBu-i-6-Me] D-1 [2-OBu-i-3-CF₃] D-1 [2-OBu-i-4-CF₃] D-1 [2-OBu-i-5-CF₃] D-1 [2-OBu-i-6-CF₃] D-1 [2-OBu-i-3-OCHF₂] D-1 [2-OBu-i-4-OCHF₂] D-1 [2-OBu-i-5-OCHF₂] D-1 [2-OBu-i-6-OCHF₂] D-1 [2-OBu-i-3-OCF₃] D-1 [2-OBu-i-4-OCF₃] D-1 [2-OBu-i-5-OCF₃] D-1 [2-OBu-i-6-OCF₃] D-1 [2-OBu-i-3-CN] D-1 [2-OBu-i-4-CN] D-1 [2-OBu-i-5-CN] D-1 [2-OBu-i-6-CN] D-1 [2-OBu-i-3-NO₂] D-1 [2-OBu-i-4-NO₂] D-1 [2-OBu-i-5-NO₂] D-1 [2-OBu-i-6-NO₂] D-1 [2-OBu-i-3-C(O)Me] D-1 [2-OBu-i-4-C(O)Me] D-1 [2-OBu-i-5-C(O)Me] D-1 [2-OBu-i-6-C(O)Me] D-1 [2-OBu-i-3-C(═NOMe)Me] D-1 [2-OBu-i-4-C(═NOMe)Me] D-1 [2-OBu-i-5-C(═NOMe)Me] D-1 [2-OBu-i-6-C(═NOMe)Me] D-1 [2-OBu-t-3-F] D-1 [2-OBu-t-4-F] D-1 [2-OBu-tert-5-F] D-1 [2-OBu-tert-3-Cl] D-1 [2-OBu-tert-4-Cl] D-1 [2-OBu-tert-5-Cl] D-1 [2-OBu-tert-3-Me] D-1 [2-OBu-tert-4-Me] D-1 [2-OBu-tert-5-Me] D-1 [2-OBu-ertt-6-Me] D-1 [2-OBu-tert-3-CF₃] D-1 [2-OBu-tert-4-CF₃] D-1 [2-OBu-tert-5-CF₃] D-1 [2-OBu-tert-6-CF₃] D-1 [2-OBu-tert-3-OCHF₂] D-1 [2-OBu-tert-4-OCHF₂] D-1 [2-OBu-tert-5-OCHF₂] D-1 [2-OBu-tert-6-OCHF₂] D-1 [2-OBu-tert-3-OCF₃] D-1 [2-OBu-tert-4-OCF₃] D-1 [2-OBu-tert-5-OCF₃] D-1 [2-OBu-tert-6-OCF₃] D-1 [2-OBu-tert-3-CN] D-1 [2-OBu-tert-4-CN] D-1 [2-OBu-tert-5-CN] D-1 [2-OBu-tert-6-CN] D-1 [2-OBu-tert-3-NO₂] D-1 [2-OBu-tert-4-NO₂] D-1 [2-OBu-tert-5-NO₂] D-1 [2-OBu-tert-6-NO₂] D-1 [2-OBu-tert-3-C(O)Me] D-1 [2-OBu-tert-4-C(O)Me] D-1 [2-OBu-tert-5-C(O)Me] D-1 [2-OBu-tert-6-C(O)Me] D-1 [2-OBu-tert-3-C(═NOMe)Me] D-1 [2-OBu-tert-4-C(═NOMe)Me] D-1 [2-OBu-tert-5-C(═NOMe)Me] D-1 [2-OBu-tert-6-C(═NOMe)Me] D-1 [2-OCH₂CH═CH₂-3-F] D-1 [2-OCH₂CH═CH₂-4-F] D-1 [2-OCH₂CH═CH₂-5-F] D-1 [2-OCH₂CH═CH₂-3-Cl] D-1 [2-OCH₂CH═CH₂-4-Cl] D-1 [2-OCH₂CH═CH₂-5-Cl] D-1 [2-OCH₂CH═CH₂-3-Me] D-1 [2-OCH₂CH═CH₂-4-Me] D-1 [2-OCH₂CH═CH₂-5-Me] D-1 [2-OCH₂CH═CH₂-6-Me] D-1 [2-OCH₂CH═CH₂-3-CF₃] D-1 [2-OCH₂CH═CH₂-4-CF₃] D-1 [2-OCH₂CH═CH₂-5-CF₃] D-1 [2-OCH₂CH═CH₂-6-CF₃] D-1 [2-OCH₂CH═CH₂-3-OCHF₂] D-1 [2-OCH₂CH═CH₂-4-OCHF₂] D-1 [2-OCH₂CH═CH₂-5-OCHF₂] D-1 [2-OCH₂CH═CH₂-6-OCHF₂] D-1 [2-OCH₂CH═CH₂-3-OCF₃] D-1 [2-OCH₂CH═CH₂-4-OCF₃] D-1 [2-OCH₂CH═CH₂-5-OCF₃] D-1 [2-OCH₂CH═CH₂-6-OCF₃] D-1 [2-OCH₂CH═CH₂-3-CN] D-1 [2-OCH₂CH═CH₂-4-CN] D-1 [2-OCH₂CH═CH₂-5-CN] D-1 [2-OCH₂CH═CH₂-6-CN] D-1 [2-OCH₂CH═CH₂-3-NO₂] D-1 [2-OCH₂CH═CH₂-4-NO₂] D-1 [2-OCH₂CH═CH₂-5-NO₂] D-1 [2-OCH₂CH═CH₂-6-NO₂] D-1 [2-OCH₂CH═CH₂-3-C(O)Me] D-1 [2-OCH₂CH═CH₂-4-C(O)Me] D-1 [2-OCH₂CH═CH₂-5-C(O)Me] D-1 [2-OCH₂CH═CH₂-6-C(O)Me] D-1 [2-OCH₂CH═CH₂-3-C(═NOMe)Me] D-1 [2-OCH₂CH═CH₂-4-C(═NOMe)Me] D-1 [2-OCH₂CH═CH₂-5-C(═NOMe)Me] D-1 [2-OCH₂CH═CH₂-6-C(═NOMe)Me] D-1 [2-OCH₂C≡CH-3-F] D-1 [2-OCH₂C≡CH-4-F] D-1 [2-OCH₂C≡CH-5-F] D-1 [2-OCH₂C≡CH-3-Cl] D-1 [2-OCH₂C≡CH-4-Cl] D-1 [2-OCH₂C≡CH-5-Cl] D-1 [2-OCH₂C≡CH-3-Me] D-1 [2-OCH₂C≡CH-4-Me] D-1 [2-OCH₂C≡CH-5-Me] D-1 [2-OCH₂C≡CH-6-Me] D-1 [2-OCH₂C≡CH-3-CF₃] D-1 [2-OCH₂C≡CH-4-CF₃] D-1 [2-OCH₂C≡CH-5-CF₃] D-1 [2-OCH₂C≡CH-6-CF₃] D-1 [2-OCH₂C≡CH-3-OCHF₂] D-1 [2-OCH₂C≡CH-4-OCHF₂] D-1 [2-OCH₂C≡CH-5-OCHF₂] D-1 [2-OCH₂C≡CH-6-OCHF₂] D-1 [2-OCH₂C≡CH-3-OCF₃] D-1 [2-OCH₂C≡CH-4-OCF₃] D-1 [2-OCH₂C≡CH-5-OCF₃] D-1 [2-OCH₂C≡CH-6-OCF₃] D-1 [2-OCH₂C≡CH-3-CN] D-1 [2-OCH₂C≡CH-4-CN] D-1 [2-OCH₂C≡CH-5-CN] D-1 [2-OCH₂C≡CH-6-CN] D-1 [2-OCH₂C≡CH-3-NO₂] D-1 [2-OCH₂C≡CH-4-NO₂] D-1 [2-OCH₂C≡CH-5-NO₂] D-1 [2-OCH₂C≡CH-6-NO₂] D-1 [2-OCH₂C≡CH-3-C(O)Me] D-1 [2-OCH₂C≡CH-4-C(O)Me] D-1 [2-OCH₂C≡CH-5-C(O)Me] D-1 [2-OCH₂C≡CH-6-C(O)Me] D-1 [2-OCH₂C≡CH-3-C(═NOMe)Me] D-1 [2-OCH₂C≡CH-4-C(═NOMe)Me] D-1 [2-OCH₂C≡CH-5-C(═NOMe)Me] D-1 [2-OCH₂C≡CH-6-C(═NOMe)Me] D-1 [2-OCH₂CN-3-F] D-1 [2-OCH₂CN-4-F] D-1 [2-OCH₂CN-5-F] D-1 [2-OCH₂CN-3-Cl] D-1 [2-OCH₂CN-4-Cl] D-1 [2-OCH₂CN-5-Cl] D-1 [2-OCH₂CN-3-Me] D-1 [2-OCH₂CN-4-Me] D-1 [2-OCH₂CN-5-Me] D-1 [2-OCH₂CN-6-Me] D-1 [2-OCH₂CN-3-CF₃] D-1 [2-OCH₂CN-4-CF₃] D-1 [2-OCH₂CN-5-CF₃] D-1 [2-OCH₂CN-6-CF₃] D-1 [2-OCH₂CN-3-OCHF₂] D-1 [2-OCH₂CN-4-OCHF₂] D-1 [2-OCH₂CN-5-OCHF₂] D-1 [2-OCH₂CN-6-OCHF₂] D-1 [2-OCH₂CN-3-OCF₃] D-1 [2-OCH₂CN-4-OCF₃] D-1 [2-OCH₂CN-5-OCF₃] D-1 [2-OCH₂CN-6-OCF₃] D-1 [2-OCH₂CN-3-CN] D-1 [2-OCH₂CN-4-CN] D-1 [2-OCH₂CN-5-CN] D-1 [2-OCH₂CN-6-CN] D-1 [2-OCH₂CN-3-NO₂] D-1 [2-OCH₂CN-4-NO₂] D-1 [2-OCH₂CN-5-NO₂] D-1 [2-OCH₂CN-6-NO₂] D-1 [2-OCH₂CN-3-C(O)Me] D-1 [2-OCH₂CN-4-C(O)Me] D-1 [2-OCH₂CN-5-C(O)Me] D-1 [2-OCH₂CN-6-C(O)Me] D-1 [2-OCH₂CN-3-C(═NOMe)Me] D-1 [2-OCH₂CN-4-C(═NOMe)Me] D-1 [2-OCH₂CN-5-C(═NOMe)Me] D-1 [2-OCH₂CN-6-C(═NOMe)Me] D-1 [2-OCF₃-3-F] D-1 [2-OCF₃-4-F] D-1 [2-OCF₃-5-F] D-1 [2-OCF₃-3-Cl] D-1 [2-OCF₃-4-Cl] D-1 [2-OCF₃-5-Cl] D-1 [2-OCF₃-3-Me] D-1 [2-OCF₃-4-Me] D-1 [2-OCF₃-5-Me] D-1 [2-OCF₃-6-Me] D-1 [2-OCF₃-3-CF₃] D-1 [2-OCF₃-4-CF₃] D-1 [2-OCF₃-5-CF₃] D-1 [2-OCF₃-6-CF₃] D-1 [2-OCF₃-3-OCHF₂] D-1 [2-OCF₃-4-OCHF₂] D-1 [2-OCF₃-5-OCHF₂] D-1 [2-OCF₃-6-OCHF₂] D-1 [2-OCF₃-3-OCF₃] D-1 [2-OCF₃-4-OCF₃] D-1 [2-OCF₃-5-OCF₃] D-1 [2-OCF₃-6-OCF₃] D-1 [2-OCF₃-3-CN] D-1 [2-OCF₃-4-CN] D-1 [2-OCF₃-5-CN] D-1 [2-OCF₃-6-CN] D-1 [2-OCF₃-3-NO₂] D-1 [2-OCF₃-4-NO₂] D-1 [2-OCF₃-5-NO₂] D-1 [2-OCF₃-6-NO₂] D-1 [2-OCF₃-3-C(O)Me] D-1 [2-OCF₃-4-C(O)Me] D-1 [2-OCF₃-5-C(O)Me] D-1 [2-OCF₃-6-C(O)Me] D-1 [2-OCF₃-3-C(═NOMe)Me] D-1 [2-OCF₃-4-C(═NOMe)Me] D-1 [2-OCF₃-5-C(═NOMe)Me] D-1 [2-OCF₃-6-C(═NOMe)Me] D-1 [2-OCH₂CHF₂-3-F] D-1 [2-OCH₂CHF₂-4-F] D-1 [2-OCH₂CHF₂-5-F] D-1 [2-OCH₂CHF₂-3-Cl] D-1 [2-OCH₂CHF₂-4-Cl] D-1 [2-OCH₂CHF2-5-Cl] D-1 [2-OCH₂CHF₂-3-Me] D-1 [2-OCH₂CHF₂-4-Me] D-1 [2-OCH₂CHF₂-5-Me] D-1 [2-OCH₂CHF₂-6-Me] D-1 [2-OCH₂CHF₂-3-CF₃] D-1 [2-OCH₂CHF2-4-CF₃] D-1 [2-OCH₂CHF₂-5-CF₃] D-1 [2-OCH₂CHF₂-6-CF₃] D-1 [2-OCH₂CHF₂-3-OCHF₂] D-1 [2-OCH₂CHF₂-4-OCHF₂] D-1 [2-OCH₂CHF₂-5-OCHF₂] D-1 [2-OCH₂CHF₂-6-OCHF₂] D-1 [2-OCH₂CHF₂-3-OCF₃] D-1 [2-OCH₂CHF₂-4-OCF₃] D-1 [2-OCH₂CHF₂-5-OCF₃] D-1 [2-OCH₂CHF₂-6-OCF₃] D-1 [2-OCH₂CHF₂-3-CN] D-1 [2-OCH₂CHF₂-4-CN] D-1 [2-OCH₂CHF₂-5-CN] D-1 [2-OCH₂CHF₂-6-CN] D-1 [2-OCH₂CHF₂-3-NO₂] D-1 [2-OCH₂CHF₂-4-NO₂] D-1 [2-OCH₂CHF₂-5-NO₂] D-1 [2-OCH₂CHF₂-6-NO₂] D-1 [2-OCH₂CHF₂-3-C(O)Me] D-1 [2-OCH₂CHF₂-4-C(O)Me] D-1 [2-OCH₂CHF₂-5-C(O)Me] D-1 [2-OCH₂CHF₂-6-C(O)Me] D-1 [2-OCH₂CHF₂-3-C(═NOMe)Me] D-1 [2-OCH₂CHF₂-4-C(═NOMe)Me] D-1 [2-OCH₂CHF₂-5-C(═NOMe)Me] D-1 [2-OCH₂CHF₂-6-C(═NOMe)Me] D-1 [2-OCH₂CF₃-3-F] D-1 [2-OCH₂CF₃-4-F] D-1 [2-OCH₂CF₃-5-F] D-1 [2-OCH₂CF₃-3-Cl] D-1 [2-OCH₂CF₃-4-Cl] D-1 [2-OCH₂CF₃-5-Cl] D-1 [2-OCH₂CF₃-3-Me] D-1 [2-OCH₂CF₃-4-Me] D-1 [2-OCH₂CF₃-5-Me] D-1 [2-OCH₂CF₃-6-Me] D-1 [2-OCH₂CF₃-3-CF₃] D-1 [2-OCH₂CF₃-4-CF₃] D-1 [2-OCH₂CF₃-5-CF₃] D-1 [2-OCH₂CF₃-6-CF₃] D-1 [2-OCH₂CF₃-3-OCHF₂] D-1 [2-OCH₂CF₃-4-OCHF₂] D-1 [2-OCH₂CF₃-5-OCHF₂] D-1 [2-OCH₂CF₃-6-OCHF₂] D-1 [2-OCH₂CF₃-3-OCF₃] D-1 [2-OCH₂CF₃-4-OCF₃] D-1 [2-OCH₂CF₃-5-OCF₃] D-1 [2-OCH₂CF₃-6-OCF₃] D-1 [2-OCH₂CF₃-3-CN] D-1 [2-OCH₂CF₃-4-CN] D-1 [2-OCH₂CF₃-5-CN] D-1 [2-OCH₂CF₃-6-CN] D-1 [2-OCH₂CF₃-3-NO₂] D-1 [2-OCH₂CF₃-4-NO₂] D-1 [2-OCH₂CF₃-5-NO₂] D-1 [2-OCH₂CF₃-6-NO₂] D-1 [2-OCH₂CF₃-3-C(O)Me] D-1 [2-OCH₂CF₃-4-C(O)Me] D-1 [2-OCH₂CF₃-5-C(O)Me] D-1 [2-OCH₂CF₃-6-C(O)Me] D-1 [2-OCH₂CF₃-3-C(═NOMe)Me] D-1 [2-OCH₂CF₃-4-C(═NOMe)Me] D-1 [2-OCH₂CF₃-5-C(═NOMe)Me] D-1 [2-OCH₂CF₃-6-C(═NOMe)Me] D-1 [2-SMe-3-F] D-1 [2-SMe-4-F] D-1 [2-SMe-5-F] D-1 [2-SMe-3-Cl] D-1 [2-SMe-4-Cl] D-1 [2-SMe-5-Cl] D-1 [2-SMe-3-Me] D-1 [2-SMe-4-Me] D-1 [2-SMe-5-Me] D-1 [2-SMe-6-Me] D-1 [2-SMe-3-CF₃] D-1 [2-SMe-4-CF₃] D-1 [2-SMe-5-CF₃] D-1 [2-SMe-6-CF₃] D-1 [2-SMe-3-OCHF₂] D-1 [2-SMe-4-OCHF₂] D-1 [2-SMe-5-OCHF₂] D-1 [2-SMe-6-OCHF₂] D-1 [2-SMe-3-OCF₃] D-1 [2-SMe-4-OCF₃] D-1 [2-SMe-5-OCF₃] D-1 [2-SMe-6-OCF₃] D-1 [2-SMe-3-CN] D-1 [2-SMe-4-CN] D-1 [2-SMe-5-CN] D-1 [2-SMe-6-CN] D-1 [2-SMe-3-NO₂] D-1 [2-SMe-4-NO₂] D-1 [2-SMe-5-NO₂] D-1 [2-SMe-6-NO₂] D-1 [2-SMe-3-C(O)Me] D-1 [2-SMe-4-C(O)Me] D-1 [2-SMe-5-C(O)Me] D-1 [2-SMe-6-C(O)Me] D-1 [2-SMe-3-C(═NOMe)Me] D-1 [2-SMe-4-C(═NOMe)Me] D-1 [2-SMe-5-C(═NOMe)Me] D-1 [2-SMe-6-C(═NOMe)Me] D-1 [2-S(O)Me-3-F] D-1 [2-S(O)Me-4-F] D-1 [2-S(O)Me-5-F] D-1 [2-S(O)Me-3-Cl] D-1 [2-S(O)Me-4-Cl] D-1 [2-S(O)Me-5-Cl] D-1 [2-S(O)Me-3-Me] D-1 [2-S(O)Me-4-Me] D-1 [2-S(O)Me-5-Me] D-1 [2-S(O)Me-6-Me] D-1 [2-S(O)Me-3-CF₃] D-1 [2-S(O)Me-4-CF₃] D-1 [2-S(O)Me-5-CF₃] D-1 [2-S(O)Me-6-CF₃] D-1 [2-S(O)Me-3-OCHF₂] D-1 [2-S(O)Me-4-OCHF₂] D-1 [2-S(O)Me-5-OCHF₂] D-1 [2-S(O)Me-6-OCHF₂] D-1 [2-S(O)Me-3-OCF₃] D-1 [2-S(O)Me-4-OCF₃] D-1 [2-S(O)Me-5-OCF₃] D-1 [2-S(O)Me-6-OCF₃] D-1 [2-S(O)Me-3-CN] D-1 [2-S(O)Me-4-CN] D-1 [2-S(O)Me-5-CN] D-1 [2-S(O)Me-6-CN] D-1 [2-S(O)Me-3-NO₂] D-1 [2-S(O)Me-4-NO₂] D-1 [2-S(O)Me-5-NO₂] D-1 [2-S(O)Me-6-NO₂] D-1 [2-S(O)Me-3-C(O)Me] D-1 [2-S(O)Me-4-C(O)Me] D-1 [2-S(O)Me-5-C(O)Me] D-1 [2-S(O)Me-6-C(O)Me] D-1 [2-S(O)Me-3-C(═NOMe)Me] D-1 [2-S(O)Me-4-C(═NOMe)Me] D-1 [2-S(O)Me-5-C(═NOMe)Me] D-1 [2-S(O)Me-6-C(═NOMe)Me] D-1 [2-S(O)₂Me-3-F] D-1 [2-S(O)₂Me-4-F] D-1 [2-S(O)₂Me-5-F] D-1 [2-S(O)₂Me-3-Cl] D-1 [2-S(O)₂Me-4-Cl] D-1 [2-S(O)₂Me-5-Cl] D-1 [2-S(O)₂Me-3-Me] D-1 [2-S(O)₂Me-4-Me] D-1 [2-S(O)₂Me-5-Me] D-1 [2-S(O)₂Me-6-Me] D-1 [2-S(O)₂Me-3-CF₃] D-1 [2-S(O)₂Me-4-CF₃] D-1 [2-S(O)₂Me-5-CF₃] D-1 [2-S(O)₂Me-6-CF₃] D-1 [2-S(O)₂Me-3-OCHF₂] D-1 [2-S(O)₂Me-4-OCHF₂] D-1 [2-S(O)₂Me-5-OCHF₂] D-1 [2-S(O)₂Me-6-OCHF₂] D-1 [2-S(O)₂Me-3-OCF₃] D-1 [2-S(O)₂Me-4-OCF₃] D-1 [2-S(O)₂Me-5-OCF₃] D-1 [2-S(O)₂Me-6-OCF₃] D-1 [2-S(O)₂Me-3-CN] D-1 [2-S(O)₂Me-4-CN] D-1 [2-S(O)₂Me-5-CN] D-1 [2-S(O)₂Me-6-CN] D-1 [2-S(O)₂Me-3-NO₂] D-1 [2-S(O)₂Me-4-NO₂] D-1 [2-S(O)₂Me-5-NO₂] D-1 [2-S(O)₂Me-6-NO₂] D-1 [2-S(O)₂Me-3-C(O)Me] D-1 [2-S(O)₂Me-4-C(O)Me] D-1 [2-S(O)₂Me-5-C(O)Me] D-1 [2-S(O)₂Me-6-C(O)Me] D-1 [2-S(O)₂Me-3-C(═NOMe)Me] D-1 [2-S(O)₂Me-4-C(═NOMe)Me] D-1 [2-S(O)₂Me-5-C(═NOMe)Me] D-1 [2-S(O)₂Me-6-C(═NOMe)Me] D-1 [2-SEt-3-F] D-1 [2-SEt-4-F] D-1 [2-SEt-5-F] D-1 [2-SEt-3-Cl] D-1 [2-SEt-4-Cl] D-1 [2-SEt-5-Cl] D-1 [2-SEt-3-Me] D-1 [2-SEt-4-Me] D-1 [2-SEt-5-Me] D-1 [2-SEt-6-Me] D-1 [2-SEt-3-CF₃] D-1 [2-SEt-4-CF₃] D-1 [2-SEt-5-CF₃] D-1 [2-SEt-6-CF₃] D-1 [2-SEt-3-OCHF₂] D-1 [2-SEt-4-OCHF₂] D-1 [2-SEt-5-OCHF₂] D-1 [2-SEt-6-OCHF₂] D-1 [2-SEt-3-OCF₃] D-1 [2-SEt-4-OCF₃] D-1 [2-SEt-5-OCF₃] D-1 [2-SEt-6-OCF₃] D-1 [2-SEt-3-CN] D-1 [2-SEt-4-CN] D-1 [2-SEt-5-CN] D-1 [2-SEt-6-CN] D-1 [2-SEt-3-NO₂] D-1 [2-SEt-4-NO₂] D-1 [2-SEt-5-NO₂] D-1 [2-SEt-6-NO₂] D-1 [2-SEt-3-C(O)Me] D-1 [2-SEt-4-C(O)Me] D-1 [2-SEt-5-C(O)Me] D-1 [2-SEt-6-C(O)Me] D-1 [2-SEt-3-C(═NOMe)Me] D-1 [2-SEt-4-C(═NOMe)Me] D-1 [2-SEt-5-C(═NOMe)Me] D-1 [2-SEt-6-C(═NOMe)Me] D-1 [2-S(O)Et-3-F] D-1 [2-S(O)Et-4-F] D-1 [2-S(O)Et-5-F] D-1 [2-S(O)Et-3-Cl] D-1 [2-S(O)Et-4-Cl] D-1 [2-S(O)Et-5-Cl] D-1 [2-S(O)Et-3-Me] D-1 [2-S(O)Et-4-Me] D-1 [2-S(O)Et-5-Me] D-1 [2-S(O)Et-6-Me] D-1 [2-S(O)Et-3-CF₃] D-1 [2-S(O)Et-4-CF₃] D-1 [2-S(O)Et-5-CF₃] D-1 [2-S(O)Et-6-CF₃] D-1 [2-S(O)Et-3-OCHF₂] D-1 [2-S(O)Et-4-OCHF₂] D-1 [2-S(O)Et-5-OCHF₂] D-1 [2-S(O)Et-6-OCHF₂] D-1 [2-S(O)Et-3-OCF₃] D-1 [2-S(O)Et-4-OCF₃] D-1 [2-S(O)Et-5-OCF₃] D-1 [2-S(O)Et-6-OCF₃] D-1 [2-S(O)Et-3-CN] D-1 [2-S(O)Et-4-CN] D-1 [2-S(O)Et-5-CN] D-1 [2-S(O)Et-6-CN] D-1 [2-S(O)Et-3-NO₂] D-1 [2-S(O)Et-4-NO₂] D-1 [2-S(O)Et-5-NO₂] D-1 [2-S(O)Et-6-NO₂] D-1 [2-S(O)Et-3-C(O)Me] D-1 [2-S(O)Et-4-C(O)Me] D-1 [2-S(O)Et-5-C(O)Me] D-1 [2-S(O)Et-6-C(O)Me] D-1 [2-S(O)Et-3-C(═NOMe)Me] D-1 [2-S(O)Et-4-C(═NOMe)Me] D-1 [2-S(O)Et-5-C(═NOMe)Me] D-1 [2-S(O)Et-6-C(═NOMe)Me] D-1 [2-S(O)₂Et-3-F] D-1 [2-S(O)₂Et-4-F] D-1 [2-S(O)₂Et-5-F] D-1 [2-S(O)₂Et-3-Cl] D-1 [2-S(O)₂Et-4-Cl] D-1 [2-S(O)₂Et-5-Cl] D-1 [2-S(O)₂Et-3-Me] D-1 [2-S(O)₂Et-4-Me] D-1 [2-S(O)₂Et-5-Me] D-1 [2-S(O)₂Et-6-Me] D-1 [2-S(O)₂Et-3-CF₃] D-1 [2-S(O)₂Et-4-CF₃] D-1 [2-S(O)₂Et-5-CF₃] D-1 [2-S(O)₂Et-6-CF₃] D-1 [2-S(O)₂Et-3-OCHF₂] D-1 [2-S(O)₂Et-4-OCHF₂] D-1 [2-S(O)₂Et-5-OCHF₂] D-1 [2-S(O)₂Et-6-OCHF₂] D-1 [2-S(O)₂Et-3-OCF₃] D-1 [2-S(O)₂Et-4-OCF₃] D-1 [2-S(O)₂Et-5-OCF₃] D-1 [2-S(O)₂Et-6-OCF₃] D-1 [2-S(O)₂Et-3-CN] D-1 [2-S(O)₂Et-4-CN] D-1 [2-S(O)₂Et-5-CN] D-1 [2-S(O)₂Et-6-CN] D-1 [2-S(O)₂Et-3-NO₂] D-1 [2-S(O)₂Et-4-NO₂] D-1 [2-S(O)₂Et-5-NO₂] D-1 [2-S(O)₂Et-6-NO₂] D-1 [2-S(O)₂Et-3-C(O)Me] D-1 [2-S(O)₂Et-4-C(O)Me] D-1 [2-S(O)₂Et-5-C(O)Me] D-1 [2-S(O)₂Et-6-C(O)Me] D-1 [2-S(O)₂Et-3-C(═NOMe)Me] D-1 [2-S(O)₂Et-4-C(═NOMe)Me] D-1 [2-S(O)₂Et-5-C(═NOMe)Me] D-1 [2-S(O)₂Et-6-C(═NOMe)Me] D-2 [3-F] D-2 [4-F] D-2 [5-F] D-2 [6-F] D-2 [3-Br] D-2 [4-Br] D-2 [5-Br] D-2 [6-Br] D-2 [3-Me] D-2 [4-Me] D-2 [5-Me] D-2 [6-Me] D-2 [3-SMe] D-2 [4-SMe] D-2 [5-SMe] D-2 [6-SMe] D-2 [3-CF₃] D-2 [4-CF₃] D-2 [5-CF₃] D-2 [6-CF₃] D-2 [3,5-Cl₂] D-2 [3-Cl-5-CF₃] D-2 [3,6-Cl₂] D-2 [3,5,6-Cl₃] D-2 [3-OEt] D-2 [3-OPr-n] D-2 [3-OPr-i] D-2 [3-OBu-tert] D-2 [5-OEt] D-2 [5-OPr-n] D-2 [5-OPr-i] D-2 [5-OBu-i] D-2 [5-OPr-c] D-2 [5-OBu-n] D-2 [5-OBu-i] D-2 [5-OBu-sec] D-2 [5-OBu-tert] D-2 [5-OBu-c] D-2 [5-OPen-c] D-2 [5-OHex-c] D-2 [5-OCH₂CH═CH₂] D-2 [5-OCH₂C≡CH] D-2 [5-OCH₂CH═C(Me)₂] D-2 [5-OCH₂C≡CMe] D-2 [5-OCHF₂] D-2 [5-OCF₃] D-2 [5-OCH₂CH₂F] D-2 [5-OCH₂CH₂Cl] D-2 [5-OCH₂CHF₂] D-2 [5-OCH₂CH₂CF₃] D-2 [5-OCH₂CF₂CHF₂] D-2 [5-OCH₂CF₂CF₃] D-2 [5-OCH₂CH═CF₂] D-2 [5-OCH₂CH═CCl₂] D-2 [5-OCH₂CH₂CF═CF₂] D-2 [5-OCH₂CH₂CH═CF₂] D-2 [5-OCH₂C≡CCl] D-2 [5-OCH₂C≡CBr] D-2 [5-OCH₂CH₂OMe] D-2 [5-OCH₂CH₂SMe] D-2 [5-OCH₂CH₂S(O)Me] D-2 [5-OCH₂CH₂S(O)₂Me] D-2 [5-SEt] D-2 [5-SPr-n] D-2 [5-SPr-i] D-2 [5-SBu-i] D-2 [5-SPr-c] D-2 [5-SBu-n] D-2 [5-SBu-i] D-2 [5-SBu-sec] D-2 [5-SBu-tert] D-2 [5-SBu-c] D-2 [5-SPen-c] D-2 [5-SHex-c] D-2 [5-SCH₂CH═CH₂] D-2 [5-SCH₂C≡CH] D-2 [5-SCH₂CH═C(Me)₂] D-2 [5-SCH₂C≡CMe] D-2 [5-SCHF₂] D-2 [5-SCF₃] D-2 [5-SCH₂CH₂F] D-2 [5-SCH₂CH₂Cl] D-2 [5-SCH₂CHF₂] D-2 [5-SCH₂CH₂CF₃] D-2 [5-SCH₂CF₂CHF₂] D-2 [5-SCH₂CF₂CF₃] D-2 [5-SCH₂CH═CF₂] D-2 [5-SCH₂CH═CCl₂] D-2 [5-SCH₂CH₂CF═CF₂] D-2 [5-SCH₂CH₂CH═CF₂] D-2 [5-SCH₂C≡CCl] D-2 [5-SCH₂C≡CBr] D-2 [5-SCH₂CH₂OMe] D-2 [5-SCH₂CH₂SMe] D-2 [5-S(O)Et] D-2 [5-S(O)Pr-n] D-2 [5-S(O)Pr-i] D-2 [5-S(O)Bu-i] D-2 [5-S(O)Pr-c] D-2 [5-S(O)Bu-n] D-2 [5-S(O)Bu-i] D-2 [5-S(O)Bu-sec] D-2 [5-S(O)Bu-tert] D-2 [5-S(O)Bu-c] D-2 [5-S(O)Pen-c] D-2 [5-S(O)Hex-c] D-2 [5-S(O)CH₂CH═CH₂] D-2 [5-S(O)CH₂C≡CH] D-2 [5-S(O)CH₂CH═C(Me)₂] D-2 [5-S(O)CH₂C≡CMe] D-2 [5-S(O)CHF₂] D-2 [5-S(O)CF₃] D-2 [5-S(O)CH₂CH₂F] D-2 [5-S(O)CH₂CH₂Cl] D-2 [5-S(O)CH₂CHF₂] D-2 [5-S(O)CH₂CH₂CF₃] D-2 [5-S(O)CH₂CF₂CHF₂] D-2 [5-S(O)CH₂CF₂CF₃] D-2 [5-S(O)CH₂CH═CF₂] D-2 [5-S(O)CH₂CH═CCl₂] D-2 [5-S(O)CH₂CH₂CF═CF₂] D-2 [5-S(O)CH₂CH₂CH═CF₂] D-2 [5-S(O)CH₂C≡CCl] D-2 [5-S(O)CH₂C≡CBr] D-2 [5-S(O)CH₂CH₂OMe] D-2 [5-S(O)CH₂CH₂SMe] D-2 [5-S(O)₂Et] D-2 [5-S(O)₂Pr-n] D-2 [5-S(O)₂Pr-i] D-2 [5-S(O)₂Bu-i] D-2 [5-S(O)₂Pr-c] D-2 [5-S(O)₂Bu-n] D-2 [5-S(O)₂Bu-i] D-2 [5-S(O)₂Bu-sec] D-2 [5-S(O)₂Bu-tert] D-2 [5-S(O)₂Bu-c] D-2 [5-S(O)₂Pen-c] D-2 [5-S(O)₂Hex-c] D-2 [5-S(O)₂CH₂CH≡CH₂] D-2 [5-S(O)₂CH₂C≡CH] D-2 [5-S(O)₂CH₂CH═C(Me)₂] D-2 [5-S(O)₂CH₂C≡CMe] D-2 [5-S(O)₂CHF₂] D-2 [5-S(O)₂CF₃] D-2 [5-S(O)₂CH₂CH₂F] D-2 [5-S(O)₂CH₂CH₂Cl] D-2 [5-S(O)₂CH₂CHF₂] D-2 [5-S(O)₂CH₂CH₂CF₃] D-2 [5-S(O)₂CH₂CF₂CHF₂] D-2 [5-S(O)₂CH₂CF₂CF₃] D-2 [5-S(O)₂CH₂CH═CF₂] D-2 [5-S(O)₂CH₂CH═CCl₂] D-2 [5-S(O)₂CH₂CH₂CF═CF₂] D-2 [5-S(O)₂CH₂CH₂CH═CF₂] D-2 [5-S(O)₂CH₂C≡CCl] D-2 [5-S(O)₂CH₂C≡CBr] D-2 [5-S(O)₂CH₂CH₂OMe] D-2 [5-S(O)₂CH₂CH₂SMe] D-2 [5-S(O)₂CH₂CH₂S(O)Me] D-2 [5-S(O)₂CH₂CH₂S(O)₂Me] D-3 [2-F] D-3 [4-F] D-3 [5-F] D-3 [6-F] D-3 [2-Br] D-3 [4-Br] D-3 [5-Br] D-3 [6-Br] D-3 [2-Me] D-3 [4-Me] D-3 [5-Me] D-3 [6-Me] D-3 [2-SMe] D-3 [4-SMe] D-3 [5-SMe] D-3 [6-SMe] D-3 [2-CF₃] D-3 [4-CF₃] D-3 [5-CF₃] D-3 [6-CF₃] D-3 [2,4-Cl₂] D-3 [2-Cl-4-CF₃] D-3 [2-OCHF₂] D-3 [2-OCF₃] D-3 [2-OEt] D-3 [2-OPr-n] D-3 [2-OPr-i] D-3 [2-OBu-tert] D-3 [2-OEt] D-3 [2-OPr-n] D-3 [2-OPr-i] D-3 [2-OBu-i] D-3 [2-OPr-c] D-3 [2-OBu-n] D-3 [2-OBu-i] D-3 [2-OBu-sec] D-3 [2-OBu-tert] D-3 [2-OBu-c] D-3 [2-OPen-c] D-3 [2-OHex-c] D-3 [2-OCH₂CH═CH₂] D-3 [2-OCH₂C≡CH] D-3 [2-OCH₂CH═C(Me)₂] D-3 [2-OCH₂C≡CMe] D-3 [2-OCHF₂] D-3 [2-OCF₃] D-3 [2-OCH₂CH₂F] D-3 [2-OCH₂CH₂Cl] D-3 [2-OCH₂CHF₂] D-3 [2-OCH₂CH₂CF₃] D-3 [2-OCH₂CF₂CHF₂] D-3 [2-OCH₂CF₂CF₃] D-3 [2-OCH₂CH═CF₂] D-3 [2-OCH₂CH═C02] D-3 [2-OCH₂CH₂CF═CF₂] D-3 [2-OCH₂CH₂CH═CF₂] D-3 [2-OCH₂C≡CCl] D-3 [2-OCH₂C≡CBr] D-3 [2-OCH₂CH₂OMe] D-3 [2-OCH₂CH₂SMe] D-3 [2-OCH₂CH₂S(O)Me] D-3 [2-OCH₂CH₂S(O)₂Me] D-3 [2-SEt] D-3 [2-SPr-n] D-3 [2-SPr-i] D-3 [2-SBu-tert] D-3 [2-SEt] D-3 [2-SPr-n] D-3 [2-SPr-i] D-3 [2-SBu-i] D-3 [2-SPr-c] D-3 [2-SBu-n] D-3 [2-SBu-i] D-3 [2-SBu-sec] D-3 [2-SBu-tert] D-3 [2-SBu-c] D-3 [2-SPen-c] D-3 [2-SHex-c] D-3 [2-SCH₂CH═CH₂] D-3 [2-SCH₂C≡CH] D-3 [2-SCH₂CH═C(Me)₂] D-3 [2-SCH₂C≡CMe] D-3 [2-SCHF₂] D-3 [2-SCF₃] D-3 [2-SCH₂CH₂F] D-3 [2-SCH₂CH₂Cl] D-3 [2-SCH₂CHF₂] D-3 [2-SCH₂CH₂CF₃] D-3 [2-SCH₂CF₂CHF₂] D-3 [2-SCH₂CF₂CF₃] D-3 [2-SCH₂CH═CF₂] D-3 [2-SCH₂CH═CCl₂] D-3 [2-SCH₂CH₂CF═CF₂] D-3 [2-SCH₂CH₂CH═CF₂] D-3 [2-SCH₂C≡CCl] D-3 [2-SCH₂C≡CBr] D-3 [2-SCH₂CH₂OMe] D-3 [2-SCH₂CH₂SMe] D-3 [2-SCH₂CH₂S(O)Me] D-3 [2-SCH₂CH₂S(O)₂Me] D-3 [2-S(O)Et] D-3 [2-S(O)Pr-n] D-3 [2-S(O)Pr-i] D-3 [2-S(O)Bu-tert] D-3 [2-S(O)Et] D-3 [2-S(O)Pr-n] D-3 [2-S(O)Pr-i] D-3 [2-S(O)Bu-i] D-3 [2-S(O)Pr-c] D-3 [2-S(O)Bu-n] D-3 [2-S(O)Bu-i] D-3 [2-S(O)Bu-sec] D-3 [2-S(O)Bu-tert] D-3 [2-S(O)Bu-c] D-3 [2-S(O)Pen-c] D-3 [2-S(O)Hex-c] D-3 [2-S(O)CH₂CH═CH₂] D-3 [2-S(O)CH₂C≡CH] D-3 [2-S(O)CH₂CH═C(Me)₂] D-3 [2-S(O)CH₂C≡CMe] D-3 [2-S(O)CHF₂] D-3 [2-S(O)CF₃] D-3 [2-S(O)CH₂CH₂F] D-3 [2-S(O)CH₂CH₂Cl] D-3 [2-S(O)CH₂CHF₂] D-3 [2-S(O)CH₂CH₂CF₃] D-3 [2-S(O)CH₂CF₂CHF₂] D-3 [2-S(O)CH₂CF₂CF₃] D-3 [2-S(O)CH₂CH═CF₂] D-3 [2-S(O)CH₂CH═CCl₂] D-3 [2-S(O)CH₂CH₂CF═CF₂] D-3 [2-S(O)CH₂CH₂CH═CF₂] D-3 [2-S(O)CH₂C≡CCl] D-3 [2-S(O)CH₂C≡CBr] D-3 [2-S(O)CH₂CH₂OMe] D-3 [2-S(O)CH₂CH₂SMe] D-3 [2-S(O)CH₂CH₂S(O)Me] D-3 [2-S(O)CH₂CH₂S(O)₂Me] D-3 [2-S(O)₂Et] D-3 [2-S(O)₂Pr-n] D-3 [2-S(O)₂Pr-i] D-3 [2-S(O)₂Bu-tert] D-3 [2-S(O)₂Et] D-3 [2-S(O)₂Pr-n] D-3 [2-S(O)₂Pr-i] D-3 [2-S(O)₂Bu-i] D-3 [2-S(O)₂Pr-c] D-3 [2-S(O)₂Bu-n] D-3 [2-S(O)₂Bu-i] D-3 [2-S(O)₂Bu-sec] D-3 [2-S(O)₂Bu-tert] D-3 [2-S(O)₂Bu-c] D-3 [2-S(O)₂Pen-c] D-3 [2-S(O)₂Hex-c] D-3 [2-S(O)₂CH₂CH═CH₂] D-3 [2-S(O)₂CH₂C≡CH] D-3 [2-S(O)₂CH₂CH═C(Me)₂] D-3 [2-S(O)₂CH₂C≡CMe] D-3 [2-S(O)₂CHF₂] D-3 [2-S(O)₂CF₃] D-3 [2-S(O)₂CH₂CH₂F] D-3 [2-S(O)₂CH₂CH₂Cl] D-3 [2-S(O)₂CH₂CHF₂] D-3 [2-S(O)₂CH₂CH₂CF₃] D-3 [2-S(O)₂CH₂CF₂CHF₂] D-3 [2-S(O)₂CH₂CF₂CF₃] D-3 [2-S(O)₂CH₂CH═CF₂] D-3 [2-S(O)₂CH₂CH═CCl₂] D-3 [2-S(O)₂CH₂CH₂CF═CF₂] D-3 [2-S(O)₂CH₂CH₂CH═CF₂] D-3 [2-S(O)₂CH₂C≡CCl] D-3 [2-S(O)₂CH₂C≡CBr] D-3 [2-S(O)₂CH₂CH₂OMe] D-3 [2-S(O)₂CH₂CH₂SMe] D-3 [2-S(O)₂CH₂CH₂S(O)Me] D-3 [2-S(O)₂CH₂CH₂S(O)₂Me] D-3 [4-OEt] D-3 [4-OPr-n] D-3 [4-OPr-i] D-3 [4-OBu-t] D-3 [4-OEt] D-3 [4-OPr-n] D-3 [4-OPr-i] D-3 [4-OBu-i] D-3 [4-OPr-c] D-3 [4-OBu-n] D-3 [4-OBu-i] D-3 [4-OBu-sec] D-3 [4-OBu-tert] D-3 [4-OBu-c] D-3 [4-OPen-c] D-3 [4-OHex-c] D-3 [4-OCH₂CH═CH₂] D-3 [4-OCH₂C≡CH] D-3 [4-OCH₂CH═C(Me)₂] D-3 [4-OCH₂C≡CMe] D-3 [4-OCHF₂] D-3 [4-OCF₃] D-3 [4-OCH₂CH₂F] D-3 [4-OCH₂CH₂Cl] D-3 [4-OCH₂CHF2] D-3 [4-OCH₂CH₂CF₃] D-3 [4-OCH₂CF₂CHF₂] D-3 [4-OCH₂CF₂CF₃] D-3 [4-OCH₂CH═CF₂] D-3 [4-OCH₂CH═CCl₂] D-3 [4-OCH₂CH₂CF═CF₂] D-3 [4-OCH₂CH₂CH═CF₂] D-3 [4-OCH₂C≡CCl] D-3 [4-OCH₂C≡CBr] D-3 [4-OCH₂CH₂OMe] D-3 [4-OCH₂CH₂SMe] D-3 [4-SEt] D-3 [4-SPr-n] D-3 [4-SPr-i] D-3 [4-SBu-tert] D-3 [4-SEt] D-3 [4-SPr-n] D-3 [4-SPr-i] D-3 [4-SBu-i] D-3 [4-SPr-c] D-3 [4-SBu-n] D-3 [4-SBu-i] D-3 [4-SBu-sec] D-3 [4-SBu-tert] D-3 [4-SBu-c] D-3 [4-SPen-c] D-3 [4-SHex-c] D-3 [4-SCH₂CH═CH₂] D-3 [4-SCH₂C≡CH] D-3 [4-SCH₂CH═C(Me)₂] D-3 [4-SCH₂C≡CMe] D-3 [4-SCHF₂] D-3 [4-SCF₃] D-3 [4-SCH₂CH₂F] D-3 [4-SCH₂CH₂Cl] D-3 [4-SCH₂CHF₂] D-3 [4-SCH₂CH₂CF₃] D-3 [4-SCH₂CF₂CHF₂] D-3 [4-SCH₂CF₂CF₃] D-3 [4-SCH₂CH═CF₂] D-3 [4-SCH₂CH═CCl₂] D-3 [4-SCH₂CH₂CF═CF₂] D-3 [4-SCH₂CH₂CH═CF₂] D-3 [4-SCH₂C≡CCl] D-3 [4-SCH₂C≡CBr] D-3 [4-SCH₂CH₂OMe] D-3 [4-SCH₂CH₂SMe] D-3 [4-SCH₂CH₂S(O)Me] D-3 [4-SCH₂CH₂S(O)₂Me] D-3 [4-S(O)Et] D-3 [4-S(O)Pr-n] D-3 [4-S(O)Pr-i] D-3 [4-S(O)Bu-tert] D-3 [4-S(O)Et] D-3 [4-S(O)Pr-n] D-3 [4-S(O)Pr-i] D-3 [4-S(O)Bu-i] D-3 [4-S(O)Pr-c] D-3 [4-S(O)Bu-n] D-3 [4-S(O)Bu-i] D-3 [4-S(O)Bu-sec] D-3 [4-S(O)Bu-tert] D-3 [4-S(O)Bu-c] D-3 [4-S(O)Pen-c] D-3 [4-S(O)Hex-c] D-3 [4-S(O)CH₂CH═CH₂] D-3 [4-S(O)CH₂C≡CH] D-3 [4-S(O)CH₂CH═C(Me)₂] D-3 [4-S(O)CH₂C≡CMe] D-3 [4-S(O)CHF₂] D-3 [4-S(O)CF₃] D-3 [4-S(O)CH₂CH₂F] D-3 [4-S(O)CH₂CH₂Cl] D-3 [4-S(O)CH₂CHF₂] D-3 [4-S(O)CH₂CH₂CF₃] D-3 [4-S(O)CH₂CF₂CHF₂] D-3 [4-S(O)CH₂CF₂CF₃] D-3 [4-S(O)CH₂CH═CF₂] D-3 [4-S(O)CH₂CH═CCl₂] D-3 [4-S(O)CH₂CH₂CF═CF₂] D-3 [4-S(O)CH₂CH₂CH═CF₂] D-3 [4-S(O)CH₂C≡CCl] D-3 [4-S(O)CH₂C≡CBr] D-3 [4-S(O)CH₂CH₂OMe] D-3 [4-S(O)CH₂CH₂SMe] D-3 [4-S(O)CH₂CH₂S(O)Me] D-3 [4-S(O)CH₂CH₂S(O)₂Me] D-3 [4-S(O)₂Et] D-3 [4-S(O)₂Pr-n] D-3 [4-S(O)₂Pr-i] D-3 [4-S(O)₂Bu-tert] D-3 [4-S(O)₂Et] D-3 [4-S(O)₂Pr-n] D-3 [4-S(O)₂Pr-i] D-3 [4-S(O)₂Bu-i] D-3 [4-S(O)₂Pr-c] D-3 [4-S(O)₂Bu-n] D-3 [4-S(O)₂Bu-i] D-3 [4-S(O)₂Bu-sec] D-3 [4-S(O)₂Bu-tert] D-3 [4-S(O)₂Bu-c] D-3 [4-S(O)₂Pen-c] D-3 [4-S(O)₂Hex-c] D-3 [4-S(O)₂CH₂CH═CH₂] D-3 [4-S(O)₂CH₂C≡CH] D-3 [4-S(O)₂CH₂CH═C(Me)₂] D-3 [4-S(O)₂CH₂C≡CMe] D-3 [4-S(O)₂CHF₂] D-3 [4-S(O)₂CF₃] D-3 [4-S(O)₂CH₂CH₂F] D-3 [4-S(O)₂CH₂CH₂Cl] D-3 [4-S(O)₂CH₂CHF₂] D-3 [4-S(O)₂CH₂CH₂CF₃] D-3 [4-S(O)₂CH₂CF₂CHF₂] D-3 [4-S(O)₂CH₂CF₂CF₃] D-3 [4-S(O)₂CH₂CH═CF₂] D-3 [4-S(O)₂CH₂CH═CCl₂] D-3 [4-S(O)₂CH₂CH₂CF═CF₂] D-3 [4-S(O)₂CH₂CH₂CH═CF₂] D-3 [4-S(O)₂CH₂C≡CCl] D-3 [4-S(O)₂CH₂C≡CBr] D-3 [4-S(O)₂CH₂CH₂OMe] D-3 [4-S(O)₂CH₂CH₂SMe] D-3 [4-S(O)₂CH₂CH₂S(O)Me] D-3 [4-S(O)₂CH₂CH₂S(O)₂Me] D-4 [2-F] D-4 [3-F] D-4 [2-Br] D-4 [3-Br] D-4 [2-Me] D-4 [3-Me] D-4 [2,6-F₂] D-4 [2,6-Cl₂] D-4 [2,6-(Me)₂] D-4 [2,3,5,6-F₄] D-4 [2,3,5,6-Cl₄] D-4 [2-N(Me)₂] D-4 [2-CHF₂] D-4 [2-CF₃] D-4 [2-OEt] D-4 [2-OPr-n] D-4 [2-OPr-i] D-4 [2-OBu-tert] D-4 [2-OEt] D-4 [2-OPr-n] D-4 [2-OPr-i] D-4 [2-OBu-i] D-4 [2-OPr-c] D-4 [2-OBu-n] D-4 [2-OBu-i] D-4 [2-OBu-sec] D-4 [2-OBu-tert] D-4 [2-OBu-c] D-4 [2-OPen-c] D-4 [2-OHex-c] D-4 [2-OCH₂CH═CH₂] D-4 [2-OCH₂C≡CH] D-4 [2-OCH₂CH═C(Me)₂] D-4 [2-OCH₂C≡CMe] D-4 [2-OCHF₂] D-4 [2-OCF₃] D-4 [2-OCH₂CH₂F] D-4 [2-OCH₂CH₂Cl] D-4 [2-OCH₂CHF₂] D-4 [2-OCH₂CH₂CF₃] D-4 [2-OCH₂CF₂CHF₂] D-4 [2-OCH₂CF₂CF₃] D-4 [2-OCH₂CH═CF₂] D-4 [2-OCH₂CH═CCl₂] D-4 [2-OCH₂CH₂CF═CF₂] D-4 [2-OCH₂CH₂CH═CF₂] D-4 [2-OCH₂C≡CCl] D-4 [2-OCH₂C≡CBr] D-4 [2-OCH₂CH₂OMe] D-4 [2-OCH₂CH₂SMe] D-4 [2-OCH₂CH₂S(O)Me] D-4 [2-OCH₂CH₂S(O)₂Me] D-4 [2-SEt] D-4 [2-SPr-n] D-4 [2-SPr-i] D-4 [2-SBu-tert] D-4 [2-SEt] D-4 [2-SPr-n] D-4 [2-SPr-i] D-4 [2-SBu-i] D-4 [2-SPr-c] D-4 [2-SBu-n] D-4 [2-SBu-i] D-4 [2-SBu-sec] D-4 [2-SBu-tert] D-4 [2-SBu-c] D-4 [2-SPen-c] D-4 [2-SHex-c] D-4 [2-SCH₂CH═CH₂] D-4 [2-SCH₂C≡CH] D-4 [2-SCH₂CH═C(Me)₂] D-4 [2-SCH₂C≡CMe] D-4 [2-SCHF₂] D-4 [2-SCF₃] D-4 [2-SCH₂CH₂F] D-4 [2-SCH₂CH₂Cl] D-4 [2-SCH₂CHF₂] D-4 [2-SCH₂CH₂CF₃] D-4 [2-SCH₂CF₂CHF₂] D-4 [2-SCH₂CF₂CF₃] D-4 [2-SCH₂CH═CF₂] D-4 [2-SCH₂CH═CCl₂] D-4 [2-SCH₂CH₂CF═CF₂] D-4 [2-SCH₂CH₂CH═CF₂] D-4 [2-SCH₂C≡CCl] D-4 [2-SCH₂C≡CBr] D-4 [2-SCH₂CH₂OMe] D-4 [2-SCH₂CH₂SMe] D-4 [2-SCH₂CH₂S(O)Me] D-4 [2-SCH₂CH₂S(O)₂Me] D-4 [2-S(O)Et] D-4 [2-S(O)Pr-n] D-4 [2-S(O)Pr-i] D-4 [2-S(O)Bu-tert] D-4 [2-S(O)Et] D-4 [2-S(O)Pr-n] D-4 [2-S(O)Pr-i] D-4 [2-S(O)Bu-i] D-4 [2-S(O)Pr-c] D-4 [2-S(O)Bu-n] D-4 [2-S(O)Bu-i] D-4 [2-S(O)Bu-sec] D-4 [2-S(O)Bu-tert] D-4 [2-S(O)Bu-c] D-4 [2-S(O)Pen-c] D-4 [2-S(O)Hex-c] D-4 [2-S(O)CH₂CH═CH₂] D-4 [2-S(O)CH₂C≡CH] D-4 [2-S(O)CH₂CH═C(Me)₂] D-4 [2-S(O)CH₂C≡CMe] D-4 [2-S(O)CHF₂] D-4 [2-S(O)CF₃] D-4 [2-S(O)CH₂CH₂F] D-4 [2-S(O)CH₂CH₂Cl] D-4 [2-S(O)CH₂CHF₂] D-4 [2-S(O)CH₂CH₂CF₃] D-4 [2-S(O)CH₂CF₂CHF₂] D-4 [2-S(O)CH₂CF₂CF₃] D-4 [2-S(O)CH₂CH═CF₂] D-4 [2-S(O)CH₂CH═CCl₂] D-4 [2-S(O)CH₂CH₂CF═CF₂] D-4 [2-S(O)CH₂CH₂CH═CF₂] D-4 [2-S(O)CH₂C≡CCl] D-4 [2-S(O)CH₂C≡CBr] D-4 [2-S(O)CH₂CH₂OMe] D-4 [2-S(O)CH₂CH₂SMe] D-4 [2-S(O)CH₂CH₂S(O)Me] D-4 [2-S(O)CH₂CH₂S(O)₂Me] D-4 [2-S(O)₂Et] D-4 [2-S(O)₂Pr-n] D-4 [2-S(O)₂Pr-i] D-4 [2-S(O)₂Bu-tert] D-4 [2-S(O)₂Et] D-4 [2-S(O)₂Pr-n] D-4 [2-S(O)₂Pr-i] D-4 [2-S(O)₂Bu-i] D-4 [2-S(O)₂Pr-c] D-4 [2-S(O)₂Bu-n] D-4 [2-S(O)₂Bu-i] D-4 [2-S(O)₂Bu-sec] D-4 [2-S(O)₂Bu-tert] D-4 [2-S(O)₂Bu-c] D-4 [2-S(O)₂Pen-c] D-4 [2-S(O)₂Hex-c] D-4 [2-S(O)₂CH₂CH═CH₂] D-4 [2-S(O)₂CH₂C≡CH] D-4 [2-S(O)₂CH₂CH═C(Me)₂] D-4 [2-S(O)₂CH₂C≡CMe] D-4 [2-S(O)₂CHF₂] D-4 [2-S(O)₂CF₃] D-4 [2-S(O)₂CH₂CH₂F] D-4 [2-S(O)₂CH₂CH₂Cl] D-4 [2-S(O)₂CH₂CHF₂] D-4 [2-S(O)₂CH₂CH₂CF₃] D-4 [2-S(O)₂CH₂CF₂CHF₂] D-4 [2-S(O)₂CH₂CF₂CF₃] D-4 [2-S(O)₂CH₂CH═CF₂] D-4 [2-S(O)₂CH₂CH═CCl₂] D-4 [2-S(O)₂CH₂CH₂CF═CF₂] D-4 [2-S(O)₂CH₂CH₂CH═CF₂] D-4 [2-S(O)₂CH₂C≡CCl] D-4 [2-S(O)₂CH₂C≡CBr] D-4 [2-S(O)₂CH₂CH₂OMe] D-4 [2-S(O)₂CH₂CH₂SMe] D-4 [2-S(O)₂CH₂CH₂S(O)Me] D-4 [2-S(O)₂CH₂CH₂S(O)₂Me] D-4 [3-OEt] D-4 [3-OPr-n] D-4 [3-OPr-i] D-4 [3-OBu-tert] D-4 [3-OEt] D-4 [3-OPr-n] D-4 [3-OPr-i] D-4 [3-OBu-i] D-4 [3-OPr-c] D-4 [3-OBu-n] D-4 [3-OBu-i] D-4 [3-OBu-sec] D-4 [3-OBu-tert] D-4 [3-OBu-c] D-4 [3-OPen-c] D-4 [3-OHex-c] D-4 [3-OCH₂CH═CH₂] D-4 [3-OCH₂C≡CH] D-4 [3-OCH₂CH═C(Me)₂] D-4 [3-OCH₂C≡CMe] D-4 [3-OCHF₂] D-4 [3-OCF₃] D-4 [3-OCH₂CH₂F] D-4 [3-OCH₂CH₂Cl] D-4 [3-OCH₂CHF₂] D-4 [3-OCH₂CH₂CF₃] D-4 [3-OCH₂CF₂CHF₂] D-4 [3-OCH₂CF₂CF₃] D-4 [3-OCH₂CH═CF₂] D-4 [3-OCH₂CH═CCl₂] D-4 [3-OCH₂CH₂CF═CF₂] D-4 [3-OCH₂CH₂CH═CF₂] D-4 [3-OCH₂C≡CCl] D-4 [3-OCH₂C≡CBr] D-4 [3-OCH₂CH₂OMe] D-4 [3-OCH₂CH₂SMe] D-4 [3-OCH₂CH₂S(O)Me] D-4 [3-OCH₂CH₂S(O)₂Me] D-4 [3-SEt] D-4 [3-SPr-n] D-4 [3-SPr-i] D-4 [3-SBu-tert] D-4 [3-SEt] D-4 [3-SPr-n] D-4 [3-SPr-i] D-4 [3-SBu-i] D-4 [3-SPr-c] D-4 [3-SBu-n] D-4 [3-SBu-i] D-4 [3-SBu-sec] D-4 [3-SBu-tert] D-4 [3-SBu-c] D-4 [3-SPen-c] D-4 [3-SHex-c] D-4 [3-SCH₂CH═CH₂] D-4 [3-SCH₂C≡CH] D-4 [3-SCH₂CH═C(Me)₂] D-4 [3-SCH₂C≡CMe] D-4 [3-SCHF₂] D-4 [3-SCF₃] D-4 [3-SCH₂CH₂F] D-4 [3-SCH₂CH₂Cl] D-4 [3-SCH₂CHF₂] D-4 [3-SCH₂CH₂CF₃] D-4 [3-SCH₂CF₂CHF₂] D-4 [3-SCH₂CF₂CF₃] D-4 [3-SCH₂CH═CF₂] D-4 [3-SCH₂CH═CCl₂] D-4 [3-SCH₂CH₂CF═CF₂] D-4 [3-SCH₂CH₂CH═CF₂] D-4 [3-SCH₂C≡CCl] D-4 [3-SCH₂C≡CBr] D-4 [3-SCH₂CH₂OMe] D-4 [3-SCH₂CH₂SMe] D-4 [3-SCH₂CH₂S(O)Me] D-4 [3-SCH₂CH₂S(O)₂Me] D-4 [3-S(O)Et] D-4 [3-S(O)Pr-n] D-4 [3-S(O)Pr-i] D-4 [3-S(O)Bu-tert] D-4 [3-S(O)Et] D-4 [3-S(O)Pr-n] D-4 [3-S(O)Pr-i] D-4 [3-S(O)Bu-i] D-4 [3-S(O)Pr-c] D-4 [3-S(O)Bu-n] D-4 [3-S(O)Bu-i] D-4 [3-S(O)Bu-sec] D-4 [3-S(O)Bu-tert] D-4 [3-S(O)Bu-c] D-4 [3-S(O)Pen-c] D-4 [3-S(O)Hex-c] D-4 [3-S(O)CH₂CH═CH₂] D-4 [3-S(O)CH₂C≡CH] D-4 [3-S(O)CH₂CH═C(Me)₂] D-4 [3-S(O)CH₂C≡CMe] D-4 [3-S(O)CHF₂] D-4 [3-S(O)CF₃] D-4 [3-S(O)CH₂CH₂F] D-4 [3-S(O)CH₂CH₂Cl] D-4 [3-S(O)CH₂CHF₂] D-4 [3-S(O)CH₂CH₂CF₃] D-4 [3-S(O)CH₂CF₂CHF₂] D-4 [3-S(O)CH₂CF₂CF₃] D-4 [3-S(O)CH₂CH═CF₂] D-4 [3-S(O)CH₂CH═CCl₂] D-4 [3-S(O)CH₂CH₂CF═CF₂] D-4 [3-S(O)CH₂CH₂CH═CF₂] D-4 [3-S(O)CH₂C≡CCl] D-4 [3-S(O)CH₂C≡CBr] D-4 [3-S(O)CH₂CH₂OMe] D-4 [3-S(O)CH₂CH₂SMe] D-4 [3-S(O)CH₂CH₂S(O)Me] D-4 [3-S(O)CH₂CH₂S(O)₂Me] D-4 [3-S(O)₂Et] D-4 [3-S(O)₂Pr-n] D-4 [3-S(O)₂Pr-i] D-4 [3-S(O)₂Bu-tert] D-4 [3-S(O)₂Et] D-4 [3-S(O)₂Pr-n] D-4 [3-S(O)₂Pr-i] D-4 [3-S(O)₂Bu-i] D-4 [3-S(O)₂Pr-c] D-4 [3-S(O)₂Bu-n] D-4 [3-S(O)₂Bu-i] D-4 [3-S(O)₂Bu-sec] D-4 [3-S(O)₂Bu-tert] D-4 [3-S(O)₂Bu-c] D-4 [3-S(O)₂Pen-c] D-4 [3-S(O)₂Hex-c] D-4 [3-S(O)₂CH₂CH═CH₂] D-4 [3-S(O)₂CH₂C≡CH] D-4 [3-S(O)₂CH₂CH═C(Me)₂] D-4 [3-S(O)₂CH₂C≡CMe] D-4 [3-S(O)₂CHF₂] D-4 [3-S(O)₂CF₃] D-4 [3-S(O)₂CH₂CH₂F] D-4 [3-S(O)₂CH₂CH₂Cl] D-4 [3-S(O)₂CH₂CHF₂] D-4 [3-S(O)₂CH₂CH₂CF₃] D-4 [3-S(O)₂CH₂CF₂CHF₂] D-4 [3-S(O)₂CH₂CF₂CF₃] D-4 [3-S(O)₂CH₂CH═CF₂] D-4 [3-S(O)₂CH₂CH═CCl₂] D-4 [3-S(O)₂CH₂CH₂CF═CF₂] D-4 [3-S(O)₂CH₂CH₂CH═CF₂] D-4 [3-S(O)₂CH₂C≡CCl] D-4 [3-S(O)₂CH₂C≡CBr] D-4 [3-S(O)₂CH₂CH₂OMe] D-4 [3-S(O)₂CH₂CH₂SMe] D-4 [3-S(O)₂CH₂CH₂S(O)Me] D-4 [3-S(O)₂CH₂CH₂S(O)₂Me] D-5 [—] D-5 [3-Cl] D-5 [4-Cl] D-5 [5-Cl] D-5 [3-Br] D-5 [4-Br] D-5 [5-Br] D-5 [3-OMe] D-5 [4-OMe] D-5 [5-OMe] D-5 [3-Me] D-5 [4-Me] D-5 [5-Me] D-5 [5-Pr-c] D-5 [5-CF₃] D-5 [5-Pr-c] D-6 [—] D-6 [2-Cl] D-6 [4-Cl] D-6 [5-Cl] D-6 [2-Br] D-6 [4-Br] D-6 [5-Br] D-6 [2-OMe] D-6 [4-OMe] D-6 [5-OMe] D-7 [—] D-7 [3-Cl] D-7 [4-Cl] D-7 [5-Cl] D-7 [3-Br] D-7 [4-Br] D-7 [5-Br] D-7 [3-OMe] D-7 [4-OMe] D-7 [5-OMe] D-7 [3-CF₃] D-7 [5-CF₃] D-7 [5-SMe] D-7 [5-SEt] D-7 [5-S(O)Me] D-7 [5-S(O)Et] D-7 [5-S(O)₂Me] D-7 [5-S(O)₂Et] D-7 [5-SPr-n] D-7 [5-SEt] D-7 [5-S(O)Pr-n] D-7 [5-S(O)Et] D-7 [5-S(O)₂Pr-n] D-7 [5-S(O)₂Et] D-7 [5-SPr-n] D-7 [5-SPr-i] D-7 [5-S(O)Pr-n] D-7 [5-S(O)Pr-i] D-7 [5-S(O)₂Pr-n] D-7 [5-S(O)₂Pr-i] D-8 [—] D-8 [2-Cl] D-8 [4-Cl] D-8 [5-Cl] D-8 [2-Br] D-8 [4-Br] D-8 [5-Br] D-8 [2-OMe] D-8 [4-OMe] D-8 [5-OMe] D-9 [—] D-9 [3-Cl] D-9 [3-Br] D-9 [3-I] D-9 [3-CN] D-9 [3-CF₃] D-10 [—] D-10 [3-Cl] D-10 [3-Br] D-10 [3-I] D-10 [3-CN] D-10 [3-CF₃] D-11 [—] D-12 [—] D-13 [—] D-13 [2-Cl] D-13 [3-Cl] D-13 [2-Br] D-13 [3-Br] D-13 [2-I] D-13 [3-I] D-13 [2-Me] D-13 [3-Me] D-13 [2-OMe] D-13 [3-OMe] D-13 [2-SMe] D-13 [3-SMe] D-13 [2-S(O)Me] D-13 [3-S(O)Me] D-13 [2-S(O)₂Me] D-13 [3-S(O)₂Me] D-13 [2-CN] D-13 [3-CN] D-13 [2-CF₃] D-13 [3-CF₃] D-13 [2,3-Cl₂] D-14 [—] D-14 [2-Cl] D-14 [3-Cl] D-14 [2-Br] D-14 [3-Br] D-14 [2-I] D-14 [3-I] D-14 [2-Me] D-14 [3-Me] D-14 [2-OMe] D-14 [3-OMe] D-14 [2-SMe] D-14 [3-SMe] D-14 [2-S(O)Me] D-14 [3-S(O)Me] D-14 [2-S(O)₂Me] D-14 [3-S(O)₂Me] D-14 [2-CN] D-14 [3-CN] D-14 [2-CF₃] D-14 [3-CF₃] D-14 [2,3-Cl₂] D-15 [—] D-15 [2-Cl] D-15 [3-Cl] D-15 [2-Br] D-15 [3-Br] D-15 [2-I] D-15 [3-I] D-15 [2-Me] D-15 [3-Me] D-15 [2-OMe] D-15 [3-OMe] D-15 [2-SMe] D-15 [3-SMe] D-15 [2-S(O)Me] D-15 [3-S(O)Me] D-15 [2-S(O)₂Me] D-15 [3-S(O)₂Me] D-15 [2-CN] D-15 [3-CN] D-15 [2-CF₃] D-15 [3-CF₃] D-15 [2,3-Cl₂] D-16 [—] D-16 [2-Cl] D-16 [3-Cl] D-16 [2-Br] D-16 [3-Br] D-16 [2-I] D-16 [3-I] D-16 [2-Me] D-16 [3-Me] D-16 [2-OMe] D-16 [3-OMe] D-16 [2-SMe] D-16 [3-SMe] D-16 [2-S(O)Me] D-16 [3-S(O)Me] D-16 [2-S(O)₂Me] D-16 [3-S(O)₂Me] D-16 [2-CN] D-16 [3-CN] D-16 [2-CF₃] D-16 [3-CF₃] D-16 [2,3-Cl₂] D-17 [—] D-18 [—] D-18 [6-F] D-18 [6-Cl] D-18 [6-Me] D-18 [6-CF₃] D-18 [6-OMe] D-18 [6-OCHF₂] D-18 [6-OCF₃] D-18 [6-SMe] D-18 [6-S(O)Me] D-18 [6-S(O)₂Me] D-18 [6-SCHF₂] D-18 [6-S(O)CHF₂] D-18 [6-S(O)₂CHF₂] D-18 [6-SCF₃] D-18 [6-S(O)CF₃] D-18 [6-S(O)₂CF₃] D-18 [6-CN] D-18 [6,8-F2] D-18 [6,8-Cl₂] D-18 [6-Cl-8-Me] D-18 [8-CF₃] D-19 [—] D-20 [—] D-21 [—] D-22 [—] D-23 [—] D-24 [—] D-25 [—] D-25 [4-F] D-25 [4-Cl] D-25 [4-Br] D-25 [4-I] D-25 [4-Me] D-26 [1-Me-4-OMe] D-26 [1-Me-4-Cl] D-26 [1-Me-4-Br] D-26 [1-Me-5-Cl] D-26 [1-Me-4-Br] D-26 [1-Me-5-CF₃] D-26 [1-Me-5-SMe] D-26 [1-Me-5-S(O)Me] D-26 [1-Me-5-S(O)₂Me] D-26 [1-Me] D-27 [1-Me] D-27 [1-Me-3-Cl] D-27 [1-Me-3-CF₃] D-27 [1-Me-5-CF₃] D-27 [1-CH₂CH₂OMe] D-27 [1-CH₂CH₂SMe] D-27 [1-CH₂CH₂S(O)Me] D-27 [1-CH₂CH₂S(O)₂Me] D-28 [—] D-28 [2-Cl] D-28 [2-OMe] D-28 [2-OEt] D-28 [2-OPr-n] D-28 [2-OPr-i] D-28 [2-SMe] D-28 [2-SEt] D-28 [2-SPr-n] D-28 [2-SPr-i] D-28 [2-S(O)Me] D-28 [2-S(O)Et] D-28 [2-S(O)Pr-n] D-28 [2-S(O)Pr-i] D-28 [2-S(O)₂Me] D-28 [2-S(O)₂Et] D-28 [2-S(O)₂Pr-n] D-28 [2-S(O)₂Pr-i] D-29 [—] D-30 [—] D-31 [—] D-32 [—] D-33 [1-Me] D-34 [1-Me] D-35 [1-Me] D-36 [1-Me] D-37 [1-Me] D-38 [1-Me] D-39 [2-Me] D-40 [2-Me] D-41 [—] D-42 [—] D-43 [—] D-44 [—] D-45 [—] D-46 [—] D-47 [—] D-48 [—] D-49 [—] D-49 [—] D-51 [—] D-52 [—]

Table 1-2 has the same structure as Table 1, except that the condition of Table 1 (i.e., R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹) is “-” (no substitution)) is replaced with the following condition (i.e., R¹ is Me, R² is Me, W¹ is O, G is Me, X is O, and (Z¹)_(n) is “-” (no substitution)).

Specifically, the “condition” described in Table 1-2 of Table 2 corresponds to a compound of Formula (1) wherein R¹ is methyl, R² is methyl, W¹ is an oxygen atom, G is methyl, X is 0, (Z¹) is “-” (i.e., n is 0, and the substituent Z¹ is not present), R³ is D-1, and (Y¹) is “-” (no substitution). The same shall apply to Tables 1-3 to 1-1342.

TABLE 2 Table Condition Table 1-2 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is “—”. Table 1-3 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-F. Table 1-4 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-F. Table 1-5 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-F. Table 1-6 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-F. Table 1-7 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-F. Table 1-8 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-F. Table 1-9 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-F. Table 1-10 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-F. Table 1-11 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-Cl. Table 1-12 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-Cl. Table 1-13 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Cl. Table 1-14 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Cl. Table 1-15 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-Cl. Table 1-16 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-Cl. Table 1-17 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-Cl. Table 1-18 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-Cl. Table 1-19 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-Me. Table 1-20 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-Me. Table 1-21 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Me. Table 1-22 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Me. Table 1-23 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-Me. Table 1-24 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-Me. Table 1-25 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-Me. Table 1-26 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-Me. Table 1-27 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-OMe. Table 1-28 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-OMe. Table 1-29 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OMe. Table 1-30 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OMe. Table 1-31 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OMe. Table 1-32 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OMe. Table 1-33 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OMe. Table 1-34 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OMe. Table 1-35 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is “—”. Table 1-36 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is “—”. Table 1-37 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-F. Table 1-38 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-F. Table 1-39 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-F. Table 1-40 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-F. Table 1-41 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-F. Table 1-42 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-F. Table 1-43 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-F. Table 1-44 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-F. Table 1-45 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-Cl. Table 1-46 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-Cl. Table 1-47 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Cl. Table 1-48 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Cl. Table 1-49 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-Cl. Table 1-50 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-Cl. Table 1-51 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-Cl. Table 1-52 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-Cl. Table 1-53 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-Me. Table 1-54 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-Me. Table 1-55 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Me. Table 1-56 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Me. Table 1-57 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-Me. Table 1-58 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-Me. Table 1-59 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-Me. Table 1-60 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-Me. Table 1-61 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-OMe. Table 1-62 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-OMe. Table 1-63 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OMe. Table 1-64 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OMe. Table 1-65 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OMe. Table 1-66 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OMe. Table 1-67 R¹ is Me, R² is H, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OMe. Table 1-68 R¹ is Me, R² is H, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OMe. Table 1-69 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is “—”. Table 1-70 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is “—”. Table 1-71 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-F. Table 1-72 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-F. Table 1-73 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-F. Table 1-74 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-F. Table 1-75 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-F. Table 1-76 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-F. Table 1-77 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-F. Table 1-78 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-F. Table 1-79 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-Cl. Table 1-80 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-Cl. Table 1-81 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Cl. Table 1-82 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Cl. Table 1-83 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-Cl. Table 1-84 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-Cl. Table 1-85 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-Cl. Table 1-86 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-Cl. Table 1-87 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-Me. Table 1-88 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-Me. Table 1-89 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Me. Table 1-90 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Me. Table 1-91 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-Me. Table 1-92 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-Me. Table 1-93 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-Me. Table 1-94 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-Me. Table 1-95 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-OMe. Table 1-96 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-OMe. Table 1-97 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OMe. Table 1-98 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OMe. Table 1-99 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OMe. Table 1-100 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OMe. Table 1-101 R¹ is Me, R² is Cl, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OMe. Table 1-102 R¹ is Me, R² is Cl, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OMe. Table 1-103 R¹ is Me, R² is Me, W¹ is O, G is Me, X is S, and (Z¹)_(n) is “—”. Table 1-104 R¹ is Me, R² is Me, W¹ is O, G is Me, X is O, and (Z¹)_(n) is “—”. Table 1-105 R¹ is Me, R² is Me, W¹ is O, G is Me, X is S, and (Z¹)_(n) is 5-F. Table 1-106 R¹ is Me, R² is Me, W¹ is O, G is Me, X is O, and (Z¹)_(n) is 5-F. Table 1-107 R¹ is Me, R² is Me, W¹ is O, G is Me, X is S, and (Z¹)_(n) is 6-F. Table 1-108 R¹ is Me, R² is Me, W¹ is O, G is Me, X is O, and (Z¹)_(n) is 6-F. Table 1-109 R¹ is Me, R² is Me, W¹ is O, G is Me, X is S, and (Z¹)_(n) is 7-F. Table 1-110 R¹ is Me, R² is Me, W¹ is O, G is Me, X is O, and (Z¹)_(n) is 7-F. Table 1-111 R¹ is Me, R² is Me, W¹ is O, G is Me, X is S, and (Z¹)_(n) is 5-Cl. Table 1-112 R¹ is Me, R² is Me, W¹ is O, G is Me, X is O, and (Z¹)_(n) is 5-Cl. Table 1-113 R¹ is Me, R² is Me, W¹ is O, G is Me, X is S, and (Z¹)_(n) is 6-Cl. Table 1-114 R¹ is Me, R² is Me, W¹ is O, G is Me, X is O, and (Z¹)_(n) is 6-Cl. Table 1-115 R¹ is Me, R² is Me, W¹ is O, G is Me, X is S, and (Z¹)_(n) is 7-Cl. Table 1-116 R¹ is Me, R² is Me, W¹ is O, G is Me, X is O, and (Z¹)_(n) is 7-Cl. Table 1-117 R¹ is Me, R² is Me, W¹ is O, G is Me, X is S, and (Z¹)_(n) is 5-Me. Table 1-118 R¹ is Me, R² is Me, W¹ is O, G is Me, X is O, and (Z¹)_(n) is 5-Me. Table 1-119 R¹ is Me, R² is Me, W¹ is O, G is Me, X is S, and (Z¹)_(n) is 6-Me. Table 1-120 R¹ is Me, R² is Me, W¹ is O, G is Me, X is O, and (Z¹)_(n) is 6-Me. Table 1-121 R¹ is Me, R² is Me, W¹ is O, G is Me, X is S, and (Z¹)_(n) is 7-Me. Table 1-122 R¹ is Me, R² is Me, W¹ is O, G is Me, X is O, and (Z¹)_(n) is 7-Me. Table 1-123 R¹ is Me, R² is Me, W¹ is O, G is Me, X is S, and (Z¹)_(n) is 5-OMe. Table 1-124 R¹ is Me, R² is Me, W¹ is O, G is Me, X is O, and (Z¹)_(n) is 5-OMe. Table 1-125 R¹ is Me, R² is Me, W¹ is O, G is Me, X is S, and (Z¹)_(n) is 6-OMe. Table 1-126 R¹ is Me, R² is Me, W¹ is O, G is Me, X is O, and (Z¹)_(n) is 6-OMe. Table 1-127 R¹ is Me, R² is Me, W¹ is O, G is Me, X is S, and (Z¹)_(n) is 7-OMe. Table 1-128 R¹ is Me, R² is Me, W¹ is O, G is Me, X is O, and (Z¹)_(n) is 7-OMe. Table 1-129 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is “—”. Table 1-130 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is “—”. Table 1-131 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 5-F. Table 1-132 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 5-F. Table 1-133 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 6-F. Table 1-134 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 6-F. Table 1-135 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 7-F. Table 1-136 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 7-F. Table 1-137 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 5-Cl. Table 1-138 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 5-Cl. Table 1-139 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 6-Cl. Table 1-140 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 6-Cl. Table 1-141 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 7-Cl. Table 1-142 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(η) is 7-Cl. Table 1-143 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 5-Me. Table 1-144 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 5-Me. Table 1-145 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 6-Me. Table 1-146 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 6-Me. Table 1-147 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 7-Me. Table 1-148 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 7-Me. Table 1-149 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 5-OMe. Table 1-150 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 5-OMe. Table 1-151 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 6-OMe. Table 1-152 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 6-OMe. Table 1-153 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 7-OMe. Table 1-154 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 7-OMe. Table 1-155 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is “—”. Table 1-156 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is “—”. Table 1-157 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 5-F. Table 1-158 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 5-F. Table 1-159 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 6-F. Table 1-160 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 6-F. Table 1-161 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 7-F. Table 1-162 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 7-F. Table 1-163 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 5-Cl. Table 1-164 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 5-Cl. Table 1-165 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 6-Cl. Table 1-166 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 6-Cl. Table 1-167 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 7-Cl. Table 1-168 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 7-Cl. Table 1-169 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 5-Me. Table 1-170 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 5-Me. Table 1-171 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 6-Me. Table 1-172 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 6-Me. Table 1-173 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 7-Me. Table 1-174 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 7-Me. Table 1-175 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 5-OMe. Table 1-176 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 5-OMe. Table 1-177 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 6-OMe. Table 1-178 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 6-OMe. Table 1-179 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 7-OMe. Table 1-180 R¹ is Me, R² is H, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 7-OMe. Table 1-181 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is “—”. Table 1-182 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is “—”. Table 1-183 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 5-F. Table 1-184 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 5-F. Table 1-185 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 6-F. Table 1-186 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 6-F. Table 1-187 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 7-F. Table 1-188 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 7-F. Table 1-189 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 5-Cl. Table 1-190 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 5-Cl. Table 1-191 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 6-Cl. Table 1-192 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 6-Cl. Table 1-193 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 7-Cl. Table 1-194 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 7-Cl. Table 1-195 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 5-Me. Table 1-196 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 5-Me. Table 1-197 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 6-Me. Table 1-198 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 6-Me. Table 1-199 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 7-Me. Table 1-200 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 7-Me. Table 1-201 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 5-OMe. Table 1-202 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 5-OMe. Table 1-203 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 6-OMe. Table 1-204 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 6-OMe. Table 1-205 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is S, and (Z¹)_(n) is 7-OMe. Table 1-206 R¹ is Me, R² is Cl, W¹ is O, G is C(O)Pr-n, X is O, and (Z¹)_(n) is 7-OMe. Table 1-207 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is S, and (Z¹)_(n) is “—”. Table 1-208 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is O, and (Z¹)_(n) is “—”. Table 1-209 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is S, and (Z¹)_(n) is 5-F. Table 1-210 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is O, and (Z¹)_(n) is 5-F. Table 1-211 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is S, and (Z¹)_(n) is 6-F. Table 1-212 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is O, and (Z¹)_(n) is 6-F. Table 1-213 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is S, and (Z¹)_(n) is 7-F. Table 1-214 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is O, and (Z¹)_(n) is 7-F. Table 1-215 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is S, and (Z¹)_(n) is 5-Cl. Table 1-216 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is O, and (Z¹)_(n) is 5-Cl. Table 1-217 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is S, and (Z¹)_(n) is 6-Cl. Table 1-218 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is O, and (Z¹)_(n) is 6-Cl. Table 1-219 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is S, and (Z¹)_(n) is 7-Cl. Table 1-220 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is O, and (Z¹)_(n) is 7-Cl. Table 1-221 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is S, and (Z¹)_(n) is 5-Me. Table 1-222 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is O, and (Z¹)_(n) is 5-Me. Table 1-223 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is S, and (Z¹)_(n) is 6-Me. Table 1-224 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is O, and (Z¹)_(n) is 6-Me. Table 1-225 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is S, and (Z¹)_(n) is 7-Me. Table 1-226 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is O, and (Z¹)_(n) is 7-Me. Table 1-227 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is S, and (Z¹)_(n) is 5-OMe. Table 1-228 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is O, and (Z¹)_(n) is 5-OMe. Table 1-229 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is S, and (Z¹)_(n) is 6-OMe. Table 1-230 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is O, and (Z¹)_(n) is 6-OMe. Table 1-231 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is S, and (Z¹)_(n) is 7-OMe. Table 1-232 R¹ is Me, R² is Me, W¹ is O, G is C(O)Pr-i, X is O, and (Z¹)_(n) is 7-OMe. Table 1-233 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is S, and (Z¹)_(n) is “—”. Table 1-234 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is O, and (Z¹)_(n) is “—”. Table 1-235 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is S, and (Z¹)_(n) is 5-F. Table 1-236 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is O, and (Z¹)_(n) is 5-F. Table 1-237 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is S, and (Z¹)_(n) is 6-F. Table 1-238 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is O, and (Z¹)_(n) is 6-F. Table 1-239 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is S, and (Z¹)_(n) is 7-F. Table 1-240 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is O, and (Z¹)_(n) is 7-F. Table 1-241 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is S, and (Z¹)_(n) is 5-Cl. Table 1-242 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is O, and (Z¹)_(n) is 5-Cl. Table 1-243 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is S, and (Z¹)_(n) is 6-Cl. Table 1-244 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is O, and (Z¹)_(n) is 6-Cl. Table 1-245 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is S, and (Z¹)_(n) is 7-Cl. Table 1-246 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is O, and (Z¹)_(n) is 7-Cl. Table 1-247 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is S, and (Z¹)_(n) is 5-Me. Table 1-248 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is O, and (Z¹)_(n) is 5-Me. Table 1-249 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is S, and (Z¹)_(n) is 6-Me. Table 1-250 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is O, and (Z¹)_(n) is 6-Me. Table 1-251 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is S, and (Z¹)_(n) is 7-Me. Table 1-252 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is O, and (Z¹)_(n) is 7-Me. Table 1-253 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is S, and (Z¹)_(n) is 5-OMe. Table 1-254 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is O, and (Z¹)_(n) is 5-OMe. Table 1-255 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is S, and (Z¹)_(n) is 6-OMe. Table 1-256 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is O, and (Z¹)_(n) is 6-OMe. Table 1-257 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is S, and (Z¹)_(n) is 7-OMe. Table 1-258 R¹ is Me, R² is Me, W¹ is O, G is C(O)OMe, X is O, and (Z¹)_(n) is 7-OMe. Table 1-259 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is S, and (Z¹)_(n) is “—”. Table 1-260 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is O, and (Z¹)_(n) is “—”. Table 1-261 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is S, and (Z¹)_(n) is 5-F. Table 1-262 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is O, and (Z¹)_(n) is 5-F. Table 1-263 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is S, and (Z¹)_(n) is 6-F. Table 1-264 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is O, and (Z¹)_(n) is 6-F. Table 1-265 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is S, and (Z¹)_(n) is 7-F. Table 1-266 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is O, and (Z¹)_(n) is 7-F. Table 1-267 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is S, and (Z¹)_(n) is 5-Cl. Table 1-268 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is O, and (Z¹)_(n) is 5-Cl. Table 1-269 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is S, and (Z¹)_(n) is 6-Cl. Table 1-270 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is O, and (Z¹)_(n) is 6-Cl. Table 1-271 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is S, and (Z¹)_(n) is 7-Cl. Table 1-272 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is O, and (Z¹)_(n) is 7-Cl. Table 1-273 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is S, and (Z¹)_(n) is 5-Me. Table 1-274 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is O, and (Z¹)_(n) is 5-Me. Table 1-275 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is S, and (Z¹)_(n) is 6-Me. Table 1-276 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is O, and (Z¹)_(n) is 6-Me. Table 1-277 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is S, and (Z¹)_(n) is 7-Me. Table 1-278 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is O, and (Z¹)_(n) is 7-Me. Table 1-279 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is S, and (Z¹)_(n) is 5-OMe. Table 1-280 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is O, and (Z¹)_(n) is 5-OMe. Table 1-281 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is S, and (Z¹)_(n) is 6-OMe. Table 1-282 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is O, and (Z¹)_(n) is 6-OMe. Table 1-283 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is S, and (Z¹)_(n) is 7-OMe. Table 1-284 R¹ is Me, R² is Me, W¹ is O, G is C(O)OEt, X is O, and (Z¹)_(n) is 7-OMe. Table 1-285 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is S, and (Z¹)_(n) is “—”. Table 1-286 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is O, and (Z¹)_(n) is “—”. Table 1-287 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is S, and (Z¹)_(n) is 5-F. Table 1-288 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is O, and (Z¹)_(n) is 5-F. Table 1-289 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is S, and (Z¹)_(n) is 6-F. Table 1-290 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is O, and (Z¹)_(n) is 6-F. Table 1-291 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is S, and (Z¹)_(n) is 7-F. Table 1-292 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is O, and (Z¹)_(n) is 7-F. Table 1-293 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is S, and (Z¹)_(n) is 5-Cl. Table 1-294 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is O, and (Z¹)_(n) is 5-Cl. Table 1-295 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is S, and (Z¹)_(n) is 6-Cl. Table 1-296 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is O, and (Z¹)_(n) is 6-Cl. Table 1-297 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is S, and (Z¹)_(n) is 7-Cl. Table 1-298 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is O, and (Z¹)_(n) is 7-Cl. Table 1-299 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is S, and (Z¹)_(n) is 5-Me. Table 1-300 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is O, and (Z¹)_(n) is 5-Me. Table 1-301 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is S, and (Z¹)_(n) is 6-Me. Table 1-302 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is O, and (Z¹)_(n) is 6-Me. Table 1-303 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is S, and (Z¹)_(n) is 7-Me. Table 1-304 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is O, and (Z¹)_(n) is 7-Me. Table 1-305 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is S, and (Z¹)_(n) is 5-OMe. Table 1-306 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is O, and (Z¹)_(n) is 5-OMe. Table 1-307 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is S, and (Z¹)_(n) is 6-OMe. Table 1-308 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is O, and (Z¹)_(n) is 6-OMe. Table 1-309 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is S, and (Z¹)_(n) is 7-OMe. Table 1-310 R¹ is Me, R² is Me, W¹ is O, G is C(O)OCH₂CH₂OMe, X is O, and (Z¹)_(n) is 7-OMe. Table 1-311 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is S, and (Z¹)_(n) is “—”. Table 1-312 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is O, and (Z¹)_(n) is “—”. Table 1-313 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is S, and (Z¹)_(n) is 5-F. Table 1-314 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is O, and (Z¹)_(n) is 5-F. Table 1-315 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is S, and (Z¹)_(n) is 6-F. Table 1-316 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is O, and (Z¹)_(n) is 6-F. Table 1-317 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is S, and (Z¹)_(n) is 7-F. Table 1-318 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is O, and (Z¹)_(n) is 7-F. Table 1-319 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is S, and (Z¹)_(n) is 5-Cl. Table 1-320 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is O, and (Z¹)_(n) is 5-Cl. Table 1-321 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is S, and (Z¹)_(n) is 6-Cl. Table 1-322 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is O, and (Z¹)_(n) is 6-Cl. Table 1-323 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is S, and (Z¹)_(n) is 7-Cl. Table 1-324 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is O, and (Z¹)_(n) is 7-Cl. Table 1-325 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is S, and (Z¹)_(n) is 5-Me. Table 1-326 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is O, and (Z¹)_(n) is 5-Me. Table 1-327 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is S, and (Z¹)_(n) is 6-Me. Table 1-328 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is O, and (Z¹)_(n) is 6-Me. Table 1-329 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is S, and (Z¹)_(n) is 7-Me. Table 1-330 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is O, and (Z¹)_(n) is 7-Me. Table 1-331 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is S, and (Z¹)_(n) is 5-OMe. Table 1-332 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is O, and (Z¹)_(n) is 5-OMe. Table 1-333 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is S, and (Z¹)_(n) is 6-OMe. Table 1-334 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is O, and (Z¹)_(n) is 6-OMe. Table 1-335 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is S, and (Z¹)_(n) is 7-OMe. Table 1-336 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Q-2], X is O, and (Z¹)_(n) is 7-OMe. Table 1-337 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is S, and (Z¹)_(n) is “—”. Table 1-338 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is O, and (Z¹)_(n) is “—”. Table 1-339 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is S, and (Z¹)_(n) is 5-F. Table 1-340 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is O, and (Z¹)_(n) is 5-F. Table 1-341 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is S, and (Z¹)_(n) is 6-F. Table 1-342 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is O, and (Z¹)_(n) is 6-F. Table 1-343 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is S, and (Z¹)_(n) is 7-F. Table 1-344 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is O, and (Z¹)_(n) is 7-F. Table 1-345 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is S, and (Z¹)_(n) is 5-Cl. Table 1-346 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is O, and (Z¹)_(n) is 5-Cl. Table 1-347 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is S, and (Z¹)_(n) is 6-Cl. Table 1-348 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is O, and (Z¹)_(n) is 6-Cl. Table 1-349 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is S, and (Z¹)_(n) is 7-Cl. Table 1-350 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is O, and (Z¹)_(n) is 7-Cl. Table 1-351 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is S, and (Z¹)_(n) is 5-Me. Table 1-352 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is O, and (Z¹)_(n) is 5-Me. Table 1-353 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is S, and (Z¹)_(n) is 6-Me. Table 1-354 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is O, and (Z¹)_(n) is 6-Me. Table 1-355 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is S, and (Z¹)_(n) is 7-Me. Table 1-356 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is O, and (Z¹)_(n) is 7-Me. Table 1-357 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is S, and (Z¹)_(n) is 5-OMe. Table 1-358 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is O, and (Z¹)_(n) is 5-OMe. Table 1-359 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is S, and (Z¹)_(n) is 6-OMe. Table 1-360 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is O, and (Z¹)_(n) is 6-OMe. Table 1-361 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is S, and (Z¹)_(n) is 7-OMe. Table 1-362 R¹ is Me, R² is Me, W¹ is O, G is C(O)[U-1a], X is O, and (Z¹)_(n) is 7-OMe. Table 1-363 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is S, and (Z¹)_(n) is “—”. Table 1-364 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is O, and (Z¹)_(n) is “—”. Table 1-365 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is S, and (Z¹)_(n) is 5-F. Table 1-366 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is O, and (Z¹)_(n) is 5-F. Table 1-367 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is S, and (Z¹)_(n) is 6-F. Table 1-368 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is O, and (Z¹)_(n) is 6-F. Table 1-369 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is S, and (Z¹)_(n) is 7-F. Table 1-370 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is O, and (Z¹)_(n) is 7-F. Table 1-371 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is S, and (Z¹)_(n) is 5-Cl. Table 1-372 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is O, and (Z¹)_(n) is 5-Cl. Table 1-373 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is S, and (Z¹)_(n) is 6-Cl. Table 1-374 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is O, and (Z¹)_(n) is 6-Cl. Table 1-375 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is S, and (Z¹)_(n) is 7-Cl. Table 1-376 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is O, and (Z¹)_(n) is 7-Cl. Table 1-377 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is S, and (Z¹)_(n) is 5-Me. Table 1-378 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is O, and (Z¹)_(n) is 5-Me. Table 1-379 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is S, and (Z¹)_(n) is 6-Me. Table 1-380 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is O, and (Z¹)_(n) is 6-Me. Table 1-381 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is S, and (Z¹)_(n) is 7-Me. Table 1-382 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is O, and (Z¹)_(n) is 7-Me. Table 1-383 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is S, and (Z¹)_(n) is 5-OMe. Table 1-384 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is O, and (Z¹)_(n) is 5-OMe. Table 1-385 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is S, and (Z¹)_(n) is 6-OMe. Table 1-386 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is O, and (Z¹)_(n) is 6-OMe. Table 1-387 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is S, and (Z¹)_(n) is 7-OMe. Table 1-388 R¹ is Me, R² is Me, W¹ is O, G is C(O)[Ph-2-Me], X is O, and (Z¹)_(n) is 7-OMe. Table 1-389 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is S, and (Z¹)_(n) is “—”. Table 1-390 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is O, and (Z¹)_(n) is “—”. Table 1-391 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is S, and (Z¹)_(n) is 5-F. Table 1-392 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is O, and (Z¹)_(n) is 5-F. Table 1-393 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is S, and (Z¹)_(n) is 6-F. Table 1-394 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is O, and (Z¹)_(n) is 6-F. Table 1-395 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is S, and (Z¹)_(n) is 7-F. Table 1-396 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is O, and (Z¹)_(n) is 7-F. Table 1-397 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is S, and (Z¹)_(n) is 5-Cl. Table 1-398 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is O, and (Z¹)_(n) is 5-Cl. Table 1-399 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is S, and (Z¹)_(n) is 6-Cl. Table 1-400 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is O, and (Z¹)_(n) is 6-Cl. Table 1-401 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is S, and (Z¹)_(n) is 7-Cl. Table 1-402 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is O, and (Z¹)_(n) is 7-Cl. Table 1-403 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is S, and (Z¹)_(n) is 5-Me. Table 1-404 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is O, and (Z¹)_(n) is 5-Me. Table 1-405 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is S, and (Z¹)_(n) is 6-Me. Table 1-406 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is O, and (Z¹)_(n) is 6-Me. Table 1-407 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is S, and (Z¹)_(n) is 7-Me. Table 1-408 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is O, and (Z¹)_(n) is 7-Me. Table 1-409 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is S, and (Z¹)_(n) is 5-OMe. Table 1-410 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is O, and (Z¹)_(n) is 5-OMe. Table 1-411 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is S, and (Z¹)_(n) is 6-OMe. Table 1-412 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is O, and (Z¹)_(n) is 6-OMe. Table 1-413 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is S, and (Z¹)_(n) is 7-OMe. Table 1-414 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂Me, X is O, and (Z¹)_(n) is 7-OMe. Table 1-415 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is S, and (Z¹)_(n) is “—”. Table 1-416 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is O, and (Z¹)_(n) is “—”. Table 1-417 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is S, and (Z¹)_(n) is 5-F. Table 1-418 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is O, and (Z¹)_(n) is 5-F. Table 1-419 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is S, and (Z¹)_(n) is 6-F. Table 1-420 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is O, and (Z¹)_(n) is 6-F. Table 1-421 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is S, and (Z¹)_(n) is 7-F. Table 1-422 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is O, and (Z¹)_(n) is 7-F. Table 1-423 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is S, and (Z¹)_(n) is 5-Cl. Table 1-424 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is O, and (Z¹)_(n) is 5-Cl. Table 1-425 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is S, and (Z¹)_(n) is 6-Cl. Table 1-426 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is O, and (Z¹)_(n) is 6-Cl. Table 1-427 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is S, and (Z¹)_(n) is 7-Cl. Table 1-428 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is O, and (Z¹)_(n) is 7-Cl. Table 1-429 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is S, and (Z¹)_(n) is 5-Me. Table 1-430 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is O, and (Z¹)_(n) is 5-Me. Table 1-431 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is S, and (Z¹)_(n) is 6-Me. Table 1-432 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is O, and (Z¹)_(n) is 6-Me. Table 1-433 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is S, and (Z¹)_(n) is 7-Me. Table 1-434 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is O, and (Z¹)_(n) is 7-Me. Table 1-435 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is S, and (Z¹)_(n) is 5-OMe. Table 1-436 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is O, and (Z¹)_(n) is 5-OMe. Table 1-437 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is S, and (Z¹)_(n) is 6-OMe. Table 1-438 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is O, and (Z¹)_(n) is 6-OMe. Table 1-439 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is S, and (Z¹)_(n) is 7-OMe. Table 1-440 R¹ is Me, R² is Me, W¹ is O, G is S(O)₂[Ph-4-Me], X is O, and (Z¹)_(n) is 7-OMe. Table 1-441 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is S, and (Z¹)_(n) is “—”. Table 1-442 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is O, and (Z¹)_(n) is “—”. Table 1-443 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is S, and (Z¹)_(n) is 5-F. Table 1-444 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is O, and (Z¹)_(n) is 5-F. Table 1-445 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is S, and (Z¹)_(n) is 6-F. Table 1-446 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is O, and (Z¹)_(n) is 6-F. Table 1-447 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is S, and (Z¹)_(n) is 7-F. Table 1-448 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is O, and (Z¹)_(n) is 7-F. Table 1-449 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is S, and (Z¹)_(n) is 5-Cl. Table 1-450 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is O, and (Z¹)_(n) is 5-Cl. Table 1-451 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is S, and (Z¹)_(n) is 6-Cl. Table 1-452 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is O, and (Z¹)_(n) is 6-Cl. Table 1-453 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is S, and (Z¹)_(n) is 7-Cl. Table 1-454 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is O, and (Z¹)_(n) is 7-Cl. Table 1-455 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is S, and (Z¹)_(n) is 5-Me. Table 1-456 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is O, and (Z¹)_(n) is 5-Me. Table 1-457 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is S, and (Z¹)_(n) is 6-Me. Table 1-458 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is O, and (Z¹)_(n) is 6-Me. Table 1-459 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is S, and (Z¹)_(n) is 7-Me. Table 1-460 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is O, and (Z¹)_(n) is 7-Me. Table 1-461 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is S, and (Z¹)_(n) is 5-OMe. Table 1-462 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is O, and (Z¹)_(n) is 5-OMe. Table 1-463 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is S, and (Z¹)_(n) is 6-OMe. Table 1-464 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is O, and (Z¹)_(n) is 6-OMe. Table 1-465 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is S, and (Z¹)_(n) is 7-OMe. Table 1-466 R¹ is Me, R² is Me, W¹ is O, G is C(O)CH₂OPh, X is O, and (Z¹)_(n) is 7-OMe. Table 1-467 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is “—”. Table 1-468 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is “—”. Table 1-469 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-F. Table 1-470 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-F. Table 1-471 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-F. Table 1-472 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-F. Table 1-473 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-F. Table 1-474 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-F. Table 1-475 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-F. Table 1-476 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-F. Table 1-477 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-Cl. Table 1-478 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-Cl. Table 1-479 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Cl. Table 1-480 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Cl. Table 1-481 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-Cl. Table 1-482 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-Cl. Table 1-483 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-Cl. Table 1-484 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-Cl. Table 1-485 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-Me. Table 1-486 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-Me. Table 1-487 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Me. Table 1-488 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Me. Table 1-489 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-Me. Table 1-490 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-Me. Table 1-491 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-Me. Table 1-492 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(η) is 7-Me. Table 1-493 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-OMe. Table 1-494 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-OMe. Table 1-495 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OMe. Table 1-496 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OMe. Table 1-497 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OMe. Table 1-498 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OMe. Table 1-499 R¹ is Et, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OMe. Table 1-500 R¹ is Et, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OMe. Table 1-501 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is “—”. Table 1-502 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is “—”. Table 1-503 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-F. Table 1-504 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-F. Table 1-505 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-F. Table 1-506 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-F. Table 1-507 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-F. Table 1-508 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-F. Table 1-509 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-F. Table 1-510 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-F. Table 1-511 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-Cl. Table 1-512 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-Cl. Table 1-513 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Cl. Table 1-514 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Cl. Table 1-515 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-Cl. Table 1-516 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-Cl. Table 1-517 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-Cl. Table 1-518 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-Cl. Table 1-519 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-Me. Table 1-520 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-Me. Table 1-521 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Me. Table 1-522 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Me. Table 1-523 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-Me. Table 1-524 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-Me. Table 1-525 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-Me. Table 1-526 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-Me. Table 1-527 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-OMe. Table 1-528 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-OMe. Table 1-529 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OMe. Table 1-530 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OMe. Table 1-531 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OMe. Table 1-532 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OMe. Table 1-533 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OMe. Table 1-534 R¹ is CH₂CH═CH₂, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OMe. Table 1-535 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is “—”. Table 1-536 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is “—”. Table 1-537 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-F. Table 1-538 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-F. Table 1-539 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-F. Table 1-540 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-F. Table 1-541 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-F. Table 1-542 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-F. Table 1-543 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-F. Table 1-544 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-F. Table 1-545 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-Cl. Table 1-546 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-Cl. Table 1-547 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Cl. Table 1-548 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Cl. Table 1-549 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-Cl. Table 1-550 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-Cl. Table 1-551 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-Cl. Table 1-552 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-Cl. Table 1-553 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-Me. Table 1-554 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-Me. Table 1-555 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Me. Table 1-556 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Me. Table 1-557 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-Me. Table 1-558 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-Me. Table 1-559 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-Me. Table 1-560 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-Me. Table 1-561 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 4-OMe. Table 1-562 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 4-OMe. Table 1-563 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OMe. Table 1-564 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OMe. Table 1-565 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OMe. Table 1-566 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OMe. Table 1-567 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OMe. Table 1-568 R¹ is CH₂C≡CH, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OMe. Table 1-569 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OEt. Table 1-570 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OEt. Table 1-571 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OEt. Table 1-572 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OEt. Table 1-573 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OEt. Table 1-574 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OEt. Table 1-575 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OPr-n. Table 1-576 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OPr-n. Table 1-577 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OPr-n. Table 1-578 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OPr-n. Table 1-579 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OPr-n. Table 1-580 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OPr-n. Table 1-581 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OPr-i. Table 1-582 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OPr-i. Table 1-583 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OPr-i. Table 1-584 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OPr-i. Table 1-585 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OPr-i. Table 1-586 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OPr-i. Table 1-587 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OBu-n. Table 1-588 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OBu-n. Table 1-589 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OBu-n. Table 1-590 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OBu-n. Table 1-591 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OBu-n. Table 1-592 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OBu-n. Table 1-593 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OBu-i. Table 1-594 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OBu-i. Table 1-595 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OBu-i. Table 1-596 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OBu-i. Table 1-597 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OBu-i. Table 1-598 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OBu-i. Table 1-599 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OBu-se. Table 1-600 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OBu-sec. Table 1-601 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OBu-sec. Table 1-602 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OBu-sec. Table 1-603 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OBu-sec. Table 1-604 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OBu-sec. Table 1-605 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OBu-tert. Table 1-606 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OBu-tert. Table 1-607 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OBu-tert. Table 1-608 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OBu-tert. Table 1-609 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OBu-tert. Table 1-610 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OBu-tert. Table 1-611 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCH₂CH═CH₂. Table 1-612 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCH₂CH═CH₂. Table 1-613 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CH═CH₂. Table 1-614 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CH═CH₂. Table 1-615 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCH₂CH═CH₂. Table 1-616 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCH₂CH═CH₂. Table 1-617 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCH₂C≡CH. Table 1-618 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCH₂C≡CH. Table 1-619 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂C≡CH. Table 1-620 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂C≡CH. Table 1-621 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCH₂C≡CH. Table 1-622 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCH₂C≡CH. Table 1-623 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCHF₂. Table 1-624 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCHF₂. Table 1-625 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCHF₂. Table 1-626 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCHF₂. Table 1-627 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCHF₂. Table 1-628 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCHF₂. Table 1-629 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCF₃. Table 1-630 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCF₃. Table 1-631 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCF₃. Table 1-632 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCF₃. Table 1-633 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCF₃. Table 1-634 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCF₃. Table 1-635 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCH₂CH₂F. Table 1-636 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCH₂CH₂F. Table 1-637 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CH₂F. Table 1-638 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CH₂F. Table 1-639 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCH₂CH₂F. Table 1-640 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCH₂CH₂F. Table 1-641 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCH₂CHF₂. Table 1-642 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCH₂CHF₂. Table 1-643 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CHF₂. Table 1-644 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CHF₂. Table 1-645 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCH₂CHF₂. Table 1-646 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCH₂CHF₂. Table 1-647 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCH₂CF₃. Table 1-648 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCH₂CF₃. Table 1-649 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CF₃. Table 1-650 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CF₃. Table 1-651 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCH₂CF₃. Table 1-652 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCH₂CF₃. Table 1-653 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCH₂CH═C(F)₂. Table 1-654 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCH₂CH═C(F)₂. Table 1-655 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CH═C(F)₂. Table 1-656 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CH═C(F)₂. Table 1-657 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCH₂CH═C(F)₂. Table 1-658 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCH₂CH═C(F)₂. Table 1-659 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCH₂CH═C(Cl)₂. Table 1-660 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCH₂CH═C(Cl)₂. Table 1-661 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CH═C(Cl)₂. Table 1-662 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CH═C(Cl)₂. Table 1-663 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCH₂CH═C(Cl)₂. Table 1-664 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCH₂CH═C(Cl)₂. Table 1-665 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCH₂C≡CCl. Table 1-666 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCH₂C≡CCl. Table 1-667 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂C≡CCl. Table 1-668 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂C≡CCl. Table 1-669 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCH₂C≡CCl. Table 1-670 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCH₂C≡CCl. Table 1-671 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCH₂C≡CBr. Table 1-672 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCH₂C≡CBr. Table 1-673 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂C≡CBr. Table 1-674 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂C≡CBr. Table 1-675 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCH₂C≡CBr. Table 1-676 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCH₂C≡CBr. Table 1-677 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCH₂(T-1-1). Table 1-678 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCH₂(T-1-1). Table 1-679 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂(T-1-1). Table 1-680 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂(T-1-1). Table 1-681 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCH₂(T-1-1). Table 1-682 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCH₂(T-1-1). Table 1-683 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCH₂(U-1a). Table 1-684 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCH₂(U-1a). Table 1-685 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂(U-1a). Table 1-686 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂(U-1a). Table 1-687 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCH₂(U-1a). Table 1-688 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCH₂(U-1a). Table 1-689 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCH₂CH₂OMe. Table 1-690 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCH₂CH₂OMe. Table 1-691 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CH₂OMe. Table 1-692 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CH₂OMe. Table 1-693 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCH₂CH₂OMe. Table 1-694 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCH₂CH₂OMe. Table 1-695 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCH₂CH₂SMe. Table 1-696 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCH₂CH₂SMe. Table 1-697 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CH₂SMe. Table 1-698 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CH₂SMe. Table 1-699 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCH₂CH₂SMe. Table 1-700 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCH₂CH₂SMe. Table 1-701 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCH₂CH₂S(O)Me. Table 1-702 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCH₂CH₂S(O)Me. Table 1-703 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CH₂S(O)Me. Table 1-704 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CH₂S(O)Me. Table 1-705 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCH₂CH₂S(O)Me. Table 1-706 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCH₂CH₂S(O)Me. Table 1-707 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-OCH₂CH₂S(O)₂Me. Table 1-708 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-OCH₂CH₂S(O)₂Me. Table 1-709 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CH₂S(O)₂Me. Table 1-710 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CH₂S(O)₂Me. Table 1-711 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-OCH₂CH₂S(O)₂Me. Table 1-712 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-OCH₂CH₂S(O)₂Me. Table 1-713 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-NO₂. Table 1-714 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-NO₂. Table 1-715 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-NO₂. Table 1-716 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-NO₂. Table 1-717 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-NO₂. Table 1-718 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-NO₂. Table 1-719 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-NH₂. Table 1-720 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-NH₂. Table 1-721 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-NH₂. Table 1-722 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-NH₂. Table 1-723 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-NH₂. Table 1-724 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-NH₂. Table 1-725 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-C(O)OH. Table 1-726 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-C(O)OH. Table 1-727 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-C(O)OH. Table 1-728 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-C(O)OH. Table 1-729 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-C(O)OH. Table 1-730 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-C(O)OH. Table 1-731 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-C(O)OMe. Table 1-732 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-C(O)OMe. Table 1-733 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-C(O)OMe. Table 1-734 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-C(O)OMe. Table 1-735 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-C(O)OMe. Table 1-736 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-C(O)OMe. Table 1-737 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-C(O)OEt. Table 1-738 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-C(O)OEt. Table 1-739 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-C(O)OEt. Table 1-740 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-C(O)OEt. Table 1-741 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-C(O)OEt. Table 1-742 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-C(O)OEt. Table 1-743 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-CF₃. Table 1-744 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-CF₃. Table 1-745 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-CF₃. Table 1-746 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-CF₃. Table 1-747 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-CF₃. Table 1-748 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-CF₃. Table 1-749 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-(T-1-5). Table 1-750 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-(T-1-5). Table 1-751 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-(T-1-5). Table 1-752 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-(T-1-5). Table 1-753 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-(T-1-5). Table 1-754 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-(T-1-5). Table 1-755 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Pr-c. Table 1-756 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Pr-c. Table 1-757 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-Pr-c. Table 1-758 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-Pr-c. Table 1-759 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-Pr-c. Table 1-760 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-Pr-c. Table 1-761 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-CN. Table 1-762 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-CN. Table 1-763 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-CN. Table 1-764 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-CN. Table 1-765 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-CN. Table 1-766 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-CN. Table 1-767 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-CH₂OMe. Table 1-768 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-CH₂OMe. Table 1-769 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-CH₂OMe. Table 1-770 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-CH₂OMe. Table 1-771 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-CH₂OMe. Table 1-772 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-CH₂OMe. Table 1-773 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-CH₂OCH₂CF₃. Table 1-774 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-CH₂OCH₂CF₃. Table 1-775 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-CH₂OCH₂CF₃. Table 1-776 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-CH₂OCH₂CF₃. Table 1-777 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-CH₂OCH₂CF₃. Table 1-778 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-CH₂OCH₂CF₃. Table 1-779 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-CH₂SMe. Table 1-780 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-CH₂SMe. Table 1-781 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-CH₂SMe. Table 1-782 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-CH₂SMe. Table 1-783 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-CH₂SMe. Table 1-784 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-CH₂SMe. Table 1-785 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-CH₂S(O)Me. Table 1-786 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-CH₂S(O)Me. Table 1-787 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-CH₂S(O)Me. Table 1-788 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-CH₂S(O)Me. Table 1-789 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-CH₂S(O)Me. Table 1-790 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-CH₂S(O)Me. Table 1-791 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-CH₂S(O)₂Me. Table 1-792 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-CH₂S(O)₂Me. Table 1-793 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-CH₂S(O)₂Me. Table 1-794 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-CH₂S(O)₂Me. Table 1-795 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-CH₂S(O)₂Me. Table 1-796 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-CH₂S(O)₂Me. Table 1-797 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SMe. Table 1-798 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SMe. Table 1-799 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SMe. Table 1-800 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SMe. Table 1-801 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SMe. Table 1-802 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SMe. Table 1-803 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SEt. Table 1-804 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SEt. Table 1-805 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SEt. Table 1-806 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SEt. Table 1-807 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SEt. Table 1-808 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SEt. Table 1-809 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SPr-n. Table 1-810 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SPr-n. Table 1-811 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SPr-n. Table 1-812 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SPr-n. Table 1-813 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SPr-n. Table 1-814 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SPr-n. Table 1-815 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SPr-i. Table 1-816 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SPr-i. Table 1-817 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SPr-i. Table 1-818 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SPr-i. Table 1-819 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SPr-i. Table 1-820 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SPr-i. Table 1-821 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SBu-n. Table 1-822 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SBu-n. Table 1-823 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SBu-n. Table 1-824 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SBu-n. Table 1-825 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SBu-n. Table 1-826 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SBu-n. Table 1-827 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SBu-i. Table 1-828 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SBu-i. Table 1-829 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SBu-i. Table 1-830 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SBu-i. Table 1-831 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SBu-i. Table 1-832 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SBu-i. Table 1-833 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SBu-sec. Table 1-834 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SBu-sec. Table 1-835 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SBu-sec. Table 1-836 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SBu-sec. Table 1-837 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SBu-sec. Table 1-838 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SBu-sec. Table 1-839 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SBu-tert. Table 1-840 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SBu-tert. Table 1-841 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SBu-tert. Table 1-842 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SBu-tert. Table 1-843 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SBu-tert. Table 1-844 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SBu-tert. Table 1-845 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCH₂CH═CH₂. Table 1-846 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCH₂CH═CH₂. Table 1-847 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCH₂CH═CH₂. Table 1-848 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCH₂CH═CH₂. Table 1-849 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCH₂CH═CH₂. Table 1-850 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCH₂CH═CH₂. Table 1-851 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCH₂C≡CH. Table 1-852 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCH₂C≡CH. Table 1-853 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCH₂C≡CH. Table 1-854 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCH₂C≡CH. Table 1-855 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCH₂C≡CH. Table 1-856 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCH₂C≡CH. Table 1-857 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCHF₂. Table 1-858 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCHF₂. Table 1-859 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCHF₂. Table 1-860 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCHF₂. Table 1-861 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCHF₂. Table 1-862 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCHF₂. Table 1-863 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCF₃. Table 1-864 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCF₃. Table 1-865 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCF₃. Table 1-866 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCF₃. Table 1-867 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCF₃. Table 1-868 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCF₃. Table 1-869 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCH₂CH₂F. Table 1-870 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCH₂CH₂F. Table 1-871 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCH₂CH₂F. Table 1-872 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCH₂CH₂F. Table 1-873 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCH₂CH₂F. Table 1-874 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCH₂CH₂F. Table 1-875 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCH₂CHF₂. Table 1-876 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCH₂CHF₂. Table 1-877 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCH₂CHF₂. Table 1-878 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCH₂CHF₂. Table 1-879 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCH₂CHF₂. Table 1-880 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCH₂CHF₂. Table 1-881 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCH₂CF₃. Table 1-882 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCH₂CF₃. Table 1-883 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCH₂CF₃. Table 1-884 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCH₂CF₃. Table 1-885 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCH₂CF₃. Table 1-886 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCH₂CF₃. Table 1-887 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCH₂CH═C(F)₂. Table 1-888 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCH₂CH═C(F)₂. Table 1-889 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCH₂CH═C(F)₂. Table 1-890 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCH₂CH═C(F)₂. Table 1-891 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCH₂CH═C(F)₂. Table 1-892 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCH₂CH═C(F)₂. Table 1-893 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCH₂CH═C(Cl)₂. Table 1-894 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCH₂CH═C(Cl)₂. Table 1-895 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCH₂CH═C(Cl)₂. Table 1-896 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCH₂CH═C(Cl)₂. Table 1-897 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCH₂CH═C(Cl)₂. Table 1-898 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCH₂CH═C(Cl)₂. Table 1-899 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCH₂C≡CCl. Table 1-900 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCH₂C≡CCl. Table 1-901 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCH₂C≡CCl. Table 1-902 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCH₂C≡CCl. Table 1-903 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCH₂C≡CCl. Table 1-904 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCH₂C≡CCl. Table 1-905 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCH₂C≡CBr. Table 1-906 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCH₂C≡CBr. Table 1-907 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCH₂C≡CBr. Table 1-908 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCH₂C≡CBr. Table 1-909 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCH₂C≡CBr. Table 1-910 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCH₂C≡CBr. Table 1-911 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCH₂(T-1-1). Table 1-912 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCH₂(T-1-1). Table 1-913 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCH₂(T-1-1). Table 1-914 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCH₂(T-1-1). Table 1-915 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCH₂(T-1-1). Table 1-916 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCH₂(T-1-1). Table 1-917 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCH₂(U-1a). Table 1-918 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCH₂(U-1a). Table 1-919 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCH₂(U-1a). Table 1-920 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCH₂(U-1a). Table 1-921 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCH₂(U-1a). Table 1-922 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCH₂(U-1a). Table 1-923 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCH₂CH₂OMe. Table 1-924 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCH₂CH₂OMe. Table 1-925 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCH₂CH₂OMe. Table 1-926 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCH₂CH₂OMe. Table 1-927 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCH₂CH₂OMe. Table 1-928 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCH₂CH₂OMe. Table 1-929 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCH₂CH₂SMe. Table 1-930 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCH₂CH₂SMe. Table 1-931 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCH₂CH₂SMe. Table 1-932 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCH₂CH₂SMe. Table 1-933 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCH₂CH₂SMe. Table 1-934 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCH₂CH₂SMe. Table 1-935 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCH₂CH₂S(O)Me. Table 1-936 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCH₂CH₂S(O)Me. Table 1-937 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCH₂CH₂S(O)Me. Table 1-938 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCH₂CH₂S(O)Me. Table 1-939 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCH₂CH₂S(O)Me. Table 1-940 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCH₂CH₂S(O)Me. Table 1-941 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-SCH₂CH₂S(O)₂Me. Table 1-942 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-SCH₂CH₂S(O)₂Me. Table 1-943 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-SCH₂CH₂S(O)₂Me. Table 1-944 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-SCH₂CH₂S(O)₂Me. Table 1-945 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-SCH₂CH₂S(O)₂Me. Table 1-946 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-SCH₂CH₂S(O)₂Me. Table 1-947 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)Me. Table 1-948 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)Me. Table 1-949 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)Me. Table 1-950 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)Me. Table 1-951 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)Me. Table 1-952 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)Me. Table 1-953 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)Et. Table 1-954 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)Et. Table 1-955 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)Et. Table 1-956 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)Et. Table 1-957 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)Et. Table 1-958 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)Et. Table 1-959 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)Pr-n. Table 1-960 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)Pr-n. Table 1-961 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)Pr-n. Table 1-962 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)Pr-n. Table 1-963 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)Pr-n. Table 1-964 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)Pr-n. Table 1-965 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)Pr-i. Table 1-966 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)Pr-i. Table 1-967 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)Pr-i. Table 1-968 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)Pr-i. Table 1-969 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)Pr-i. Table 1-970 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)Pr-i. Table 1-971 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)Bu-n. Table 1-972 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)Bu-n. Table 1-973 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)Bu-n. Table 1-974 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)Bu-n. Table 1-975 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)Bu-n. Table 1-976 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)Bu-n. Table 1-977 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)Bu-i. Table 1-978 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)Bu-i. Table 1-979 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)Bu-i. Table 1-980 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)Bu-i. Table 1-981 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)Bu-i. Table 1-982 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)Bu-i. Table 1-983 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)Bu-sec. Table 1-984 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)Bu-sec. Table 1-985 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)Bu-sec. Table 1-986 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)Bu-sec. Table 1-987 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)Bu-sec. Table 1-988 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)Bu-sec. Table 1-989 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)Bu-tert. Table 1-990 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)Bu-tert. Table 1-991 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)Bu-tert. Table 1-992 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)Bu-tert. Table 1-993 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)Bu-tert. Table 1-994 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)Bu-tert. Table 1-995 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CH₂CH═CH₂. Table 1-996 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CH₂CH═CH₂. Table 1-997 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CH₂CH═CH₂. Table 1-998 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CH₂CH═CH₂. Table 1-999 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CH₂CH═CH₂. Table 1-1000 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CH₂CH═CH₂. Table 1-1001 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CH₂C≡CH. Table 1-1002 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CH₂C≡CH. Table 1-1003 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CH₂C≡CH. Table 1-1004 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CH₂C≡CH. Table 1-1005 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CH₂C≡CH. Table 1-1006 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CH₂C≡CH. Table 1-1007 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CHF₂. Table 1-1008 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CHF₂. Table 1-1009 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CHF₂. Table 1-1010 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CHF₂. Table 1-1011 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CHF₂. Table 1-1012 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CHF₂. Table 1-1013 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CF₃. Table 1-1014 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CF₃. Table 1-1015 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CF₃. Table 1-1016 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CF₃. Table 1-1017 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CF₃. Table 1-1018 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CF₃. Table 1-1019 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CH₂CH₂F. Table 1-1020 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CH₂CH₂F. Table 1-1021 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CH₂CH₂F. Table 1-1022 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CH₂CH₂F. Table 1-1023 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CH₂CH₂F. Table 1-1024 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CH₂CH₂F. Table 1-1025 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CH₂CHF₂. Table 1-1026 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CH₂CHF₂. Table 1-1027 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CH₂CHF₂. Table 1-1028 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CH₂CHF₂. Table 1-1029 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CH₂CHF₂. Table 1-1030 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CH₂CHF₂. Table 1-1031 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CH₂CF₃. Table 1-1032 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CH₂CF₃. Table 1-1033 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CH₂CF₃. Table 1-1034 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CH₂CF₃. Table 1-1035 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CH₂CF₃. Table 1-1036 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CH₂CF₃. Table 1-1037 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CH₂CH═C(F)₂. Table 1-1038 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CH₂CH═C(F)₂. Table 1-1039 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CH₂CH═C(F)₂. Table 1-1040 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CH₂CH═C(F)₂. Table 1-1041 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CH₂CH═C(F)₂. Table 1-1042 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CH₂CH═C(F)₂. Table 1-1043 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CH₂CH═C(Cl)₂. Table 1-1044 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CH₂CH═C(Cl)₂. Table 1-1045 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CH₂CH═C(Cl)₂. Table 1-1046 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CH₂CH═C(Cl)₂. Table 1-1047 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CH₂CH═C(Cl)₂. Table 1-1048 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CH₂CH═C(Cl)₂. Table 1-1049 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CH₂C≡CCl. Table 1-1050 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CH₂C≡CCl. Table 1-1051 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CH₂C≡CCl. Table 1-1052 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CH₂C≡CCl. Table 1-1053 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CH₂C≡CCl. Table 1-1054 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CH₂C≡CCl. Table 1-1055 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CH₂C≡CBr. Table 1-1056 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CH₂C≡CBr. Table 1-1057 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CH₂C≡CBr. Table 1-1058 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CH₂C≡CBr. Table 1-1059 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CH₂C≡CBr. Table 1-1060 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CH₂C≡CBr. Table 1-1061 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CH₂(T-1-1). Table 1-1062 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CH₂(T-1-1). Table 1-1063 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CH₂(T-1-1). Table 1-1064 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CH₂(T-1-1). Table 1-1065 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CH₂(T-1-1). Table 1-1066 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CH₂(T-1-1). Table 1-1067 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CH₂(U-1a). Table 1-1068 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CH₂(U-1a). Table 1-1069 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CH₂(U-1a). Table 1-1070 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CH₂(U-1a). Table 1-1071 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CH₂(U-1a). Table 1-1072 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CH₂(U-1a). Table 1-1073 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CH₂CH₂OMe. Table 1-1074 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CH₂CH₂OMe. Table 1-1075 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CH₂CH₂OMe. Table 1-1076 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CH₂CH₂OMe. Table 1-1077 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CH₂CH₂OMe. Table 1-1078 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CH₂CH₂OMe. Table 1-1079 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CH₂CH₂SMe. Table 1-1080 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CH₂CH₂SMe. Table 1-1081 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CH₂CH₂SMe. Table 1-1082 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CH₂CH₂SMe. Table 1-1083 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CH₂CH₂SMe. Table 1-1084 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CH₂CH₂SMe. Table 1-1085 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CH₂CH₂S(O)Me. Table 1-1086 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CH₂CH₂S(O)Me. Table 1-1087 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CH₂CH₂S(O)Me. Table 1-1088 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CH₂CH₂S(O)Me. Table 1-1089 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CH₂CH₂S(O)Me. Table 1-1090 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CH₂CH₂S(O)Me. Table 1-1091 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)CH₂CH₂S(O)₂Me. Table 1-1092 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)CH₂CH₂S(O)₂Me. Table 1-1093 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)CH₂CH₂S(O)₂Me. Table 1-1094 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)CH₂CH₂S(O)₂Me. Table 1-1095 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)CH₂CH₂S(O)₂Me. Table 1-1096 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)CH₂CH₂S(O)₂Me. Table 1-1097 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂Me. Table 1-1098 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂Me. Table 1-1099 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂Me. Table 1-1100 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂Me. Table 1-1101 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂Me. Table 1-1102 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂Me. Table 1-1103 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂Et. Table 1-1104 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂Et. Table 1-1105 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂Et. Table 1-1106 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂Et. Table 1-1107 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂Et. Table 1-1108 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂Et. Table 1-1109 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂Pr-n. Table 1-1110 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂Pr-n. Table 1-1111 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂Pr-n. Table 1-1112 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂Pr-n. Table 1-1113 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂Pr-n. Table 1-1114 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂Pr-n. Table 1-1115 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂Pr-i. Table 1-1116 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂Pr-i. Table 1-1117 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂Pr-i. Table 1-1118 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂Pr-i. Table 1-1119 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂Pr-i. Table 1-1120 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂Pr-i. Table 1-1121 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂Bu-n. Table 1-1122 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂Bu-n. Table 1-1123 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂Bu-n. Table 1-1124 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂Bu-n. Table 1-1125 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂Bu-n. Table 1-1126 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂Bu-n. Table 1-1127 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂Bu-i. Table 1-1128 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂Bu-i. Table 1-1129 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂Bu-i. Table 1-1130 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂Bu-i. Table 1-1131 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂Bu-i. Table 1-1132 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂Bu-i. Table 1-1133 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂Bu-sec. Table 1-1134 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂Bu-sec. Table 1-1135 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂Bu-sec. Table 1-1136 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂Bu-sec. Table 1-1137 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂Bu-sec. Table 1-1138 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂Bu-sec. Table 1-1139 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂Bu-tert. Table 1-1140 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂Bu-tert. Table 1-1141 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂Bu-tert. Table 1-1142 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂Bu-tert. Table 1-1143 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂Bu-tert. Table 1-1144 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂Bu-tert. Table 1-1145 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CH₂CH═CH₂. Table 1-1146 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CH₂CH═CH₂. Table 1-1147 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CH₂CH═CH₂. Table 1-1148 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CH₂CH═CH₂. Table 1-1149 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CH₂CH═CH₂. Table 1-1150 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CH₂CH═CH₂. Table 1-1151 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CH₂C≡CH. Table 1-1152 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CH₂C≡CH. Table 1-1153 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CH₂C≡CH. Table 1-1154 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CH₂C≡CH. Table 1-1155 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CH₂C≡CH. Table 1-1156 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CH₂C≡CH. Table 1-1157 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CHF₂. Table 1-1158 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CHF₂. Table 1-1159 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CHF₂. Table 1-1160 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CHF₂. Table 1-1161 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CHF₂. Table 1-1162 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CHF₂. Table 1-1163 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CF₃. Table 1-1164 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CF₃. Table 1-1165 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CF₃. Table 1-1166 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CF₃. Table 1-1167 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CF₃. Table 1-1168 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CF₃. Table 1-1169 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CH₂CH₂F. Table 1-1170 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CH₂CH₂F. Table 1-1171 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CH₂CH₂F. Table 1-1172 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CH₂CH₂F. Table 1-1173 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CH₂CH₂F. Table 1-1174 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CH₂CH₂F. Table 1-1175 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CH₂CHF₂. Table 1-1176 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CH₂CHF₂. Table 1-1177 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CH₂CHF₂. Table 1-1178 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CH₂CHF₂. Table 1-1179 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CH₂CHF₂. Table 1-1180 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CH₂CHF₂. Table 1-1181 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CH₂CF₃. Table 1-1182 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CH₂CF₃. Table 1-1183 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CH₂CF₃. Table 1-1184 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CH₂CF₃. Table 1-1185 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CH₂CF₃. Table 1-1186 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CH₂CF₃. Table 1-1187 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CH₂CH═C(F)₂. Table 1-1188 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CH₂CH═C(F)₂. Table 1-1189 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CH₂CH═C(F)₂. Table 1-1190 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CH₂CH═C(F)₂. Table 1-1191 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CH₂CH═C(F)₂. Table 1-1192 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CH₂CH═C(F)₂. Table 1-1193 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CH₂CH═C(Cl)₂. Table 1-1194 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CH₂CH═C(Cl)₂. Table 1-1195 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CH₂CH═C(Cl)₂. Table 1-1196 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CH₂CH═C(Cl)₂. Table 1-1197 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CH₂CH═C(Cl)₂. Table 1-1198 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CH₂CH═C(Cl)₂. Table 1-1199 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CH₂C≡CCl. Table 1-1200 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CH₂C≡CCl. Table 1-1201 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CH₂C≡CCl. Table 1-1202 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CH₂C≡CCl. Table 1-1203 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CH₂C≡CCl. Table 1-1204 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CH₂C≡CCl. Table 1-1205 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CH₂C≡CBr. Table 1-1206 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CH₂C≡CBr. Table 1-1207 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CH₂C≡CBr. Table 1-1208 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CH₂C≡CBr. Table 1-1209 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CH₂C≡CBr. Table 1-1210 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CH₂C≡CBr. Table 1-1211 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CH₂(T-1-1). Table 1-1212 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CH₂(T-1-1). Table 1-1213 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CH₂(T-1-1). Table 1-1214 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CH₂(T-1-1). Table 1-1215 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CH₂(T-1-1). Table 1-1216 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CH₂(T-1-1). Table 1-1217 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CH₂(U-1a). Table 1-1218 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CH₂(U-1a). Table 1-1219 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CH₂(U-1a). Table 1-1220 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CH₂(U-1a). Table 1-1221 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CH₂(U-1a). Table 1-1222 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CH₂(U-1a). Table 1-1223 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CH₂CH₂OMe. Table 1-1224 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CH₂CH₂OMe. Table 1-1225 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CH₂CH₂OMe. Table 1-1226 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CH₂CH₂OMe. Table 1-1227 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CH₂CH₂OMe. Table 1-1228 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CH₂CH₂OMe. Table 1-1229 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CH₂CH₂SMe. Table 1-1230 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CH₂CH₂SMe. Table 1-1231 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CH₂CH₂SMe. Table 1-1232 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CH₂CH₂SMe. Table 1-1233 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CH₂CH₂SMe. Table 1-1234 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CH₂CH₂SMe. Table 1-1235 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CH₂CH₂S(O)Me. Table 1-1236 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)₂CH₂CH₂S(O)Me. Table 1-1237 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CH₂CH₂S(O)Me. Table 1-1238 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CH₂CH₂S(O)Me. Table 1-1239 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CH₂CH₂S(O)Me. Table 1-1240 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CH₂CH₂S(O)Me. Table 1-1241 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-S(O)₂CH₂CH₂S(O)₂Me. Table 1-1242 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-S(O)2CH₂CH₂S(O)₂Me. Table 1-1243 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-S(O)₂CH₂CH₂S(O)₂Me. Table 1-1244 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-S(O)₂CH₂CH₂S(O)₂Me. Table 1-1245 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 7-S(O)₂CH₂CH₂S(O)₂Me. Table 1-1246 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 7-S(O)₂CH₂CH₂S(O)₂Me. Table 1-1247 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5,6-F₂. Table 1-1248 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5,6-F₂. Table 1-1249 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5,7-F₂. Table 1-1250 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5,7-F₂. Table 1-1251 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6,7-F₂. Table 1-1252 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6,7-F₂. Table 1-1253 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5,6-Cl₂. Table 1-1254 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5,6-Cl₂. Table 1-1255 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5,7-Cl₂. Table 1-1256 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5,7-Cl₂. Table 1-1257 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6,7-Cl ₂. Table 1-1258 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6,7-Cl ₂. Table 1-1259 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5,6-(Me)₂. Table 1-1260 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5,6-(Me)₂. Table 1-1261 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5,7-(Me)₂. Table 1-1262 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5,7-(Me)₂. Table 1-1263 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6,7-(Me)₂. Table 1-1264 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6,7-(Me)₂. Table 1-1265 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5,6-(OMe)₂. Table 1-1266 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5,6-(OMe)₂. Table 1-1267 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5,7-(OMe)₂. Table 1-1268 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5,7-(OMe)₂. Table 1-1269 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6,7-(Me)₂. Table 1-1270 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6,7-(Me)₂. Table 1-1271 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-F-6-OMe. Table 1-1272 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-F-6-OMe. Table 1-1273 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-F-6-OEt. Table 1-1274 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-F-6-OEt. Table 1-1275 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-F-6-OPr-n. Table 1-1276 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-F-6-OPr-n. Table 1-1277 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-F-6-OPr-i. Table 1-1278 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-F-6-OPr-i. Table 1-1279 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-F-6-OCHF₂. Table 1-1280 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-F-6-OCHF₂. Table 1-1281 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-F-6-OCF₃. Table 1-1282 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-F-6-OCF₃. Table 1-1283 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-F-6-OCH₂CH₂F. Table 1-1284 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-F-6-OCH₂CH₂F. Table 1-1285 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-F-6-OCH₂CHF₂. Table 1-1286 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-F-6-OCH₂CHF₂. Table 1-1287 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-F-6-OCH₂CF₃. Table 1-1288 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-F-6-OCH₂CF₃. Table 1-1289 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Cl-6-OMe. Table 1-1290 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Cl-6-OMe. Table 1-1291 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Cl-6-OEt. Table 1-1292 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Cl-6-OEt. Table 1-1293 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Cl-6-OPr-n. Table 1-1294 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Cl-6-OPr-n. Table 1-1295 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Cl-6-OPr-i. Table 1-1296 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Cl-6-OPr-i. Table 1-1297 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Cl-6-OCHF₂. Table 1-1298 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Cl-6-OCHF₂. Table 1-1299 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Cl-6-OCF₃. Table 1-1300 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Cl-6-OCF₃. Table 1-1301 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Cl-6-OCH₂CH₂F. Table 1-1302 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Cl-6-OCH₂CH₂F. Table 1-1303 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Cl-6-OCH₂CHF₂. Table 1-1304 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Cl-6-OCH₂CHF₂. Table 1-1305 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 5-Cl-6-OCH₂CF₃. Table 1-1306 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 5-Cl-6-OCH₂CF₃. Table 1-1307 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OMe-7-Cl. Table 1-1308 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OMe-7-Cl. Table 1-1309 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OEt-7-Cl. Table 1-1310 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OEt-7-Cl. Table 1-1311 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OPr-n-7-Cl. Table 1-1312 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OPr-n-7-Cl. Table 1-1313 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OPr-i-7-Cl. Table 1-1314 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OPr-i-7-Cl. Table 1-1315 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCHF₂-7-Cl. Table 1-1316 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCHF₂-7-Cl. Table 1-1317 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCF₃-7-Cl. Table 1-1318 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCF₃-7-Cl. Table 1-1319 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CH₂F-7-Cl. Table 1-1320 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CH₂F-7-Cl. Table 1-1321 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CHF₂-7-Cl. Table 1-1322 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CHF₂-7-Cl. Table 1-1323 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CF₃-7-Cl. Table 1-1324 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CF₃-7-Cl. Table 1-1325 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OMe-7-Br. Table 1-1326 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OMe-7-Br. Table 1-1327 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OEt-7-Br. Table 1-1328 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OEt-7-Br. Table 1-1329 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OPr-n-7-Br. Table 1-1330 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OPr-n-7-Br. Table 1-1331 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OPr-i-7-Br. Table 1-1332 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OPr-i-7-Br. Table 1-1333 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCHF₂-7-Br. Table 1-1334 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCHF₂-7-Br. Table 1-1335 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCF₃-7-Br. Table 1-1336 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCF₃-7-Br. Table 1-1337 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CH₂F-7-Br. Table 1-1338 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CH₂F-7-Br. Table 1-1339 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CHF₂-7-Br. Table 1-1340 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CHF₂-7-Br. Table 1-1341 R¹ is Me, R² is Me, W¹ is O, G is H, X is S, and (Z¹)_(n) is 6-OCH₂CF₃-7-Br. Table 1-1342 R¹ is Me, R² is Me, W¹ is O, G is H, X is O, and (Z¹)_(n) is 6-OCH₂CF₃-7-Br.

The compound of the present invention can be used as a herbicide for paddy fields in both soil treatment and foliage treatment under submerged conditions. Examples of paddy field weeds include Gramineae weeds, such as chinese sprangletop (Leptochloa chinensis), bearded sprangletop (Leptochloa fascicularis), barnyard grass (Echinochloa crus-galli), junglerice (Echinochloa colonum), late watergrass (Echinochloa oryzicola), southern cutgrass (Leersia hexandra), knotgrass (Paspalum distichum) saramollagrass (Ischaemum rugosum), itchgrass (Rottboellia cochinchinensis), broadleaf signalgrass (Brachiaria platyphylla), Alexandergrass (Brachiaria plantaginea), large crabgrass (Digitaria sanguinalis), crowfoot grass (Dactyloctenium aegyptium), goosegrass (Eleusine indica), red rice (Oryza sativa), bermuda grass (Cynodon dactylon), and fall panicum (Panicum dichotomiflorum); Cyperaceae weeds, such as Eleocharis kuroguwai, globe fringerush (Fimbristylis miliacea), Japanese bulrush (Schoenoplectus juncoides), Schoenoplectus nipponicus, ricefield bulrush (Schoenoplectus mucronatus), Cyperus serotinus, smallflower umbrella sedge (Cyperus difformis), rice flat sedge (Cyperus iria), purple nutsedge (Cyperus rotundus), yellow nutsedge (Cyperus esculentus), and cosmopolitan bulrush (Bolboschoenus martimus); Alismataceae weeds, such as water plantain (Alisma canaliculatum), pygmy arrowhead (Sagittaria pygmaea), and threeleaf arrowhead (Sagittaria trifolia); Commelinaceae weeds, such as asian spiderwort (Murdannia keisak) and benghal dayflower (Commelina benghalensis); Pontederiaceae weeds, such as heartleaf false pickerelweed (Monochoria korsakowii), oval-leafed pondweed (Monochoria vaginalis), ducksalad (Heteranthera limosa), and water hyacinth (Eichhornia crassipes); Elatinaceae weeds, such as threestamen waterwort (Elatine triandra); Lythraceae weeds, such as redstem (Ammannia coccinea) and indian toothcup (Rotala indica); Oenotheraceae weeds, such as Ludwigia epilobioides and mexican primrose-willow (Ludwigia octovalvis); Scrophulariaceae weeds, such as rushlike dopatrium (Dopatrium junceum), Gratiola japonica, dwarf ambulia (Limnophila sessiliflora), prostrate false pimpernel (Lindernia pyxidaria), and yellowseed false pimpernel (Lindernia dubia); Amaranthaceae weeds, such as alligator weed (Alternanthera philoxeroides) and spiny amaranth (Amaranthus spinosus); Polygonaceae weeds, such as water pepper (Polygonum hydropiper); Sphenocleaceae weeds, such as gooseweed (Sphenoclea zeylanica); Fabaceae weeds, Indian jointvetch (Aeschynomene indica) and hemp sesbania (Sesbania exaltata); Asteraceae weeds, such as devil's beggarticks (Bidens frondosa), three-lobe beggarticks (Bidens tripartita), false daisy (Eclipta prostrata), and goatweed (Ageratum conyzoides); Convolvulaceae weeds, such as swamp morningglory (Ipomoea aquatica); Marsileaceae weeds, such as water clover (Marsilea minuta); Lemnaceae weeds, such as common duckmeat (Spirodela polyrhiza) and duckweed (Lemna paucicostata); and Potamogetonaceae weeds, such as roundleaf pondweed (Potamogeton distinctus).

When the composition of the present invention is used in paddy fields, the treatment can be performed before and after rice planting in a usual manner, and can also be performed in parallel with rice planting.

The compound of the present invention can also be used as a herbicide for farmlands and orchards in any of soil treatment, soil incorporation treatment, and foliage treatment. Examples of farmland weeds include Poaceae weeds, such as fall panicum (Panicum dichotomiflorum), shattercane (Sorgham bicolor), Johnson grass (Sorghum halepense), barnyard grass (Echinochloa crus-galli var crus-galli), cockspur grass (Echinochloa crus-galli var. praticola), Japanese barnyard millet (Echinochloa utilis), southern crabgrass (Digitaria ciliaris), sourgrass (Digitaria insularis), Jamaican crabgrass (Digitaria horizontalis), wild oat (Avena fatua), blackgrass (Alopecurus myosuroides), shortawn foxtail (Alopecurus aequalis), windgrass (Apera spica-venti), downy brome (Bromus tectorum), Italian ryegrass (Lolium multiflorum), rigid ryegrass (Lolium rigidum), littleseed canarygrass (Phalaris minor), annual bluegrass (Poa annua), goosegrass (Eleusine indica), green foxtail (Setaria viridis), giant foxtail (Setaria faberi), signalgrass (Brachiaria decumbens), and southern sandbur (Cenchrus echinatus); Cyperaceae weeds, such as purple nutsedge (Cyperus rotundus); Solanaceae weeds, such as black nightshade (Solanum nigrum) and jimsonweed (Datura stramonium); Malvaceae weeds, velvetleaf (Abutilon theophrasti) and prickly sida (Sida spinosa); Convolvulaceae weeds, such as tall morning-glory (Ipomoea purpurea), ivyleaf morning-glory (Ipomoea hederacea), and Japanese bindweed (Calystegia hederacea); Amaranthaceae weeds, such as purple amaranth (Amaranthus lividus), redroot pigweed (Amaranthus retroflexus), palmer amaranth (Amaranthus palmeri), and tall waterhemp (Amaranthus tuberculatus); Asteraceae weeds, such as common cocklebur (Xanthium strumarium), common ragweed (Ambrosia artemisiifolia), giant ragweed (Ambrosia trifida), horseweed (Conyza canadensis), common sunflower (Helianthus annuus), pineappleweed (Matricaria matricarioides), hairy galinsoga (Galinsoga ciliata), Canada thistle (Cirsium arvense), common groundsel (Senecio vulgaris), and annual fleabane (Erigeron annuus); Brassicaceae weeds, such as variable leaf yellowcress (Rorippa indica), wild mustard (Sinapis arvensis), and shepherd's purse (Capsella bursa pastoris); Polygonaceae weeds, such as oriental lady's thumb (Persicaria longiseta) and wild buckwheat (Polygonum convolvulus); Portulacaceae weeds, such as common purslane (Portulaca oleracea); Chenopodiaceae weeds, such as lamb squarters (Chenopodium album), figleaved goosefoot (Chenopodium ficifolium), kochia (Kochia scoparia), and Russian thistle (Salsola tragus); Caryophyllaceae weeds, such as common chickweed (Stellaria media); Plantaginaceae weeds, such as Persian speedwell (Veronica persica); Commelinaceae weeds, such as Asiatic dayflower (Commelina communis) and Benghal dayflowe (Commelina benghalensis); Lamiaceae weeds, such as henbit (Lamium amplexicaule) and purple deadnettle (Lamium purpureum); Euphorbiaceae weeds, such as wild poinsettia (Euphorbia heterophylla) and spotted spurge (Euphorbia maculata); Rubiaceae weeds, such as false cleavers (Galium spurium) and Asian madder (Rubia akane); Violaceae weeds, such as pansy (Viola tricolor); Papaveraceae weeds, such as filed poppy (Papaver rhoeas); Fabaceae weeds, such as hemp sesbania (Sesbania exaltata) and sicklepod (Cassia obtusifolia); and Oxalidaceae weeds, such as creeping woodsorrel (Oxalis corniculata).

The compound of the present invention can be used for any of soil treatment, soil incorporation treatment, and foliage treatment in non-agricultural lands such as turfs, play grounds, open grounds, road sides, and line ends, other than the agricultural and horticultural fields, such as paddy fields, farmlands, and orchards. Examples of the weeds in these non-agricultural lands include, besides the aforementioned weeds in farmlands and orchards, annual bluegrass (Poa annua), dandelion (Taraxacum officinale), hairy fleabane (Conyza bonariensis), horseweed (Conyza canadensis), guernsey fleabane (Conyza sumatrensis), wavy bittercress (Cardamine flexuosa), white clover (Trifohum repens), lawn pennywort (Hydrocotyle sibthorpioides), Chinese plantain (Plantago asiatica), green kyllinga (Kyllinga brevifolia), and field horsetail (Equisetum arvense).

The composition of the present invention can be applied to a useful plant, a place where the useful plant is to be grown or where it is growing, or a non-agricultural land in a simultaneous or separate manner, to thereby control the growth of an unwanted plants relative to the useful plant. The aforementioned useful plant encompasses, for example, a field crop or a paddy crop, a horticultural crop, turf, and a fruit tree.

Specific examples of the term “useful plant” as used herein include, but are not limited to, crops, such as corn, rice, wheat, barley, rye, oat, sorghum, cotton, soybean, peanut, buckwheat, beet, rapeseed, sunflower, sugar cane, and tobacco; vegetables, such as solanaceous vegetables (e.g., eggplant, tomato, pepper, capsicum, and potato), cucurbitaceous vegetables (e.g., cucumber, pumpkin, zucchini, watermelon, and melon), brassicaceous vegetables (e.g., radish, turnip, horseradish, kohlrabi, Chinese cabbage, cabbage, mustard, broccoli, and cauliflower), Asteraceous vegetables (e.g., burdock, garland chrysanthemum, artichoke, and lettuce), liliaceae vegetables (e.g., leek, onion, garlic, and asparagus), ammiaceous vegetables (e.g., carrot, parsley, celery, and parsnip), chenopodiaceous vegetables (e.g., spinach and Swiss chard), labiatae vegetables (e.g., beefsteak plant, mint, and basil), strawberry, sweet potato, Japanese yam, and aroid; fruits, such as pomaceous fruits (e.g., apple, pear, Japanese pear, quince, and marmelo), stone fleshy fruits (e.g., peach, plum, nectarine, Japanese apricot, cherry, apricot, and prune), citrus fruits (e.g., Citrus unshiu, orange, lemon, lime, and grapefruit), nuts (e.g., chestnut, walnut, hazelnut, almond, pistachio, cashew nut, and macadamia nut), berry fruits (e.g., blueberry, cranberry, blackberry, and raspberry), grape, persimmon, olive, loquat, banana, coffee, date palm, coconut, and oil palm; trees other than fruit trees, such as tea, mulberry, street trees (e.g., ash, birch, dogwood, eucalyptus, ginkgo, lilac, maple, oak, poplar, cercis, liquidambar, plane, zelkova, Japanese arborvitae, Japanese fir, hemlock, juniper, pine, spruce, yew, elm, and buckeye), sweet viburnum, shrubby Japanese yew, cedar, cypress, croton, Japanese spindle, and Japanese photinia; turfs, such as Korean lawn grass (e.g., Zoysia japonica, and Zoysia tenuifolia), Bermuda grass (e.g., Cynodon dactylon), bent grass (e.g., creeping bent, Agrostis stolonifera, and Agrostis capillaris), bluegrass (e.g., Kentucky bluegrass and rough bluegrass), fescue (e.g., Festuca arundinacea, Festuca rubra var. commutate, and creeping red fescue), ryegrass (e.g., darnel, rye grass, and Italian grass), cocksfoot, and timothy grass; oil crops, such as oil palm and Jatropha curcas; flowers and ornamental plants (e.g., rose, carnation, chrysanthemum, prairie gentian, gypsophila, gerbera, marigold, salvia, petunia, verbena, tulip, aster, gentian, lily, pansy, cyclamen, orchid, lily of the valley, lavender, stock, ornamental cabbage, primrose, poinsettia, gladiolus, cattleya, daisy, verbena, cymbidium, and begonia); and foliage plants.

Examples of the term “useful plant” as used herein also include plants that are provided with resistance to HPPD inhibitors (e.g., isoxaflutole), ALS inhibitors (e.g., imazethapyr and thifensulfuron-methyl), EPSP synthase inhibitors (e.g., glyphosate), glutamine synthase inhibitors (e.g., glufosinate), acetyl-CoA carboxylase inhibitors (e.g., sethoxydim), PPO inhibitors (e.g., flumioxazin), and herbicides (e.g., bromoxynil, dicamba, and 2,4-D) by a classical breeding method and a genetic transformation technique.

Examples of the “agricultural and horticultural plant” provided with resistance by a classical breeding method include rapeseed, wheat, sunflower, rice, and corn exhibiting resistance to an imidazolinone-based ALS inhibitory herbicide (e.g., imazethapyr), which are already commercially available under a trade name of Clearfield <registered trademark>.

Similarly, there is soybean provided with resistance to a sulfonylurea-based ALS inhibitory herbicide (e.g., thifensulfuron-methyl) by a classical breeding method, which is already commercially available under a trade name of STS soybean. Similarly, examples of the agricultural and horticultural plant provided with resistance to an acetyl-CoA carboxylase inhibitor (e.g., trione oxime or aryloxy phenoxypropionic acid herbicide) by a classical breeding method include SR corn. The agricultural and horticultural plant provided with resistance to an acetyl-CoA carboxylase inhibitor is described in, for example, Proceedings of the National Academy of Sciences of the United States of America (Proc. Natl. Acad. Sci. USA), Vol. 87, pp. 7175-7179 (1990). A variant acetyl-CoA carboxylase resistant to an acetyl-CoA carboxylase inhibitor is reported in, for example, Weed Science, Vol. 53, pp. 728-746 (2005) and a plant resistant to an acetyl-CoA carboxylase inhibitor can be generated by introducing the gene of such a variant acetyl-CoA carboxylase into a plant by genetically engineering technology, or by introducing a resistant-imparting variation into a crop acetyl-CoA carboxylase. Furthermore, a plant resistant to a acetyl-CoA carboxylase inhibitor/herbicide can be generated by inducing a site-specific amino acid substitution variation in a crop (acetyl-CoA carboxylase/herbicide target) gene through introduction, into a plant cell, of a nucleic acid into which a base substitution variation, such as a chimeraplasty technique (Gura T. 1999. Repairing the Genome's Spelling Mistakes. Science 285: 316-318) has been introduced.

Examples of the agricultural and horticultural plant provided with resistance by genetic engineering technology include corn, soybean, cotton, rapeseed, and sugar beet resistant to glyphosate, which are already commercially available under trade names of, for example, RoundupReady <registered trademark> and Agrisure GT <registered trademark>. Similarly, there are corn, soybean, cotton, and rapeseed provided with resistance to glufosinate by genetic engineering technology, which are already commercially available under a trade name of, for example, LibertyLink <registered trademark>. Also, cotton provided with resistance to bromoxynil by genetic engineering technology is already commercially available under a trade name of BXN.

The aforementioned “agricultural and horticultural plant” includes plants that are produced by genetic engineering technology, and can synthesize, for example, selective toxins known in the genus Bacillus.

Examples of insecticidal toxins expressed in such genetically engineered plants include insecticidal proteins derived from Bacillus cereus or Bacillus popilliae; δ-endotoxins derived from Bacillus thuringiensis, such as Cry1Ab, Cry1Ac, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1, or Cry9C; insecticidal proteins, such as VIP1, VIP2, VIP3, or VIP3A; insecticidal proteins derived from nematodes; toxins generated by animals, such as scorpion toxin, spider toxin, bee toxin, or insect-specific neurotoxins; mold fungi toxins; plant lectin; agglutinin; protease inhibitors, such as a trypsin inhibitor, a serine protease inhibitor, patatin, cystatin, and a papain inhibitor; ribosome-inactivating proteins (RIP), such as lysine, corn-RIP, abrin, saporin, and briodin; steroid-metabolizing enzymes, such as 3-hydroxysteroid oxidase, ecdysteroid-UDP-glucosyl transferase, and cholesterol oxidase; an ecdysone inhibitor; HMG-COA reductase; ion channel inhibitors, such as sodium channel inhibitor and calcium channel inhibitor; juvenile hormone esterase; diuretic hormone receptor; stilbene synthase; bibenzyl synthase; chitinase; and glucanase.

Examples of toxins expressed in such genetically engineered plants include hybrid toxins of δ-endotoxin proteins, such as Cry1Ab, Cry1Ac, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1, or Cry9C and insecticidal proteins, such as VIP1, VIP2, VIP3, or VIP3A; partially deleted toxins; and modified toxins. Such hybrid toxins are produced from a new combination of the different domains of such proteins by using a genetic engineering technology. A known example of a partially deleted toxin is Cry1Ab wherein a portion of the amino acid sequence is deleted. A modified toxin is produced by substitution of one or more amino acids of a natural toxin.

Examples of such toxins and genetically engineered plants capable of synthesizing the toxins are described in patent documents, such as EP-A-0374753, WO 93/07278, WO 95/34656, EP-A-0427529, EP-A-451878, and WO 03/052073. Toxins contained in such genetically engineered plants provide the plants with resistance particularly to insect pests belonging to Coleoptera, Diptera, and Lepidoptera.

Genetically engineered plants containing one or more insecticidal pest-resistant genes and expressing one or more toxins have already been known, and some of the genetically engineered plants are commercially available. Examples of the genetically engineered plants include YieldGard <registered trademark> (a corn variety expressing Cry1Ab toxin), YieldGard Rootworm <registered trademark> (a corn variety for expressing Cry3Bb1 toxin), YieldGard Plus <registered trademark> (a corn variety expressing Cry1Ab and Cry3Bb1 toxins), Herculex I<registered trademark> (a corn variety expressing phosphinotricine N-acetyl transferase (PAT) for imparting resistance to Cry1Fa2 toxin and glufosinate), NuCOTN33B <registered trademark> (a cotton variety expressing Cry1Ac toxin), Bollgard I<registered trademark> (a cotton variety expressing Cry1Ac toxin), Bollgard II<registered trademark> (a cotton variety expressing Cry1Ac and Cry2Ab toxins), VIPCOT <registered trademark> (a cotton variety expressing VIP toxin), NewLeaf <registered trademark> (a potato variety expressing Cry3A toxin), NatureGard <registered trademark> Agri sure <registered trademark> GT Advantage (GA21 glyphosate-resistant trait), Agrisure <registered trademark> CB Advantage (Bt11 corn borer (CB) trait), and Protecta <registered trademark>.

The aforementioned useful plant also encompasses plants produced by a genetic engineering technology and exhibiting the ability to generate anti-pathogenic substances having selective action.

Examples of such anti-pathogenic substances include PR proteins (PRPs, described in EP-A-0392225); ion channel inhibitors, such as a sodium channel inhibitor and a calcium channel inhibitor (e.g., KP1, KP4, and KP6 toxins produced by viruses are known); stilbene synthase; bibenzyl synthase; chitinase; glucanase; and anti-pathogenic substances generated by microorganisms, such as a peptide antibiotic, an antibiotic having a hetero ring, and a protein factor associated with resistance to plant diseases (which is called a plant disease-resistant gene and is described in WO 03/000906). These anti-pathogenic substances and genetically engineered plants producing the substances are described in, for example, EP-A-0392225, WO 95/33818, and EP-A-0353191.

The aforementioned useful plant also encompasses plants provided with useful properties (e.g., improved oil ingredient and increased amino acid content) by genetically engineering technology. Examples of such plants include VISTIVE <registered trademark> (low linolenic soybean having reduced linolenic content) or high-lysine (high-oil) corn (corn having increased lysine or oil content).

The aforementioned useful plant also encompasses stack varieties including combinations of a plurality of useful properties, such as the aforementioned classic herbicidal properties or herbicide-resistant genes, harmful insect-resistant genes, anti-pathogenic substance-producing genes, and useful properties (e.g., improved oil ingredient, and increased amino acid content).

During formulation or spraying, the compound of the present invention may optionally be applied in the form of a mixture with, for example, another herbicide, any insecticide, a bactericide, a plant growth regulator, or a synergist.

In particular, the application of the compound with another herbicide is expected to cause cost reduction resulting from reduced amount of the applied herbicide, an increase in herbicidal spectrum attributed to synergistic effects of the mixed herbicide, and a higher herbicidal effect. In this case, the compound may be used in combination of a plurality of known herbicides.

Examples of preferred herbicides used in combination with the compound of the present invention include 4-CPA, 4-CPA-salts, 4-CPB, 4-CPP, 2,4-D (2,4-PA), 2,4-D-salts, 2,4-D-esters, 3,4-DA, 2,4-DB, 2,4-DB-salts, 2,4-DB-esters, 3,4-DB, 2,4-DEB, 2,4-DEP, 3,4-DP, 2,4,5-T, 2,4,5-T-salts, 2,4,5-T-esters, 2,4,5-TB, 2,3,6-TBA (TCBA), 2,3,6-TBA-salts, acetochlor, acifluorfen, acifluorfen-methyl, acifluorfen-sodium, aclonifen, acrolein, alachlor, allidochlor (CDAA), alloxydim, alloxydim-sodium, allyl alcohol, alorac, ametridione, ametryn, amibuzin, amicarbazone, amidochlor, amidosulfuron, aminocyclopyrachlor, aminocyclopyrachlor-methyl, aminocyclopyrachlor-potassium, aminopyralid, aminopyralid-salts, amiprophos, amiprophos-methyl, amitrole (aminotriazole, ATA), ammonium sulfamate (AMS), anilofos, anisuron, asulam, asulam-salts, atraton, atrazine, azafenidin, azimsulfuron, aziprotryne (azyprotryn), barban (CBN), BCPC, beflubutamid, beflubutamid-M, benazolin, benazolin-ethyl, benazolin-salts, bencarbazone, benfluralin (benefin), benfuresate, bensulfuron, bensulfuron-methyl, bensulide (SAP), bentazon (bentazone), bentazone-sodium, bentranil, benzadox, benzadox-ammonium, benzfendizone, benzipram, benzobicyclon, benzofenap, benzofluor, benzoylprop, benzoylprop-ethyl, benzthiazuron, bicyclopyrone, bifenox, bilanafos (bialaphos), bilanafos-sodium, binapacryl, bispyribac, bispyribac-sodium, bixlozone, borax, bromacil, bromacil-salts, bromobonil, bromobutide, bromofenoxim, bromopyrazon, bromoxynil, bromoxynil-potassium, bromoxynil-esters, butachlor, butafenacil, butamifos, butenachlor, butralin (butraline), buthidazole, buthiuron, butroxydim, buturon, butylate, cafenstrole, calcium cyanamide, cambendichlor, calcium chlorate, carbasulam, carbetamide, carboxazole, carfentrazone, carfentrazone-ethyl, CDEA, CEPC, chlomethoxyfen (chlomethoxynil), chloramben, chloramben-salts, chloramben-methyl, chloramben-methylammonium, chloranocryl (dicryl), chlorazifop, chlorazifop-propargyl, chlorazine, chlorbromuron, chlorbufam (BIPC), chloreturon, chlorfenac (fenac), chlorfenac-salts, chlorfenprop, chlorfenprop-methyl, chlorflurazole, chlorflurenol, chlorflurenol-methyl, chloridazon (PAC, pyrazon), chlorimuron, chlorimuron-ethyl, chlornidine, chlornitrofen (CNP), chloroacetic acid (monochloroacetic acid), sodium chloroacetate (SMA), chlorotoluron, chloroxuron, chloroxynil, chlorprocarb, chlorphtalim, chlorpropham (IPC), chlorsulfuron, chlorthal (TCTP), chlorthal-esters, chlorthiamid (DCBN), cinidon-ethyl, cinmethylin, cinosulfuron, cisanilide, clacyfos, clethodim, cliodinate, clodinafop, clodinafop-propargyl, clofop, clofop-isobutyl, clomazone, clomeprop, cloprop, cloproxydim, clopyralid, clopyralid-methyl, clopyralid-salts, cloransulam, cloransulam-methyl, copper sulfate, CPMF, CPPC, credazine, cresol, cumyluron, cyanatryn, cyanamide, cyanazine, cycloate, cyclopyranil, cyclopyrimorate, cyclosulfamuron, cycloxydim, cycluron (COMU), cyhalofop, cyhalofop-butyl, cyperquat, cyperquat-chloride, cyprazine, cyprazole, cypromid, daimuron (dymron), dalapon, dalapon-salts, dazomet, dazomet-sodium, delachlor, desmedipham, desmetryn, di-allate, dicamba (MDBA), dicamba-salts, dicamba-esters, dichlobenil (DBN), dichloraurea (DCU), dichlormate, o-dichlorobenzene, (DCB), dichlorprop, dichlorprop-salts, dichlorprop-esters, dichlorprop-P, dichlorprop-P-salts, dichlorprop-P-esters, diclofop, diclofop-methyl, diclofop-P, diclofop-P-methyl, diclosulam, diethamquat, diethamquat dichloride, diethatyl, diethatyl-ethyl, difenopenten, difenopenten-ethyl, difenoxuron, difenzoquat, difenzoquat methyl sulfate, diflufenican, diflufenzopyr, diflufenzopyr-sodium, dimefuron, dimepiperate, dimesulfazet, dimethachlor, dimethametryn, dimethenamid, dimethenamid-p, dimexano, dimidazon, dimethyl disulfide, dinitramine, dinofenate, dinoprop, dinosam, dinoseb (DNBP), dinoseb-salts, dinoseb-esters, dinoterb, dinoterb-salts, dinoterb-esters, diphenamid, dipropalin, dipropetryn, diquqt, diquqt dibromide, disul (2,4-PS), disul-sodium, dithiopyr, diuron (DCMU), DMPA, DNOC, DNOC-salts, EBEP, eglinazine, eglinazine-ethyl, endothal, endothal-salts, epronaz, EPTC, epyrifenacil, erbon, esprocarb, ethachlor, ethalfluralin, ethametsulfuron, ethametsulfuron-methyl, ethaprochlor, ethidimuron, ethiolate, ethiozin, ethofumesate, ethoxyfen, ethoxyfen-ethyl, ethoxysulfuron, etinofen, etnipromid, etobenzanid, EXD, fenasulam, fenoprop (2,4,5-TP, silvex), fenoprop-salts, fenoprop-esters, fenoxaprop, fenoxaprop-ethyl, fenoxaprop-p, fenoxaprop-p-ethyl, fenoxasulfone, fenquinotrione, fenteracol, fenthiaprop, fenthiaprop-ethyl, fentrazamide, ferrous sulfate, fenuron, fenuron-TCA, flamprop, flamprop-esters, flamprop-M, flamprop-M-esters, flazasulfuron, florasulam, florpyrauxifen, florpyrauxifen-benzyl, fluazifop, fluazifop-esters, fluazifop-P, fluazifop-p-esters, fluazolate, flucarbazone, flucarbazone-sodium, flucetosulfuron, fluchloralin, flufenacet, flufenican, flufenpyr, flufenpyr-ethyl, flumetsulam, flumezin, flumiclorac, flumiclorac-pentyl, flumioxazin, flumipropyn, fluometuron, fluorodifen, fluoroglycofen, fluoroglycofen-ethyl, fluoromidine, fluoronitrofen (CFNP), fluothiuron, flupoxam, flupropacil, flupropanate (tetrapion), flupropanate-sodium, flupyrsulfuron, flupyrsulfuron-methyl, flupyrsulfuron-sodium, flupyrsulfuron-methyl-sodium, fluridone, flurochloridone, fluroxypyr, fluroxypyr-esters, flurtamone, fluthiacet, fluthiacet-methyl, fomesafen, fomesafen-sodium, foramsulfuron, fosamine, fosamine-ammonium, furyloxyfen, glufosinate, glufosinate-salts, glufosinate-P, glufosinate-P-salts, glyphosate, glyphosate-salts, halauxifen, halauxifen-methyl, halosafen, halosulfuron, halosulfuron-methyl, haloxydine, haloxyfop, haloxyfop-sodium, haloxyfop-esters, haloxyfop-P, haloxyfop-P-esters, herbimycin, hexachloroacetone (HCA), hexazinone, imazamethabenz, imazamethabenz-methyl, imazamox, imazamox-ammonium, imazapic, imazapic-ammonium, imazapyr, imazapyr-i sopropylammonium, imazaquin, imazaquin-methyl, imazaquin-salts, imazethapyr, imazethapyr-ammonium, imazosulfuron, indanofan, indaziflam, iodobonil, iodosulfuron, iodosulfuron-sodium, iodosulfuron-methyl, iodosulfuron-methyl-sodium, iofensulfuron, iofensulfuron-sodium, ioxynil, ioxynil-salts, ioxynil-esters, ipazine, ipfencarbazone, iprymidam, isocarbamid, isocil (isoprocil), isomethiozin, isonoruron, isopolinate, isopropalin, isoproturon, isouron, isoxaben, isoxachlortole, isoxaflutole, isoxapyrifop, karbutilate, ketospiradox, ketospiradox-potassium, lactofen, lancotrione, lancotrione-sodium, lenacil, linuron, MCPA, MCPA-salts, MCPA-esters, MCPB, MCPB-salts, MCPB-esters, mecoprop (MCPP), mecoprop-salts, mecoprop-esters, mecoprop-P, mecoprop-P-salts, mecoprop-P-esters, medinoterb, medinoterb acetate, mefenacet, mefluidide, mefluidide-salts, mesoprazine, mesosulfuron, mesosulfuron-methyl, mesotrione, metam (carbam), metam-salts, metamifop, metamitron, metazachlor, metazosulfuron, metflurazon, methabenzthiazuron (methibenzuron), methalpropalin, methazole, methiobencarb, methiuron, methometon, methoprotryne (methoprotryn), methoxyphenone, methiopyrisulfuron, methiozolin, methyl azide, methyl bromide, methyl dymron, methyl iodide, methyl isothiocyanate, metobenzuron, metobromuron, metolachlor, S-metolachlor, metosulam, metoxuron, metribuzin, metsulfuron, metsulfuron-methyl, molinate, monalide, monisouron, monolinuron, monosulfuron, monosulfuron-methyl, monuron (CMU), monuron-TCA, morfamquat, morfamquat dichloride, naproanilide, napropamide, napropamide-M, naptalam (NPA), naptalam-sodium, neburon, nicosulfuron, nipyraclofen, nitralin, nitrofen (NIP, niclofen), nitrofluorfen, norflurazon, noruron (norea), OCH, oleic acid, orbencarb, orthosulfamuron, oryzalin, oxadiargyl, oxadiazon, oxapyrazon, oxapyrazon-salts, oxasulfuron, oxaziclomefone, oxyfluorfen, parafluron, paraquat, paraquat dichloride, paraquat dimethylsulfate, pebulate, pelargonic acid (nonanoic acid), pendimethalin, penoxsulam, pentachlorophenol, sodium pentachlorophenoxide, pentachlorophenyl laurate, pentanochlor (solan, CMMP), pentoxazone, perfluidone, pethoxamid, phenisopham, phenmedipham, phenmedipham-ethyl, phenobenzuron, picloram, picloram-salts, picloram-esters, picolinafen, pinoxaden, piperophos, potassium azide, potassium cyanate, pretilachlor, primisulfuron, primisulfuron-methyl, procyazine, prodiamine, profluazol, profluralin, profoxydim, proglinazine, proglinazine-ethyl, prometon, prometryn (prometryne), propachlor, propanil (DCPA), propaquizafop, propazine, propham, propisochlor, propoxycarbazone, propoxycarbazone-sodium, propyrisulfuron, propyzamide (pronamide), prosulfalin, prosulfocarb, prosulfuron, proxan (IPX), proxan-sodium, prynachlor, pydanon, pyraclonil, pyraflufen, pyraflufen-ethyl, pyrasulfotole, pyrazolynate (pyrazolate), pyrazosulfuron, pyrazosulfuron-ethyl, pyrazoxyfen, pyribambenz-isopropyl, pyribambenz-propyl, pyribenzoxim, pyributicarb, pyriclor, pyridafol, pyridate, pyriftalid, pyriminobac, pyriminobac-methyl, pyrimisulfan, pyrithiobac, pyrithiobac-sodium, pyroxasulfone, pyroxsulam, quinclorac, quinclorac-dimethylammonium, quinclorac-methyl, quinmerac, quinoclamine (ACN), quinonamid, quizalofop, quizalofop-esters, quizalofop-P, quizalofop-P-esters, rhodethanil, rimsulfuron, saflufenacil, sebuthylazine, secbumeton, sethoxydim, siduron, simazine (CAT), simeton, simetryn (simetryne), sodium azide, sodium chlorate, sulcotrione, sulfallate (CDEC), sulfentrazone, sulfometuron, sulfometuron-methyl, sulfosulfuron, sulfuric acid, sulglycapin, swep (MCC), tavron, TCA (trichloroacetic acid), TCA-salts, TCA-ethadyl, tebutam (butam), tebuthiuron, tefuryltrione, tembotrione, tepraloxydim, terbacil, terbucarb (terbutol, MPMC), terbuchlor, terbumeton, terbuthylazine, terbutryn, tetflupyrolimet, tetrafluron, thenylchlor, thiazafluron, thiazopyr, thidiazimin, thidiazuron, thiencarbazone, thiencarbazone-methyl, thifensulfuron, thifensulfuron-methyl, thiobencarb (benthiocarb), tiafenacil, tiocarbazil, tioclorim, tolpyralate, topramezone, tralkoxydim, triafamone, triallate (tri-allate), triasulfuron, triaziflam, tribenuron, tribenuron-methyl, tricamba, triclopyr, triclopyr-salts, triclopyr-esters, tridiphane, trietazine, trifloxysulfuron, trifloxysulfuron-sodium, trifludimoxadin, trifluralin, triflusulfuron, triflusulfuron-methyl, trifop, trifop-methyl, trifopsime, trihydroxytriazine (cyanuric acid), trimeturon, tripropindan, tritac, tritosulfuron, vernolate, xylachlor, 6-{(difluoromethyl)thio}-N2,N4-diisopropyl-1,3,5-triazine-2,4-diamine (CAS 103427-73-2), methyl

(R)-2-[{7-(2-chloro-4-(trifluoromethyl)phenoxy)naphthalen-2-yl}oxy]propanoate (CAS 103055-25-0), propan-2-one O-(12H-dibenzo[d,g][1,3]dioxocin-6-carbonyl)oxime (CAS 503819-68-9), [{(2-(N-methylmethylsulfonamido)-2-oxoethyl)amino}methyl]phosphonic acid (CAS 98565-18-5), ethyl 2-[{2-(4-((6-chloroquinoxalin-2-yl)oxy)phenoxy)propanoyl}oxy]-3-methyl-3-butenoate (CAS 1191932-79-2), O-(2,4-dimethyl-6-nitrophenyl) O-methylisopropylphosphoramide thioate (CAS 189517-75-7), methyl 5-[N—{(4,6-dimethylpyrimidin-2-yl)carbamoyl}sulfamoyl]-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylate (CAS 104770-29-8), 4-[2-chloro-3-{(3,5-dimethyl-1H-pyrazol-1-yl)methyl}-4-(methylsulfonyl)benzoyl]-1,3-dimethyl-1H-pyrazol-5-yl 1,3-dimethyl-1H-pyrazole-4-carboxylate (CAS 1911613-97-2), 4-[2-chloro-4-(methylsulfonyl)-3-{(2,2,2-trifluoroethoxy)methyl}benzoyl]-1-ethyl-1H-pyrazol-5-yl 1,3-dimethyl-1H-pyrazole-4-carboxylate (CAS 1992017-55-6), 1-{2-chloro-3-(3-cyclopropyl-5-hydroxy-1-methyl-1H-pyrazole-4-carbonyl)-6-(trifluoro methyl)phenyl}piperidin-2-one (CAS 1855929-45-1), 1,3-dimethyl-4-{2-(methyl sulfonyl)-4-(trifluoromethyl)benzoyl}-1H-pyrazol-5-yl 1,3-dimethyl-1H-pyrazole-4-carboxylate (CAS 1622908-18-2), ethyl 2-[{3-(2-chloro-4-fluoro-5-(3-methyl-2,6-dioxo-4-(trifluoromethyl)-3,6-dihydropyrimidin-1(2H)-yl)phenoxy)pyridin-2-yl}oxy]acetate (CAS 353292-31-6), 2-methyl-N-(5-methyl-1,3,4-oxadiazol-2-yl)-3-(methylsulfonyl)-4-(trifluoromethyl)benzamide (CAS 1400904-50-8), 2-chloro-N-(1-methyl-1H-tetrazol-5-yl)-3-(methylthio)-4-(trifluoromethyl)benzamide (CAS 1361139-71-0), 2-chloro-N-(1-methyl-1H-tetrazol-5-yl)-3-(methylsulfonyl)-4-(trifluoromethyl)benzamide (CAS 1361139-73-2), F4050 (test name), F9600 (test name), F9960 (test name), OK-701 (test name), and SL-1201 (test name). These ingredients may be used alone or in combination of two or more species. When two or more species are used in combination, the proportions thereof may be arbitrarily determined.

Examples of the safener include benoxacor, BPCMS (CSB), cloquintocet, cloquintocet-mexyl, cumyluron, cyometrinil, cyprosulfamide, daimuron (dymron), dichlormid, dicyclonon (diclonon), dietholate, dimepiperate, disulphoton, fenchlorazole, fenchlorazole-ethyl, fenclorim, flurazole, fluxofenim, furilazole, hexim, isoxadifen, isoxadifen-ethyl, MCPA, mecoprop, mefenpyr, mefenpyr-diethyl, mephenate, metcamifen, methoxyphenone, 1,8-naphthalic anhydride (NA), octamethylene-diamine, oxabetrinil, 4-(dichloroacetyl)-1-oxa-4-azaspiro[4.5]decane (AD67, MON4660), 4-carboxy-3,4-dihydro-2H-oxo-benzopyran-4-acetic acid (CL304415), 2,2-dichloro-N-[2-oxo-2(propenylamino)ethyl]-N-2-propenylacetamide (DKA-24), 2-(dichloromethyl)-2-methyl-1,3-dioxolane (MG191), 2-propenyl 1-oxa-4-azaspiro[4,5]decane-4-carbodithioate (MG838), (3-dichloroacetyl-5-(2-furyl)-2,2-dimethyloxazolidine) (MON13900), (N-allyl-N-[(1,3-dioxolan-2-yl)methyl]dichloroacetamide (PPG-1292), 3-(dichloroacetyl)-2,2-dimethyl-1,3-oxazolidine (R28725), 3-(dichloroacetyl)-2,2,5-trimethyl-1,3-oxazolidine (R29148), and 1-dichloroacetylazepane (TI-35). These ingredients may be used alone or in combination of two or more species. When two or more species are used in combination, the proportions thereof may be arbitrarily determined.

When the compound of the present invention is applied as a herbicide, the compound is usually mixed with an appropriate solid carrier or liquid carrier. If desired, the mixture may be further mixed with a surfactant, a penetrant, a spreading agent, a thickener, an antifreezing agent, a binder, an anticaking agent, a disintegrant, and a stabilizing agent, and the resultant mixture may be practically used in any herbicidal formulation, such as a water-dispersible powder, an emulsion, a flowable agent, a dry flowable agent, a liquid, a powder, a granule, or a gel. From the viewpoint of power saving and an improvement in safety, the aforementioned herbicidal formulation may be encapsulated in a water-soluble package for supply.

Examples of the solid carrier include natural minerals, such as quartz, kaolinite, pyrophyllite, sericite, talc, bentonite, acid clay, attapulgite, zeolite, and diatomaceous earth; inorganic salts, such as calcium carbonate, ammonium sulfate, sodium sulfate, and potassium chloride; synthetic silicic acid; and synthetic silicates.

Examples of the liquid carrier include alcohols, such as ethylene glycol, propylene glycol, and isopropanol; aromatic hydrocarbons, such as xylene, alkylbenzene, and alkylnaphthalene; ethers, such as butyl cellosolve; ketones, such as cyclohexanone; esters, such as γ-butyrolactone; acid amides, such as N-methyl-2-pyrrolidone and N-octyl-2-pyrrolidone; vegetable oils, such as soybean oil, rapeseed oil, cotton seed oil, and castor oil; and water.

These solid and liquid carriers may be used alone or in combination of two or more species.

Examples of the surfactant include nonionic surfactants, such as polyoxyethylene alkyl ethers, polyoxyethylene alkylaryl ethers, polyoxyethylene styrylphenyl ethers, polyoxyethylene-polyoxypropylene block copolymers, polyoxyethylene fatty acid esters, sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters; anionic surfactants, such as alkyl sulfates, alkylbenzene sulfonates, lignin sulfonates, alkyl sulfosuccinates, naphthalene sulfonate, alkylnaphthalene sulfonates, salts of naphthalene sulfonic acid-formalin condensate, salts of alkylnaphthalene sulfonic acid-formalin condensate, polyoxyethylene alkylaryl ether sulfates and phosphates, polyoxyethylene styrylphenyl ether sulfates and phosphates, polycarboxylates, and polystyrene sulfonates; cationic surfactants, such as alkylamine salts and alkyl quaternary ammonium salts; and amphoteric surfactants, such as amino acid-type surfactants and betaine-type surfactants.

No particular limitation is imposed on the amount of such a surfactant contained in the formulation of the present invention, but the amount of the surfactant is preferably 0.05 to 20 parts by mass relative to 100 parts by mass of the formulation. The aforementioned surfactants may be used alone or in combination of two or more species.

During formulation or spraying, the compound of the present invention may optionally be applied in the form of a mixture with, for example, another herbicide, any insecticide, a bactericide, a plant growth regulator, or a synergist.

In particular, the application of the compound with another herbicide is expected to cause cost reduction resulting from reduced amount of the applied herbicide, an increase in herbicidal spectrum attributed to synergistic effects of the mixed herbicide, and a higher herbicidal effect. In this case, the compound may be used in combination of a plurality of known herbicides.

The amount of application of the compound of the present invention varies depending on, for example, the situation of application, the timing of application, the method of application, or the type of cultivated crop. In general, the appropriate amount of the compound is about 0.005 to 50 kg per hectare (ha) in terms of the amount of an active ingredient.

FORMULATION EXAMPLES

Next will be described specific agricultural chemical formation examples containing the compound of the present invention as an active ingredient. However, the present invention is not limited to these examples. In the following formulation examples, the term “part(s)” refers to part(s) by mass.

[Formulation Example 1] Water-Dispersible Powder

Compound of the present invention No.1-024 20 parts Pyrophyllite 76 parts Sorpol 5039 2 parts (trade name, anionic surfactant: available from TOHO Chemical Industry Co., Ltd.) Carplex #80 2 parts (trade name, synthetic hydrous silicic acid: available from SHIONOGI & CO., LTD.)

These ingredients are homogeneously mixed and pulverized to prepare a water-dispersible powder.

[Formulation Example 2] Emulsion

Compound of the present invention No.3-009 5 parts Xylene 75 parts N-methyl-2-pyrrolidone 15 parts Sorpol 2680 5 parts (trade name, anionic surfactant: available from TOHO Chemical Industry Co., Ltd.)

These ingredients are homogeneously mixed to prepare an emulsion.

[Formulation Example 3] Flowable Agent

Compound of the present invention No.3-065 25 parts Agri sol S-710 10 parts (trade name, nonionic surfactant: available from Kao Corporation) Runox 1000C 0.5 parts (trade name, anionic surfactant: available from TOHO Chemical Industry Co., Ltd.) Xanthan gum 0.02 parts Water 64.48 parts

These ingredients are homogeneously mixed and then wet-pulverized to prepare a flowable agent.

[Formulation Example 4] Dry Flowable Agent

Compound of the present invention No.1-045 75 parts Hitenol NE-15 5 parts (trade name, anionic surfactant: available from DKS Co.Ltd.) Vanillex N 10 parts (trade name, anionic surfactant: available from Nippon Paper Industries Co., Ltd.) Carplex #80 10 parts (trade name, synthetic hydrous silicic acid: available from SHIONOGI & CO., LTD.)

These ingredients are homogeneously mixed and pulverized, and a small amount of water is added to the pulverized mixture, followed by mixing and kneading with stirring. The resultant product is granulated with an extrusion granulator and then dried to prepare a dry flowable agent.

[Formulation Example 5] Granule

Compound of the present invention No. 3-089 1 part Bentonite 55 parts Talc 44 parts

These ingredients are homogeneously mixed and pulverized, and a small amount of water is added to the pulverized mixture, followed by mixing and kneading with stirring. The resultant product is granulated with an extrusion granulator and then dried to prepare a granule.

EXAMPLES

The present invention will next be described in more detail with reference to Synthesis Examples and Test Examples of the compound of the present invention. However, the present invention should not be construed as being limited to these Examples.

The medium-pressure preparative liquid chromatography described in Synthesis Examples was performed with a medium-pressure preparative apparatus YFLC-Wprep (flow rate: 18 mL/min, column of silica gel 40 μm) available from Yamazen Corporation.

The chemical shift values of proton nuclear magnetic resonance spectroscopy (hereinafter referred to as “¹H-NMR”) described bellow were measured at 300 MHz (model: JNM-ECX300 or JNM-ECP300, available from JEOL Ltd.) in deuterated chloroform solvent by use of Me₄Si (tetramethylsilane) as a reference substance. In the case of measurement in deuterated dimethyl sulfoxide solvent, “(DMSO-d6)” is described in chemical shift value data. The symbols of the chemical shift values of ¹H-NMR have the following meanings:

s: singlet, d: doublet, dd: double doublet, dt: doublet triplet, td: triplet doublet, ddd: double double doublet, t: triplet, q: quartet, sep: septet, m: multiplet, and brs: broad singlet. For the signals that can be analyzed when two or more stereoisomers are present, the chemical shift values of each of the signals are marked with “and.”

SYNTHESIS EXAMPLES Synthesis Example 1 Synthesis of 5-hydroxy-2,6-dimethyl-4-(2-(4-cyanophenyl)benzo[b]thiophen-3-yl)pyridazin-3(2H)-one (compound No. 1-045) Step 1: Synthesis of 5-methoxy-2,6-dimethyl-4-(2-(4-cyanophenyl)benzo[b]thiophen-3-yl)pyridazin-3 (2H)-one

Firstly, 322 mg of p-cyanophenylboronic acid, 349 mg of potassium phosphate, 51 mg of 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl, and 12 mg of palladium acetate were added to a mixture of 200 mg of 4-(2-bromobenzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one and 3 mL of toluene at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction mixture was stirred at 110° C. for three hours. After completion of the stirring, insoluble matter was filtered with celite, and the residue was washed with chloroform (10 mL×2). The resultant filtrate was concentrated under reduced pressure, and the residue was purified by silica gel chromatography with a gradient of [ethyl acetate:n-hexane=5:95 to 20:80 (by volume, the same shall apply hereinafter)], to thereby yield 90 mg of the target product as a yellow solid.

Melting point: 219-221° C.

¹H NMR: δ 7.85-7.95 (m, 1H), 7.55-7.70 (m, 4H), 7.35-7.50 (m, 3H), 3.77 (s, 3H), 3.33 (s, 3H), 2.24 (s, 3H).

Step 2: Synthesis of 5-hydroxy-2,6-dimethyl-4-(2-(4-cyanophenyl)benzo[b]thiophen-3-yl)pyridazin-3(2H)-one (Compound No. 1-045)

Firstly, 2 mL of morpholine was added to 90 mg of 5-methoxy-2,6-dimethyl-4-(2-(4-cyanophenyl)benzo[b]thiophen-3-yl)pyridazin-3 (2H)-one at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction mixture was stirred at 95° C. for five hours. After completion of the stirring, the solvent contained in the reaction mixture was distilled off under reduced pressure. The resultant residue was dissolved in 10 mL of chloroform, and 1 mol/L hydrochloric acid was added to the solution under ice cooling so as to achieve a pH of 1, followed by stirring of the resultant mixture at room temperature for one hour. After completion of the stirring, the organic phase was separated from the mixture. The resultant organic phase was washed with 5 mL of 1 mol/L hydrochloric acid, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. Thereafter, the solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel chromatography (with a gradient of ethyl acetate:n-hexane=20:80 to 75:25), to thereby yield 83 mg of the target product as a white solid.

Melting point: 240-242° C.

¹H NMR: δ 7.75-7.85 (m, 1H), 7.25-7.50 (m, 7H), 3.47 (s, 3H), 2.17 (s, 3H).

Synthesis Example 2 Synthesis of 5-hydroxy-2,6-dimethyl-4-(2-(4-chloro-1H-pyrazol-1-yl)benzo[b]thiophen-3-yl)pyridazin-3(2H)-one (Compound No. 1-097) Step 1: Synthesis of 1,3-dimethyl-6-oxo-5-(2-(4-chloro-1H-pyrazol-1-yl)benzo[b]thiophen-3-yl)-1,6-dihydropyridazin-4-yl=(n-butyrate) (Compound No. 1-098)

Firstly, 68 mg of 4-chloropyrazole, 206 mg of potassium carbonate, 11 mg of copper iodide, and 21 mg of (1S,2S)-(+)—N,N′-dimethylcyclohexane-1,2-diamine were added to a mixture of 200 mg of 4-(2-bromobenzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one and 5 mL of N,N-dimethylacetamide at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction mixture was stirred at 130° C. for eight hours. After completion of the stirring, 20 mL of ethyl acetate and 20 mL of 28% by mass aqueous ammonia were added to the reaction mixture, and the precipitated insoluble matter was filtered with celite. Subsequently, 35% by mass hydrochloric acid was added to the resultant filtrate under ice cooling so as to achieve a pH of 1, and the resultant mixture was subjected to extraction with 20 mL of ethyl acetate. A solution of 58 mg of lithium hydroxide in 20 mL of water was added to the resultant organic phase at room temperature, to thereby separate the aqueous phase from the mixture. Thereafter, 35% by mass hydrochloric acid was added to the resultant aqueous phase under ice cooling so as to achieve a pH of 1, and then the precipitated solid was filtered. The resultant solid was dissolved in 2 mL of dichloromethane, and 61 mg of triethylamine and 70 mg of n-butyryl chloride were added to the solution under ice cooling. After completion of the addition, the resultant reaction mixture was stirred at room temperature for one hour. After completion of the stirring, the solvent contained in the reaction mixture was distilled off under reduced pressure, and the resultant residue was purified by silica gel chromatography (with a gradient of ethyl acetate:n-hexane=2:98 to 30:70), to thereby yield 57 mg of the target product as a yellow oily product.

¹H NMR: δ 7.75-7.85 (m, 1H), 7.72 (s, 1H), 7.63 (s, 1H), 7.30-7.40 (m, 3H), 3.83 (s, 3H), 2.30 (s, 3H), 2.10-2.20 (m, 2H), 1.20-1.35 (m, 2H), 0.58 (t, J=7.5 Hz, 3H).

Step 2: Synthesis of 5-hydroxy-2,6-dimethyl-4-(2-(4-chloro-1H-pyrazol-1-yl)benzo[b]thiophen-3-yl)pyridazin-3(2H)-one (Compound No. 1-097)

Firstly, a solution of 10 mg of lithium hydroxide in 2 mL of water was added to a mixture of 36 mg of 1,3-dimethyl-6-oxo-5-(2-(4-chloro-1H-pyrazol-1-yl)benzo[b]thiophen-3-yl)-1,6-dihydropyridazin-4-yl=(n-butyrate) and 1 mL of tetrahydrofuran at room temperature. After completion of the addition, the reaction mixture was stirred at room temperature for one hour. After completion of the stirring, the solvent contained in the reaction mixture was distilled off under reduced pressure. Subsequently, 35% by mass hydrochloric acid was added to the resultant residue so as to achieve a pH of 1, and the precipitated solid was filtered, to thereby yield 30 mg of the target product as a white solid.

¹H NMR (DMSO-d6): δ 8.30 (s, 1H), 8.09 (s, 1H), 7.95-8.05 (m, 1H), 7.90 (s, 1H), 7.30-7.45 (m, 2H), 7.20-7.30 (m, 1H), 3.58 (s, 3H), 2.26 (s, 3H).

Synthesis Example 3 Synthesis of 5-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl=(n-butyrate) (Compound No. 3-066) Step 1: Synthesis of methyl 2-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)acetate

Firstly, 27.0 g of 2-bromoanisole, 649 mg of palladium acetate, 1.5 g of triphenylphosphine, and 12.0 g of potassium carbonate were added to a mixture of 12.9 g of 2-(6-methoxybenzo[b]thiophen-3-yl)acetic acid and 115 mL of N,N-dimethylformamide at room temperature. After completion of the addition, air in the reaction container was replaced with nitrogen gas, and the reaction mixture was stirred at 100° C. for 11 hours. After completion of the stirring, the reaction mixture was cooled to room temperature, and 24.0 g of potassium carbonate and 49.2 g of methyl iodide were added to the reaction mixture, followed by stirring at room temperature for 13 hours. After completion of the stirring, 200 mL of toluene was added to the reaction mixture, and insoluble matter was filtered with celite. The residue was washed with 20 mL of toluene, and the resultant filtrate was washed with 100 mL of water. Thereafter, the resultant filtrate was dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel column chromatography (with a gradient of ethyl acetate:n-hexane=1:99 to 20:80), to thereby yield 7.93 g of the target product as a colorless oily product.

¹H NMR: δ 7.61 (d, J=8.9 Hz, 1H), 7.35-7.45 (m, 2H), 7.32 (d, J=2.4 Hz, 1H), 6.95-7.10 (m, 3H), 3.89 (s, 3H), 3.79 (s, 3H), 3.69 (s, 2H), 3.67 (s, 3H).

Step 2: Synthesis of 2-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl) acetic Acid

Firstly, a solution of 3.4 g of sodium hydroxide in 100 mL of water was added to a mixture of 9.0 g of methyl 2-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)acetate and 60 mL of tetrahydrofuran at room temperature. After completion of the addition, the resultant mixture was stirred at room temperature for 12 hours. After completion of the stirring, the solvent contained in the reaction mixture was distilled off under reduced pressure. Subsequently, 20 mL of water and 50 mL of hexane were added to the resultant residue, and the aqueous phase was separated from the reaction mixture. Thereafter, 35% by mass hydrochloric acid was added to the resultant aqueous phase under ice cooling so as to achieve a pH of 1, and the precipitated solid was recovered through filtration. The resultant solid was washed sequentially with 20 mL of water and 20 mL of hexane, to thereby yield 7.0 g of the target product as a white solid.

Melting point: 232-234° C.

¹H NMR: δ 7.65-7.80 (m, 2H), 7.43 (d, J=2.4 Hz, 1H), 7.30-7.45 (m, 1H), 7.10 (d, J=8.4 Hz, 1H), 6.95-7.05 (m, 1H), 6.94 (dd, J=8.4, 2.4 Hz, 1H), 3.81 (s, 3H), 3.76 (s, 3H), 3.34 (s, 2H).

Step 3: Synthesis of ethyl 2-(2-(2-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)acetyl-2-methylhydrazinyl idene)propionate

Firstly, 4.5 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 4.3 g of pentafluorophenol were added to a mixture of 7.0 g of 2-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)acetic acid and 22 mL of dichloromethane at room temperature. After completion of the addition, the resultant mixture was stirred at room temperature for five hours. Subsequently, 8.3 g of diisopropylethylamine was added at room temperature to a mixture of 6.2 g of methylhydrazine sulfate and 30 mL of dichloromethane prepared in another reaction container. After completion of the addition, the resultant mixture was stirred at room temperature for five hours. After completion of the stirring, the previously prepared mixture of 2-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)acetic acid and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride was added to this reaction mixture at room temperature. After completion of the addition, the resultant mixture was stirred at room temperature for three hours. After completion of the stirring, 40 mL of water was added to the reaction mixture, and the resultant mixture was subjected to extraction with 30 mL of dichloromethane. The resultant organic phase was washed with water (30 mL×2), and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. Thereafter, the solvent was distilled off under reduced pressure. The resultant residue was dissolved in 62 mL of ethanol, and 5.0 g of ethyl pyruvate was added to the solution at room temperature. After completion of the addition, the resultant mixture was stirred at room temperature for 12 hours. After completion of the stirring, the solvent contained in the reaction mixture was distilled off under reduced pressure. The resultant residue was purified by silica gel column chromatography (with a gradient of ethyl acetate:n-hexane=1:99 to 15:85), to thereby yield 7.5 g of the target product as a brown oily product.

¹H NMR: δ 7.55-7.70 (m, 1H), 7.25-7.45 (m, 3H), 6.90-7.05 (m, 3H), 4.24 (q, J=6.9 Hz, 2H), 4.06 (s, 2H), 3.88 (s, 3H), 3.79 (s, 3H), 3.32 (s, 3H), 2.19 (s, 3H), 1.28 (t, J=6.9 Hz, 3H).

Step 4: Synthesis of 5-hydroxy-4-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-2,6-dimethylpyridazin-3(2H)-one (Compound No. 3-065)

Firstly, 2.1 g of 1,8-diazabicyclo[5,4,0]-7-undecene was added to a mixture of 3.1 g of ethyl 2-(2-(2-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)acetyl)-2-methylhydrazinylidene)propionate and 70 mL of acetonitrile at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the mixture was stirred at 80° C. for five hours. After completion of the stirring, the solvent contained in the reaction mixture was distilled off under reduced pressure. The resultant residue was dissolved in 120 mL of ethyl acetate, and 10 mL of 1 mol/L hydrochloric acid was added to the solution at room temperature. After completion of the addition, the resultant mixture was stirred at room temperature for one hour. After completion of the stirring, the organic phase was separated from the mixture. The resultant organic phase was dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. Subsequently, 20 mL of diisopropyl ether was added to the resultant residue, and the precipitated solid was recovered through filtration. The resultant solid was washed with 5 mL of a mixture of diisopropyl ether and acetonitrile (20:1), to thereby yield 952 mg of the target product as a white solid.

Melting point: 243-244° C.

¹H NMR: δ 7.25-7.40 (m, 4H), 6.90-7.05 (m, 3H), 6.32 (s, 1H), 3.89 (s, 3H), 3.82 (s, 3H), 3.75 (s, 3H), 2.18 (s, 3H).

Step 5: Synthesis of 5-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl=(n-butyrate) (Compound No. 3-066)

Firstly, 30 mg of triethylamine was added to a mixture of 100 mg of 5-hydroxy-4-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-2,6-dimethylpyridazin-3(2H)-one and 2 mL of dichloromethane under ice cooling. After completion of the addition, the resultant mixture was stirred at room temperature for 30 minutes. After completion of the stirring, 29 mg of n-butyryl chloride was added to the mixture at room temperature. After completion of the addition, the resultant mixture was stirred at room temperature for one hour. After completion of the stirring, 5 mL of water was added to the reaction mixture, and the resultant mixture was subjected to extraction with 5 mL of ethyl acetate. The resultant organic phase was washed with 2 mL of water, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel column chromatography (with a gradient of ethyl acetate:n-hexane=1:99 to 25:75), to thereby yield 116 mg of the target product as a yellow oily product.

¹H NMR: δ 7.25-7.35 (m, 4H), 6.85-7.00 (m, 3H), 3.86 (s, 3H), 3.83 (s, 3H), 3.72 (s, 3H), 2.12 (t, J=7.5 Hz, 2H), 2.10 (s, 3H), 1.25-1.45 (m, 2H), 0.68 (t, J=7.3 Hz, 3H).

Synthesis Example 4 Synthesis of 4-(2-(4-(difluoromethoxy)phenyl)-5-fluorobenzo[b]thiophen-3-yl)-5-hydroxy-2,6-dimethylpyridazin-3(2H)-one (Compound No. 2-042) Step 1: Synthesis of methyl 2-(2-(4-(difluoromethoxy)phenyl)-5-fluorobenzo[b]thiophen-3-yl)acetate

Firstly, 1.0 g of 2-(5-fluorobenzo[b]thiophen-3-yl)acetic acid, 250 mg of triphenylphosphine, 987 mg of potassium carbonate, and 107 mg of palladium acetate were added to a mixture of 1.3 g of 1-bromo-4-(difluoromethoxy)benzene and 5 mL of N,N-dimethylformamide at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction mixture was stirred at 100° C. for five hours. After completion of the stirring, 789 mg of potassium carbonate and 1.0 g of methyl iodide were added to the reaction mixture under ice cooling, and the resultant mixture was stirred at room temperature for one hour. After completion of the stirring, insoluble matter was filtered with celite, and the residue was washed with 150 mL of toluene. The resultant filtrate was washed with water (15 mL×2), and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel chromatography (with a gradient of chloroform:n-hexane=1:99 to 15:85), to thereby yield 1.0 g of the target product as a white solid.

Melting point: 111-113° C.

¹H NMR: δ 7.74 (dd, J=8.7, 4.8 Hz, 1H), 7.55-7.65 (m, 2H), 7.43 (dd, J=9.6, 2.4 Hz, 1H), 7.25-7.15 (m, 2H), 7.05 (ddd, J=8.7, 8.7, 2.4 Hz, 1H), 6.57 (t, J=73.8 Hz, 1H), 3.78 (s, 2H), 3.74 (s, 3H).

Step 2: Synthesis of 2-(2-(4-(difluoromethoxy)phenyl)-5-fluorobenzo[b]thiophen-3-yl)acetic Acid

Firstly, 30 mL of 10% by mass aqueous lithium hydroxide solution was added to a mixture of 2.1 g of methyl 2-(2-(4-(difluoromethoxy)phenyl)-5-fluorobenzo[b]thiophen-3-yl)acetate, 15 mL of tetrahydrofuran, and 15 mL of ethanol at room temperature. After completion of the addition, the reaction mixture was stirred at room temperature for three hours. After completion of the stirring, the solvent contained in the reaction mixture was distilled off under reduced pressure. Subsequently, 35% by mass hydrochloric acid was added to the resultant residue under ice cooling so as to achieve a pH of 1, and the precipitated solid was recovered through filtration. The resultant solid was washed with water (15 mL×2), to thereby yield 1.8 g of the target product as a white solid.

Melting point: 203-204° C.

¹H NMR: δ 7.75 (dd, J=9.0, 4.8 Hz, 1H), 7.55-7.65 (m, 2H), 7.45 (dd, J=9.6, 2.4 Hz, 1H), 7.20-7.30 (m, 2H), 7.12 (ddd, J=9.0, 9.0, 2.4 Hz, 1H), 6.57 (t, J=73.8 Hz, 1H), 3.82 (s, 2H).

Step 3: Synthesis of ethyl 2-(2-(2-(2-(4-(difluoromethoxy)phenyl)-5-fluorobenzo[b]thiophen-3-yl)acetyl)-2-methylhydrazinylidene)propionate

Firstly, 1.1 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 1.0 g of pentafluorophenol were added to a mixture of 1.8 g of 2-(2-(4-(difluoromethoxy)phenyl)-5-fluorobenzo[b]thiophen-3-yl)acetic acid and 9 mL of dichloromethane at room temperature. After completion of the addition, the resultant mixture was stirred at room temperature for two hours. Subsequently, 2.2 g of triethylamine was added dropwise under ice cooling to a mixture of 1-6 g of methylhydrazine sulfate and 5 mL of dichloromethane prepared in another reaction container. After completion of the dropwise addition, the resultant mixture was stirred at room temperature for three hours. After completion of the stirring, the previously prepared mixture of 2-(2-(4-(difluoromethoxy)phenyl)-5-fluorobenzo[b]thiophen-3-yl)acetic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, and pentafluorophenol was added dropwise to the reaction mixture under ice cooling. After completion of the dropwise addition, the resultant mixture was stirred at room temperature for 14 hours. After completion of the stirring, 15 mL of water was added to the reaction mixture, and the organic phase was separated. The resultant organic phase was washed with 15 mL of aqueous saturated sodium hydrogen carbonate solution, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The resultant residue was dissolved in 8 mL of ethanol, and 1.2 g of ethyl pyruvate was added to the solution at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction mixture was stirred at 80° C. for four hours. After completion of the stirring, the solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel column chromatography (with a gradient of ethyl acetate:n-hexane=3:97 to 25:75), to thereby yield 1.5 g of the target product as a pale yellow solid.

Melting point: 100-101° C.

¹H NMR: δ 7.73 (dd, J=8.7, 4.8 Hz, 1H), 7.55-7.65 (m, 2H), 7.35-7.50 (m, 1H), 7.15-7.25 (m, 2H), 7.12 (ddd, J=8.7, 8.7, 2.4 Hz, 1H), 6.56 (t, J=73.8 Hz, 1H), 4.29 (q, J=7.5 Hz, 2H), 4.16 (s, 2H), 3.40 (s, 3H), 2.10 (s, 3H), 1.31 (t, J=7.5 Hz, 3H).

Step 4: Synthesis of 4-(2-(4-(difluoromethoxy)phenyl)-5-fluorobenzo[b]thiophen-3-yl)-5-hydroxy-2,6-dimethylpyridazin-3(2H)-one (Compound No. 2-042)

Firstly, 904 mg of 1,8-diazabicyclo[5,4,0]-7-undecene was added to a mixture of 1.4 g of ethyl 2-(2-(2-(2-(4-(difluoromethoxy)phenyl)-5-fluorobenzo[b]thiophen-3-yl)acetyl)-2-methylhydrazinylidene)propionate and 30 mL of acetonitrile at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the resultant mixture was heated to 90° C. and stirred for one hour. After completion of the stirring, the solvent contained in the reaction mixture was distilled off under reduced pressure. The resultant residue was dissolved in 14 mL of ethyl acetate, and 1 mol/L hydrochloric acid was added to the solution so as to achieve a pH of 1 under ice cooling. The resultant mixture was stirred at room temperature for one hour. After completion of the stirring, the organic phase was separated from the mixture. The resultant organic phase was washed with 5 mL of 1 mol/L hydrochloric acid, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. Subsequently, 10 mL of diisopropyl ether and 0.5 mL of acetonitrile were added to the resultant residue, and the precipitated solid was recovered through filtration, to thereby yield 469 mg of the target product as a white solid.

Melting point: 164-165° C.

¹H NMR (DMSO-d6): δ 10.54 (brs, 1H), 8.06 (dd, J=8.7, 4.8 Hz, 1H), 7.40-7.50 (m, 2H), 7.27 (t, J=74.1 Hz, 1H), 7.20-7.25 (m, 1H), 7.15-7.20 (m, 2H), 7.10 (dd, J=9.9, 2.4 Hz, 1H), 3.57 (s, 3H), 2.19 (s, 3H).

Synthesis Example 5 Synthesis of 4-(2-(4-chlorophenyl)-5-fluorobenzo[b]thiophen-3-yl)-5-hydroxy-2,6-dimethylpyridazin-3(2H)-one (Compound No. 2-010) Step 1: Synthesis of 3-bromomethyl-2-(4-chlorophenyl)-5-fluorobenzo[b]thiophene

Firstly, 30% by mass hydrogen bromide-acetic acid solution was added dropwise under ice cooling to a mixture of 10.5 g of 2-(4-chlorophenyl)-5-fluorobenzo[b]thiophene, 3.2 g of paraformaldehyde, and 60 mL of chloroform, and the resultant mixture was stirred at 40° C. for three hours. After completion of the stirring, 200 mL of water was added to the reaction mixture, and the resultant mixture was subjected to extraction with 40 mL of chloroform. The resultant organic phase was washed with 100 mL of water and 100 mL of aqueous saturated sodium hydrogen carbonate solution, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. Subsequently, 50 mL of n-hexane was added to the resultant residue, and then the precipitated solid was recovered through filtration, to thereby yield 12.4 g of the target product as a gray solid.

Melting point: 124-126° C.

¹H NMR: δ 7.76 (dd, J=8.7, 4.8 Hz, 1H), 7.45-7.65 (m, 5H), 7.10-7.20 (m, 1H), 4.66 (s, 2H).

Step 2: Synthesis of 2-(2-(4-chlorophenyl)-5-fluorobenzo[b]thiophen-3-yl)acetonitrile

Firstly, 1.7 g of potassium carbonate and 1.2 g of trimethylsilyl cyanide were added to a mixture of 3.6 g of 3-bromomethyl-2-(4-chlorophenyl)-5-fluorobenzo[b]thiophene and 15 mL of acetonitrile at room temperature, and the resultant mixture was stirred at 80° C. for 12 hours. After completion of the stirring, 20 mL of 10% by mass aqueous sodium hydroxide solution was added to the reaction mixture under ice cooling, and the resultant mixture was subjected to extraction with 40 mL of dichloromethane. The resultant organic phase was washed with 10 mL of water, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. Subsequently, 50 mL of n-hexane and 5 mL of diisopropyl ether were added to the resultant residue, and then the precipitated solid was recovered through filtration, to thereby yield 2.8 g of the target product as a pale yellow solid.

Melting point: 161-163° C.

¹H NMR: δ 7.81 (dd, J=8.1, 4.8 Hz, 1H), 7.40-7.55 (m, 5H), 7.15-7.25 (m, 1H), 3.81 (s, 2H).

Step 3: Synthesis of 2-(2-(4-chlorophenyl)-5-fluorobenzo[b]thiophen-3-yl)acetic Acid (compound No. 12-002)

Firstly, 10 mL of concentrated sulfuric acid was added to a mixture of 10.0 g of 2-(2-(4-chlorophenyl)-5-fluorobenzo[b]thiophen-3-yl)acetonitrile, 60 mL of acetic acid, and 20 mL of water under ice cooling. After completion of the addition, the reaction mixture was stirred under reflux with heating for 12 hours. After completion of the stirring, the reaction mixture was added dropwise to 200 mL of water under ice cooling, and the precipitated solid was recovered through filtration. To the resultant solid were added 150 mL of 5% by mass aqueous potassium hydroxide solution and 150 mL of dichloromethane at room temperature, and the organic phase was separated through a phase separation process. The resultant organic phase was subjected to extraction with 150 mL of 5% by mass aqueous potassium hydroxide solution. The resultant aqueous phases were combined and then washed with 50 mL of dichloromethane. Subsequently, 20 mL of 35% by mass hydrochloric acid was added to the resultant aqueous phase under ice cooling, and the resultant mixture was subjected to extraction with 200 mL of ethyl acetate. The resultant organic phase was dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. Subsequently, 300 mL of n-hexane and 30 mL of diisopropyl ether were added to the resultant residue, and then the precipitated solid was recovered through filtration, to thereby yield 7.7 g of the target product as a white solid.

Melting point: 202-204° C.

¹H NMR: δ 7.76 (dd, J=9.0, 4.8 Hz, 1H), 7.50-7.60 (m, 2H), 7.40-7.50 (m, 3H), 7.10-7.20 (m, 1H), 3.82 (s, 2H).

Step 4: Synthesis of ethyl 2-(2-(2-(2-(4-chlorophenyl)-5-fluorobenzo[b]thiophen-3-yl)acetyl)-2-methylhydrazinylidene)propionate

Firstly, 10.2 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 9.8 g of pentafluorophenol were added to a mixture of 17.1 g of 2-(2-(4-chlorophenyl)-5-fluorobenzo[b]thiophen-3-yl)acetic acid and 150 mL of dichloromethane at room temperature. After completion of the addition, the resultant mixture was stirred at room temperature for 18 hours. In another reaction container, 21.6 g of triethylamine was added dropwise to a mixture of 15.4 g of methylhydrazine sulfate and 90 mL of dichloromethane under ice cooling. After completion of the dropwise addition, the resultant mixture was stirred under ice cooling for one hour. After completion of the stirring, the previously prepared mixture of 2-(2-(4-chlorophenyl)-5-fluorobenzo[b]thiophen-3-yl)acetic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, and pentafluorophenol was added dropwise to the reaction mixture under ice cooling. After completion of the dropwise addition, the resultant mixture was stirred at room temperature for 18 hours. After completion of the stirring, 200 mL of water was added to the reaction mixture at room temperature, and the resultant mixture was subjected to extraction with 150 mL of dichloromethane. The resultant organic phase was dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The resultant residue was dissolved in 100 mL of ethanol, and 12.4 g of ethyl pyruvate was added to the solution. After completion of the addition, the resultant mixture was stirred at 70° C. for two hours. After completion of the stirring, the solvent was distilled off under reduced pressure. Subsequently, 100 mL of water was added to the resultant residue, and the resultant mixture was subjected to extraction with 150 mL of diethyl ether. The resultant organic phase was washed with 5% by mass aqueous potassium carbonate solution (100 mL×2), and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, to thereby yield 11.1 g of the target product as a white solid.

Melting point: 125-127° C.

¹H NMR: δ 7.74 (dd, J=8.9, 4.8 Hz, 1H), 7.56 (d, J=8.5 Hz, 2H), 7.37-7.48 (m, 3H), 7.05-7.14 (m, 1H), 4.30 (q, J=7.2 Hz, 2H), 4.16 (s, 2H), 3.41 (s, 3H), 2.29 (s, 3H), 1.31 (t, J=7.2 Hz, 3H).

Step 5: Synthesis of 4-(2-(4-chlorophenyl)-5-fluorobenzo[b]thiophen-3-yl)-5-hydroxy-2,6-dimethylpyridazin-3 (2H)-one (Compound No. 2-010)

Firstly, 11.3 g of 1,8-diazabicyclo[5.4.0]-7-undecene was added to a mixture of 11.1 g of ethyl 2-(2-(2-(2-(4-chlorophenyl)-5-fluorobenzo[b]thiophen-3-yl)acetyl)-2-methylhydrazinylidene)propionate and 50 mL of acetonitrile at room temperature. After completion of the addition, the reaction mixture was stirred at 80° C. for six hours. After completion of the stirring, the solvent was distilled off under reduced pressure. The resultant residue was dissolved in 500 mL of ethyl acetate, and 100 mL of 1 mol/L hydrochloric acid and 200 mL of water were added to the solution under ice cooling. Thereafter, the organic phase was separated through a phase separation process. The resultant aqueous phase was subjected to extraction with ethyl acetate (300 mL×2). The resultant organic phases were combined, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. Subsequently, 50 mL of diisopropyl ether and 5 mL of acetonitrile were added to the resultant residue, and then the precipitated solid was recovered through filtration, to thereby yield 9.9 g of the target product as a white solid.

Melting point: 258-259° C.

¹H NMR: δ 7.75 (dd, J=8.9, 4.8 Hz, 1H), 7.24-7.26 (m, 4H), 7.07-7.16 (m, 1H), 6.94-7.01 (m, 1H), 6.31 (brs, 1H), 3.63 (s, 3H), 2.19 (s, 3H).

¹H NMR (DMSO-d6): δ 10.57 (brs, 1H), 8.08 (dd, J=8.9, 4.8 Hz, 1H), 7.40-7.50 (m, 4H), 7.25-7.35 (m, 1H), 7.11 (dd, J=9.9, 2.4 Hz, 1H), 3.57 (s, 3H), 2.19 (s, 3H).

Synthesis Example 6 Synthesis of 4-(5-chloro-2-(4-fluoro-2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-hydroxy-2,6-dimethylpyridazin-3(2H)-one (Compound No. 2-095) Step 1: Synthesis of ethyl 2-(2-bromo-5-chlorobenzo[b]thiophen-3-yl)acetate

Firstly, 24.5 g of N-bromosuccinimide was added to a mixture of 33.4 g of ethyl 2-(5-chlorobenzo[b]thiophen-3-yl)acetate, 140 mL of N,N-dimethylformamide, and 14 mL of acetic acid at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the resultant mixture was heated to 60° C. and stirred at 60° C. for four hours. After completion of the stirring, 14.0 g of N-bromosuccinimide was added to the mixture at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the resultant mixture was heated to 60° C. and stirred at 60° C. for one hour. After completion of the stirring, the reaction mixture was added dropwise to 140 mL of water under ice cooling. After completion of the dropwise addition, the reaction mixture was subjected to extraction with 150 mL of diethyl ether. The resultant organic phase was washed sequentially with 50 mL of water, 20 mL of aqueous saturated ammonium chloride solution, and 20 mL of 5% by mass aqueous sodium hydrogen sulfite solution. The resultant organic phase was dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. Subsequently, 100 mL of hexane was added to the resultant residue, and the resultant mixture was stirred at room temperature for 12 hours. Thereafter, the precipitated solid was recovered through filtration, and the resultant solid was washed with 20 mL of hexane, to thereby yield 26.3 g of the target product as a pale yellow solid.

Melting point: 70-71° C.

¹H NMR: δ 7.60-7.70 (m, 2H), 7.31 (dd, J=8.7, 1.9 Hz, 1H), 4.18 (q, J=7.2 Hz, 2H), 3.84 (s, 2H), 1.26 (t, J=7.2 Hz, 3H).

Step 2: Synthesis of ethyl 2-(5-chloro-2-(4-fluoro-2-methoxyphenyl)benzo[b]thiophen-3-yl)acetate

Firstly, 3.8 g of 4-fluoro-2-methoxyphenylboronic acid, 8.3 g of potassium carbonate, and 1.7 g of tetrakis(triphenylphosphine)palladium were added to a mixture of 5.0 g of ethyl 2-(2-bromo-5-chlorobenzo[b]thiophen-3-yl)acetate, 50 mL of 1,4-dioxane, and 10 mL of water at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction mixture was stirred in a nitrogen atmosphere at 90° C. for three hours. After completion of the stirring, 50 mL of water and 100 mL of ethyl acetate were added to the reaction mixture at room temperature. After completion of the addition, insoluble matter was filtered with celite. The organic phase was separated from the resultant filtrate. The resultant organic phase was washed with 50 mL of water, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel chromatography (with a gradient of ethyl acetate:n-hexane=2:98 to 10:90), to thereby yield 3.7 g of the target product as a pale yellow solid.

Melting point: 103-105° C.

¹H NMR: δ 7.65-7.75 (m, 2H), 7.25-7.45 (m, 2H), 6.70-6.80 (m, 2H), 4.14 (q, J=7.2 Hz, 2H), 3.77 (s, 3H), 3.64 (s, 2H), 1.23 (t, J=7.2 Hz, 3H).

Step 3: Synthesis of 2-(5-chloro-2-(4-fluoro-2-methoxyphenyl)benzo[b]thiophen-3-yl)acetic Acid

Firstly, a mixture of 6.8 g of sodium hydroxide and 190 mL of water was added dropwise to a mixture of 21.6 g of ethyl 2-(5-chloro-2-(4-fluoro-2-methoxyphenyl)benzo[b]thiophen-3-yl)acetate, 266 mL of tetrahydrofuran, and 150 mL of water under ice cooling. After completion of the dropwise addition, the reaction mixture was stirred at room temperature for 13 hours. After completion of the stirring, the organic solvent was distilled off under reduced pressure. Subsequently, 35% by mass hydrochloric acid was added to the resultant residue under ice cooling so as to achieve a pH of 1, and the precipitated solid was recovered through filtration. The resultant solid was washed sequentially with water (20 mL×2) and 20 mL of hexane, to thereby yield 19.9 g of the target product as a white solid.

Melting point: 186-188° C.

¹H NMR: δ 7.65-7.75 (m, 2H), 7.25-7.40 (m, 2H), 6.70-6.80 (m, 2H), 3.77 (s, 3H), 3.68 (s, 2H).

Step 4: Synthesis of ethyl 2-(2-(2-(5-chloro-2-(4-fluoro-2-methoxyphenyl)benzo[b]thiophen-3-yl)acetyl)-2-methylhydrazinylidene)propionate

Firstly, 12.0 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 11.5 g of pentafluorophenol were added to a mixture of 20.0 g of 2-(5-chloro-2-(4-fluoro-2-methoxyphenyl)benzo[b]thiophen-3-yl)acetic acid and 300 mL of dichloromethane at room temperature. After completion of the addition, the resultant mixture was stirred at room temperature for 13 hours. In another reaction container, 29.5 g of diisopropylethylamine was added dropwise to a mixture of 24.6 g of methylhydrazine sulfate and 300 mL of dichloromethane at room temperature. After completion of the dropwise addition, the resultant mixture was stirred at room temperature for 13 hours. After completion of the stirring, the previously prepared mixture of 2-(5-chloro-2-(4-fluoro-2-methoxyphenyl)benzo[b]thiophen-3-yl)acetic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, and pentafluorophenol was added dropwise to the reaction mixture under ice cooling. After completion of the dropwise addition, the resultant mixture was stirred at room temperature for three hours. After completion of the stirring, 500 mL of water was added to the reaction mixture, and the organic phase was separated through a phase separation process. The resultant organic phase was washed with 500 mL of water, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The resultant residue was dissolved in 180 mL of ethanol, and 13.2 g of ethyl pyruvate was added to the solution at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction mixture was stirred in a nitrogen atmosphere at 45° C. for 10 hours. After completion of the stirring, the solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel chromatography (with a gradient of ethyl acetate:n-hexane=2:98 to 20:80). Subsequently, 50 mL of diisopropyl ether was added to the resultant crude product, and the precipitated solid was recovered through filtration. The resultant solid was washed with 10 mL of diisopropyl ether, to thereby yield 15.9 g of the target product as a white solid.

Melting point: 126-128° C.

¹H NMR: δ 7.65-7.75 (m, 2H), 7.35-7.45 (m, 1H), 7.25-7.35 (m, 1H), 6.65-6.80 (m, 2H), 4.26 (q, J=7.2 Hz, 2H), 4.03 (s, 2H), 3.77 (s, 3H), 3.34 (s, 3H), 2.24 (s, 3H), 1.30 (t, J=7.2 Hz, 3H).

Step 5: Synthesis of 4-(5-chloro-2-(4-fluoro-2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-hydroxy-2,6-dimethyl pyridazin-3(2H)-one (Compound No. 2-095)

Firstly, 8.6 g of 1,8-diazabicyclo[5,4,0]-7-undecene was added to a mixture of 13.4 g of ethyl 2-(2-(2-(5-chloro-2-(4-fluoro-2-methoxyphenyl)benzo[b]thiophen-3-yl)acetyl)-2-methylhydrazinylidene)propionate and 57 mL of acetonitrile at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the resultant mixture was heated to 90° C. and stirred at 90° C. for five hours. After completion of the stirring, the solvent contained in the reaction mixture was distilled off under reduced pressure. Subsequently, 50 mL of water and 350 mL of ethyl acetate were added to the resultant residue, and 35% by mass hydrochloric acid was added to the mixture under ice cooling so as to achieve a pH of 1. The organic phase was separated from the resultant mixture. The resultant organic phase was washed sequentially with 1 mol/L hydrochloric acid (50 mL×2) and 100 mL of water, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. Subsequently, 100 mL of diisopropyl ether and 2 mL of acetonitrile were added to the resultant residue. After completion of the addition, the precipitated solid was recovered through filtration, to thereby yield 11.3 g of the target product as a white solid.

Melting point: 221-223° C.

¹H NMR: δ 7.70-7.80 (m, 1H), 7.20-7.40 (m, 3H), 6.60-6.75 (m, 2H), 6.02 (s, 1H), 3.79 (s, 3H), 3.73 (s, 3H), 2.21 (s, 3H).

Synthesis Example 7 Synthesis of 4-(5-cyclopropyl-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-hydroxy-2,6-dimethylpyridazin-3(2H)-one (Compound No. 2-160) Step 1: Synthesis of 4-(5-chloro-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one (Compound No. 2-102)

Firstly, 3.7 g of 2-methoxyphenylboronic acid, 10.6 g of potassium phosphate, and 1.2 g of tetrakis(triphenylphosphine)palladium were added to a mixture of 8.0 g of 4-(2-bromo-5-chlorobenzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one and 60 mL of toluene at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction mixture was stirred in a nitrogen atmosphere at 110° C. for four hours. After completion of the stirring, insoluble matter was filtered with celite, and the residue was washed with 100 mL of ethyl acetate. The resultant filtrate was washed with 100 mL of water, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel chromatography (with a gradient of ethyl acetate:n-hexane=20:80 to 40:60), to thereby yield 7.0 g of the target product as an ocher solid.

Melting point: 174-175° C.

¹H NMR: δ 7.72 (d, J=8.7 Hz 1H), 7.43 (dd, J=2.1, 0.6 Hz, 1H), 7.28-7.36 (m, 3H), 6.86-6.96 (m, 2H), 3.74 (s, 3H), 3.70 (s, 3H), 3.36 (s, 3H), 2.11 (s, 3H).

Step 2: Synthesis of tert-butyl (3-(5-methoxy-2,6-dimethyl-3-oxo-2,3-dihydropyridazin-4-yl)-2-(2-methoxyphenyl)benzo[b]thiophen-5-yl)carbamate (Compound No. 2-182)

Firstly, 1.5 g of tert-butyl carbamate, 127 mg of 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl, 3.0 g of cesium carbonate, and 42 mg of palladium acetate were added to a mixture of 1.2 g of 4-(5-chloro-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one and 15 mL of 1,4-dioxane at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction mixture was stirred in a nitrogen atmosphere at 110° C. for six hours. After completion of the stirring, insoluble matter was filtered with celite, and the residue was washed with 30 mL of ethyl acetate. The resultant filtrate was washed with 20 mL of water, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, to thereby yield 1.4 g of the target product as a pale yellow oily product. This product was used in the next step without further purification.

¹H NMR: δ 7.72 (d, J=9.0 Hz, 1H), 7.40-7.50 (m, 1H), 7.28-7.38 (m, 3H), 6.88-6.95 (m, 1H), 6.87 (d, J=9.0 Hz, 1H), 6.60 (brs, 1H), 3.74 (s, 3H), 3.69 (s, 3H), 3.36 (s, 3H), 2.08 (s, 3H), 1.50 (s, 9H).

Step 3: Synthesis of 4-(5-amino-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one (Compound No. 2-174)

Firstly, 5 mL of trifluoroacetic acid was added to a mixture of 1.4 g of tert-butyl (3-(5-methoxy-2,6-dimethyl-3-oxo-2,3-dihydropyridazin-4-yl)-2-(2-methoxyphenyl)benzo[b]thiophen-5-yl)carbamate and 10 mL of dichloromethane under ice cooling. After completion of the addition, the resultant mixture was stirred at room temperature for 20 hours. After completion of the stirring, the solvent was distilled off under reduced pressure. Subsequently, 80 mL of ethyl acetate was added to the resultant residue, and the mixture was washed with 30 mL of aqueous saturated sodium hydrogen carbonate solution and 20 mL of water. The resultant organic phase was dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. Subsequently, 20 mL of diisopropyl ether was added to the resultant residue, and then the precipitated solid was recovered through filtration, to thereby yield 390 mg of the target product as a pale yellow solid.

Melting point: 219-221° C.

¹H NMR: δ 7.57 (d, J=9.3 Hz, 1H), 7.35 (dd, J=7.5, 1.5 Hz, 1H), 7.20-7.28 (m, 2H), 6.75-6.95 (m, 3H), 3.74 (s, 3H), 3.68 (s, 3H), 3.37 (s, 3H), 2.09 (s, 3H), 1.61 (brs, 2H).

Step 4: Synthesis of 4-(5-iodo-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one (Compound No. 2-131)

Firstly, 4.4 g of 35% by mass hydrochloric acid was added to a mixed suspension of 1.7 g of 4-(5-amino-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one and 15 mL of water under ice cooling. After completion of the addition, a mixture of 345 mg of sodium nitrite and 2.5 mL of water was added dropwise to the mixed suspension under ice cooling, and the resultant mixture was stirred under ice cooling for 30 minutes. After completion of the stirring, a mixture of 1.9 g of sodium iodide and 5.5 mL of water was added dropwise to the resultant mixture under ice cooling. After completion of the dropwise addition, the reaction mixture was stirred at room temperature for 20 hours. After completion of the stirring, 30 mL of water was added to the reaction mixture, and the resultant mixture was subjected to extraction with 50 mL of ethyl acetate. The resultant organic phase was washed with 5% by mass aqueous sodium thiosulfate solution (30 mL×2), and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel chromatography (with a gradient of ethyl acetate:n-hexane=20:80 to 40:60), to thereby yield 1.5 g of the target product as an orange solid.

Melting point: 161-163° C.

¹H NMR: δ 7.76-7.78 (m, 1H), 7.53-7.62 (m, 2H), 7.26-7.36 (m, 2H), 6.92 (dd, J=7.5, 1.2 Hz, 1H), 6.87 (d, J=7.5 Hz, 1H), 3.74 (s, 3H), 3.70 (s, 3H), 3.35 (s, 3H), 2.11 (s, 3H).

Step 5: Synthesis of 4-(5-cyclopropyl-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one (Compound No. 2-161)

Firstly, 62 mg of cyclopropylboronic acid, 256 mg of potassium phosphate, and 28 mg of tetrakis(triphenylphosphine)palladium were added to a mixture of 250 mg of 4-(5-iodo-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one and 3 mL of toluene at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction mixture was stirred in a nitrogen atmosphere at 110° C. for two hours. After completion of the stirring, insoluble matter was filtered with celite, and the residue was washed with 10 mL of ethyl acetate. The resultant filtrate was washed with water (5 mL×2), and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel chromatography (with a gradient of ethyl acetate:n-hexane=20:80 to 40:60), to thereby yield 157 mg of the target product as an orange oily product.

¹H NMR: δ 7.69 (d, J=7.8 Hz, 1H), 7.26-7.36 (m, 2H), 7.20 (d, J=1.8 Hz, 1H), 6.85-7.00 (m, 3H), 3.74 (s, 3H), 3.68 (s, 3H), 3.37 (s, 3H), 2.12 (s, 3H), 1.95-2.05 (m, 1H), 0.92-1.00 (m, 2H), 0.62-0.70 (m, 2H).

Step 6: Synthesis of 4-(5-cyclopropyl-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-hydroxy-2,6-dimethylpyridazin-3(2H)-one (Compound No. 2-160)

Firstly, a mixture of 140 mg of 4-(5-cyclopropyl-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one and 1.5 mL of morpholine was stirred at 100° C. for eight hours. After completion of the stirring, 5 mL of water was added to the reaction mixture, and 35% by mass hydrochloric acid was added to the mixture under ice cooling so as to achieve a pH of 1. After completion of the addition, the resultant mixture was subjected to extraction with 15 mL of ethyl acetate. The resultant organic phase was washed with 5 mL of water, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. Subsequently, 5 mL of diisopropyl ether was added to the resultant residue, and then the precipitated solid was recovered through filtration, to thereby yield 42 mg of the target product as a white solid.

Melting point: 182-184° C.

¹H NMR: δ 7.72 (d, J=8.4 Hz, 1H), 7.30-7.40 (m, 2H), 7.15-7.18 (m, 1H), 7.02-7.08 (m, 1H), 6.90-7.00 (m, 2H), 6.39 (brs, 1H), 3.78 (s, 3H), 3.74 (s, 3H), 2.17 (s, 3H), 1.92-2.04 (m, 1H), 0.90-1.00 (m, 2H), 0.65-0.75 (m, 2H).

Synthesis Example 8 Synthesis of 5-hydroxy-4-(2-(2-methoxyphenyl)-5-((trifluoromethyl)thio)benzo[b]thiophen-3-yl)-2,6-di methylpyridazin-3(2H)-one (Compound No. 2-378) Step 1: Synthesis of 5-methoxy-4-(2-(2-methoxyphenyl)-5-((trifluoromethyl)thio)benzo[b]thiophen-3-yl)-2,6-di methylpyridazin-3(2H)-one (Compound No. 2-379)

Firstly, trifluoromethanethiol copper (I) was added to a mixture of 150 mg of 4-(5-iodo-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one and 1.5 mL of 1,3-dimethyl-2-imidazolidine at room temperature. After completion of the addition, the reaction mixture was stirred at 130° C. for three hours. After completion of the stirring, insoluble matter was filtered with celite, and the residue was washed with 10 mL of ethyl acetate. The resultant filtrate was washed with 10 mL of aqueous saturated ammonium chloride solution and 5 mL of water, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel chromatography (with a gradient of ethyl acetate:n-hexane=10:90 to 30:70), to thereby yield 126 mg of the target product as a pale yellow solid.

Melting point: 152-155° C.

¹H NMR: δ 7.87 (d, J=8.4 Hz, 1H), 7.75 (d, J=1.8 Hz, 1H), 7.55-7.62 (m, 1H), 7.30-7.38 (m, 2H), 6.86-6.98 (m, 2H), 3.74 (s, 3H), 3.72 (s, 3H), 3.36 (s, 3H), 2.13 (s, 3H).

Step 2: Synthesis of 5-hydroxy-4-(2-(2-methoxyphenyl)-5-((trifluoromethyl)thio)benzo[b]thiophen-3-yl)-2,6-di methylpyridazin-3(2H)-one (Compound No. 2-378)

Firstly, a mixture of 110 mg of 5-methoxy-4-(2-(2-methoxyphenyl)-5-((trifluoromethyl)thio)benzo[b]thiophen-3-yl)-2,6-di methylpyridazin-3(2H)-one and 1.5 mL of morpholine was stirred at 100° C. for seven hours. After completion of the stirring, 5 mL of water was added to the reaction mixture, and 35% by mass hydrochloric acid was added to the mixture under ice cooling so as to achieve a pH of 1. After completion of the addition, the resultant mixture was subjected to extraction with 15 mL of ethyl acetate. The resultant organic phase was washed with 5 mL of water, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. Subsequently, 5 mL of diisopropyl ether was added to the resultant residue, and then the precipitated solid was recovered through filtration, to thereby yield 65 mg of the target product as a white solid.

Melting point: 183-186° C.

¹H NMR: δ 7.89 (d, J=8.1 Hz, 1H), 7.60-7.70 (m, 2H), 7.28-7.42 (m, 2H), 6.94-7.00 (m, 2H), 6.33 (brs, 1H), 3.81 (s, 3H), 3.74 (s, 3H), 2.20 (s, 3H).

Synthesis Example 9

Synthesis of 6-chloro-5-hydroxy-4-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-2-methylpyridazin-3(2H)-one (Compound No. 3-088)

Step 1: Synthesis of ethyl 2-(dibenzylamino)-2-(2-methylhydrazinylidene)acetate

Firstly, a mixture of 1.3 g of ethyl 2-(2-methylhydrazinylidene)acetate and 10 mL of N,N-dimethylformamide was heated to 50° C., and 1.5 g of N-chlorosuccinimide was added to the mixture at 50° C. After completion of the addition, the reaction mixture was stirred at 50 to 60° C. for three hours. After completion of the stirring, 30 mL of water was added to the reaction mixture, and the resultant mixture was subjected to extraction with tert-butyl methyl ether (30 mL×2). The resultant organic phase was washed with 30 mL of water, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. Subsequently, 10 mL of tert-butyl methyl ether and 1.0 g of dibenzylamine were added to the resultant residue at room temperature. After completion of the addition, the reaction mixture was cooled to 0° C., and 1.1 g of 1,8-diazabicyclo[5,4,0]-7-undecene was added to the mixture at 0° C. After completion of the addition, the reaction mixture was stirred at room temperature for 18 hours. After completion of the stirring, 30 mL of water was added to the reaction mixture, and the resultant mixture was subjected to extraction with ethyl acetate (30 mL×2). The resultant organic phase was washed with 30 mL of water, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel column chromatography (with a gradient of ethyl acetate:n-hexane=5:95 to 10:90), to thereby yield 714 mg of the target product as a colorless oily product.

¹H NMR: δ 7.02-7.34 (m, 10H), 4.26 (q, 7.2 Hz, 2H), 4.02 (s, 4H), 2.86 (d, J=4.2 Hz, 3H), 1.31 (t, J=7.2 Hz, 3H).

Step 2: Synthesis of ethyl 2-(dibenzylamino)-2-(2-(2-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)acetyl)-2-methylhydrazinylidene)acetate

Firstly, 458 mg of oxalyl chloride and 10 mg of N,N-dimethylformamide were added to a mixture of 790 mg of 2-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)acetic acid produced in step 2 of Synthesis Example 3 and 8 mL of dichloromethane at room temperature. After completion of the addition, the reaction mixture was stirred at room temperature for two hours. After completion of the stirring, the solvent was distilled off under reduced pressure. The resultant residue was dissolved in 10 mL of toluene, and 712 mg of ethyl 2-(dibenzylamino)-2-(2-methylhydrazinylidene)acetate and 243 mg of pyridine were added to the solution. After completion of the addition, the resultant mixture was stirred at 100° C. for one hour. After completion of the stirring, 30 mL of water was added to the mixture, and the resultant mixture was subjected to extraction with ethyl acetate (50 mL×2). The resultant organic phase was washed with 20 mL of water, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel column chromatography (with a gradient of ethyl acetate:n-hexane=5:95 to 50:50), to thereby yield 743 mg of the target product as a yellow oily product.

¹H NMR: δ 7.57 (d, J=8.7 Hz, 1H), 7.49 (dd, J=7.5, 1.5 Hz, 1H), 7.25-7.28 (m, 9H), 7.18-7.20 (m, 3H), 6.91-6.99 (m, 3H), 4.32 (brs, 4H), 4.28 (q, J=7.2 Hz, 2H), 3.85 (s, 3H), 3.78 (s, 3H), 3.73 (s, 2H), 3.14 (s, 3H), 1.22 (t, J=7.2 Hz, 3H).

Step 3: Synthesis of 6-(dibenzylamino)-5-hydroxy-4-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-2-methylpyridazin-3(2H)-one (Compound No. 3-086)

Firstly, a mixture of 743 mg of ethyl 2-(dibenzylamino)-2-(2-(2-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)acetyl 1)-2-methylhydrazinylidene)acetate and 5 mL of tetrahydrofuran was cooled to 0° C., and 387 mg of potassium tert-butoxide was added to the mixture at 0° C. After completion of the addition, the reaction mixture was stirred at 0° C. for one hour. After completion of the stirring, 5 mL of 1 mol/L hydrochloric acid and 20 mL of water were added to the mixture, and then the precipitated solid was recovered through filtration. The resultant solid was washed sequentially with 5 mL of water and 5 mL of diisopropyl ether, to thereby yield 576 mg of the target product as a yellow solid.

Melting point: 163-166° C.

¹H NMR: δ 7.24-7.35 (m, 10H), 7.08-7.11 (m, 4H), 6.95-7.00 (m 2H), 6.88 (d, J=7.8 Hz, 1H), 6.57 (brs, 1H), 4.00-4.30 (m, 4H), 3.88 (s, 3H), 3.69 (s, 3H), 3.58 (s, 3H).

Step 4: Synthesis of 6-amino-5-hydroxy-4-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-2-methyl pyridazin-3(2H)-one (Compound No. 3-087)

Firstly, 550 mg of 5% palladium carbon (available from N.E.CHEMCAT CORPORATION, STD type, 50% hydrous product) was added to a mixture of 549 mg of 6-(dibenzylamino)-5-hydroxy-4-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-2-methylpyridazin-3(2H)-one, 5 mL of methanol, and 0.5 mL of 35% by mass hydrochloric acid, and the reaction container was purged with hydrogen gas. After completion of the hydrogen gas purging, the reaction mixture was stirred at room temperature for 20 hours. After completion of the stirring, insoluble matter was filtered with celite, and the residue was washed with 10 mL of methanol. The resultant filtrate was concentrated under reduced pressure. The resultant residue was purified by silica gel column chromatography (with a gradient of ethyl acetate:n-hexane=50:50 to 100:0), to thereby yield 260 mg of the target product as a white solid.

Melting point: 286-288° C.

¹H NMR: δ 7.30-7.38 (m, 4H), 6.97-7.01 (m, 3H), 6.56 (s, 1H), 4.15 (brs, 2H), 3.88 (s, 3H), 3.82 (s, 3H), 3.63 (s, 3H).

Step 5: Synthesis of 6-chloro-5-hydroxy-4-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-2-methylpyridazin-3(2H)-one (Compound No. 3-088)

Firstly, a mixture of 242 mg of 6-amino-5-hydroxy-4-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-2-methyl pyridazin-3(2H)-one, 3 mL of acetonitrile, and 2 mL of 35% by mass hydrochloric acid was cooled to 0° C., and 110 mg of sodium nitrite was added to the mixture. After completion of the addition, the resultant mixture was stirred at room temperature for five hours. After completion of the stirring, 30 mL of water was added to the reaction mixture, and the resultant mixture was subjected to extraction with ethyl acetate (30 mL×2). The resultant organic phase was dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel column chromatography (with a gradient of ethyl acetate:n-hexane=30:70 to 70:30), to thereby yield 51 mg of the target product as a white solid.

Melting point: 209-211° C.

¹H NMR: δ 7.28-7.40 (m, 4H), 6.95-7.02 (m, 3H), 6.73 (brs, 1H), 3.88 (s, 3H), 3.82 (s, 3H), 3.75 (s, 3H).

Synthesis Example 10 Synthesis of 5-hydroxy-4-(2-(2-methoxyphenyl)-6-(2,2,2-trifluoroethoxy)benzo[b]thiophen-3-yl)-2,6-di methylpyridazin-3 (2H)-one (Compound No. 3-116) Step 1: Synthesis of ethyl 2-(2-bromo-6-methoxybenzo[b]thiophen-3-yl)acetate

Firstly, 8.5 g of N-bromosuccinimide was added to a mixture of 12.9 g of ethyl 2-(6-methoxybenzo[b]thiophen-3-yl)acetate and 70 mL of acetonitrile under ice cooling, and the resultant mixture was stirred under ice cooling for one hour. After completion of the stirring, the solvent was distilled off under reduced pressure. Subsequently, 200 mL of aqueous saturated ammonium chloride solution was added to the resultant residue, and the resultant mixture was subjected to extraction with ethyl acetate (200 mL×2). The resultant organic phase was dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, to thereby yield 12.1 g of the target product as a brown solid. This product was used in the next step without further purification.

Melting point: 143-148° C.

¹H NMR: δ 7.53-7.58 (m, 1H), 7.18-7.22 (m, 1H), 6.95-7.05 (m, 1H), 4.16 (q, J=7.2 Hz, 2H), 3.82 (s, 2H), 3.86 (s, 3H), 1.24 (t, J=7.2 Hz, 3H).

Step 2: Synthesis of ethyl 2-(6-(benzyloxy)-2-bromobenzo[b]thiophen-3-yl)acetate

Firstly, 60 mL of 1 mol/L dichloromethane solution of boron tribromide was added dropwise under ice cooling to a mixture of 12.1 g of ethyl 2-(2-bromo-6-methoxybenzo[b]thiophen-3-yl)acetate and 100 mL of dichloromethane, and the resultant mixture was stirred under ice cooling for one hour. After completion of the stirring, the reaction mixture was poured into 200 mL of water cooled at 0° C., and then the precipitated solid was recovered through filtration. The resultant solid was washed with 50 mL of water and 50 mL of diisopropyl ether. Subsequently, 8.4 g of potassium carbonate and 8.5 g of benzyl bromide were added to a mixture of the resultant solid and 30 mL of N,N-dimethylformamide at room temperature, and the resultant mixture was stirred at room temperature overnight. After completion of the stirring, 100 mL of water was added to the resultant mixture, and the mixture was subjected to extraction with a mixed solvent of 100 mL of diethyl ether and 100 mL of ethyl acetate. The resultant organic phase was washed with 100 mL of water, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. Diisopropyl ether was added to the resultant residue, and then the precipitated solid was recovered through filtration, to thereby yield 9.2 g of the target product as a pale orange solid.

Melting point: 103-105° C.

¹H NMR: δ 7.53-7.58 (m, 1H), 7.30-7.45 (m, 5H), 7.25-7.28 (m, 1H), 7.03-7.08 (m, 1H), 5.11 (s, 2H), 4.15 (q, J=7.2 Hz, 2H), 3.79 (s, 2H), 1.23 (t, J=7.2 Hz, 3H).

Step 3: Synthesis of 2-(6-(benzyloxy)-2-bromobenzo[b]thiophen-3-yl)acetic Acid

Firstly, 18 mL of 10% by mass aqueous sodium hydroxide solution was added to a mixture of 9.2 g of ethyl 2-(6-(benzyloxy)-2-bromobenzo[b]thiophen-3-yl)acetate, 30 mL of methanol, and 30 mL of tetrahydrofuran under ice cooling. After completion of the addition, the reaction mixture was stirred at room temperature for 18 hours. After completion of the stirring, the organic solvent was distilled off under reduced pressure, and 20 mL of 35% by mass hydrochloric acid was added to the resultant residue under ice cooling. After completion of the addition, the precipitated solid was recovered through filtration, and then washed with 50 mL of water, to thereby yield 8.5 g of the target product as a white solid.

Melting point: 170-172° C.

¹H NMR (DMSO-d6): δ 12.56 (brs, 1H), 7.60-7.70 (m, 2H), 7.25-7.50 (m, 5H), 7.11 (dd, J=8.8, 2.3 Hz, 1H), 5.16 (s, 2H), 3.79 (s, 2H).

Step 4: Synthesis of 4-(6-(benzyloxy)-2-bromobenzo[b]thiophen-3-yl)-5-hydroxy-2,6-dimethylpyridazin-3(2H)-one

Firstly, 4.3 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and 4.2 g of pentafluorophenol were added to a mixture of 8.5 g of 2-(6-(benzyloxy)-2-bromobenzo[b]thiophen-3-yl)acetic acid and 50 mL of dichloromethane at room temperature. After completion of the addition, the resultant mixture was stirred at room temperature for 18 hours. In another reaction container, 6.9 g of triethylamine was added dropwise to a mixture of 6.5 g of methylhydrazine sulfate and 50 mL of dichloromethane under ice cooling. After completion of the dropwise addition, the resultant mixture was stirred under ice cooling for one hour. After completion of the stirring, the previously prepared mixture of 2-(6-(benzyloxy)-2-bromobenzo[b]thiophen-3-yl)acetic acid, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, and pentafluorophenol was added dropwise to the reaction mixture under ice cooling. After completion of the dropwise addition, the resultant mixture was stirred at room temperature for 18 hours. After completion of the stirring, 100 mL of water was added to the reaction mixture at room temperature, and the resultant mixture was subjected to extraction with 100 mL of dichloromethane. The resultant organic phase was dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure.

The resultant residue was dissolved in 50 mL of ethanol, and 5.2 g of ethyl pyruvate was added to the solution at room temperature. After completion of the addition, the resultant mixture was stirred at 70° C. for two hours. After completion of the stirring, the solvent was distilled off from the reaction mixture under reduced pressure. Subsequently, 100 mL of water was added to the resultant residue, and the resultant mixture was subjected to extraction with 100 mL of diethyl ether. The resultant organic phase was dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure.

The resultant residue was dissolved in 50 mL of acetonitrile, and 2.6 g of 1,8-diazabicyclo[5.4.0]-7-undecene was added to the solution at room temperature, followed by stirring at 80° C. for six hours. After completion of the stirring, the solvent was distilled off under reduced pressure. The resultant residue was dissolved in 50 mL of ethyl acetate, and 35 mL of 1 mol/L hydrochloric acid and 15 mL of water were added to the solution under ice cooling, followed by separation of the organic phase and the aqueous phase. The resultant aqueous phase was subjected to extraction with ethyl acetate (50 mL×2). The resultant organic phases were combined, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, to thereby yield 2.6 g of the crude target product as a brown amorphous product. This product was used in the next step without further purification.

¹H NMR: δ 7.10-7.50 (m, 7H), 7.02 (dd, J=9.0, 2.5 Hz, 1H), 5.97 (brs, 1H), 5.12 (s, 2H), 3.75 (s, 3H), 2.35 (s, 3H).

Step 5: Synthesis of 4-(6-(benzyloxy)-2-bromobenzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one

Firstly, 2.4 g of potassium carbonate and 1-6 g of iodomethane were added to a mixture of 2.6 g of 4-(6-(benzyloxy)-2-bromobenzo[b]thiophen-3-yl)-5-hydroxy-2,6-dimethylpyridazin-3(2H)-one and 10 mL of N,N-dimethylformamide. After completion of the addition, the resultant mixture was stirred at room temperature for 18 hours. After completion of the stirring, 50 mL of water was added to the reaction mixture, and the resultant mixture was subjected to extraction with 50 mL of ethyl acetate. The resultant organic phase was dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel chromatography (with a gradient of ethyl acetate:n-hexane=5:95 to 25:75), to thereby yield 1.8 g of the target product as a pale yellow solid.

Melting point: 167-169° C.

¹H NMR: δ 7.25-7.50 (m, 7H), 7.04 (dd, J=8.9, 2.4 Hz, 1H), 5.11 (s, 2H), 3.75 (s, 3H), 3.43 (s, 3H), 2.32 (s, 3H).

Step 6: Synthesis of 4-(6-(benzyloxy)-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3 (2H)-one

Firstly, 2.5 g of potassium phosphate, 1.2 g of (2-methoxyphenyl)boronic acid, and 450 mg of tetrakis(triphenylphosphine)palladium were added to a mixture of 1.2 g of 4-(6-(benzyloxy)-2-bromobenzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one and 15 mL of toluene. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction mixture was stirred in a nitrogen atmosphere at 100° C. for two hours. After completion of the stirring, insoluble matter was filtered with celite. The resultant filtrate was concentrated under reduced pressure. The resultant residue was purified by silica gel chromatography (with a gradient of ethyl acetate:n-hexane=10:90 to 50:50), to thereby yield 1.9 g of the target product as a dark red amorphous product.

¹H NMR: δ 7.28-7.48 (m, 9H), 7.04-7.10 (m, 1H), 6.68-7.02 (m, 2H), 5.14 (s, 2H), 3.74 (s, 3H), 3.70 (s, 3H), 3.37 (s, 3H), 2.10 (s, 3H).

Step 7: Synthesis of 4-(6-hydroxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one (Compound No. 3-172)

Firstly, 1.9 g of 5% palladium carbon (available from N.E.CHEMCAT CORPORATION, STD type, 50% hydrous product) was added to a mixture of 1.9 g of 4-(6-(benzyloxy)-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one, 40 mL of methanol, and 20 mL of tetrahydrofuran. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction container was purged with hydrogen gas. After completion of the hydrogen gas purging, the reaction mixture was stirred at room temperature for 48 hours. After completion of the stirring, the palladium carbon was separated through filtration with celite, and the residue was washed with 100 mL of chloroform. The solvent was distilled off from the resultant filtrate under reduced pressure, to thereby yield 1.5 g of the target product as a pale yellow solid.

¹H NMR: δ 7.74 (s, 1H), 7.27-7.40 (m, 2H), 7.03-7.11 (m, 1H), 6.82-6.99 (m, 2H), 6.68-6.73 (m, 1H), 6.56-6.61 (m, 1H), 3.81 (s, 3H), 3.71 (s, 3H), 3.45 (s, 3H), 2.13 (s, 3H).

Step 8: Synthesis of 5-methoxy-4-(2-(2-methoxyphenyl)-6-(2,2,2-trifluoroethoxy)benzo[b]thiophen-3-yl)-2,6-di methylpyridazin-3(2H)-one (Compound No. 3-117)

Firstly, 200 mg of potassium carbonate and 340 mg of 2,2,2-trifluoroethyl trifluoromethanesulfonate were added to a mixture of 200 mg of 4-(6-hydroxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one and 3 mL of acetonitrile at room temperature. After completion of the addition, the reaction mixture was stirred at room temperature for 18 hours. After completion of the stirring, insoluble matter was filtered with celite, and the resultant filtrate was concentrated under reduced pressure. The resultant residue was purified by silica gel chromatography (with a gradient of ethyl acetate:n-hexane=5:95 to 25:75), to thereby yield 162 mg of the target product as a colorless oily product.

¹H NMR: δ 7.24-7.44 (m, 4H), 7.03 (dd, J=8.9, 2.4 Hz, 1H), 6.83-6.95 (m, 2H), 4.40 (q, J=8.2 Hz, 2H), 3.73 (s, 3H), 3.69 (s, 3H), 3.35 (s, 3H), 2.09 (s, 3H).

Step 9: Synthesis of 5-hydroxy-4-(2-(2-methoxyphenyl)-6-(2,2,2-trifluoroethoxy)benzo[b]thiophen-3-yl)-2,6-di methylpyridazin-3(2H)-one (Compound No. 3-116)

Firstly, 1 mL of morpholine was added to a mixture of 162 mg of 5-methoxy4-(2-(2-methoxyphenyl)-6-(2,2,2-trifluoroethoxy)benzo[b]thiophen-3-yl)-2,6-di methylpyridazin-3(2H)-one and 3 mL of N-methyl-2-pyrrolidone at room temperature, and the resultant mixture was stirred at 100° C. for three hours. After completion of the stirring, 20 mL of 1 mol/L hydrochloric acid was added to the reaction mixture under ice cooling, and the resultant mixture was subjected to extraction with ethyl acetate (30 mL×2). The resultant organic phase was dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. Subsequently, 2 mL of diisopropyl ether was added to the resultant residue, and then the precipitated solid was recovered through filtration, to thereby yield 19 mg of the target product as a white solid.

Melting point: 216-218° C.

¹H NMR: δ 7.35-7.40 (m, 3H), 7.27-7.34 (m, 1H), 7.01-7.07 (m, 1H), 6.91-6.99 (m, 2H), 4.42 (q, J=8.2 Hz, 2H), 3.81 (s, 3H), 3.74 (s, 3H), 2.18 (s, 3H).

Synthesis Example 11 Synthesis of 4-(7-chloro-6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-hydroxy-2,6-dimeth ylpyridazin-3-(2H)-one (Compound No. 7-001)

Firstly, 33 mg of N-chlorosuccinimide was added to a mixture of 100 mg of 4-(6-methoxy-2-(2-methoxyphenyl)benzo[b]thiophen-3-yl)-5-hydroxy-2,6-dimethylpyridazin-3-(2H)-one and 3 mL of N,N-dimethylformamide at room temperature. After completion of the addition, the reaction mixture was stirred at 80° C. for one hour. After completion of the stirring, 10 mL of 1 mol/L hydrochloric acid was added to the reaction mixture under ice cooling, and the resultant mixture was subjected to extraction with 20 mL of ethyl acetate. The resultant organic phase was washed with 5 mL of 1 mol/L hydrochloric acid, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel chromatography (with a gradient of ethyl acetate:n-hexane=5:95 to 30:70), to thereby yield 75 mg of the target product as a white solid.

Melting point: 229-231° C.

¹H NMR: δ 7.25-7.40 (m, 3H), 7.06 (d, J=8.5 Hz, 1H), 6.90-7.00 (m, 2H), 6.45 (brs, 1H), 3.97 (s, 3H), 3.82 (s, 3H), 3.73 (s, 3H), 2.17 (s, 3H).

Synthesis Example 12 Synthesis of 5-hydroxy-4-(2-(4-(2-methoxyethoxy)phenyl)benzofuran-3-yl)-2,6-dimethylpyridazin-3-(2H)-one (Compound No. 8-007) Step 1: Synthesis of 4-(2-(4-(benzyloxy)phenyl)benzofuran-3-yl)-5-methoxy-2,6-dimethylpyridazin-3-(2H)-one

Firstly, 872 mg of p-benzyloxyphenylboronic acid, 1-6 g of potassium phosphate, and 294 mg of tetrakis(triphenylphosphine)palladium were added to a mixture of 890 mg of 4-(2-bromobenzofuran-3-yl)-5-methoxy-2,6-dimethylpyridazin-3-(2H)-one and 20 mL of toluene at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction mixture was stirred in a nitrogen atmosphere at 110° C. for three hours. After completion of the stirring, insoluble matter was filtered with celite, and the residue was washed with chloroform (10 mL×2). The resultant filtrate was concentrated under reduced pressure. The resultant residue was purified by silica gel chromatography (with a gradient of ethyl acetate:n-hexane=5:95 to 25:75), to thereby yield 1.3 g of the target product as a pale yellow oily product.

¹H NMR: δ 7.60-7.70 (m, 2H), 7.20-7.55 (m, 9H), 6.95-7.05 (m, 2H), 5.08 (s, 2H), 3.76 (s, 3H), 3.48 (s, 3H), 2.32 (s, 3H).

Step 2: Synthesis of 4-(2-(4-hydroxyphenyl)benzofuran-3-yl)-5-methoxy-2,6-dimethylpyridazin-3-(2H)-one (compound No. 8-006)

Firstly, 650 mg of 10% palladium carbon (available from N.E.CHEMCAT CORPORATION, PE type, 50% hydrous product) was suspended in 20 mL of tetrahydrofuran, and 1.3 g of 4-(2-(4-(benzyloxy)phenyl)benzofuran-3-yl)-5-methoxy-2,6-dimethylpyridazin-3-(2H)-one was added to the suspension at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction container was purged with hydrogen gas. After completion of the hydrogen gas purging, the reaction mixture was stirred at room temperature for three hours. After completion of the stirring, insoluble matter was filtered with celite, and the residue was washed with chloroform (20 mL×2). The resultant filtrate was concentrated under reduced pressure. Subsequently, 40 mL of diisopropyl ether was added to the resultant residue, and then the precipitated solid was recovered through filtration, to thereby yield 770 mg of the target product as a white solid.

Melting point: 251-253° C.

¹H NMR: δ 7.10-7.55 (m, 6H), 6.55-6.60 (m, 2H), 3.82 (brs, 3H), 3.54 (s, 3H), 2.37 (brs, 3H).

Step 3: Synthesis of 5-methoxy-4-(2-(4-(2-methoxyethoxy)phenyl)benzofuran-3-yl)-2,6-dimethylpyridazin-3-(2H)-one

Firstly, 86 mg of potassium carbonate and 69 mg of 1-bromo-2-methoxyethane were added to a mixture of 150 mg of 4-(2-(4-hydroxyphenyl)benzofuran-3-yl)-5-methoxy-2,6-dimethylpyridazin-3-(2H)-one and 3 mL of acetonitrile at room temperature. After completion of the addition, the reaction mixture was stirred at 90° C. for three hours. After completion of the stirring, 5 mL of water was added to the reaction mixture, and the resultant mixture was subjected to extraction with 10 mL of ethyl acetate. The resultant organic phase was dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel column chromatography (with a gradient of ethyl acetate:n-hexane=5:95 to 30:70), to thereby yield 148 mg of the target product as a colorless oily product.

¹H NMR: δ 7.60-7.70 (m 2H), 7.50-7.55 (m, 1H), 7.15-7.35 (m, 3H), 6.90-7.00 (m, 2H), 4.10-4.20 (m, 2H), 3.70-3.80 (m, 5H), 3.48 (s, 3H), 3.46 (s, 3H), 2.32 (s, 3H). Step 4: Synthesis of 5-hydroxy-4-(2-(4-(2-methoxyethoxy)phenyl)benzofuran-3-yl)-2,6-dimethylpyridazin-3-(2H)-one (Compound No. 8-007)

Firstly, 1 mL of morpholine was added to a mixture of 148 mg of 5-methoxy-4-(2-(4-(2-methoxyethoxy)phenyl)benzofuran-3-yl)-2,6-dimethylpyridazin-3-(2H)-one and 1 mL of N-methyl-2-pyrrolidone at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction mixture was stirred in a nitrogen atmosphere at 100° C. for six hours. After completion of the stirring, 1 mol/L hydrochloric acid was added to the mixture under ice cooling so as to achieve a pH of 1, and the resultant mixture was subjected to extraction with 20 mL of ethyl acetate. The resultant organic phase was washed with 1 mol/L hydrochloric acid (5 mL×2), and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and then the resultant residue was purified by silica gel chromatography (with a gradient of ethyl acetate:n-hexane=20:80 to 75:25), to thereby yield 78 mg of the target product as a white solid.

Melting point: 214-216° C.

¹H NMR: δ 7.50-7.65 (m, 3H), 7.15-7.35 (m, 3H), 6.85-6.95 (m, 2H), 5.96 (brs, 1H), 4.10-4.15 (m, 2H), 3.70-3.80 (m, 5H), 3.43 (s, 3H), 2.30 (s, 3H).

Synthesis Example 13 Synthesis of 4-(5-fluoro-2-(4-methoxyphenyl)benzofuran-3-yl)-5-hydroxy-2,6-dimethylpyridazin-3(2H)-one (Compound No. 9-020) Step 1: Synthesis of 5-(5-fluoro-2-(4-methoxyphenyl)benzofuran-3-yl)-1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl=(n-butyrate)

Firstly, 86 mg of p-methoxyphenylboronic acid, 240 mg of potassium phosphate, and 44 mg of tetrakis(triphenylphosphine)palladium were added to a mixture of 160 mg of 5-(2-bromo-5-fluorobenzofuran-3-yl)-1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl=(n-butyrate) and 6 mL of toluene at room temperature. After completion of the addition, the reaction container was purged with nitrogen gas. After completion of the nitrogen gas purging, the reaction mixture was stirred in a nitrogen atmosphere at 110° C. for three hours. After completion of the stirring, insoluble matter was filtered with celite, and the residue was washed with chloroform (10 mL×2). The resultant filtrate was concentrated under reduced pressure, and then the residue was purified by silica gel chromatography (with a gradient of ethyl acetate:n-hexane=5:95 to 20:80), to thereby yield 53 mg of the target product as a pale yellow oily product.

¹H NMR: δ 7.65-7.75 (m, 2H), 7.35-7.45 (m, 1H), 6.85-7.05 (m, 4H), 3.83 (s, 3H), 3.80 (s, 3H), 2.29 (s, 3H), 2.00-2.25 (m, 2H), 1.20-1.40 (m, 2H), 0.59 (t, J=7.5 Hz, 3H).

Step 2: Synthesis of 4-(5-fluoro-2-(4-methoxyphenyl)benzofuran-3-yl)-5-hydroxy-2,6-dimethylpyridazin-3(2H)-one (Compound No. 9-020)

Firstly, a solution of 50 mg of lithium hydroxide in 1 mL of water was added to a mixture of 53 mg of 5-(5-fluoro-2-(4-methoxyphenyl)benzofuran-3-yl)-1,3-dimethyl-6-oxo-1,6-dihydropyridazin-4-yl=(n-butyrate) and 2 mL of tetrahydrofuran at room temperature. After completion of the addition, the reaction mixture was stirred at room temperature for one hour. After completion of the stirring, the solvent contained in the reaction mixture was distilled off under reduced pressure. Subsequently, 35% by mass hydrochloric acid was added to the resultant residue so as to achieve a pH of 1, and then the precipitated solid was recovered through filtration, to thereby yield 39 mg of the target product as a white solid.

Melting point: 248-250° C.

¹H NMR: δ 7.60-7.70 (m, 2H), 7.40-7.50 (m, 1H), 6.85-7.05 (m, 4H), 3.82 (s, 3H), 3.77 (s, 3H), 2.33 (s, 3H).

The compound of the present invention can be produced according to the aforementioned production methods and Examples. Pyridazinone compounds produced in the same manner as in Synthesis Examples 1 to 13, which are included in the compound of the present invention, will be shown in Tables 3 to 13, and exemplary production intermediates of the pyridazinone compounds will be shown in Table 14. The pyridazinone compounds included in the present invention and the intermediates of the compounds are not limited to those shown below.

In the following Tables, Me denotes methyl; n-Pr and Pr-n, normal propyl; i-Pr and Pr-i, isopropyl; c-Pr and Pr-c, cyclopropyl; n-Bu and Bu-n, normal butyl; i-Bu and Bu-i, isobutyl; t-Bu and Bu-t, tertiary butyl; n-Pen and Pen-n, normal pentyl; c-Pen and Pen-c, cyclopentyl; n-Hex and Hex-n, normal hexyl; c-Hex and Hex-c, cyclohexyl; Ph, phenyl; and Bn, benzyl. In the following Tables, the symbol “=” denotes a double bond, and the symbol “≡” denotes a triple bond.

In the following Tables, the expression “m.p.” denotes a melting point. The expression “*1” in the column of melting point refers to the case where the corresponding compound is in an oily form or a resin form.

D-1, D-2, D-3, D-4, D-5, D-6, D-7, D-8, D-9, D-10, D-11, D-12, D-13, D-14, D-15, D-16, D-17, D-18, D-19a, D-20a, D-21a, D-22a, D-23, D-24a, D-25, D-26, D-27, and D-28 in the Tables correspond to the following structures.

The expression “(Y¹)” in the Tables refers to (Y¹)_(p7), (Y¹)_(p6), (Y¹)_(p5), (Y¹)_(P4), (Y¹)_(P3), or (Y¹)_(p7) corresponding to each of the aforementioned structures of D-1 to D-28 specified in the column of R³. The substitution position number corresponds to the numbered position in each of the aforementioned structural formulae. The expression “−” in the column of “(Y¹)” refers to no substitution.

U-1a to U-6a, Q-1, Q-2a to Q-4a, Q-17a, Q-17b, and T-1-1 to T-3 in the Tables correspond to the following structures.

TABLE 3

No. R¹ R² R³ (Y¹) G mp (° C.) 1-001 Me H D-1 4-F H 122-129 1-002 Me H D-1 4-F Me 147-149 1-003 Me Me D-1 2-Et H 237-239 1-004 Me Me D-1 2-Et Me 123-125 1-005 Me Me D-1 4-Bu-n H 146-148 1-006 Me Me D-1 4-Bu-n C(O)Pr-n *1 1-007 Me Me D-1 2-CF₃ H 235-236 1-008 Me Me D-1 2-CF₃ Me 124-126 1-009 Me Me D-1 2-OH H 269-271 1-010 Me Me D-1 2-OH Me 187-189 1-011 Me Me D-1 2-OEt H 196-198 1-012 Me Me D-1 2-OEt C(O)Pr-n 143-145 1-013 Me Me D-1 4-OEt H 154-156 1-014 Me Me D-1 4-OEt C(O)Pr-n 129-131 1-015 Me Me D-1 2-OPr-n H 188-190 1-016 Me Me D-1 2-OPr-n Me *1 1-017 Me Me D-1 2-OPr-i H 197-198 1-018 Me Me D-1 2-OPr-i Me 155-156 1-019 Me Me D-1 4-OPr-n H 80-82 1-020 Me Me D-1 4-OPr-i H 137-139 1-021 Me Me D-1 4-OPr-i C(O)Pr-n *1 1-022 Me Me D-1 2-OBu-n H 179-181 1-023 Me Me D-1 2-OBu-n C(O)Pr-n *1 1-024 Me Me D-1 4-OBu-n H 114-116 1-025 Me Me D-1 4-OBu-n C(O)Pr-n *1 1-026 Me Me D-1 4-OPen-n H 100-102 1-027 Me Me D-1 4-OPen-n C(O)Pr-n *1 1-028 Me Me D-1 4-OHex-n H 81-83 1-029 Me Me D-1 4-OHex-n C(O)Pr-n *1 1-030 Me Me D-1 2-OCF₃ H 220-221 1-031 Me Me D-1 4-OCF₃ H 112-114 1-032 Me Me D-1 4-OCF₃ C(O)Pr-n *1 1-033 Me Me D-1 2-OPh H 242-244 1-034 Me Me D-1 2-SMe H 216-218 1-035 Me Me D-1 2-SMe C(O)Pr-n *1 1-036 Me Me D-1 4-SMe H 110-112 1-037 Me Me D-1 4-SMe C(O)Pr-n *1 1-038 Me Me D-1 2-S(O)₂Et H 268-270 1-039 Me Me D-1 4-NMe₂ H 145-146 1-040 Me Me D-1 4-NMe₂ C(O)Pr-n 162-164 1-041 Me Me D-1 4-C(O)Me H 239-241 1-042 Me Me D-1 4-C(O)Me C(O)Pr-n *1 1-043 Me Me D-1 4-C(═N—OMe)Me H 161-163 1-044 Me Me D-1 4-C(═N—OMe)Me C(O)Pr-n *1 1-045 Me Me D-1 4-CN H 240-242 1-046 Me Me D-1 3,4-F₂ H 239-241 1-047 Me Me D-1 3,4-F₂ C(O)Pr-n *1 1-048 Me Me D-1 2-F-3-OMe H 162-163 1-049 Me Me D-1 3-F-4-OMe H 233-234 1-050 Me Me D-1 3-F-4-OMe Me 127-129 1-051 Me Me D-1 3-Me-4-F H 211-213 1-052 Me Me D-1 3-Me-4-F C(O)Pr-n *1 1-053 Me Me D-1 2-F-5-OMe H 226-228 1-054 Me Me D-1 2-OMe-3-F H 200-201 1-055 Me Me D-1 2-OMe-4-F H 229-231 1-056 Me Me D-1 2-OMe-4-F C(O)Pr-n 163-165 1-057 Me Me D-1 2-OMe-4-F Me 193-194 1-058 Me Me D-1 2-OMe-5-F H 228-230 1-059 Me Me D-1 2-OMe-5-F C(O)Pr-n *1 1-060 Me Me D-1 2-OMe-4-Cl H 221-223 1-061 Me Me D-1 2-OEt-4-F H 202-203 1-062 Me Me D-1 2-OEt-4-F C(O)Pr-n 144-146 1-063 Me Me D-1 2-SMe-4-F H 226-228 1-064 Me Me D-1 2-SMe-4-F C(O)Pr-n *1 1-065 Me Me D-1 3,4-Me₂ H 225-227 1-066 Me Me D-1 3,4-Me₂ C(O)Pr-n 124-126 1-067 Me Me D-1 2-OMe-3-Me H 197-199 1-068 Me Me D-1 3-Me-4-OMe H 149-151 1-069 Me Me D-1 3-Me-4-OMe C(O)Pr-n 100-102 1-070 Me Me D-1 2,4-(OMe)₂ H 131-133 1-071 Me Me D-1 2,4-(OMe)₂ C(O)Pr-n *1 1-072 Me Me D-1 3,4-(OMe)₂ H 205-207 1-073 Me Me D-1 3,4-(OMe)₂ C(O)Pr-n 127-130 1-074 Me Me D-1 3,5-Me₂-4-OMe H 126-128 1-075 Me Me D-1 3,5-Me₂-4-OMe C(O)Pr-n *1 1-076 Me Me D-3 4-OEt H 186-188 1-077 Me Me D-3 4-OEt C(O)Pr-n *1 1-078 Me Me D-3 4-CF₃ H 129-132 1-079 Me Me D-3 2,4-(OMe)₂ H 206-208 1-080 Me Me D-3 2,4-(OMe)₂ C(O)Pr-n *1 1-081 Me Me D-6 — H 233-235 1-082 Me Me D-6 — C(O)Pr-n 140-142 1-083 Me Me D-8 — H 240-242 1-084 Me Me D-8 — C(O)Pr-n 133-135 1-085 Me Me D-20a — H 231-233 1-086 Me Me D-20a — Me 173-175 1-087 Me Me D-22a — H 252-254 1-088 Me Me D-22a — C(O)Pr-n 134-136 1-089 Me Me D-24a — H 210-212 1-090 Me Me D-24a — C(O)Pr-n 61-63 1-091 Me Me D-24a — C(O)OMe *1 1-092 Me Me D-24a — C(O)SBu-t *1 1-093 Me Me D-24a — C(O)(Ph-2-Me) *1 1-094 Me Me D-24a — S(O)₂Me *1 1-095 Me Me D-24a 7-Cl H 230-233 1-096 Me Me D-24a 7-Cl C(O)Pr-n 96-98 1-097 Me Me D-25 4-Cl H 232-234 1-098 Me Me D-25 4-Cl C(O)Pr-n *1 1-099 Me Me D-23 — H 129-131 1-100 Me Me D-23 — C(O)Pr-n *1 1-101 Me Me D-21a — H 159-161 1-102 Me Me D-21a — C(O)Pr-n *1 1-103 Me Me D-19a — H 224-225 1-104 Me Me D-19a — Me *1 1-105 Me Me D-26 1-Me-4-OMe H 186-188 1-106 Me Me D-26 1-Me-4-OMe Me 214-216 1-107 Me Me D-26 1-H-4-OMe Me 181-183 1-108 Me Me D-18 — H 279-281 1-109 Me Me D-18 — Me *1 1-110 Me Me D-1 2-OCH₂CH═CH₂ H 193-195 1-111 Me Me D-1 2-OCH₂CH═CH₂ Me *1 1-112 Me Me D-1 2-OCH₂C≡CH H 189-190 1-113 Me Me D-1 2-OCH₂Pr-c H 194-195 1-114 Me Me D-1 2-OCH₂Pr-c Me *1 1-115 Me Me D-1 2-OCH₂OMe C(O)Pr-n 70-72 1-116 Me Me D-1 2-OCH₂CHF₂ H 203-205 1-117 Me Me D-1 2-OCH₂CHF₂ Me 178-179 1-118 Me Me D-1 2-OCH₂CF₃ H 205-206 1-119 Me Me D-1 2-OCH₂CF₃ Me 146-148 1-120 Me Me D-1 2-OCH₂[T-1-1] H 198-199 1-121 Me Me D-1 2-OCH₂[T-1-1] Me *1 1-122 Me Me D-1 2-OCH₂[(Q-1)-2-Cl] Me *1 1-123 Me Me D-1 3-CN H 233-235 1-124 Me Me D-1 3-CN C(O)Pr-n 147-149 1-125 Me Me D-1 4-Pr-i H 135-137 1-126 Me Me D-1 4-Pr-i C(O)Pr-n *1 1-127 Me Me D-1 4-CH═CH₂ H 214-216 1-128 Me Me D-1 4-CH═CH₂ C(O)Pr-n *1 1-129 Me Me D-1 4-CF₃ H 219-221 1-130 Me Me D-1 4-CF₃ C(O)Pr-n 109-111 1-131 Me Me D-1 4-CH₂OMe H *1 1-132 Me Me D-1 4-CH₂OMe Me 140-142 1-133 Me Me D-1 4-OCH₂Ph H *1 1-134 Me Me D-1 4-OCH₂Ph Me 125-127 1-135 Me Me D-1 4-OCH₂Ph CH₂OMe *1 1-136 Me Me D-1 4-OCH₂C≡CH H *1 1-137 Me Me D-1 4-OCH₂CN H 125-127 1-138 Me Me D-1 4-OCH₂[T-1-1] H *1 1-139 Me Me D-1 4-OCH₂CH═CH₂ H *1 1-140 Me Me D-1 4-OCH₂CF₃ H 183-185 1-141 Me Me D-1 4-OCH₂CH₂SMe H 114-115 1-142 Me Me D-1 4-OCH₂Pr-c H *1 1-143 Me Me D-1 4-OCH₂C(O)Me H *1 1-144 Me Me D-1 4-OCH₂[(Q-1)-2-Cl] H *1 1-145 Me Me D-1 4-OCH₂C(O)NHCH₂CF₃ H *1 1-146 Me Me D-1 4-OS(O)₂Me H *1 1-147 Me Me D-1 4-OS(O)₂CF₃ H *1 1-148 Me Me D-1 4-OCH₂CH₂OMe H *1 1-149 Me Me D-1 4-OPh H 112-114 1-150 Me Me D-1 4-OPh C(O)Pr-n *1 1-151 Me Me D-1 4-NO₂ H 143-145 1-152 Me Me D-1 4-NO₂ C(O)Pr-n 122-125 1-153 Me Me D-1 4-SiMe₃ H 126-127 1-154 Me Me D-1 4-SiMe₃ C(O)Pr-n *1 1-155 Me Me D-1 2-OMe-4-CF₃ H 227-229 1-156 Me Me D-1 2-OMe-4-CF₃ C(O)Pr-n *1 1-157 Me Me D-1 2-OMe-5-Br Me *1 1-158 Me Me D-1 2,6-(OMe)₂ H 145-147 1-159 Me Me D-1 2-Cl-6-OMe H 182-184 1-160 Me OMe D-1 3-OCF₃ H 217-219 1-161 Me OMe D-1 3-OCF₃ C(O)Pr-n *1 1-162 Me OMe D-1 4-OCF₃ H 209-211 1-163 Me OMe D-1 4-OCF₃ C(O)Pr-n *1 1-164 Me OMe D-1 4-OPh H 272-274 1-165 Me OMe D-1 4-OPh C(O)Pr-n *1 1-166 Me OMe D-1 4-Ph H 276-277 1-167 Me OMe D-1 4-Ph C(O)Pr-n 144-146 1-168 Me OMe D-1 4-NO₂ H 190-192 1-169 Me OMe D-1 4-NO₂ C(O)Pr-n 69-71 1-170 Me OMe D-1 4-CN H 248-250 1-171 Me OMe D-1 4-CN C(O)Pr-n 167-169 1-172 Me OMe D-1 3,4-F₂ H 216-218 1-173 Me OMe D-1 3,4-F₂ C(O)Pr-n 121-123 1-174 Me OMe D-1 3-Me-4-F H 222-224 1-175 Me OMe D-1 3-Me-4-F C(O)Pr-n *1 1-176 Me OMe D-1 2-OMe-4-F H 222-224 1-177 Me OMe D-1 2-OMe-4-F C(O)Pr-n 75-77 1-178 Me OMe D-1 2-OMe-5-Cl H 140-143 1-179 Me OMe D-1 2-OMe-5-Cl C(O)Pr-n 122-124 1-180 Me OMe D-1 2,4-(OMe)₂ H 135-137 1-181 Me OMe D-1 2,4-(OMe)₂ C(O)Pr-n *1 1-182 Me OMe D-1 3,4-(OMe)₂ H 137-139 1-183 Me OMe D-1 3,4-(OMe)₂ C(O)Pr-n 146-148 1-184 Me OMe D-1 3,5-(OMe)₂ H 219-221 1-185 Me OMe D-1 3,5-(OMe)₂ C(O)Pr-n *1 1-186 Me OMe D-1 3,4,5-F₃ H 197-199 1-187 Me OMe D-1 3,4,5-F₃ C(O)Pr-n 122-124 1-188 Me OMe D-1 2,4,6-Me₃ H *1 1-189 Me OMe D-1 2,4,6-Me₃ C(O)Pr-n *1 1-190 Me OMe D-6 — H 145-147 1-191 Me OMe D-6 — C(O)Pr-n *1 1-192 Me OMe D-8 — H 181-183 1-193 Me OMe D-8 — C(O)Pr-n 146-148 1-194 Me OMe D-9 — H 160-162 1-195 Me OMe D-9 — C(O)Pr-n *1 1-196 Me OMe D-10 — H 255-257 1-197 Me OMe D-10 — C(O)Pr-n *1 1-198 Me OMe D-24a — H 230-232 1-199 Me OMe D-24a — C(O)Pr-n 89-91 1-200 Me Me D-1 4-OH H *1 1-201 Me Me D-1 4-OCHF₂ H 169-171 1-202 Me Me D-1 4-OCHF₂ CH₂OCH₂CH₂OMe *1 1-203 Me Me D-1 4-OCH₂CHF₂ H *1 1-204 Me Me D-1 4-OCH₂CH₂Br H *1 1-205 Me Me D-1 4-OCH₂CH₂Br CH₂OCH₂CH₂OMe *1 1-206 Me Me D-1 4-OCH₂CH₂CF₃ H *1 1-207 Me Me D-1 4-OCH₂CH₂CH═CH₂ H 118-120 1-208 Me Me D-1 4-OCH₂C(Me)═CH₂ H *1 1-209 Me Me D-1 4-OCH₂C(Me)═CH₂ CH₂OCH₂CH₂OMe *1 1-210 Me Me D-1 4-OCH₂CH₂C(Me)═CH₂ H 84-86 1-211 Me Me D-1 4-OCH₂CH═CHCH₃ H *1 1-212 Me Me D-1 4-OCH₂CH═CHCH₃ CH₂OCH₂CH₂OMe *1 1-213 Me Me D-1 4-OCH(Me)CH₂CH═CH₂ H 177-179 1-214 Me Me D-1 4-OCH(Me)CH₂CH═CH₂ CH₂OCH₂CH₂OMe *1 1-215 Me Me D-1 4-OCH₂C(Br)═CH₂ H 146-149 1-216 Me Me D-1 4-OCH₂C(Br)═CH₂ CH₂OCH₂CH₂OMe *1 1-217 Me Me D-1 4-OCH(Me)C≡CH H *1 1-218 Me Me D-1 4-OCH(Me)C≡CH CH₂OCH₂CH₂OMe *1 1-219 Me Me D-1 4-OCH₂C≡CMe H 167-168 1-220 Me Me D-1 4-OCH₂≡CMe CH₂OCH₂CH₂OMe *1 1-221 Me Me D-1 4-OCH₂CH₂SMe CH₂OCH₂CH₂OMe *1 1-222 Me Me D-1 4-OCH₂CH₂CH₂SMe H 124-126 1-223 Me Me D-1 4-OCH₂CH₂[U-3a] H *1 1-224 Me Me D-1 4-OCH₂CH₂[U-3a] CH₂OCH₂CH₂OMe *1 1-225 Me Me D-1 4-OCH₂CH₂ON═C(Me)₂ CH₂OCH₂CH₂OMe *1 1-226 Me Me D-1 4-OCH₂CH₂OPr-i H 129-131 1-227 Me Me D-1 4-OCH₂CH₂OCH₂CH₂Cl H 125-127 1-228 Me Me D-1 4-OCH(Me)CH₂OMe H 158-163 1-229 Me Me D-1 4-OCH(Me)CH₂OMe CH₂OCH₂CH₂OMe *1 1-230 Me Me D-1 4-OCH₂CH(Et)OMe H 167-170 1-231 Me Me D-1 4-OCH₂CH(Et)OMe CH₂OCH₂CH₂OMe *1 1-232 Me Me D-1 4-OCH₂C(O)OMe H 139-141 1-233 Me Me D-1 4-OCH₂C(O)OMe CH₂OCH₂CH₂OMe *1 1-234 Me Me D-1 4-OCH(Me)C(O)OMe H 229-231 1-235 Me Me D-1 4-OCH(Me)C(O)OMe CH₂OCH₂CH₂OMe *1 1-236 Me Me D-1 4-OCH(Me)CN H *1 1-237 Me Me D-1 4-OCH(Me)CN CH₂OCH₂CH₂OMe *1 1-238 Me Me D-1 4-CH₂OH H 260-261 1-239 Me Me D-1 4-CH₂OH Me 194-195 1-240 Me Me D-1 4-CH₂Cl Me 167-168 1-241 Me Me D-1 4-CH₂OCH₂CH═CH₂ H *1 1-242 Me Me D-1 4-CH₂SH Me *1 1-243 Me Me D-1 4-CH₂SPr-i H 184-185 1-244 Me Me D-1 4-CH₂SPr-i Me *1 1-245 Me Me D-1 4-CH₂SCH₂CH═CH₂ H *1 1-246 Me Me D-1 4-CH₂SCH₂CH═CH₂ Me *1 1-247 Me Me D-1 4-CH₂SCH₂C≡CH H *1 1-248 Me Me D-1 4-CH₂SCH₂C≡CH Me *1 1-249 Me Me D-1 4-CH₂SCH₂CF₃ H 129-131 1-250 Me Me D-1 4-CH₂SCH₂CF₃ Me *1 1-251 Me Me D-1 4-CH₂SCH₂CH₂OMe H *1 1-252 Me Me D-1 4-CH₂SCH₂CH₂OMe Me *1 1-253 Me Me D-1 4-CH₂SCH₂CH₂SMe H *1 1-254 Me Me D-1 4-CH₂SCH₂CH₂SMe Me *1 1-255 Me Me D-1 4-CH₂OCH₂CH₂OMe H *1 1-256 Me Me D-1 4-CH₂OCH₂CH₂OMe Me *1

TABLE 4

No. R¹ R² R³ (Y¹) G Z mp (° C.) 2-001 Me Me D-1 4-F H F 248-250 2-002 Me Me D-1 4-F C(O)Pr-n F 147-149 2-003 Me Me D-1 4-F C(O)CH₂CH₂OMe F *1 2-004 Me Me D-1 4-F C(O)OEt F *1 2-005 Me Me D-1 4-F C(O)[Ph-2-Cl] F *1 2-006 Me Me D-1 4-F CH₂C≡CH F 173-175 2-007 Me Me D-1 4-F C(O)[U-6a] F 265-267 2-008 Me Me D-1 4-F CH₂C(O)Ph F 197-198 2-009 Me Me D-1 4-F S(O)₂NMe₂ F 177-179 2-010 Me Me D-1 4-Cl H F 258-259 2-011 Me Me D-1 4-Cl C(O)Pr-n F 163-165 2-012 Me Me D-1 4-Me H F 229-231 2-013 Me Me D-1 4-Me C(O)Pr-n F 64-66 2-014 Me Me D-1 4-Pr-i H F 233-235 2-015 Me Me D-1 4-Pr-i CH₂OCH₂CH₂OMe F 112-115 2-016 Me Me D-1 4-Et C(O)Pr-n F *1 2-017 Me Me D-1 4-Bu-tert C(O)Pr-n F *1 2-018 Me Me D-1 4-CH═CH₂ H F 216-218 2-019 Me Me D-1 4-CH═CH₂ C(O)Pr-n F *1 2-020 Me Me D-1 4-CF₃ H F 249-251 2-021 Me Me D-1 4-CF₃ C(O)Pr-n F 154-156 2-022 Me Me D-1 4-CH₂OMe H F  99-101 2-023 Me Me D-1 4-CH₂OMe C(O)Pr-n F *1 2-024 Me Me D-1 2-OMe H F 226-228 2-025 Me Me D-1 2-OMe C(O)Pr-n F *1 2-026 Me Me D-1 4-OMe H F 197-199 2-027 Me Me D-1 4-OMe C(O)Pr-n F *1 2-028 Me Me D-1 2-OEt H F 195-197 2-029 Me Me D-1 2-OEt C(O)Pr-n F *1 2-030 Me Me D-1 4-OEt H F 119-121 2-031 Me Me D-1 4-OEt C(O)Pr-n F 153-155 2-032 Me Me D-1 4-OPr-n H F 197-199 2-033 Me Me D-1 4-OPr-n C(O)Pr-n F *1 2-034 Me Me D-1 4-OPr-i H F 131-133 2-035 Me Me D-1 4-OPr-i C(O)Pr-n F *1 2-036 Me Me D-1 4-OBu-n H F 157-159 2-037 Me Me D-1 4-OBu-n C(O)Pr-n F *1 2-038 Me Me D-1 4-OPen-n C(O)Pr-n F *1 2-039 Me Me D-1 4-OPen-c H F *1 2-040 Me Me D-1 4-OPen-c Me F 200-201 2-041 Me Me D-1 4-OHex-n C(O)Pr-n F *1 2-042 Me Me D-1 4-OCHF₂ H F 164-165 2-043 Me Me D-1 2-OCF₃ H F 232-234 2-044 Me Me D-1 2-OCF₃ C(O)Pr-n F *1 2-045 Me Me D-1 4-OCF₃ H F 179-181 2-046 Me Me D-1 4-OCF₃ C(O)Pr-n F 133-135 2-047 Me Me D-1 4-OCH₂CH₂F H F *1 2-048 Me Me D-1 4-OCH₂CH₂F Me F 205-206 2-049 Me Me D-1 4-OCH₂CF₃ H F 200-202 2-050 Me Me D-1 4-OCH₂CF₃ Me F 177-178 2-051 Me Me D-1 4-OCH₂CH═CH₂ H F *1 2-052 Me Me D-1 4-OCH₂CH═CH₂ Me F 134-136 2-053 Me Me D-1 4-OCH₂C≡CH H F *1 2-054 Me Me D-1 4-OCH₂C≡CH CH₂C≡CH F *1 2-055 Me Me D-1 4-OCH₂C≡CH CH₂OCH₂CH₂OMe F *1 2-056 Me Me D-1 4-OCH₂CH₂OMe H F *1 2-057 Me Me D-1 4-OCH₂CH₂OMe Me F *1 2-058 Me Me D-1 4-OCH₂CH₂SMe H F *1 2-059 Me Me D-1 4-OCH₂CH₂SMe CH₂OCH₂CH₂OMe F *1 2-060 Me Me D-1 4-OCH₂Pr-c H F *1 2-061 Me Me D-1 4-OCH₂Pr-c Me F 169-170 2-062 Me Me D-1 4-OCH₂Ph H F 123-125 2-063 Me Me D-1 4-OCH₂Ph Me F 143-145 2-064 Me Me D-1 4-OCH₂Ph CH₂OCH₂CH₂OMe F 112-113 2-065 Me Me D-1 4-OCH₂Ph CH₂Ph F 168-170 2-066 Me Me D-1 4-OCH₂CN H F *1 2-067 Me Me D-1 4-OCH₂CN CH₂OCH₂CH₂OMe F *1 2-068 Me Me D-1 4-OCH₂C(O)Me H F *1 2-069 Me Me D-1 4-OCH₂C(═NOMe)Me H F *1 2-070 Me Me D-1 4-OCH₂C(O)OMe H F 226-228 2-071 Me Me D-1 4-OCH₂C(O)OMe CH₂OCH₂CH₂OMe F *1 2-072 Me Me D-1 4-OPh H F 233-235 2-073 Me Me D-1 4-OPh C(O)Pr-n F *1 2-074 Me Me D-1 4-O[U-2a] H F 208-210 2-075 Me Me D-1 4-OS(O)₂CF₃ H F 210-212 2-076 Me Me D-1 4-SMe H F 178-180 2-077 Me Me D-1 4-SMe C(O)Pr-n F 146-148 2-078 Me Me D-1 4-C(O)Me C(O)Pr-n F 152-154 2-079 Me Me D-1 4-C(═NOMe)Me H F 164-166 2-080 Me Me D-1 4-C(═NOMe)Me C(O)Pr-n F *1 2-081 Me Me D-1 3,4-Cl₂ H F 236-238 2-082 Me Me D-1 3,4-Cl₂ C(O)Pr-n F 186-187 2-083 Me Me D-1 2-OMe-4-F H F 242-244 2-084 Me Me D-1 2-OEt-4-F H F 214-216 2-085 Me Me D-1 2-OEt-4-F C(O)Pr-n F 159-161 2-086 Me Me D-1 3-F-4-OMe H F 229-231 2-087 Me Me D-1 3-F-4-OMe C(O)Pr-n F 168-170 2-088 Me Me D-1 3,4-(OMe)₂ H F 129-131 2-089 Me Me D-1 3,4-(OMe)₂ C(O)Pr-n F 145-147 2-090 Me Me D-22a — H F 224-226 2-091 Me Me D-22a — C(O)Pr-n F 146-148 2-092 Me Me D-24a — H F 155-158 2-093 Me Me D-24a — C(O)Pr-n F 160-162 2-094 Me Me D-1 — H Cl 280-282 2-095 Me Me D-1 2-OMe-4-F H Cl 221-223 2-096 Me Me D-1 2-OMe-4-F C(O)Pr-n Cl *1 2-097 Me Me D-1 4-F H Cl 292-294 2-098 Me Me D-1 4-F C(O)Pr-n Cl 158-160 2-099 Me Me D-1 4-Cl H Cl 292-293 2-100 Me Me D-1 4-Cl C(O)Pr-n Cl 161-162 2-101 Me Me D-1 2-OMe H Cl 232-233 2-102 Me Me D-1 2-OMe Me Cl 174-175 2-103 Me Me D-1 4-OMe H Cl 336-338 2-104 Me Me D-1 4-OMe C(O)Pr-n Cl 157-159 2-105 Me Me D-1 2-OEt H Cl 205-207 2-106 Me Me D-1 2-OEt Me Cl *1 2-107 Me Me D-1 4-OPr-i H Cl 216-218 2-108 Me Me D-1 4-OPr-i C(O)Pr-n Cl *1 2-109 Me Me D-1 4-OBu-n H Cl 182-185 2-110 Me Me D-1 4-OBu-n C(O)Pr-n Cl *1 2-111 Me Me D-1 4-CF₃ H Cl 282-284 2-112 Me Me D-1 4-CN H Cl 251-253 2-113 Me Me D-1 4-C(O)OH H Cl 322-324 2-114 Me Me D-1 2-OMe-4-F C(O)OCH₂CH₂OMe Cl *1 2-115 Me Me D-1 2-OEt-4-F H Cl 227-228 2-116 Me Me D-1 2-OEt-4-F Me Cl 244-246 2-117 Me Me D-1 3-F-4-OMe H Cl *1 2-118 Me Me D-1 3-F-4-OMe C(O)Pr-n Cl 126-128 2-119 Me Me D-1 3-Me-4-OMe H Cl 163-165 2-120 Me Me D-1 3-Me-4-OMe C(O)Pr-n Cl *1 2-121 Me Me D-1 2,6-(OMe)₂ H Cl 254-256 2-122 Me Me D-1 2,6-(OMe)₂ C(O)Pr-n Cl 179-181 2-123 Me Me D-1 3,4-(OMe)₂ H Cl *1 2-124 Me Me D-1 3,4-(OMe)₂ C(O)Pr-n Cl *1 2-125 Me Me D-22a — H Cl 329-331 2-126 Me Me D-22a — C(O)Pr-n Cl 159-161 2-127 Me Me D-24a — H Cl 180-182 2-128 Me Me D-24a — C(O)Pr-n Cl 142-144 2-129 Me Me D-1 2-OMe-5-Br H Br 236-238 2-130 Me Me D-1 2-OMe H I 278-281 2-131 Me Me D-1 2-OMe Me I 161-163 2-132 Me Me D-1 — H Me 291-293 2-133 Me Me D-1 — C(O)Pr-n Me *1 2-134 Me Me D-1 4-F H Me 286-288 2-135 Me Me D-1 4-F C(O)Pr-n Me *1 2-136 Me Me D-1 4-Me H Me 269-271 2-137 Me Me D-1 4-Me C(O)Pr-n Me *1 2-138 Me Me D-1 2-OMe H Me 109-111 2-139 Me Me D-1 2-OMe C(O)Pr-n Me 176-178 2-140 Me Me D-1 4-OMe H Me *1 2-141 Me Me D-1 4-OMe C(O)Pr-n Me *1 2-142 Me Me D-1 2-SMe H Me 196-198 2-143 Me Me D-1 2-SMe C(O)Pr-n Me *1 2-144 Me Me D-1 4-NO₂ H Me 158-160 2-145 Me Me D-1 4-NO₂ C(O)Pr-n Me *1 2-146 Me Me D-1 4-CN H Me 193-195 2-147 Me Me D-1 4-CN C(O)Pr-n Me *1 2-148 Me Me D-1 2-OMe-4-F H Me 224-226 2-149 Me Me D-1 2-OMe-4-F C(O)Pr-n Me 196-198 2-150 Me Me D-1 2-OMe-5-F H Me 201-203 2-151 Me Me D-1 2-OMe-5-F C(O)Pr-n Me 166-168 2-152 Me Me D-1 3,4-(OMe)₂ H Me 188-190 2-153 Me Me D-1 3,4-(OMe)₂ C(O)Pr-n Me 151-153 2-154 Me Me D-17 — H Me 233-236 2-155 Me Me D-17 — C(O)Pr-n Me *1 2-156 Me Me D-22a — H Me 262-264 2-157 Me Me D-22a — C(O)Pr-n Me 137-139 2-158 Me Me D-24a — H Me 254-256 2-159 Me Me D-24a — C(O)Pr-n Me *1 2-160 Me Me D-1 2-OMe H Pr-c 182-184 2-161 Me Me D-1 2-OMe Me Pr-c *1 2-162 Me Me D-1 2-OMe H CF₃ 119-121 2-163 Me Me D-1 2-OMe Me CF₃ 144-146 2-164 Me Me D-1 — H OMe 211-213 2-165 Me Me D-1 2-OMe H OMe 86-88 2-166 Me Me D-1 — H Ph +22300 2-167 Me Me D-1 2-OMe-4-F H [Ph-4-OPr-i] 273-274 2-168 Me Me D-1 2-OMe-4-F Me [Ph-4-OPr-i] 174-176 2-169 Me Me D-1 2-OMe-4-F C(O)Pr-n [Ph-4-OPr-i] 223-225 2-170 Me Me D-1 2-OMe-4-F H Q-3 252-254 2-171 Me Me D-1 2-OMe-4-F Me Q-3 200-202 2-172 Me Me D-1 2-OMe Me OH 199-201 2-173 Me Me D-1 2-OMe-4-F H OPr-n 252-254 2-174 Me Me D-1 2-OMe Me NH₂ 219-221 2-175 Me Me D-1 2-OMe-4-F H NHC(O)Me 294-295 2-176 Me Me D-1 2-OMe-4-F Me NHC(O)Me 254-255 2-177 Me Me D-1 2-OMe-4-F H N(Me)C(O)Me 265-267 2-178 Me Me D-1 2-OMe-4-F Me N(Me)C(O)Me 223-225 2-179 Me Me D-1 2-OMe-4-F H NHC(O)CH₂OMe 302-304 2-180 Me Me D-1 2-OMe-4-F Me NHC(O)CH₂OMe 201-203 2-181 Me Me D-1 2-OMe H NHC(O)OBu-t 140-142 2-182 Me Me D-1 2-OMe Me NHC(O)OB3u-t *1 2-183 Me Me D-1 2-OMe-4-F H NHS(O)₂Me 160-162 2-184 Me Me D-1 2-OMe-4-F Me N(S(O)₂Me)₂ 259-261 2-185 Me Me D-1 2-OMe H CH═CH₂ 227-229 2-186 Me Me D-1 2-OMe Me CH═CH₂ *1 2-187 Me Me D-1 2-OMe H C≡CH 252-254 2-188 Me Me D-1 2-OMe H C≡CSiMe₃ 247-249 2-189 Me Me D-1 2-OMe Me C≡CSiMe₃ *1 2-190 Me Me D-1 2-OMe H CN 243-244 2-191 Me Me D-1 2-OMe Me CN 196-198 2-192 Me Me D-1 2-OMe-4-F H C(O)Me 267-269 2-193 Me Me D-1 2-OMe-4-F Me C(O)Me *1 2-194 Me Me D-1 2-OMe-4-F Me C(═NOH)Me 254-256 2-195 Me Me D-1 2-OMe-4-F H C(═NOPr-i)Me 224-225 2-196 Me Me D-1 2-OMe-4-F Me C(═NOPr-i)Me 181-182 2-197 Me Me D-1 — H F 209-211 2-198 Me Me D-1 — C(O)Pr-n F 119-121 2-199 Me Me D-1 2-F H F 223-225 2-200 Me Me D-1 2-F C(O)Pr-n F 142-144 2-201 Me Me D-1 3-F H F 249-250 2-202 Me Me D-1 3-F C(O)Pr-n F 128-130 2-203 Me Me D-1 2-Cl H F 246-248 2-204 Me Me D-1 2-Cl C(O)Pr-n F *1 2-205 Me Me D-1 4-Br H F 167-169 2-206 Me Me D-1 4-Br C(O)Pr-n F 159-160 2-207 Me Me D-1 4-Et H F 223-225 2-208 Me Me D-1 4-Bu-t H F 194-197 2-209 Me Me D-1 3-OMe H F 222-224 2-210 Me Me D-1 3-OMe C(O)Pr-n F *1 2-211 Me Me D-1 3-OEt H F 210-212 2-212 Me Me D-1 3-OEt C(O)Pr-n F *1 2-213 Me Me D-1 3-OPr-n H F 182-184 2-214 Me Me D-1 3-OPr-n C(O)Pr-n F 112-113 2-215 Me Me D-1 3-OPr-i H F 107-109 2-216 Me Me D-1 3-OPr-i C(O)Pr-n F *1 2-217 Me Me D-1 4-OPr-c H F 190-192 2-218 Me Me D-1 4-OPr-c C(O)Pr-n F *1 2-219 Me Me D-1 3-OBu-n H F 95-97 2-220 Me Me D-1 3-OBu-n C(O)Pr-n F 128-129 2-221 Me Me D-1 3-OBu-i H F 102-104 2-222 Me Me D-1 3-OBu-i C(O)Pr-n F *1 2-223 Me Me D-1 3-OBu-t H F 196-198 2-224 Me Me D-1 3-OBu-t C(O)Pr-n F *1 2-225 Me Me D-1 3-OPen-n H F  99-101 2-226 Me Me D-1 3-OHex-n H F 87-89 2-227 Me Me D-1 4-CHF₂ H F 246-248 2-228 Me Me D-1 4-CHF₂ C(O)Pr-n F 155-157 2-229 Me Me D-1 2-CF₃ H F 220-223 2-230 Me Me D-1 2-CF₃ C(O)Pr-n F *1 2-231 Me Me D-1 3-CF₃ H F 122-124 2-232 Me Me D-1 3-CF₃ C(O)Pr-n F 101-103 2-233 Me Me D-1 4-CH₂Cl Me F 107-109 2-234 Me Me D-1 3-OCHF₂ H F 171-173 2-235 Me Me D-1 3-OCHF₂ C(O)Pr-n F *1 2-236 Me Me D-1 3-OCF₃ H F 181-183 2-237 Me Me D-1 3-OCF₃ C(O)Pr-n F *1 2-238 Me Me D-1 3-OCH₂CF₃ H F 228-231 2-239 Me Me D-1 3-OCH₂CF₃ C(O)Pr-n F *1 2-240 Me Me D-1 3-SMe H F 161-163 2-241 Me Me D-1 3-SMe C(O)Pr-n F 125-127 2-242 Me Me D-1 3-SEt H F 171-173 2-243 Me Me D-1 3-SEt C(O)Pr-n F 101-103 2-244 Me Me D-1 4-SEt H F 135-137 2-245 Me Me D-1 4-SEt C(O)Pr-n F *1 2-246 Me Me D-1 3-SPr-n H F 170-172 2-247 Me Me D-1 3-SPr-n C(O)Pr-n F 121-122 2-248 Me Me D-1 4-SPr-n H F 96-98 2-249 Me Me D-1 4-SPr-n C(O)Pr-n F *1 2-250 Me Me D-1 3-SPr-i H F 182-184 2-251 Me Me D-1 3-SPr-i C(O)Pr-n F *1 2-252 Me Me D-1 4-SPr-i H F 189-191 2-253 Me Me D-1 4-SPr-i C(O)Pr-n F *1 2-254 Me Me D-1 4-SPr-c H F 222-224 2-255 Me Me D-1 4-SPr-c C(O)Pr-n F *1 2-256 Me Me D-1 4-S(O)Me H F 141-143 2-257 Me Me D-1 4-S(O)Pr-i H F 236-238 2-258 Me Me D-1 4-S(O)₂Me H F 234-236 2-259 Me Me D-1 4-S(O)₂Pr-i H F 300-302 2-260 Me Me D-1 4-SCH₂CHF₂ H F *1 2-261 Me Me D-1 4-SCH₂CHF₂ Me F 160-161 2-262 Me Me D-1 3-SCH₂CF₃ H F 121-123 2-263 Me Me D-1 3-SCH₂CF₃ C(O)Pr-n F 105-107 2-264 Me Me D-1 4-5(O)CH₂CHF₂ H F 165-167 2-265 Me Me D-1 4-SCH₂CH₂OMe H F 130-133 2-266 Me Me D-1 4-SCH₂CH₂OMe Me F *1 2-267 Me Me D-1 3-OBn H F 83-85 2-268 Me Me D-1 3-OBn C(O)Pr-n F *1 2-269 Me Me D-1 3-OCH₂CH═CH₂ H F 219-221 2-270 Me Me D-1 3-OCH₂CH═CH₂ C(O)Pr-n F *1 2-271 Me Me D-1 3-OCH₂CH₂OMe H F 198-200 2-272 Me Me D-1 3-OCH₂CH₂OMe C(O)Pr-n F *1 2-273 Me Me D-1 3-OCH₂CH₂SMe H F 214-216 2-274 Me Me D-1 3-OCH₂CH₂SMe C(O)Pr-n F *1 2-275 Me Me D-1 3-OCH₂C(O)Me H F 151-154 2-276 Me Me D-1 3-OCH₂C(O)Me C(O)Pr-n F 142-144 2-277 Me Me D-1 3-OCH(Me)CN H F 189-191 2-278 Me Me D-1 3-OCH(Me)CN C(O)Pr-n F *1 2-279 Me Me D-1 4-OS(O)₂CF₃ Me F 198-200 2-280 Me Me D-1 4-OCHF₂ C(O)Pen-c F 124-126 2-281 Me Me D-1 4-OCHF₂ C(O)C(Me)═CH₂ F  99-101 2-282 Me Me D-1 4-OCHF₂ C(O)C(Me)₂Ph F *1 2-283 Me Me D-1 4-OCHF₂ C(O)CH₂OMe F *1 2-284 Me Me D-1 4-OCHF₂ C(O)CH₂OPh F *1 2-285 Me Me D-1 4-OCHF₂ C(O)[Ph-2-Me] F 85-87 2-286 Me Me D-1 4-OCHF₂ C(O)[Ph-4-Cl] F *1 2-287 Me Me D-1 4-OCHF₂ C(O)[Q-2a] F 195-197 2-288 Me Me D-1 4-OCHF₂ C(O)[Q-4a] F 178-179 2-289 Me Me D-1 4-OCHF₂ C(O)[U-1a] F *1 2-290 Me Me D-1 4-OCHF₂ C(O)[U-6a] F 171-173 2-291 Me Me D-1 4-OCHF₂ C(O)NMe₂ F 92-94 2-292 Me Me D-1 4-OCHF₂ C(O)OEt F 123-125 2-293 Me Me D-1 4-OCHF₂ C(O)OCH₂CH₂Cl F *1 2-294 Me Me D-1 4-OCHF₂ C(O)OCH₂CH═CH₂ F *1 2-295 Me Me D-1 4-OCHF₂ C(O)OCH₂CH₂OMe F *1 2-296 Me Me D-1 4-OCHF₂ C(O)SBu-t F 155-158 2-297 Me Me D-1 4-OCHF₂ C(S)OPh F *1 2-298 Me Me D-1 4-OCHF₂ C(S)SPh F 169-171 2-299 Me Me D-1 4-OCHF₂ C(O)C(O)Ph F *1 2-300 Me Me D-1 4-OCHF₂ CH₂CH═CH₂ F *1 2-301 Me Me D-1 4-OCHF₂ CH₂C≡CH F *1 2-302 Me Me D-1 4-OCHF₂ CH₂CF₃ F *1 2-303 Me Me D-1 4-OCHF₂ CH₂CN F 134-136 2-304 Me Me D-1 4-OCHF₂ CH₂C(O)Me F 194-196 2-305 Me Me D-1 4-OCHF₂ CH₂C(O)Ph F 156-158 2-306 Me Me D-1 4-OCHF₂ CH₂C(O)OMe F 152-154 2-307 Me Me D-1 4-OCHF₂ CH₂OCH₂CH₂OMe F *1 2-308 Me Me D-1 4-OCHF₂ CH(Me)OC(O)OEt F *1 2-309 Me Me D-1 4-OCHF₂ S(O)₂Pr-i F *1 2-310 Me Me D-1 4-OCHF₂ S(O)₂NMe F 168-170 2-311 Me Me D-1 4-OCHF₂ S(O)₂[Ph-4-Cl] F 193-195 2-312 Me Me D-1 4-OCHF₂ S(O)₂[Ph-4-Me] F 181-183 2-313 Me Me D-1 4-OCHF₂ S(O)₂[Ph-3-OMe] F *1 2-314 Me Me D-1 4-CH₂OH Me F 170-172 2-315 Me Me D-1 4-CH₂OCH₂CF₃ H F 77-79 2-316 Me Me D-1 4-CH₂OCH₂CF₃ Me F *1 2-317 Me Me D-1 4-CH₂SMe H F *1 2-318 Me Me D-1 4-CH₂SMe Me F 150-151 2-319 Me Me D-1 4-CH₂SEt H F *1 2-320 Me Me D-1 4-CH₂SEt Me F 123-124 2-321 Me Me D-1 4-CH₂SPr-i H F *1 2-322 Me Me D-1 4-CH₂SPr-i Me F *1 2-323 Me Me D-1 4-CH₂SCH₂CH═CH₂ H F *1 2-324 Me Me D-1 4-CH₂SCH₂CH═CH₂ Me F *1 2-325 Me Me D-1 4-CH₂SCH₂C≡CH H F *1 2-326 Me Me D-1 4-CH₂SCH₂C≡CH Me F 107-109 2-327 Me Me D-1 4-CH₂SCH₂CH₂OMe H F *1 2-328 Me Me D-1 4-CH₂SCH₂CH₂OMe Me F *1 2-329 Me Me D-1 4-CH₂SCH₂CH₂SMe H F 172-175 2-330 Me Me D-1 4-CH₂SCH₂CHF₂ H F *1 2-331 Me Me D-1 4-CH₂SCH₂CF₃ H F *1 2-332 Me Me D-1 4-CH₂S(O)Me H F 154-156 2-333 Me Me D-1 4-CH₂S(O)Et H F 200-201 2-334 Me Me D-1 4-CH₂S(O)₂Me H F 157-159 2-335 Me Me D-1 4-CH₂S(O)₂Et H F *1 2-336 Me Me D-1 3-OH H F 171-173 2-337 Me Me D-1 4-OH H F 256-258 2-338 Me Me D-1 4-OH Me F 264-266 2-339 Me Me D-1 4-C(O)Me H F 154-156 2-340 Me Me D-1 4-CN H F 262-264 2-341 Me Me D-1 4-NO₂ H F 276-278 2-342 Me Me D-1 2,4-F₂ H F 262-264 2-343 Me Me D-1 2,4-F₂ C(O)Pr-n F 113-115 2-344 Me Me D-1 3,4-F₂ H F 284-286 2-345 Me Me D-1 3,4-F₂ C(O)Pr-n F 152-154 2-346 Me Me D-1 2,4-Cl₂ H F 280-281 2-347 Me Me D-1 2,4-Cl₂ C(O)Pr-n F 153-154 2-348 Me Me D-1 2-F-4-Cl H F 250-252 2-349 Me Me D-1 2-F-4-Cl C(O)Pr-n F 150-151 2-350 Me Me D-1 3-F-4-Cl H F 278-280 2-351 Me Me D-1 3-F-4-Cl C(O)Pr-n F 182-184 2-352 Me Me D-1 3-Cl-4-F H F 236-238 2-353 Me Me D-1 3-Cl-4-F C(O)Pr-n F 149-150 2-354 Me Me D-1 2-F-4-CF₃ H F 251-253 2-355 Me Me D-1 2-F-4-CF₃ C(O)Pr-n F 145-147 2-356 Me Me D-1 2-Cl-4-CF₃ H F 264-266 2-357 Me Me D-1 2-Cl-4-CF₃ C(O)Pr-n F 147-149 2-358 Me Me D-1 3,5-(CF₃)₂ H F 130-132 2-359 Me Me D-1 3,5-(CF₃)₂ C(O)Pr-n F 158-160 2-360 Me Me D-1 3,5-(OMe)₂ H F 226-227 2-361 Me Me D-1 3,5-(OMe)₂ C(O)Pr-n F *1 2-362 Me Me D-1 2-F-3-OMe H F 216-217 2-363 Me Me D-1 2-F-3-OMe C(O)Pr-n F 79-81 2-364 Me Me D-1 2-F-4-OMe H F 226-228 2-365 Me Me D-1 2-F-4-OMe C(O)Pr-n F 157-158 2-366 Me Me D-1 2-F-5-OMe H F 202-204 2-367 Me Me D-1 2-F-5-OMe C(O)Pr-n F *1 2-368 Me Me D-1 2-OMe-4-Cl H F 236-238 2-369 Me Me D-1 2-OMe-4-Cl C(O)Pr-n F *1 2-370 Me Me D-1 3-Cl-4-OMe H F 239-241 2-371 Me Me D-1 3-Cl-4-OMe C(O)Pr-n F 154-156 2-372 Me Me D-1 2,4,6-F₃ H F *1 2-373 Me Me D-1 4-Cl Me Cl 187-189 2-374 Me Me D-1 4-OCHF₂ H Cl 180-183 2-375 Me Me D-1 4-OCHF₂ C(O)Pr-n Cl 146-148 2-376 Me Me D-1 2-OMe-4-F H SMe 219-221 2-377 Me Me D-1 2-OMe-4-F H S(O)₂Me 230-232 2-378 Me Me D-1 2-OMe H SCF₃ 183-186 2-379 Me Me D-1 2-OMe Me SCF₃ 152-155 2-380 Me Me D-1 2-OMe-4-F Me S(T-3) *1 2-381 Me Me D-1 4-Cl Me NH₂ 223-227 2-382 Me Me D-2 6-OMe H F 264-266 2-383 Me Me D-3 4-F H F 282-284 2-384 Me Me D-3 4-F C(O)Pr-n F 154-156 2-385 Me Me D-3 4-Cl H F 260-262 2-386 Me Me D-3 4-Cl C(O)Pr-n F 148-150 2-387 Me Me D-3 4-CF₃ H F 244-246 2-388 Me Me D-3 4-CF₃ C(O)Pr-n F 183-185 2-389 Me Me D-3 4-SMe H F 152-154 2-390 Me Me D-7 5-Cl H F 266-268 2-391 Me Me D-7 5-Cl C(O)Pr-n F 113-114 2-392 Me Me D-23 — H F 138-140 2-393 Me Me D-23 — C(O)Pr-n F 154-156 2-394 Me Me D-28 2-Cl H F 174-176 2-395 Me Me D-1 2-OMe H CHO *1 2-396 Me Me D-1 2-OMe Me CHO *1 2-397 Me Me D-1 4-Cl Me N═C(Ph)₂ 235-239 2-398 Et Me D-1 4-F H F 242-244 2-399 Et Me D-1 4-F C(O)Pr-n F 115-117 2-400 Et Me D-1 4-Cl H F 242-244 2-401 Et Me D-1 4-Cl C(O)Pr-n F 128-131 2-402 Et Me D-1 4-CF₃ H F 195-197 2-403 Et Me D-1 4-CF₃ C(O)Pr-n F 136-138 2-404 Et Me D-1 2-OMe H F 216-218 2-405 Et Me D-1 2-OMe C(O)Pr-n F 183-185 2-406 Me Et D-1 4-F H F 182-184 2-407 Me Et D-1 4-F C(O)Pr-n F 125-127 2-408 Me Et D-1 4-Cl H F 224-226 2-409 Me Et D-1 4-Cl C(O)Pr-n F 127-129 2-410 Me Et D-1 4-CF₃ H F 205-207 2-411 Me Et D-1 4-CF₃ C(O)Pr-n F 156-158 2-412 Me Et D-1 4-OCF₃ H F 199-201 2-413 Me Et D-1 4-OCF₃ C(O)Pr-n F 95-97 2-414 Me Et D-1 2-OMe H F 217-219 2-415 Me Et D-1 2-OMe C(O)Pr-n F 166-167 2-416 Me Et D-1 2-OEt H F 170-172 2-417 Me Et D-1 2-OEt C(O)Pr-n F 102-104 2-418 Me Et D-1 4-OPr-n H F 121-124 2-419 Me Et D-1 4-OPr-n C(O)Pr-n F 91-94 2-420 Me Me D-1 4-OCH₂CH₂SMe CH₂CH₂SMe F *1 2-421 Me Me D-1 4-SCH₂CH₂SMe H F *1 2-422 Me Me D-1 4-SCH₂CH═CH₂ H F 67-70 2-423 Me Me D-1 4-SCH₂CN H F *1 2-424 Me Me D-1 4-SCH₂C(O)Me H F *1 2-425 Me Me D-1 4-NMe₂ H F 156-158 2-426 Me Me D-1 4-NMe₂ C(O)Pr-n F 148-151 2-427 Me Me D-4 2-F Me F 61-63 2-428 H Me D-1 4-F H F 151-154 2-429 T-2 Me D-1 4-F H F *1 2-430 CH₂CN Me D-1 4-F H F *1 2-431 CH₂CN Me D-1 2-OMe H F 189-191 2-432 Bn Me D-1 4-F H F 126-128 2-433 Bn Me D-1 4-F C(O)Pr-n F  99-101 2-434 Bn Me D-1 4-Cl H F 196-198 2-435 Bn Me D-1 4-Cl C(O)Pr-n F 74-76 2-436 Bn Me D-1 4-CF₃ H F 232-234 2-437 Bn Me D-1 4-CF₃ C(O)Pr-n F 135-137 2-438 Bn Me D-1 2-OMe H F 220-222 2-439 Bn Me D-1 2-OMe C(O)Pr-n F *1 2-440 Me Cl D-1 4-OCH₂CH₂OMe H F *1 2-441 Me H D-1 4-OCH₂CH₂OMe H F 170-173 2-442 Me Me D-1 4-OCH₂CH═CCl₂ H F *1 2-443 Me Me D-1 4-OCH₂CH₂S(O)Me H F 162-164 2-444 Me Me D-1 4-OCH₂CH₂S(O)₂Me H F *1 2-445 Me Me D-1 4-CH₂OCH₂CH₂OMe H F *1 2-446 Me Me D-1 4-CH₂OCH₂CH₂SMe H F *1 2-447 Me Me D-1 4-OCH₂CH═CCl₂ Me F 155-157 2-448 Me Me D-1 4-Cl Me OH *1 2-449 Me Me D-1 4-Cl Me OMe *1 2-450 Me Me D-1 4-Cl H OMe 164-166 2-451 Me Me D-1 4-SCH₂C(═NOMe)Me H F 87-89 2-452 Me Me D-1 4-SCH₂C(═NOH)Me H F 124-127 2-453 Me Me D-1 4-OCH₂C(═NOH)Me H F 173-175 2-454 Me Me D-1 4-S(O)CH₂CH₂OMe H F 106-109 2-455 Me Me D-1 4-S(O)₂CH₂CH₂OMe H F 223-225 2-456 Me NH₂ D-1 4-OCH₂CH₂OMe H F 135-138 2-457 Me Me D-1 4-OCF₃ H Cl 163-165 2-458 Me Me D-1 4-OCF₃ C(O)Pr-n Cl 172-174 2-459 Me Me D-1 4-OCHF₂ H Me *1 2-460 Me Me D-1 3-S(O)Et H F *1 2-461 Me Me D-6 — H F 225-227 2-462 Me Me D-6 — C(O)Pr-n F 133-135 2-463 Me Me D-8 — H F 224-226 2-464 Me Me D-8 — C(O)Pr-n F 150-152 2-465 Me Me D-1 4-SCH₂C≡CH H F *1 2-466 Me Me D-1 4-SCH₂C≡CH Me F 154-156 2-467 Me Me D-1 4-O[Q-17b] H F *1 2-468 Me Me D-1 4-O[Q-17b] CH₂OCH₂CH₂OMe F *1

TABLE 5

No. R¹ R² R³ (Y¹) G Z mp (° C.) 3-001 Me Me D-1 4-F H F 230-232 3-002 Me Me D-1 4-F C(O)Pr-n F 160-162 3-003 Me Me D-1 2-OMe H F 205-206 3-004 Me Me D-1 2-OMe C(O)Pr-n F *1 3-005 Me Me D-1 4-OMe H F 119-121 3-006 Me Me D-1 2-OEt H F 189-191 3-007 Me Me D-1 2-OEt C(O)Pr-n F *1 3-008 Me Me D-1 4-OMe C(O)Pr-n F *1 3-009 Me Me D-1 2-OMe-4-F H F 219-221 3-010 Me Me D-1 2-OMe-4-F C(O)Pr-n F *1 3-011 Me Me D-1 2-OEt-4-F H F 182-184 3-012 Me Me D-1 2-OEt-4-F C(O)Pr-n F *1 3-013 Me Me D-24a — H F 152-154 3-014 Me Me D-24a — C(O)Pr-n F 142-144 3-015 Me Me D-1 4-Cl H F 252-254 3-016 Me Me D-1 4-Cl C(O)Pr-n F *1 3-017 Me Me D-1 4-C(═NOMe)Me H F 127-129 3-018 Me Me D-1 4-C(═NOMe)Me C(O)Pr-n F 137-139 3-019 Me Me D-1 4-OPr-i H F 122-124 3-020 Me Me D-1 4-OPr-i C(O)Pr-n F *1 3-021 Me Me D-1 2-OMe C(O)CH₂OPh F 160-162 3-022 Me Me D-1 2-OMe C(O)[Ph-2-Me] F 165-167 3-023 Me Me D-1 2-OMe C(O)[Q-2a] F 200-202 3-024 Me Me D-1 2-OMe C(O)OEt F 171-173 3-025 Me Me D-1 2-OMe C(O)[U-6a] F 87-89 3-026 Me Me D-1 2-OMe C(O)SBu-t F 178-180 3-027 Me Me D-1 2-OMe S(O)₂[Ph-4-Me] F 169-171 3-028 Me Me D-1 2-OMe S(O)₂NMe₂ F 126-128 3-029 Me Me D-1 2-OMe CH(Me)OC(O)OEt F 61-64 3-030 Me Me D-1 2-OMe CH₂C(O)Ph F 198-200 3-031 Me Me D-1 4-F H Cl 114-116 3-032 Me Me D-1 4-F C(O)Pr-n Cl *1 3-033 Me Me D-1 4-Cl H Cl 248-250 3-034 Me Me D-1 4-Cl C(O)Pr-n Cl *1 3-035 Me Me D-1 2-OMe H Cl 256-258 3-036 Me Me D-1 2-OMe C(O)Pr-n Cl *1 3-037 Me Me D-1 4-OMe H Cl 151-153 3-038 Me Me D-1 4-OMe C(O)Pr-n Cl *1 3-039 Me Me D-1 2-OEt H Cl 206-208 3-040 Me Me D-1 2-OEt C(O)Pr-n Cl *1 3-041 Me Me D-1 4-OPr-i H Cl 133-135 3-042 Me Me D-1 4-OPr-i C(O)Pr-n Cl *1 3-043 Me Me D-1 2-OMe-4-F H Cl 224-226 3-044 Me Me D-1 2-OMe-4-F C(O)Pr-n Cl *1 3-045 Me Me D-1 2-OEt-4-F H Cl 210-212 3-046 Me Me D-1 2-OEt-4-F C(O)Pr-n Cl *1 3-047 Me Me D-24a — H Cl 176-178 3-048 Me Me D-24a — C(O)Pr-n Cl *1 3-049 Me Me D-1 2-OMe H Me 233-235 3-050 Me Me D-1 2-OMe C(O)Pr-n Me *1 3-051 Me Me D-1 4-OMe H Me 130-132 3-052 Me Me D-1 4-OMe C(O)Pr-n Me 159-161 3-053 Me Me D-1 2-OEt H Me 104-106 3-054 Me Me D-1 2-OEt C(O)Pr-n Me *1 3-055 Me Me D-1 2-OMe-4-F H Me 206-208 3-056 Me Me D-1 2-OMe-4-F C(O)Pr-n Me 164-166 3-057 Me Me D-1 2-OEt-4-F H Me 182-184 3-058 Me Me D-1 2-OEt-4-F C(O)Pr-n Me *1 3-059 Me Me D-24a — H Me 224-226 3-060 Me Me D-24a — C(O)Pr-n Me 107-109 3-061 Me Me D-1 — H OMe 189-191 3-062 Me Me D-1 — C(O)Pr-n OMe *1 3-063 Me Me D-1 4-F H OMe 239-241 3-064 Me Me D-1 4-F C(O)Pr-n OMe 178-180 3-065 Me Me D-1 2-OMe H OMe 243-244 3-066 Me Me D-1 2-OMe C(O)Pr-n OMe *1 3-067 Me Me D-1 2-OMe Me OMe 148-149 3-068 Me Me D-1 4-OMe H OMe 118-120 3-069 Me Me D-1 4-OMe C(O)Pr-n OMe 109-111 3-070 Me Me D-1 2-OEt H OMe 103-105 3-071 Me Me D-1 2-OEt C(O)Pr-n OMe *1 3-072 Me Me D-1 4-OEt H OMe 207-209 3-073 Me Me D-1 4-OEt C(O)Pr-n OMe 152-154 3-074 Me Me D-1 4-SMe H OMe 205-207 3-075 Me Me D-1 4-SMe C(O)Pr-n OMe *1 3-076 Me Me D-1 2-OMe-4-F H OMe 213-215 3-077 Me Me D-1 2-OMe-4-F C(O)Pr-n OMe *1 3-078 Me Me D-1 2-OEt-4-F H OMe 165-167 3-079 Me Me D-1 2-OEt-4-F C(O)Pr-n OMe *1 3-080 Me Me D-1 3,4-(OMe)₂ H OMe 138-140 3-081 Me Me D-1 3,4-(OMe)₂ C(O)Pr-n OMe 148-150 3-082 Me Me D-24a — H OMe 200-202 3-083 Me Me D-24a — C(O)Pr-n OMe 70-72 3-084 Et Me D-1 2-OMe H OMe 213-216 3-085 Et Me D-1 2-OEt H OMe 91-94 3-086 Me N(Bn)₂ D-1 2-OMe H OMe 163-166 3-087 Me NH₂ D-1 2-OMe H OMe 286-288 3-088 Me Cl D-1 2-OMe H OMe 209-211 3-089 Me Me D-1 2-OMe H OEt 225-227 3-090 Me Me D-1 2-OMe C(O)Pr-n OEt *1 3-091 Me Me D-1 4-OMe H OEt 187-189 3-092 Me Me D-1 4-OMe C(O)Pr-n OEt *1 3-093 Me Me D-1 2-OEt H OEt 122-124 3-094 Me Me D-1 2-OEt C(O)Pr-n OEt *1 3-095 Me Me D-1 2-OEt-4-F H OEt 115-117 3-096 Me Me D-1 2-OEt-4-F C(O)Pr-n OEt *1 3-097 Me Me D-1 2-OEt H OH 268-270 3-098 Me Me D-1 2-OEt Me OH 268-269 3-099 Me Me D-1 2-OMe H OPr-n 220-221 3-100 Me Me D-1 2-OMe Me OPr-n 148-150 3-101 Me Me D-1 2-OMe H OPr-i 242-244 3-102 Me Me D-1 2-OMe Me OPr-i 133-135 3-103 Me Me D-1 2-OEt H OPr-n *1 3-104 Me Me D-1 2-OEt Me OPr-n *1 3-105 Me Me D-1 2-OMe H OBu-n 203-205 3-106 Me Me D-1 2-OMe Me OBu-n *1 3-107 Me Me D-1 2-OMe H OBu-i 227-229 3-108 Me Me D-1 2-OMe H OPen-n 199-201 3-109 Me Me D-1 2-OMe H OPen-c *1 3-110 Me Me D-1 2-OMe Me OPen-c *1 3-111 Me Me D-1 2-OMe H OCH₂CH═CH₂ 194-196 3-112 Me Me D-1 2-OMe Me OCH₂CH═CH₂ 141-143 3-113 Me Me D-1 2-OMe H OCHF₂ 191-199 3-114 Me Me D-1 2-OMe H OCH₂CHF₂ *1 3-115 Me Me D-1 2-OMe Me OCH₂CHF₂ 168-169 3-116 Me Me D-1 2-OMe H OCH₂CF₃ 216-218 3-117 Me Me D-1 2-OMe Me OCH₂CF₃ *1 3-118 Me Me D-1 2-OMe H OCH₂Ph 156-158 3-119 Me Me D-1 2-OEt H OCH₂Ph 165-166 3-120 Me Me D-1 2-OEt Me OCH₂Ph 167-168 3-121 Me Me D-1 2-OMe H OCH₂CH₂OMe 196-198 3-122 Me Me D-1 2-OMe Me OCH₂CH₂OMe *1 3-123 Me Me D-1 2-OEt H OCH₂CH₂OMe 127-129 3-124 Me Me D-1 2-OEt Me OCH₂CH₂OMe 144-145 3-125 Me Me D-1 2-OMe H OCH₂CH₂SMe *1 3-126 Me Me D-1 2-OMe Me OCH₂CH₂SMe 113-114 3-127 Me Me D-1 2-OMe H OCH₂CH₂S(O)₂Me 257-259 3-128 Me Me D-1 2-OMe Me OCH₂CH₂S(O)₂Me 128-130 3-129 Me Me D-1 2-OMe H OCH₂Pr-c *1 3-130 Me Me D-1 2-OMe Me OCH₂Pr-c 133-135 3-131 Me Me D-1 2-OMe H OCH₂[T-1-1] 202-204 3-132 Me Me D-1 2-OMe Me OCH₂[T-1-1] 125-127 3-133 Me Me D-1 2-OMe H OCH₂[U-1a] 221-224 3-134 Me Me D-1 2-OMe H OS(O)₂NMe₂ 261-263 3-135 Me Me D-1 2-OMe H CH₂OH 198-200 3-136 Me Me D-1 2-OMe Me CH₂OH 121-124 3-137 Me Me D-1 2-OMe H CH₂OMe 218-220 3-138 Me Me D-1 2-OMe Me CH₂OMe 171-173 3-139 Me Me D-1 4-CF₃ H F 222-224 3-140 Me Me D-1 4-CF₃ C(O)Pr-n F 144-146 3-141 Me Me D-1 4-OCHF₂ H F 176-178 3-142 Me Me D-1 4-OCHF₂ C(O)Pr-n F *1 3-143 Me Me D-1 4-OCF₃ H F 139-141 3-144 Me Me D-1 4-OCF₃ C(O)Pr-n F 120-122 3-145 Me Me D-1 4-CF₃ H Cl 247-249 3-146 Me Me D-1 4-CF₃ C(O)Pr-n Cl 157-159 3-147 Me Me D-1 4-OCHF₂ H Cl 198-200 3-148 Me Me D-1 4-OCHF₂ C(O)Pr-n Cl *1 3-149 Me Me D-1 4-OCF₃ H Cl 187-189 3-150 Me Me D-1 4-OCF₃ C(O)Pr-n Cl 123-126 3-151 Me Me D-1 4-OCHF₂ H Me 120-122 3-152 Me Me D-1 4-OCHF₂ C(O)Pr-n Me *1 3-153 Me Me D-1 2-OMe CH₂CN OMe 152-154 3-154 Me Me D-1 2-OMe CH₂C≡CH OMe 171-173 3-155 Me Me D-1 2-OMe C(O)C(Me)═CH₂ OMe *1 3-156 Me Me D-1 2-OMe C(O)Hex-c OMe 155-157 3-157 Me Me D-1 2-OMe C(O)CH(Me)Ph OMe *1 3-158 Me Me D-1 2-OMe C(O)[Ph-2-OMe] OMe *1 3-159 Me Me D-1 4-OCHF₂ H OMe 234-236 3-160 Me Me D-1 4-OCHF₂ C(O)Pr-n OMe 180-182 3-161 Me Me D-1 2-OMe H OS(O)₂CF₃ 237-238 3-162 Me Me D-1 2-OMe Me OS(O)₂CF₃ 188-189 3-163 Me Me D-1 2-OMe H SMe 233-234 3-164 Me Me D-1 2-OMe Me SMe 112-114 3-165 Me Me D-1 2-OMe H S(O)₂Me 268-270 3-166 Me Me D-1 2-OMe Me S(O)₂Me 197-198 3-167 Me Me D-1 2-OMe Me SCH₂CH₂C(O)OEt *1 3-168 Me Me D-1 4-OCF₃ H Me 136-138 3-169 Me Me D-1 4-OCF₃ C(O)Pr-n Me 116-118 3-170 Me Me D-1 4-OCF₃ H OMe 200-202 3-171 Me Me D-1 2-OMe Me S(T-3) *1 3-172 Me Me D-1 2-OMe Me OH *1

TABLE 6

No. R¹ R² R³ (Y¹) G Z mp (° C.) 4-001 Me Me D-1 4-F H F 245-247 4-002 Me Me D-1 4-F C(O)Pr-n F *1 4-003 Me Me D-1 2-OMe H F 220-221 4-004 Me Me D-1 2-OMe C(O)Pr-n F *1 4-005 Me Me D-1 4-OMe H F 237-239 4-006 Me Me D-1 4-OMe C(O)Pr-n F *1 4-007 Me Me D-1 2-OEt H F 171-173 4-008 Me Me D-1 2-OEt C(O)Pr-n F *1 4-009 Me Me D-1 4-OPr-n H F 131-133 4-010 Me Me D-1 4-OPr-n C(O)Pr-n F *1 4-011 Me Me D-1 2-OMe-4-F H F 232-234 4-012 Me Me D-1 2-OMe-4-F C(O)Pr-n F *1 4-013 Me Me D-1 3,4-(OMe)₂ H F 156-158 4-014 Me Me D-1 3,4-(OMe)₂ C(O)Pr-n F 166-168 4-015 Me Me D-1 4-F H Cl 230-232 4-016 Me Me D-1 4-F C(O)Pr-n Cl *1 4-017 Me Me D-1 4-Cl H Cl 118-120 4-018 Me Me D-1 4-Cl C(O)Pr-n Cl *1 4-019 Me Me D-1 4-Me H Cl 153-155 4-020 Me Me D-1 4-Me C(O)Pr-n Cl *1 4-021 Me Me D-1 2-OMe H Cl 231-233 4-022 Me Me D-1 2-OMe C(O)Pr-n Cl *1 4-023 Me Me D-1 4-OMe H Cl 151-153 4-024 Me Me D-1 4-OMe C(O)Pr-n Cl *1 4-025 Me Me D-1 2-OEt H Cl 216-218 4-026 Me Me D-1 2-OEt C(O)Pr-n Cl *1 4-027 Me Me D-1 4-OPr-n H Cl 140-142 4-028 Me Me D-1 4-OPr-n C(O)Pr-n Cl *1 4-029 Me Me D-1 4-CF₃ H Cl 213-217 4-030 Me Me D-1 4-CF₃ C(O)Pr-n Cl *1 4-031 Me Me D-1 4-CN H Cl 169-171 4-032 Me Me D-1 4-CN C(O)Pr-n Cl *1 4-033 Me Me D-1 2-OMe-4-F H Cl 260-262 4-034 Me Me D-1 2-OMe-4-F C(O)Pr-n Cl *1 4-035 Me Me D-1 2-OEt-4-F H Cl 210-212 4-036 Me Me D-1 2-OEt-4-F C(O)Pr-n Cl *1 4-037 Me Me D-1 2-F-4-CF₃ H Cl 249-251 4-038 Me Me D-1 2-F-4-CF₃ C(O)Pr-n Cl *1 4-039 Me Me D-1 2-OMe H OMe *1 4-040 Me Me D-1 4-Cl H F 270-272 4-041 Me Me D-1 4-Cl C(O)Pr-n F 115-117 4-042 Me Me D-1 4-Pr-i H F 183-185 4-043 Me Me D-1 4-Pr-i C(O)Pr-n F *1 4-044 Me Me D-1 4-CF₃ H F 132-134 4-045 Me Me D-1 4-CF₃ C(O)Pr-n F *1 4-046 Me Me D-1 4-OCHF₂ H F 91-93 4-047 Me Me D-1 4-OCHF₂ C(O)Pr-n F *1 4-048 Me Me D-1 4-OCF₃ H F 167-169 4-049 Me Me D-1 4-OCF₃ C(O)Pr-n F *1 4-050 Me Me D-1 4-SMe H F 125-127 4-051 Me Me D-1 4-SMe C(O)Pr-n F 148-150 4-052 Me Me D-1 4-CN H F 155-157 4-053 Me Me D-1 4-CN C(O)Pr-n F *1 4-054 Me Me D-1 3-F-4-Cl H F 276-278 4-055 Me Me D-1 3-F-4-Cl C(O)Pr-n F *1 4-056 Me Me D-1 — H Cl 166-170 4-057 Me Me D-1 — C(O)Pr-n Cl 120-122 4-058 Me Me D-1 2-F H Cl 219-221 4-059 Me Me D-1 2-F C(O)Pr-n Cl *1 4-060 Me Me D-1 2-Me H Cl 223-225 4-061 Me Me D-1 2-Me C(O)Pr-n Cl 126-128 4-062 Me Me D-1 2-Et H Cl 259-261 4-063 Me Me D-1 2-Et C(O)Pr-n Cl 87-89 4-064 Me Me D-1 3-OMe H Cl 196-198 4-065 Me Me D-1 3-OMe C(O)Pr-n Cl *1 4-066 Me Me D-1 3-OEt H Cl 201-203 4-067 Me Me D-1 3-OEt C(O)Pr-n Cl *1 4-068 Me Me D-1 3-OBu-n H Cl 156-158 4-069 Me Me D-1 3-OBu-n C(O)Pr-n Cl *1 4-070 Me Me D-1 2-CF₃ H Cl 230-232 4-071 Me Me D-1 2-CF₃ C(O)Pr-n Cl 87-89 4-072 Me Me D-1 3-CF₃ H Cl 222-224 4-073 Me Me D-1 3-CF₃ C(O)Pr-n Cl *1 4-074 Me Me D-1 4-OCHF₂ H Cl 113-115 4-075 Me Me D-1 4-OCHF₂ C(O)Pr-n Cl *1 4-076 Me Me D-1 2-OCF₃ H Cl 280-282 4-077 Me Me D-1 2-OCF₃ C(O)Pr-n Cl *1 4-078 Me Me D-1 4-OCF₃ H Cl 228-230 4-079 Me Me D-1 4-OCF₃ C(O)Pr-n Cl *1 4-080 Me Me D-1 2-OH C(O)Pr-n Cl *1 4-081 Me Me D-1 2-CH₂OMe H Cl 202-204 4-082 Me Me D-1 2-CH₂OMe C(O)Pr-n Cl 93-95 4-083 Me Me D-1 2-OCH₂OMe H Cl 190-192 4-084 Me Me D-1 2-OCH₂OMe C(O)Pr-n Cl 143-145 4-085 Me Me D-1 2-OCH₂Ph C(O)Pr-n Cl *1 4-086 Me Me D-1 2-SMe H Cl 244-246 4-087 Me Me D-1 2-SMe C(O)Pr-n Cl *1 4-088 Me Me D-1 4-SMe H Cl 135-137 4-089 Me Me D-1 4-SMe C(O)Pr-n Cl 160-161 4-090 Me Me D-1 2-SEt H Cl 208-210 4-091 Me Me D-1 2-SEt C(O)Pr-n Cl 98-100 4-092 Me Me D-1 3-SEt H Cl 184-186 4-093 Me Me D-1 3-SEt C(O)Pr-n Cl *1 4-094 Me Me D-1 4-SEt H Cl 186-188 4-095 Me Me D-1 4-SEt C(O)Pr-n Cl *1 4-096 Me Me D-1 4-SPr-i H Cl 184-186 4-097 Me Me D-1 4-SPr-i C(O)Pr-n Cl *1 4-098 Me Me D-19a — H Cl 256-258 4-099 Me Me D-19a — C(O)Pr-n Cl 106-108 4-100 Me Me D-1 4-F H Me 214-216 4-101 Me Me D-1 4-F C(O)Pr-n Me *1 4-102 Me Me D-1 4-Cl H Me 209-215 4-103 Me Me D-1 4-Cl C(O)Pr-n Me 85-87 4-104 Me Me D-1 4-Br H Me 254-256 4-105 Me Me D-1 4-Br C(O)Pr-n Me *1 4-106 Me Me D-1 2-OMe H Me 224-226 4-107 Me Me D-1 2-OMe C(O)Pr-n Me 131-133 4-108 Me Me D-1 3-OMe H Me 191-193 4-109 Me Me D-1 3-OMe C(O)Pr-n Me *1 4-110 Me Me D-1 4-OMe H Me 170-172 4-111 Me Me D-1 4-OMe C(O)Pr-n Me 104-106 4-112 Me Me D-1 2-OEt H Me 193-195 4-113 Me Me D-1 2-OEt C(O)Pr-n Me *1 4-114 Me Me D-1 3-OEt H Me 180-182 4-115 Me Me D-1 3-OEt C(O)Pr-n Me *1 4-116 Me Me D-1 2-SMe H Me 219-221 4-117 Me Me D-1 2-SMe C(O)Pr-n Me *1 4-118 Me Me D-1 4-SMe H Me 143-145 4-119 Me Me D-1 4-SMe C(O)Pr-n Me 163-165 4-120 Me Me D-1 2-SEt H Me 199-201 4-121 Me Me D-1 2-SEt C(O)Pr-n Me 90-92 4-122 Me Me D-1 3-SEt H Me 172-174 4-123 Me Me D-1 3-SEt C(O)Pr-n Me *1 4-124 Me Me D-1 4-SEt H Me 115-117 4-125 Me Me D-1 4-SEt C(O)Pr-n Me 114-116 4-126 Me Me D-1 4-CF₃ H Me 234-236 4-127 Me Me D-1 4-CF₃ C(O)Pr-n Me 138-140 4-128 Me Me D-1 4-OCHF₂ H Me 102-104 4-129 Me Me D-1 4-OCHF₂ C(O)Pr-n Me 123-125 4-130 Me Me D-1 4-OCF₃ H Me 210-212 4-131 Me Me D-1 4-OCF₃ C(O)Pr-n Me *1

TABLE 7

No. R¹ R² R³ (Y¹) G Z′ Z″ mp (° C.) 5-001 Me Me D-1 4-F H F F 248-250 5-002 Me Me D-1 4-F C(O)Pr-n F F 157-159 5-003 Me Me D-1 4-Me H F F 226-228 5-004 Me Me D-1 4-Me C(O)Pr-n F F 153-155 5-005 Me Me D-1 4-Pr-i H F F 153-156 5-006 Me Me D-1 4-Pr-i C(O)Pr-n F F 76-78 5-007 Me Me D-1 4-CF₃ H F F 259-261 5-008 Me Me D-1 4-CF₃ C(O)Pr-n F F 182-184 5-009 Me Me D-1 4-CH₂OMe H F F 201-203 5-010 Me Me D-1 4-CH₂OMe C(O)Pr-n F F *1 5-011 Me Me D-1 2-OMe H F F 237-238 5-012 Me Me D-1 2-OMe C(O)Pr-n F F 167-169 5-013 Me Me D-1 2-OMe Me F F 171-172 5-014 Me Me D-1 4-OMe H F F 124-127 5-015 Me Me D-1 4-OMe C(O)Pr-n F F 172-174 5-016 Me Me D-1 2-OEt H F F 220-222 5-017 Me Me D-1 2-OEt C(O)Pr-n F F 146-148 5-018 Me Me D-1 2-OPr-i H F F 178-180 5-019 Me Me D-1 4-OPr-i H F F 127-130 5-020 Me Me D-1 4-OPr-i C(O)Pr-n F F 146-148 5-021 Me Me D-1 2-OCF2 H F F 246-248 5-022 Me Me D-1 2-OCF2 C(O)Pr-n F F 147-149 5-023 Me Me D-1 4-OCH₂C(O)Me H F F 86-90 5-024 Me Me D-1 4-O[U-4a] H F F 134-138 5-025 Me Me D-1 4-CN H F F 295-297 5-026 Me Me D-1 4-CN C(O)Pr-n F F 167-169 5-027 Me Me D-1 4-C(O)OH H F F 251-254 5-028 Me Me D-1 4-C(O)OMe C(O)Pr-n F F 78-80 5-029 Me Me D-1 2-OMe-4-F H F F 250-252 5-030 Me Me D-1 2-OMe-4-F C(O)Pr-n F F 176-178 5-031 Me Me D-1 2-OEt-4-F H F F 220-222 5-032 Me Me D-1 2-OEt-4-F C(O)Pr-n F F 122-124 5-033 Me Me D-1 3,4-(OMe)₂ H F F 131-133 5-034 Me Me D-1 3,4-(OMe)₂ C(O)Pr-n F F 165-167 5-035 Me Me D-22a — H F F 209-211 5-036 Me Me D-22a — C(O)Pr-n F F 174-176 5-037 Me Me D-24a — H F F 192-194 5-038 Me Me D-24a — C(O)Pr-n F F 198-200 5-039 Me Me D-1 4-F H Cl Cl 160-163 5-040 Me Me D-1 4-F C(O)Pr-n Cl Cl 197-198 5-041 Me Me D-1 2-OMe H Cl Cl 125-127 5-042 Me Me D-1 2-OMe C(O)Pr-n Cl Cl *1 5-043 Me Me D-1 4-OMe H Cl Cl 235-237 5-044 Me Me D-1 4-OMe C(O)Pr-n Cl Cl 89-91 5-045 Me Me D-1 2-OEt H Cl Cl 244-246 5-046 Me Me D-1 2-OEt C(O)Pr-n Cl Cl 131-133 5-047 Me Me D-1 4-CF₃ H Cl Cl 290-291 5-048 Me Me D-1 4-CF₃ C(O)Pr-n Cl Cl 198-200 5-049 Me Me D-1 4-CN H Cl Cl 171-173 5-050 Me Me D-1 4-CN C(O)Pr-n Cl Cl 186-188 5-051 Me Me D-1 2-OMe-4-F H Cl Cl 224-226 5-052 Me Me D-1 2-OMe-4-F C(O)Pr-n Cl Cl *1 5-053 Me Me D-1 2-OEt-4-F H Cl Cl 263-265 5-054 Me Me D-1 2-OEt-4-F C(O)Pr-n Cl Cl *1 5-055 Me Me D-1 — H OMe OMe 138-140 5-056 Me Me D-1 — C(O)Pr-n OMe OMe 176-178 5-057 Me Me D-1 4-F H OMe OMe 161-163 5-058 Me Me D-1 4-F C(O)Pr-n OMe OMe 201-203 5-059 Me Me D-1 2-OMe H OMe OMe 116-118 5-060 Me Me D-1 2-OMe-4-F H OMe OMe 131-133 5-061 Me Me D-1 2-OMe-4-F C(O)Pr-n OMe OMe *1 5-062 Me Me D-1 3,4-(OMe)₂ H OMe OMe 149-151 5-063 Me Me D-1 3,4-(OMe)₂ C(O)Pr-n OMe OMe 151-153 5-064 Me Me D-1 2-OMe H F OMe 250-252 5-065 Me Me D-1 2-OMe H F OEt 245-246 5-066 Me Me D-1 2-OMe Et F OEt 171-173 5-067 Me Me D-1 4-F H Cl OMe 189-191 5-068 Me Me D-1 2-OMe H Cl OMe 139-141 5-069 Me Me D-1 2-OMe C(O)Pr-n Cl OMe 201-203 5-070 Me Me D-1 4-OMe H Cl OMe 154-156 5-071 Me Me D-1 4-OMe C(O)Pr-n Cl OMe 190-192 5-072 Me Me D-1 2-OEt H Cl OMe 126-128 5-073 Me Me D-1 2-OEt C(O)Pr-n Cl OMe 181-183 5-074 Me Me D-1 4-CN H Cl OMe 115-117 5-075 Me Me D-1 2-OMe-4-F H Cl OMe 241-243 5-076 Me Me D-1 2-OMe-4-F C(O)Pr-n Cl OMe *1 5-077 Me Me D-1 2-OEt-4-F H Cl OMe 218-220 5-078 Me Me D-1 4-F H [Ph-4-F] OMe 187-189 5-079 Me Me D-1 2-OEt H [Ph-2-OEt] OMe 138-140 5-080 Me Me D-1 2-OEt C(O)Pr-n [Ph-2-OEt] OMe *1 5-081 Me Me D-1 2-OEt-4-F H [Ph-2-OEt-4-F] OMe 156-159 5-082 Me Me D-1 4-Cl H F F 123-125 5-083 Me Me D-1 4-Cl Bn F F 156-157 5-084 Me Me D-1 4-OCHF₂ H F F 222-224 5-085 Me Me D-1 4-OCHF₂ C(O)Pr-n F F 142-144 5-086 Me Me D-1 4-OCHF₂ H Cl Cl 127-129 5-087 Me Me D-1 4-OCHF₂ C(O)Pr-n Cl Cl 152-154 5-088 Me Me D-1 4-F H Me Me 262-264 5-089 Me Me D-1 4-F C(O)Pr-n Me Me 203-205 5-090 Me Me D-1 2-OMe H Me Me 220-222 5-091 Me Me D-1 2-OMe C(O)Pr-n Me Me 160-162 5-092 Me Me D-1 4-OMe H Me Me 142-144 5-093 Me Me D-1 4-OMe C(O)Pr-n Me Me 160-162 5-094 Me Me D-1 2-OEt H Me Me 235-237 5-095 Me Me D-1 2-OEt C(O)Pr-n Me Me 74-76 5-096 Me Me D-1 4-CF₃ H Me Me 168-170 5-097 Me Me D-1 4-CF₃ C(O)Pr-n Me Me 151-153 5-098 Me Me D-1 4-OCHF₂ H Me Me 169-171 5-099 Me Me D-1 4-OCHF₂ C(O)Pr-n Me Me 144-145 5-100 Me Me D-1 4-CN H Me Me 182-184 5-101 Me Me D-1 2-OMe-4-F H Me Me 234-236 5-102 Me Me D-1 2-OMe-4-F C(O)Pr-n Me Me 181-182 5-103 Me Me D-1 2-OEt-4-F H Me Me 202-204 5-104 Me Me D-1 2-OEt-4-F C(O)Pr-n Me Me 87-90 5-105 Me Me D-1 4-OCF₃ H F F 149-151 5-106 Me Me D-1 4-OCF₃ C(O)Pr-n F F 88-90 5-107 Me Me D-1 4-OCF₃ H Cl Cl 207-209 5-108 Me Me D-1 4-OCF₃ C(O)Pr-n Cl Cl 182-184 5-109 Me Me D-1 4-OCF₃ H Me Me 147-149 5-110 Me Me D-1 4-OCF₃ C(O)Pr-n Me Me 115-117

TABLE 8

No. R¹ R² R³ (Y¹) G Z′ Z″ mp (° C.) 6-001 Me Me D-1 2-OMe H F F 122-124 6-002 Me Me D-1 2-OMe H Me Me 221-223

TABLE 9

No. R¹ R² R³ (Y¹) G Z′ Z″ mp (° C.) 7-001 Me Me D-1 2-OMe H OMe Cl 229-231 7-002 Me Me D-1 2-OMe H OMe Br 236-238 7-003 Me Me D-1 2-OMe H OEt Cl 223-225 7-004 Me Me D-1 2-OEt H OEt Cl 203-205

TABLE 10

No. R¹ R² R³ (Y¹) G mp (° C.) 8-001 Me Me D-1 2-OMe-4-F H 235-237 8-002 Me Me D-24a — H 257-258 8-003 Me Me D-1 4-OPr-n H 229-231 8-004 Me Me D-1 4-OCH₂CH═CH₂ H 221-223 8-005 Me Me D-1 4-OCH₂CF₃ H 234-236 8-006 Me Me D-1 4-OH Me 251-253 8-007 Me Me D-1 4-OCH₂CH₂OMe H 214-216 8-008 Me Me D-1 4-OCH₂CH₂SMe H 94-96 8-009 Me Me D-1 4-OBn Me *1

TABLE 11

No. R¹ R² R³ (Y¹) G Z mp (° C.) 9-001 Me Me D-1 2-OMe H Cl 246-247 9-002 Me Me D-1 4-OMe H Cl 269-270 9-003 Me Me D-1 2-OEt H Cl 243-245 9-004 Me Me D-1 4-F H Me 284-286 9-005 Me Me D-1 4-F C(O)Pr-n Me *1 9-006 Me Me D-1 2-OMe H Me 177-179 9-007 Me Me D-1 4-OMe H Me 232-234 9-008 Me Me D-1 4-OMe C(O)Pr-n Me *1 9-009 Me Me D-1 2-OMe-4-F H Me 237-239 9-010 Me Me D-1 2-OEt-4-F C(O)Pr-n Me *1 9-011 Me Me D-1 2-OEt-4-F H Me 211-213 9-012 Me Me D-24a — H Me 198-200 9-013 Me Me D-24a — C(O)Pr-n Me 171-173 9-014 Me Me D-1 4-F H F 293-295 9-015 Me Me D-1 4-F C(O)Pr-n F 135-136 9-016 Me Me D-1 4-C1 H F 262-263 9-017 Me Me D-1 4-Me H F 214-216 9-018 Me Me D-1 4-Me C(O)Pr-n F 144-146 9-019 Me Me D-1 2-OMe H F 226-228 9-020 Me Me D-1 4-OMe H F 248-250 9-021 Me Me D-1 4-OEt H F 230-232 9-022 Me Me D-1 4-OEt C(O)Pr-n F 133-134 9-023 Me Me D-1 4-OPr-n H F 182-184 9-024 Me Me D-1 4-OPr-n C(O)Pr-n F 103-105 9-025 Me Me D-1 4-OPr-i H F 162-164 9-026 Me Me D-1 4-OPr-i C(O)Pr-n F *1 9-027 Me Me D-1 4-OBu-i H F 155-157 9-028 Me Me D-1 4-OBu-i C(O)Pr-n F 132-134 9-029 Me Me D-1 4-CF₃ H F 201-203 9-030 Me Me D-1 4-CF₃ C(O)Pr-n F 187-189 9-031 Me Me D-1 4-OCHF₂ H F 186-188 9-032 Me Me D-1 4-OCHF₂ C(O)Pr-n F 160-162 9-033 Me Me D-1 4-OCF₃ H F 174-176 9-034 Me Me D-1 4-OCF₃ C(O)Pr-n F 140-142 9-035 Me Me D-1 4-OCH₂CF₃ H F 168-170 9-036 Me Me D-1 4-OCH₂CF₃ C(O)Pr-n F 193-195 9-037 Me Me D-1 4-SMe H F 151-153 9-038 Me Me D-1 4-SMe C(O)Pr-n F 178-180 9-039 Me Me D-1 4-SEt H F 186-188 9-040 Me Me D-1 4-SEt C(O)Pr-n F *1 9-041 Me Me D-1 4-SPr-i H F 155-157 9-042 Me Me D-1 4-SPr-i C(O)Pr-n F *1 9-043 Me Me D-1 4-CH₂OMe H F 192-194 9-044 Me Me D-1 4-CH₂OMe C(O)Pr-n F 129-131 9-045 Me Me D-1 4-OCH₂CH₂OMe H F 242-244 9-046 Me Me D-1 4-OCH₂CH₂OMe C(O)Pr-n F 115-117 9-047 Me Me D-7 5-Cl H F 115-117 9-048 Me Me D-7 5-Cl C(O)Pr-n F *1 9-049 Me Me D-1 4-OPr-n H Me 224-225 9-050 Me Me D-1 4-OPr-n C(O)Pr-n Me 114-116 9-051 Me Me D-1 4-OBu-i H Me 199-201 9-052 Me Me D-1 4-OBu-i C(O)Pr-n Me 99-101 9-053 Me Me D-1 4-OCHF₂ H Me 206-208 9-054 Me Me D-1 4-OCHF₂ C(O)Pr-n Me 117-119 9-055 Me Me D-1 4-SMe H Me 229-231 9-056 Me Me D-1 4-SMe C(O)Pr-n Me 149-151 9-057 Me Me D-1 4-SEt H Me 203-205 9-058 Me Me D-1 4-SEt C(O)Pr-n Me *1 9-059 Me Me D-1 4-SPr-i H Me 180-182 9-060 Me Me D-1 4-SPr-i C(O)Pr-n Me *1 9-061 Me Me D-1 4-CH₂OMe H Me 225-227 9-062 Me Me D-1 4-CH₂OMe C(O)Pr-n Me 91-93 9-063 Me Me D-1 4-OCH₂CH₂OMe H Me 203-205 9-064 Me Me D-1 4-OCH₂CH₂OMe C(O)Pr-n Me 78-80

TABLE 12

No. R¹ R² R³ (Y¹) G Z mp (° C.) 10-001 Me Me D-1 2-OMe H OMe 204-206

TABLE 13

No. R¹ R² R³ (Y¹) G Z mp (° C.) 11-001 Me Me D-1 4-Cl H F 238-239

TABLE 14

- No. X R^(a) (Z¹)_(n) (Y¹)_(P5) mp (° C.) 12-001 S OH 4-F 4-Cl 238-239 12-002 S OH 5-F 4-Cl 202-204 12-003 S OH 5-F 4-OCHF₂ 203-204 12-004 S OH 6-F 2-OMe 156-157 12-005 S OH 5-Cl 2-OMe-4-F 186-188 12-006 S OH 5-Me — 192-194 12-007 S OH 4-OMe 2-OMe 176-178 12-008 S OH 5-OMe — 179-181 12-009 S OH 5-OMe 2-OMe 157-158 12-010 S OH 6-OMe 2-OMe 232-234 12-011 S OH 6-OMe 2-OMe-4-F 196-198 12-012 O OH 6-OMe 2-OMe 131-133 12-013 S OH 6-OBn 2-OMe 179-181 12-014 S OH 5,7-F₂ 2-OMe 184-186 12-015 S OH 5,7-Me₂ 2-OMe 171-173 12-016 S OMe 5-F 4-OCHF₂ 111-113 12-017 S OMe 5-Cl 2-OMe-4-F 95-96 12-018 S OMe 5-Me — *1 12-019 S OMe 5-OMe — 84-86 12-020 S OMe 6-OMe 2-OMe *1 12-021 S OMe 5,7-F₂ 2-OMe 144-146 12-022 S OMe 5,7-Me₂ 2-OMe 103-105 12-023 S OEt 5-F 4-Cl 49-51 12-024 S OEt 6-F 2-OMe *1 12-025 S OEt 6-OMe 2-OMe *1 12-026 S OEt 6-OMe 2-OMe-4-F 104-106 12-027 S OEt 6-O Bn 2-OMe 88-90 12-028 S N(Me)NH₂ 4-F 4-Cl 158-160 12-029 S N(Me)NH₂ 5-F 4-Cl 131-133 12-030 S N(Me)NH₂ 5-F 4-OCHF₂ 103-104 12-031 S N(Me)N═C(Me)CO₂Et 4-F 4-Cl 124-126 12-032 S N(Me)N═C(Me)CO₂Et 5-F 4-Cl 125-127 12-033 S N(Me)N═C(Me)CO₂Et 5-F 4-OCHF₂ 100-101 12-034 S N(Me)N═C(Me)CO₂Et 6-F 2-OMe 120-122 12-035 S N(Me)N═C(Me)CO₂Et 5-Cl 2-OMe-4-F 126-128 12-036 S N(Me)N═C(Me)CO₂Et 5-Me — *1 12-037 S N(Me)N═C(Me)CO₂Et 6-OMe 2-OMe 109-111 12-038 S N(Me)N═C(Me)CO₂Et 6-OMe 2-OMe-4-F 123-124 12-039 S N(Me)N═C(Me)CO₂Et 7-OMe 2-OMe *1 12-040 S N(Me)N═C(Me)CO₂Et 5,7-Me₂ 2-OMe *1

Table 15 shows the spectrum data of compounds (among the compounds shown in Tables 3 to 14) whose melting points are not described in the Tables.

TABLE 15 No. ¹H NMR 1-006 δ 7.75-7.85 (m, 1H), 7.25-7.40 (m, 5H), 7.10-7.20 (m, 2H) 3.78 (s, 3H), 2.62 (t, J = 7.5 Hz, 2H), 2.22 (s, 3H), 2.00-2.15 (m, 2H), 1.55-1.70 (m, 2H), 1.30-1.45 (m, 2H) 1.15-1.30 (m, 2H), 0.94 (t, J = 7.2 Hz, 3H), 0.56 (t, J = 7.5 Hz, 3H). 1-016 δ 7.80-7.90 (m, 1H), 7.40-7.50 (m, 1H), 7.20-7.40 (m, 4H), 6.80-7.00 (m, 2H), 3.95 (t, J = 6.7 Hz, 2H), 3.77 (s, 3H), 3.37 (s, 3H), 2.12 (s, 3H), 1.65-1.85 (m, 2H), 0.99 (t, J = 7.5 Hz, 3H). 1-021 δ 7.75-7.85 (m, 1H), 7.25-7.45 (m, 5H), 6.80-6.90 (m, 2H), 4.50-4.65 (m, 1H), 3.79 (s, 3H), 2.23 (s, 3H), 2.00-2.15 (m, 2H), 1.35 (dd, J = 6.1, 2.1 Hz, 6H), 1.20-1.30 (m, 2H), 0.56 (t, J = 7.4 Hz, 3H). 1-023 δ 7.75-7.85 (m, 1H), 7.35-7.45 (m, 1H), 7.20-7.35 (m, 4H), 6.80-7.00 (m, 2H), 4.00 (t, J = 6.8 Hz, 2H), 3.83 (s, 3H), 2.05-2.15 (m, 2H), 2.12 (s, 3H), 1.70-1.85 (m, 2H), 1.40-1.55 (m, 2H), 1.25-1.40 (m, 2H), 0.97 (t, J = 7.7 Hz, 3H), 0.64 (t, J = 7.5 Hz, 3H). 1-025 δ 7.75-7.85 (m, 1H), 7.25-7.45 (m, 5H), 6.80-6.90 (m, 2H), 3.97 (t, J = 6.6 Hz, 2H), 3.79 (s, 3H), 2.23 (s, 3H), 1.95-2.20 (m, 2H), 1.70-1.85 (m, 2H), 1.40-1.60 (m, 2H), 1.15-1.35 (m, 2H), 0.98 (t, J = 7.4 Hz, 3H), 0.56 (t, J = 7.4 Hz, 3H). 1-027 δ 7.75-7.85 (m, 1H), 7.25-7.45 (m, 5H), 6.80-6.90 (m, 2H), 3.96 (t, J = 6.6 Hz, 3H), 3.79 (s, 3H), 2.23 (s, 3H), 2.00-2.15 (m, 2H), 1.70-1.85 (m, 2H), 1.35-1.50 (m, 4H), 1.20-1.35 (m, 2H), 0.90-1.00 (m, 3H), 0.56 (t, J = 7.4 Hz, 3H). 1-029 δ 7.75-7.85 (m, 1H), 7.25-7.45 (m, 5H), 6.80-6.90 (m, 2H), 3.96 (t, J = 6.6 Hz, 2H), 3.79 (s, 3H), 2.23 (s, 3H), 2.07 (td, J = 7.3, 3.5 Hz, 2H), 1.70-1.85 (m, 2H), 1.40-1.55 (m, 2H), 1.30-1.40 (m, 4H), 1.15-1.30 (m, 2H), 0.85-0.95 (m, 3H), 0.56 (t, J = 7.4 Hz, 3H). 1-032 δ 7.80-7.90 (m, 1H), 7.50-7.60 (m, 2H), 7.30-7.45 (m, 3H), 7.15-7.25 (m, 2H), 3.76 (s, 3H), 2.26 (s, 3H), 1.95-2.20 (m, 2H), 1.15-1.35 (m, 2H), 0.54 (t, J = 7.5 Hz, 3H). 1-035 δ 7.75-7.85 (m, 1H), 7.25-7.45 (m, 6H), 7.10 (td, J = 7.2, 1.9 Hz, 1H), 3.77 (s, 3H), 2.44 (s, 3H), 2.21 (t, J = 7.3 Hz, 2H), 1.25-1.45 (m, 2H), 0.65 (t, J = 7.5 Hz, 3H). 1-037 δ 7.75-7.85 (m, 1H), 7.30-7.45 (m, 5H), 7.15-7.25 (m, 2H), 3.78 (s, 3H), 2.49 (s, 3H), 2.24 (s, 3H), 2.00-2.15 (m, 2H), 1.20-1.35 (m, 2H), 0.55 (t, J = 7.3 Hz, 3H). 1-042 δ 7.90-8.00 (m, 2H), 7.80-7.90 (m, 1H), 7.55-7.65 (m, 2H), 7.35-7.45 (m, 3H), 3.76 (s, 3H), 2.61 (s, 3H), 2.25 (s, 3H), 1.95-2.20 (m, 2H), 1.15-1.30 (m, 2H), 0.54 (t, J = 7.4 Hz, 3H). 1-044 δ 7.75-7.85 (m, 1H), 7.60-7.70 (m, 2H), 7.45-7.55 (m, 2H), 7.30-7.45 (m, 3H), 4.00 (s, 3H), 3.79 (s, 3H), 2.22 (s, 6H), 2.00-2.10 (m, 2H), 1.20-1.30 (m, 2H), 0.54 (t, J = 7.4 Hz, 3H). 1-047 δ 7.75-7.95 (m, 1H), 7.25-7.65 (m, 5H), 7.05-7.20 (m, 1H), 3.77 (s, 3H), 2.27 (s, 3H), 2.00-2.20 (m, 2H), 1.15-1.40 (m, 2H), 0.50-0.60 (m, 3H). 1-052 δ 7.75-7.85 (m, 1H), 7.20-7.45 (m, 5H), 6.95 (t, J = 8.9 Hz, 1H), 3.76 (s, 3H), 2.20-2.35 (m, 6H), 1.95-2.15 (m, 2H), 1.20-1.35 (m, 2H), 0.55 (t, J = 7.5 Hz, 3H). 1-059 δ 7.75-7.85 (m, 1H), 7.40-7.50 (m, 1H), 7.30-7.40 (m, 2H), 7.13 (dd, J = 8.9, 3.1 Hz, 1H), 6.95-7.05 (m, 1H), 6.84 (dd, J = 9.2, 4.4 Hz, 1H), 3.83 (s, 3H), 3.70 (s, 3H), 2.14 (s, 3H), 2.11 (t, J = 7.4 Hz, 2H), 1.25-1.40 (m, 2H), 0.64 (t, J = 7.3 Hz, 3H). 1-064 δ 7.75-7.85 (m, 1H), 7.30-7.45 (m , 4H), 6.94 (dd, J = 9.9, 2.4 Hz, 1H), 6.78 (td, J = 8.3, 2.4 Hz, 1H), 3.76 (s, 3H), 2.44 (s, 3H), 2.19 (t, J = 7.2 Hz, 2H), 2.16 (s, 3H), 1.25-1.40 (m, 2H), 0.64 (t, J = 7.3 Hz, 3H). 1-071 δ 7.75-7.85 (m, 1H), 7.40-7.50 (m, 1H), 7.30-7.40 (m, 2H), 6.95-7.00 (m, 1H), 6.80-6.90 (m, 2H), 3.81 (s, 3H), 3.71 (s, 3H), 3.68 (s, 3H), 2.05-2.15 (m, 5H), 1.20-1.40 (m, 2H), 0.63 (t, J = 7.3 Hz, 3H). 1-075 δ 7.75-7.85 (m, 1H), 7.25-7.40 (m, 3H), 7.14 (s, 2H), 3.79 (s, 3H), 3.73 (s, 3H), 2.25 (s, 6H), 2.34 (s, 3H), 2.08 (dt, J = 7.2, 2.1 Hz, 2H), 1.15-1.30 (m, 2H), 0.56 (t, J = 7.5 Hz, 3H). 1-077 58.30 (d, J = 2.7 Hz, 1H), 7.75-7.85 (m, 1H), 7.69 (dd, J = 8.5, 2.7 Hz, 1H), 7.30-7.40 (m, 3H), 6.71 (d, J = 8.5 Hz, 1H), 4.38 (q, J = 7.2 Hz, 2H), 3.78 (s, 3H), 2.24 (s, 3H), 1.95-2.15 (m, 2H), 1.41 (t, J = 7.2 Hz, 3H), 1.15-1.30 (m, 2H), 0.55 (t, J = 7.5, 3H). 1-080 δ 7.75-7.85 (m, 1H), 7.54 (d, J = 8.0 Hz, 1H), 7.35-7.45 (m, 1H), 7.25-7.35 (m, 2H), 6.29 (d, J = 8.0 Hz, 1H), 3.95 (s, 3H), 3.89 (s, 3H), 3.83 (s, 3H), 2.16 (s, 3H), 2.05-2.15 (m, 2H), 1.20-1.35 (m, 2H), 0.63 (t, J = 7.4 Hz, 3H). 1-091 δ 7.75-7.85 (m, 1H), 7.25-7.40 (m, 3H), 7.03 (d, J = 2.1 Hz, 1H), 6.95 (dd, J = 8.4, 2.1 Hz, 1H), 6.82 (d, J = 8.4 Hz, 1H), 4.25 (s, 4H), 3.82 (s, 3H), 3.53 (s, 3H), 2.28 (s, 3H). 1-092 δ 7.75-7.85 (m, 1H), 7.25-7.40 (m, 3H), 7.04 (d, J = 2.1 Hz, 1H), 6.95 (dd, J = 8.4, 2.1 Hz, 1H), 6.81 (d, J = 8.4 Hz, 1H), 4.26 (s, 4H), 3.83 (s, 3H), 2.25 (s, 3H), 1.15 (s, 9H). 1-093 δ 7.70-7.80 (m, 1H), 7.25-7.50 (m, 5H), 7.00-7.20 (m, 2H), 6.85-6.95 (m, 2H), 6.80 (d, J = 8.7 Hz, 1H), 4.27 (s, 4H), 3.86 (s, 3H), 2.29 (s, 3H), 2.25 (s, 3H). 1-094 δ 7.75-7.85 (m, 1H), 7.30-7.45 (m, 3H), 7.05 (d, J = 2.1 Hz, 1H), 6.95 (dd, J = 8.4, 2.1 Hz, 1H), 6.84 (d, J = 8.4 Hz, 1H), 4.28 (s, 4H), 3.80 (s, 3H), 2.47 (s, 3H), 2.28 (s, 3H). 1-098 δ 7.75-7.85 (m, 1H), 7.72 (s, 1H), 7.63 (s, 1H), 7.30-7.40 (m, 3H), 3.83 (s, 3H), 2.30 (s, 3H), 2.10-2.20 (m, 2H), 1.20-1.35 (m, 2H), 0.58 (t, J = 7.5 Hz, 3H). 1-100 δ 7.80-7.90 (m, 1H), 7.25-7.40 (m, 5H), 7.00-7.10 (m, 1H), 3.76 (s, 3H), 2.28 (s, 3H), 2.00-2.20 (m, 2H), 1.15-1.30 (m, 2H), 0.53 (t, J = 7.4 Hz, 3H). 1-102 δ 7.75-7.85 (m, 1H), 7.25-7.40 (m, 4H), 7.24 (dd, J = 8.3, 2.1 Hz, 1H), 6.74 (d, J = 8.3 Hz, 1H), 4.60 (t, J = 8.7 Hz, 2H), 3.79 (s, 3H), 3.22 (t, J = 8.7 Hz, 2H), 2.24 (s, 3H), 2.00-2.15 (m, 2H), 1.15-1.30 (m, 2H), 0.56 (t, J = 7.4 Hz, 3H). 1-104 δ 7.80-7.90 (m, 1H), 7.45-7.50 (m, 1H), 7.30-7.40 (m, 2H), 7.10-7.25 (m, 2H), 6.82 (t, J = 7.7 Hz, 1H), 4.40-4.60 (m, 2H), 3.77 (s, 3H), 3.35 (s, 3H), 3.22 (t, J = 8.7 Hz, 2H), 2.17 (s, 3H). 1-109 δ 9.01 (d, J = 2.4 Hz, 1H), 8.30 (d, J = 2.1 Hz, 1H), 8.07 (d, J = 8.5 Hz, 1H), 7.83-7.89 (m, 1H), 7.80 (dd, J = 8.2 Hz, 1.0 Hz, 1H), 7.70 (td, J = 7.7 Hz, 1.4 Hz, 1H), 7.44-7.57 (m, 2H), 7.35-7.41 (m, 2H), 3.75 (s, 3H), 3.37 (s, 3H), 2.19 (s, 3H). 1-111 δ 7.75-7.90 (m, 1H), 7.20-7.60 (m, 5H), 6.80-7.05 (m, 2H), 5.85-6.00 (m, 1H), 5.05-5.45 (m, 2H), 4.40-4.70 (m, 2H), 3.73 (s, 3H), 3.35 (s, 3H), 2.11 (s, 3H). 1-114 δ 7.80-7.90 (m, 1H), 7.40-7.55 (m, 1H), 7.20-7.40 (m, 4H), 6.80-6.95 (m, 2H), 3.76-3.90 (m, 2H), 3.74 (s, 3H), 3.40 (s, 3H), 2.12 (s, 3H), 1.10-1.25 (m, 1H), 0.45-0.65 (m, 2H), 0.20-0.45 (m, 2H). 1-121 δ 7.80 7.90 (m, 1H), 7.40-7.50 (m, 1H), 7.20-7.40 (m, 4H), 6.85-6.95 (m, 2H), 3.95-4.10 (m, 2H), 3.75 and 3.74 (s, 3H), 3.38 and 3.35 (s, 3H), 2.12 and 2.11 (s, 3H), 1.90-2.10 (m, 1H), 1.40-1.60 (m, 1H), 1.10-1.35 (m, 1H). 1-122 δ 7.80-7.90 (m, 1H), 7.25-7.50 (m, 6H), 6.90-7.05 (m, 2H), 5.05-5.25 (m, 2H), 3.71 (s, 3H), 3.30 (s, 3H), 2.12 (s, 3H). 1-126 δ 7.75-7.85 (m, 1H), 7.25-7.45 (m, 5H), 7.15-7.25 (m, 2H), 3.77 (s, 3H), 2.85-2.95 (m, 1H), 2.22 (s, 3H), 2.00-2.10 (m, 2H), 1.15-1.30 (m, 8H), 0.54 (t, J = 7.3 Hz, 3H). 1-128 δ 7.75-7.85 (m, 1H), 7.30-7.50 (m, 7H), 6.70 (dd, J = 17.6, 10.9 Hz, 1H), 5.77 (dd, J = 17.6, 0.8 Hz, 1H), 5.27 (dd, J = 10.9, 0.8 Hz, 1H), 3.78 (s, 3H), 2.22 (s, 3H), 2.00-2.10 (m, 2H), 1.15-1.30 (m, 2H), 0.54 (t, J = 7.4 Hz, 3H). 1-131 δ 7.75-7.90 (m, 1H), 7.30-7.40 (m, 5H), 7.15-7.25 (m, 2H), 6.39 (brs, 1H), 4.38 (s, 2H), 3.63 (s, 3H), 3.33 (s, 3H), 2.16 (s, 3H). 1-133 δ 7.75-7.85 (m, 1H), 7.25-7.45 (m, 10H), 6.80-6.95 (m, 2H), 6.00 (brs, 1H), 5.04 (s, 2H), 3.68 (s, 3H), 2.18 (s, 3H). 1-135 δ 7.75-7.85 (m, 1H), 7.25-7.45 (m, 10H), 6.90-7.00 (m, 2H), 5.06 (s, 2H), 4.64 (d, J = 5.5 Hz, 1H), 4.42 (d, J = 5.5 Hz, 1H), 3.76 (s, 3H), 3.16 (s, 3H), 2.30 (s, 3H). 1-136 δ 7.75-7.85 (m, 1H), 7.30-7.40 (m, 5H), 6.85-6.95 (m, 2H), 6.24 (brs, 1H), 4.67 (d, J = 2.4 Hz, 2H), 3.67 (s, 3H), 2.54 (t, J = 2.4 Hz, 1H), 2.18 (s, 3H). 1-138 δ 7.80-7.85 (m, 1H), 7.30-7.40 (m, 5H), 6.75-6.85 (m, 2H), 6.13 (s, 1H), 3.90-4.15 (m, 2H), 3.69 (s, 3H), 2.19 (s, 3H), 1.95-2.15 (m, 1H), 1.50-1.65 (m, 1H), 1.15-1.35 (m, 1H). 1-139 δ 7.75-7.90 (m, 1H), 7.30-7.40 (m, 5H), 6.80-6.90 (m, 2H), 5.95-6.15 (m, 2H), 5.35-5.45 (m, 1H), 5.25-5.35 (m, 1H), 4.50-4.55 (m, 2H), 3.71 (s, 3 H), 2.19 (s, 3 H). 1-142 δ 7.80-7.85 (m, 1H), 7.30-7.40 (m, 5H), 6.75-6.90 (m, 2H), 5.95 (brs, 1H), 3.79 (d, J = 6.8 Hz, 2H), 3.73 (s, 3H), 2.20 (s, 3H), 1.20-1.35 (m, 1H), 0.60-0.70 (m, 2H), 0.30-0.40 (m, 2H). 1-143 δ 7.80-7.85 (m, 1H), 7.30-7.40 (m, 5H), 6.75-6.85 (m, 2H), 6.14 (s, 1H), 4.50 (s, 2H), 3.71 (s, 3H), 2.25 (s, 3H), 2.21 (s, 3H). 1-144 δ 7.75-7.85 (m, 1H), 7.44 (s, 1H), 7.30-7.40 (m, 5H), 6.80-6.90 (m, 2H), 6.33 (s, 1H), 5.13 (d, J = 0.7 Hz, 2H), 3.72 (s, 3H), 2.22 (s, 3H). 1-145 δ 10.43 (brs, 1H), 7.90-8.05 (m, 1H), 7.20-7.45 (m, 5H), 6.90-7.00 (m, 2H), 5.75 (s, 1H), 4.62 (s, 2H), 3.85-4.05 (m, 2H), 3.57 (s, 3H), 2.19 (s, 3H). 1-146 δ 7.75-7.85 (m, 1H), 7.20-7.40 (m, 6H), 7.05-7.15 (m, 2H), 3.44 (s, 3H), 3.10 (s, 3H), 2.10 (s, 3H). 1-147 δ 7.80-7.90 (m, 1H), 7.30-7.45 (m, 5H), 7.10-7.20 (m, 2H), 6.40 (s, 1H), 3.59 (s, 3H), 2.19 (s, 3H). 1-148 δ 7.80-7.90 (m, 1H), 7.30-7.45 (m, 5H), 6.85-6.95 (m, 2H), 5.57 (s, 1H), 4.05-4.20 (m, 2H), 3.81 (s, 3H), 3.70-3.80 (m, 2H), 3.45 (s, 3H), 2.24 (s, 3H). 1-150 δ 7.77-7.83 (m, 1H), 7.45 (d, J = 8.9 Hz, 2H), 7.28-7.39 (m, 5H), 7.14 (t, J = 7.5 Hz, 1H), 7.02-7.08 (m, 2H), 6.95 (d, J = 8.9 Hz, 2H), 3.77 (s, 3H), 2.23 (s, 3H), 1.97-2.16 (m, 2H), 1.17-1.30 (m, 2H), 0.55 (t, J = 7.3 Hz, 3H). 1-154 δ 7.73-7.84 (m, 1H), 7.45-7.52 (m, 4H), 7.36-7.42 (m, 1H), 7.28-7.34 (m, 2H), 3.76 (s, 3H), 2.23 (s, 3H), 1.98-2.26 (m, 2H), 1.13-1.28 (m, 2H), 0.52 (t, J = 7.5 Hz, 3H), 0.26 (s, 9H). 1-156 δ 7.75-7.85 (m, 1H), 7.40-7.50 (m, 2H), 7.30-7.40 (m, 2H), 7.15-7.25 (m, 1H), 7.10-7.15 (m, 1H), 3.80 (s, 3H), 3.79 (s, 3H), 2.14 (s, 3H), 2.05-2.15 (m, 2H), 1.25-1.40 (m, 2H), 0.60 (t, J = 7.5 Hz, 3H). 1-157 δ 7.80-7.86 (m, 1H), 7.46-7.53 (m, 2H), 7.30-7.42 (m, 3H), 6.74 (d, J = 9.0 Hz, 1H), 3.75 (s, 3H), 3.66 (s, 3H), 3.33 (s, 3H), 2.14 (s, 3H). 1-161 δ 7.80-7.90 (m, 1H), 7.30-7.50 (m, 6H), 7.10-7.20 (m, 1H), 3.89 (s, 3H), 3.68 (s, 3H), 2.15 (td, J = 7.2, 1.8 Hz, 2H), 1.25-1.40 (m, 2H), 0.61 (t, J = 7.5 Hz, 3H). 1-163 δ 7.80-7.90 (m, 1H), 7.50-7.60 (m, 2H), 7.40-7.50 (m, 1H), 7.30-7.40 (m, 2H), 7.15-7.25 (m, 2H), 3.91 (s, 3H), 3.68 (s, 3H), 2.16 (td, J = 7.2, 2.1 Hz, 2H), 1.25-1.40 (m, 2H), 0.61 (t, J = 7.5 Hz, 3H). 1-165 δ 7.80-7.85 (m, 1H), 7.30-7.50 (m, 7H), 7.10-7.20 (m, 1H), 7.00-7.10 (m, 2H), 6.95-7.00 (m, 2H), 3.89 (s, 3H), 2.16 (td, J = 7.2, 1.5 Hz, 2H), 1.25-1.40 (m, 2H), 0.63 (t, J = 7.4 Hz, 3H). 1-175 δ 7.75-7.85 (m, 1H), 7.20-7.45 (m, 5H), 6.90-7.05 (m, 1H), 3.88 (s, 3H), 3.68 (s, 3H), 2.26 (d, J = 2.1 Hz, 3H), 2.15 (td, J = 7.2, 1.2 Hz, 2H), 1.25-1.45 (m, 2H), 0.62 (t, J = 7.3 Hz, 3H). 1-181 δ 7.75-7.80 (m, 1H), 7.35-7.45 (m, 1H), 7.20-7.35 (m, 3H), 6.40-6.50 (m, 2H), 3.82 (s, 6H), 3.74 (s, 3H), 3.69 (s, 3H), 2.14 (t, J = 7.4 Hz, 2H), 1.30-1.45 (m, 2H), 0.68 (t, J = 7.5 Hz, 3H). 1-185 δ 7.80-7.85 (m, 1H), 7.30-7.50 (m, 3H), 6.69 (d, J = 2.1 Hz, 2H), 6.43 (t, J = 2.1 Hz, 1H), 3.89 (s, 3H), 3.75 (s, 6H), 3.69 (s, 3H), 2.17 (t, J = 7.3 Hz, 2H), 1.25-1.40 (m, 2H), 0.60 (t, J = 7.5 Hz, 3H). 1-188 δ 7.80-7.90 (m, 1H), 7.30-7.45 (m, 3H), 6.80-6.90 (m, 2H), 5.81 (brs, 1H), 3.90 (s, 3H), 3.60 (s, 3H), 2.28 (s, 3H), 2.80 (s, 6H). 1-189 δ 7.80-7.85 (m, 1H), 7.25-7.45 (m, 3H), 6.80-6.90 (m, 2H), 3.82 (s, 3H), 3.62 (s, 3H), 2.36 (s, 3H), 2.25-2.30 (m, 8H), 1.35-1.50 (m, 2H), 0.73 (t, J = 7.5 Hz, 3H). 1-191 δ 7.75-7.85 (m, 1H), 7.60-7.65 (m, 1H), 7.40-7.45 (m, 1H), 7.25-7.40 (m, 3H), 6.50-6.55 (m, 1H), 3.93 (s, 3H), 3.73 (s, 3H), 2.10-2.20 (m, 2H), 1.25-1.40 (m, 2H), 0.60 (t, J = 7.3 Hz, 3H). 1-195 δ 7.75-7.90 (m, 1H), 7.50-7.60 (m, 1H), 7.40-7.50 (m, 2H), 7.20-7.40 (m, 4H), 6.81 (d, J = 1.0 Hz, 1H), 3.95 (s, 3H), 3.77 (s, 3H), 2.14 (t, J = 7.2 Hz, 2H), 1.20-1.35 (m, 2H), 0.58 (t, J = 7.5 Hz, 3H). 1-197 δ 7.70-7.85 (m, 3H), 7.49 (s, 1H), 7.25-7.45 (m, 5H), 3.94 (s, 3H), 3.75 (s, 3H), 2.18 (t, J = 7.2 Hz, 2H), 1.25-1.40 (m, 2H), 0.60 (t, J = 7.4 Hz, 3H). 1-200 δ 7.82-7.88 (m, 1H), 7.34-7.38 (m, 3H), 7.28 (d, J = 8.9 Hz, 2H), 6.70 (d, J = 8.9 Hz, 2H), 5.90 (brs, 1H), 5.55 (brs, 1H), 3.81 (s, 3H), 2.27 (s, 3H). 1-202 δ 7.80-7.87 (m, 1H), 7.48 (d, J = 8.5 Hz, 2H), 7.31-7.42 (m, 3H), 7.09 (d, J = 8.5 Hz, 2H), 6.53 (t, J = 73.6 Hz, 1H), 4.74 (d, J = 5.8 Hz, 1H), 4.54 (d, J = 5.8 Hz, 1H), 3.75 (s, 3H), 3.42-3.48 (m, 2H), 3.24-3.30 (m, 2H), 3.23 (s, 3H), 2.29 (s, 3H). 1-203 δ 7.75-7.85 (m, 1H), 7.20-7.40 (m, 5H), 6.70-6.80 (m, 3H), 6.06 (tt, J = 55.2, 4.2 Hz, 1H), 4.13 (td, J = 13.1, 4.2 Hz, 2H), 3.54 (s, 3H), 2.12 (s, 3H). 1-204 δ 7.80-7.90 (m, 1H), 7.30-7.45 (m, 5H), 6.80-6.95 (m, 2H), 5.59 (s, 1H), 4.30 (t, J = 6.3 Hz, 2H), 3.78 (s, 3H), 3.64 (t, J = 6.3 Hz, 2H), 2.24 (s, 3H). 1-205 δ 7.75-7.90 (m, 1H), 7.25-7.45 (m, 5H), 6.80-6.90 (m, 2H), 4.45-4.75 (m, 2H), 4.29 (t, J = 6.3 Hz, 2H), 3.77 (s, 3H), 3.64 (t, J = 6.3 Hz, 2H), 3.40-3.50 (m, 2H), 3.25-3.35 (m, 2H), 3.24 (s, 3H), 2.28 (s, 3H). 1-206 δ 7.80-7.90 (m, 1H), 7.30-7.45 (m, 5H), 6.80-6.90 (m, 2H), 5.54 (s, 1H), 4.20 (t, J = 6.6 Hz, 2H), 3.79 (s, 3H), 2.55-2.75 (m, 2H), 2.24 (s, 3H). 1-208 δ 7.80-7.90 (m, 1H), 7.30-7.45 (m, 5H), 6.80-6.95 (m, 2H), 5.60-5.70 (m, 1H), 5.05-5.15 (m, 1H), 4.95-5.05 (m, 1H), 4.43 (s, 2H), 3.78 (s, 3H), 2.23 (s, 3H), 1.83 (s, 3H). 1-209 δ 7.75-7.85 (m, 1H), 7.25-7.45 (m, 5H), 6.85-6.90 (m, 2H), 4.95-5.15 (m, 2H), 4.45-4.75 (m, 2H), 4.43 (s, 2H), 3.77 (s, 3H), 3.40-3.50 (m, 2H), 3.25-3.30 (m, 2H), 3.23 (s, 3H), 2.28 (s, 3H), 1.83 (s, 3H). 1-211 δ 7.80-7.90 (m, 1H), 7.30-7.40 (m, 5H), 6.80-6.90 (m, 2H), 5.80-5.95 (m, 1H), 5.60-5.80 (m, 2H), 4.40-4.50 (m, 2H), 3.75 (s, 3H), 2.21 (s, 3H), 1.70-1.80 (m, 3H). 1-212 δ 7.75-7.85 (m, 1H), 7.25-7.45 (m, 5H), 6.80-6.90 (m, 2H), 5.80-5.95 (m, 1H), 5.65-5.80 (m, 1H), 4.40-4.75 (m, 4H), 3.76 (s, 3H), 3.40-3.50 (m, 2H), 3.25-3.30 (m, 2H), 3.23 (s, 3H), 2.27 (s, 3H), 1.70-1.80 (m, 3H). 1-214 δ 7.75-7.85 (m, 1H), 7.25-7.40 (m, 5H), 6.80-6.90 (m, 2H), 5.75-5.95 (m, 1H), 5.05-5.20 (m, 2H), 4.50-4.75 (m, 2H), 4.35-4.50 (m, 1H), 3.77 (s, 3H), 3.40-3.50 (m, 2H), 3.25-3.35 (m, 2H), 3.23 (s, 3H), 2.30-2.60 (m, 2H), 2.28 (s, 3H), 1.32 (d, J = 6.1 Hz, 3H). 1-216 δ 7.75-7.85 (m, 1H), 7.25-7.45 (m, 5H), 6.80-6.95 (m, 2H), 5.95-6.05 (m, 1H), 5.65-5.70 (m, 1H), 4.45-4.80 (m, 4H), 3.77 (s, 3H), 3.40-3.50 (m, 2H), 3.25-3.35 (m, 2H), 3.24 (s, 3H), 2.28 (s, 3H). 1-217 δ 7.79-7.87 (m, 1H), 7.30-7.41 (m, 5H), 6.92-6.99 (m, 2H), 6.82(brs, 1H), 4.80-4.91 (m, 1H), 3.72-3.76 (m, 3H), 2.49-2.51 (m, 1H), 2.20-2.23 (m, 3H), 1.67 (d, J = 6.5 Hz, 3H). 1-218 δ 7.77-7.85 (m, 1H), 7.27-7.44 (m, 5H), 6.93-7.00 (m, 2H), 4.81-4.91 (m, 1H), 4.72 (d, J = 5.8 Hz, 1H), 4.51 (d, J = 5.8 Hz, 1H), 3.75-3.78 (s, 3H), 3.41-3.47 (m, 2H), 3.24-3.30 (m, 2H), 3.23 (s, 3H), 2.48-2.50 (m, 1H), 2.26-2.29 (m, 3H), 1.66 (d, J = 6.5 Hz, 3H). 1-220 δ 7.75-7.85 (m, 1H), 7.25-7.45 (m, 5H), 6.90-6.95 (m, 2H), 4.45-4.75 (m, 4H), 3.77 (s, 3H), 3.40-3.50 (m, 2H), 3.25-3.35 (m, 2H), 3.23 (s, 3H), 2.28 (s, 3H), 1.87 (t, J = 2.2 Hz, 3H). 1-221 δ 7.76-7.83 (m, 1H), 7.39 (d, J = 8.9 Hz, 2H), 7.25-7.37 (m, 3H), 6.86 (d, J = 8.9 Hz, 2H), 4.72 (d, J = 5.8 Hz, 1H), 4.51 (d, J = 5.8 Hz, 1H), 4.14 (t, J = 6.8 Hz, 2H), 3.76 (s, 3H), 3.41-3.47 (m, 2H), 3.24-3.30 (m, 2H), 3.22 (s, 3H), 2.86 (t, J = 6.8 Hz, 2H), 2.28 (s, 3H), 2.20 (s, 3H). 1-223 δ 7.79-7.87 (m, 1H), 7.30-7.39 (m, 5H), 6.86 (d, J = 8.9 Hz, 2H), 5.75 (brs, 1H), 5.07 (t, J = 4.8 Hz, 1H), 4.06-4.16 (m, 2H), 3.93-4.02 (m, 2H), 3.83-3.92 (m, 2H), 3.77 (s, 3H), 2.22 (s, 3H), 2.09-2.19 (m, 2H). 1-224 δ 7.76-7.86 (m, 1H), 7.27-7.41 (m, 5H), 6.85 (d, J = 8.9 Hz, 2H), 5.05-5.10 (m, 1H), 4.71 (d, J = 5.8 Hz, 1H), 4.58 (d, J = 5.8 Hz, 1H), 4.50 (d, J = 5.8 Hz, 1H), 4.08-4.15 (m, 2H), 3.93-4.02 (m, 2H), 3.83-3.92 (m, 2H), 3.76 (s, 3H), 3.40-3.48 (m, 2H), 3.24-3.31 (m, 2H), 3.23 (s, 3H), 2.27 (s, 3H), 2.11-2.20 (m, 2H). 1-225 δ 7.75-7.85 (m, 1H), 7.25-7.75 (m, 5H), 6.85-6.95 (m, 2H), 4.45-4.75 (m, 2H), 4.30-4.40 (m, 2H), 4.15-4.25 (m, 2H), 3.77 (s, 3H), 3.40-3.50 (m, 2H), 3.25-3.35 (m, 2H), 3.23 (s, 3H), 1.88 (s, 6H), 1.86 (s, 3H). 1-229 δ 7.75-7.85 (m, 1H), 7.25-7.40 (m, 5H), 6.80-6.95 (m, 2H), 4.45-4.75 (m, 3H), 3.77 (d, J = 0.9 Hz, 3H), 3.45-3.60 (m, 4H), 3.41 (s, 3H), 3.25-3.35 (m, 2H), 3.24 (s, 3H), 2.28 (d, J = 1.2 Hz, 3H), 1.25-1.35 (m, 3H). 1-231 δ 7.75-7.85 (m, 1H), 7.25-7.40 (m, 5H), 6.80-6.90 (m, 2H), 4.45-4.75 (m, 2H), 3.95-4.00 (m, 2H), 3.77 (s, 3H), 3.47 (s, 3H), 3.35-3.50 (m, 3H), 3.25-3.35 (m, 2H), 3.23 (s, 3H), 2.28 (d, J = 0.6 Hz, 3H), 1.60-1.75 (m, 2H), 0.99 (t, J = 7.4 Hz, 3H). 1-233 δ 7.77-7.85 (m, 1H), 7.41 (d, J = 8.9 Hz, 2H), 7.26-7.38 (m, 3H), 6.86 (d, J = 8.9 Hz, 2H), 4.72 (d, J = 5.8 Hz, 1H), 4.63 (s, 2H), 4.51 (d, J = 5.8 Hz, 1H), 3.80 (s, 3H), 3.76 (s, 3H), 3.41-3.47 (m, 2H), 3.24-3.30 (m, 2H), 3.23 (s, 3H), 2.28 (s, 3H). 1-235 δ 7.75-7.85 (m, 1H), 7.25-7.42 (m, 5H), 6.82 (d, J = 8.5 Hz, 2H), 4.75 (q, J = 6.8 Hz, 1H), 4.71 (dd, J = 5.6, 0.9 Hz, 1H), 4.50 (dd, J = 5.6, 0.9 Hz, 1H), 3.76 (s, 3H), 3.73 (s, 3H), 3.40-3.47 (m, 2H), 3.23-3.30 (m, 2H), 3.22 (s, 3H), 2.27 (s, 3H), 1.61 (d, J = 6.8 Hz, 3H). 1-236 δ 7.76-7.84 (m, 1H), 7.24-7.37 (m, 5H), 6.85 (d, J = 8.9 Hz, 2H), 6.80 (brs, 1H), 4.77-4.89 (m, 1H), 3.54-3.58 (m, 3H), 2.14-2.16 (m, 3H), 1.75 (d, J = 6.8 Hz, 3H). 1-237 δ 7.78-7.85 (m, 1H), 7.46 (d, J = 8.5 Hz, 2H), 7.28-7.41 (m, 3H), 6.96 (d, J = 8.5 Hz, 2H), 4.83-4.94 (m, 1H), 4.69-4.76 (m, 1H), 4.49-4.57 (m, 1H), 3.74-3.78 (m, 3H), 3.41-3.48 (m, 2H), 3.23-3.30 (m, 2H), 3.22 (s, 3H), 2.27-2.30 (m, 3H), 1.72-1.80 (m, 3H). 1-241 δ 7.75-7.90 (m, 1H), 7.20-7.40 (m, 7H), 6.33 (s, 1H), 5.85-6.00 (m, 1H), 5.15-5.35 (m, 2H), 4.47 (s, 2H), 3.95-4.05 (m, 2H), 3.61 (s, 3H), 2.14 (s, 3H). 1-242 δ 7.80-7.90 (m, 1H), 7.30-7.45 (m, 5H), 7.15-7.25 (m, 2H), 3.72 (d, J = 2.4 Hz, 3H), 3.56 (s, 2H), 3.25-3.30 (m, 3H), 2.14 (s, 3H). 1-244 δ 7.80-7.90 (m, 1H), 7.25-7.45 (m, 7H), 3.76 (s, 3H), 3.73 (s, 2H), 3.32 (s, 3H), 2.70-2.90 (m, 1H), 2.20 (s, 3H), 1.20-1.30 (m, 6H). 1-245 δ 7.80-7.90 (m, 1H), 7.20-7.45 (m, 7H), 5.70-5.90 (m, 1H), 5.62 (s, 1H), 5.00-5.20 (m, 2H), 3.76 (s, 3H), 3.65 (s, 2H), 3.03 (dt, J = 7.2, 1.0 Hz, 2H), 2.22 (s, 3H). 1-246 δ 7.80-7.90 (m, 1H), 7.25-7.45 (m, 7H), 5.70-5.95 (m, 1H), 5.00-5.20 (m, 2H), 3.76 (s, 3H), 3.65 (s, 2H), 3.32 (s, 3H), 3.00-3.10 (m, 2H), 2.20 (s, 3H). 1-247 δ 7.85-7.90 (m, 1H), 7.25-7.45 (m, 7H), 5.55 (s, 1H), 3.86 (s, 2H), 3.77 (s, 3H), 3.09 (d, J = 2.6 Hz, 2H), 2.29 (t, J = 2.6 Hz, 1H), 2.23 (s, 3H). 1-248 δ 7.80-7.90 (m, 1H), 7.25-7.50 (m, 7H), 3.86 (s, 2H), 3.76 (s, 3H), 3.33 (s, 3H), 3.09 (d, J = 2.7 Hz, 2H), 2.25-2.30 (m, 1H), 2.21 (s, 3H). 1-250 δ 7.80-7.90 (m, 1H), 7.25-7.50 (m, 7H), 3.82 (s, 2H), 3.76 (s, 3H), 3.33 (s, 3H), 2.91 (q, J = 10.1 Hz, 2H), 2.21 (s, 3H). 1-251 δ 7.80-7.90 (m, 1H), 7.30-7.40 (m, 5H), 7.20-7.30 (m, 2H), 5.95 (brs, 1H), 3.73 (s, 2H), 3.72 (s, 3H), 3.48 (t, J = 6.6 Hz, 2H), 3.31 (s, 3H), 2.59 (t, J = 6.6 Hz, 2H), 2.20 (s, 3H). 1-252 δ 7.80-7.90 (m, 1H), 7.25-7.50 (m, 7H), 3.76 (s, 3H), 3.75 (s, 2H), 3.51 (t, J = 6.5 Hz, 2H), 3.33 (s, 3H), 3.32 (s, 3H), 2.61 (t, J = 6.5 Hz, 2H), 2.21 (s, 3H). 1-253 δ 7.80-7.90 (m, 1H), 7.25-7.45 (m, 7H), 5.63 (brs, 1H), 3.76 (s, 3H), 3.74 (s, 2H), 2.60-2.70 (m, 4H), 2.23 (s, 3H), 2.06 (s, 3H). 1-254 δ 7.80-7.90 (m, 1H), 7.25-7.50 (m, 7H), 3.76 (s, 3H), 3.74 (s, 2H), 3.32 (s, 3H), 2.55-2.70 (m, 4H), 2.21 (s, 3H), 2.07 (s, 3H). 1-255 δ 7.80-7.90 (m, 1H), 7.25-7.45 (m, 7H), 5.99 (brs, 1H), 4.54 (s, 2H), 3.71 (s, 3H), 3.50-3.65 (m, 4H), 3.37 (s, 3H), 2.19 (s, 3H). 1-256 δ 7.80-7.90 (m, 1H), 7.30-7.50 (m, 7H), 4.57 (s, 2H), 3.76 (s, 3H), 3.55-3.70 (m, 4H), 3.40 (s, 3H), 3.31 (s, 3H), 2.20 (s, 3H). 2-003 δ 7.75 (dd, J = 8.9, 4.8 Hz, 1H), 7.40-7.50 (m, 2H), 7.00-7.15 (m, 4H), 3.75 (s, 3H), 3.20-3.40 (m, 2H), 3.11 (s, 3H), 2.25-2.45 (m, 2H), 2.24 (s, 3H). 2-004 δ 7.70-7.80 (m, 1H), 7.40-7.50 (m, 2H), 6.95-7.15 (m, 4H), 3.85-4.05 (m, 2H), 3.79 (s, 3H), 2.26 (s, 3H), 1.02 (t, J = 7.2 Hz, 3H). 2-005 δ 7.72 (dd, J = 8.7, 4.9 Hz, 1H), 7.35-7.45 (m, 4H), 6.95-7.25 (m, 6H), 3.82 (s, 3H), 2.32 (s, 3H). 2-010 δ 7.75 (dd, J = 8.9, 4.8 Hz, 1H), 7.24-7.26 (m, 4H), 7.07-7.16 (m, 1H), 6.94-7.01 (m, 1H), 6.31 (brs, 1H), 3.63 (s, 3H), 2.19 (s, 3H). 2-016 δ 7.70-7.74 (m, 1H), 7.36-7.40 (m, 2H), 7.15-7.18 (m, 2H), 7.01-7.10 (m, 2H), 3.77 (s, 3H), 2.65 (q, J = 7.5 Hz, 2H), 2.22 (s, 3H), 2.07-2.13 (m, 2H), 1.21-1.33 (m, 5H), 0.57 (t, J = 7.5 Hz, 3H). 2-017 δ 7.70-7.75 (m, 1H), 7.32-7.41 (m, 4H), 7.01-7.10 (m, 2H), 3.76 (s, 3H), 2.24 (s, 3H), 2.08-2.14 (m, 2H), 1.31 (s, 9H), 1.20-1.29 (m, 2H), 0.56 (t, J = 7.5 Hz, 3H). 2-019 δ 7.74 (dd, J = 8.9, 4.6 Hz, 1H), 7.35-7.50 (m, 4H), 7.00-7.15 (m, 2H), 6.70 (dd, J = 17.6, 10.9 Hz, 1H), 5.77 (dd, J = 17.6, 0.8 Hz, 1H), 5.29 (dd, J = 10.9, 0.8 Hz, 1H), 3.78 (s, 3H), 2.23 (s, 3H), 2.05-2.15 (m, 2H), 1.20-1.35 (m, 2H), 0.57 (t, J = 7.5 Hz, 3H). 2-023 δ 7.70-7.80 (m, 1H), 7.40-7.50 (m, 2H), 7.25-7.35 (m, 2H), 7.00-7.15 (m, 2H), 4.46 (s, 2H), 3.78 (s, 3H), 3.40 (s, 3H), 2.21 (s, 3H), 2.10 (td, J = 7.3, 2.3 Hz, 2H), 1.20-1.35 (m, 2H), 0.57 (t, J = 7.4 Hz, 3H). 2-025 δ 7.65-7.75 (m, 1H), 7.30-7.40 (m, 2H), 7.00-7.15 (m, 2H), 6.85-7.00 (m, 2H), 3.83 (s, 3H), 3.72 (s, 3H), 2.05-2.15 (m, 5H), 1.25-1.40 (m, 2H), 0.65 (t, J = 7.5 Hz, 3H). 2-027 δ 7.65-7.75 (m, 1H), 7.35-7.45 (m, 2H), 6.95-7.10 (m, 2H), 6.80-6.90 (m, 2H), 3.81 (s, 3H), 3.77 (s, 3H), 2.22 (s, 3H), 1.95-2.15 (m, 2H), 1.20-1.35 (m, 2H), 0.57 (t, J = 7.5 Hz, 3H). 2-029 δ 7.65-7.75 (m, 1H), 7.20-7.35 (m, 2H), 7.00-7.15 (m, 2H), 6.85-6.95 (m, 2H), 4.05 (q, J = 7.2 Hz, 2H), 3.83 (s, 3H), 2.05-2.20 (m, 5H), 1.25-1.40 (m, 5H), 0.65 (t, J = 7.2 Hz, 3H). 2-033 δ 7.72 (dd, J = 8.7, 4.9 Hz, 1H), 7.35-7.45 (m, 2H), 7.00-7.15 (m, 2H), 6.80-6.90 (m, 2H), 3.93 (t, J = 6.7 Hz, 2H), 3.79 (s, 3H), 2.24 (s, 3H), 2.05-2.15 (m, 2H), 1.75-1.90 (m, 2H), 1.20-1.35 (m, 2H), 1.04 (t, J = 7.5 Hz, 3H), 0.58 (t, J = 7.3 Hz, 3H). 2-035 δ 7.72 (dd, J = 8.7, 4.9 Hz, 1H), 7.35-7.45 (m, 2H), 7.00-7.15 (m, 2H), 6.80-6.90 (m, 2H), 4.50-4.65 (m, 1H), 3.79 (s, 3H), 2.24 (s, 3H), 2.05-2.15 (m, 2H), 1.25-1.40 (m, 8H), 0.58 (t, J = 7.5 Hz, 3H). 2-037 δ 7.72 (dd, J = 8.7, 4.9 Hz, 1H), 7.35-7.45 (m, 2H), 7.00-7.15 (m, 2H), 6.80-6.90 (m, 2H), 3.97 (t, J = 6.7 Hz, 2H), 3.79 (s, 3H), 2.24 (s, 3H), 2.05-2.15 (m, 2H), 1.70-1.85 (m, 2H), 1.40-1.55 (m, 2H), 1.20-1.35 (m, 2H), 0.98 (t, J = 7.3 Hz, 3H), 0.58 (t, J = 7.5 Hz, 3H). 2-038 δ 7.68-7.73 (m, 1H), 7.35-7.40 (m, 2H), 7.00-7.09 (m, 2H), 6.82-6.87 (m, 2H), 3.94 (t, J = 6.9 Hz, 2H), 3.77 (s, 3H), 2.22 (s, 3H), 2.07-2.13 (m, 2H), 1.74-1.83 (m, 2H), 1.33-1.46 (m, 4H), 1.26 (q, J = 7.8 Hz, 2H), 0.93 (t, J = 7.2 Hz, 3H), 0.57 (t, 7.5 Hz, 3H). 2-039 δ 7.67 (dd, J = 8.8, 4.8 Hz, 1H), 7.10-7.25 (m, 2H), 7.03 (td, J = 8.8, 2.4 Hz, 1H), 6.92 (dd, J = 9.5, 2.4 Hz, 1H), 6.65-6.80 (m, 2H) 5.54 (brs, 1H), 4.60-4.80 (m, 1H), 3.58 (s, 3H), 2.12 (s, 3H), 1.55-2.00 (m, 8H). 2-041 δ 7.68-7.73 (m, 1H), 7.36-7.39 (m, 2H), 7.00-7.09 (m, 2H), 6.83-6.87 (m, 2H), 3.95 (t, J = 6.6 Hz, 2H), 3.77 (s, 3H), 2.22 (s, 3H), 2.07-2.13 (m, 2H), 1.73-1.80 (m, 2H), 1.23-1.51 (m, 8H), 0.88-0.93 (m, 3H), 0.57 (t, J = 7.2 Hz, 3H). 2-044 δ 7.70-7.80 (m, 1H), 7.30-7.50 (m, 3H), 7.05-7.30 (m, 3H), 3.77 (s, 3H), 2.10-2.20 (m, 5H), 1.25-1.40 (m, 2H), 0.63 (t, J = 7.4 Hz, 3H). 2-047 δ 7.73 (dd, J = 8.8, 4.8 Hz, 1H), 7.25-7.35 (m, 2H), 7.09 (td, J = 8.8, 2.4 Hz, 1H).6.98 (dd, J = 9.5, 2.4 Hz, 1H), 6.75-6.90 (m, 2H), 6.29 (brs, 1H), 4.60-4.95 (m, 2H), 4.10-4.35 (m, 2H), 3.68 (s, 3H), 2.19 (s, 3H). 2-051 δ 7.73 (dd, J = 8.8, 4.8 Hz, 1H), 7.28-7.34 (m, 2H), 7.09 (td, J = 8.8, 2.6 Hz, 1H), 6.99 (dd, J = 9.4, 2.6 Hz, 1H), 6.75-6.90 (m, 2H), 6.22 (brs, 1H), 5.95-6.15 (m, 1H), 5.25-5.50 (m, 2H), 4.50-4.60 (m, 2H), 3.69 (s, 3H), 2.19 (s, 3H). 2-053 δ 7.72 (dd, J = 8.8, 4.8 Hz, 1H), 7.25-7.35 (m, 2H), 7.08 (td, J = 8.8, 2.4 Hz, 1H), 6.97 (dd, J = 9.5, 2.4 Hz, 1H), 6.80-6.95 (m, 2H), 4.69 (d, J = 2.4 Hz, 2H), 3.65 (s, 3H), 2.56 (t, J = 2.4 Hz, 1H), 2.18 (s, 3H). 2-054 δ 7.75 (dd, J = 8.5, 4.8 Hz, 1H), 7.35-7.45 (m, 2H), 7.00-7.15 (m, 2H), 6.90-7.00 (m, 2H), 4.70 (d, J = 2.4 Hz, 2H), 3.95-4.30 (m, 2H), 3.77 (s, 3H), 2.54 (t, J = 2.6 Hz, 1H), 2.36 (t, J = 2.6 Hz, 1H), 2.29 (s, 3H). 2-055 δ 7.75 (dd, J = 8.9, 4.8 Hz, 1H), 7.35-7.50 (m, 2H), 7.00-7.20 (m, 2H), 6.85-7.00 (m, 2H), 4.50-4.80 (m, 4H), 3.77 (s, 3H), 3.40-3.55 (m, 2H), 3.25-3.35 (m, 2H), 3.25 (s, 3H), 2.55 (t, J = 2.4 Hz, 1H), 2.29 (s, 3H). 2-056 δ 7.71 (dd, J = 8.8, 4.8 Hz, 1 H) 7.20-7.30 (m, 2H), 7.06 (td, J = 8.8, 2.4 Hz, 1 H) 6.95 (dd, J = 9.6, 2.4 Hz, 1 H), 6.75-6.85 (m, 2 H), 4.90 (brs, 1H), 4.00-4.15 (m, 2H), 3.70-3.75 (m, 2H), 3.65 (s, 3H), 3.41 (s, 3H), 2.16 (s, 3H). 2-057 δ 7.75 (dd, J = 8.5, 4.8 Hz, 1H), 7.30-7.50 (m, 2H), 7.00-7.15 (m, 2H), 6.80-7.00 (m, 2H), 4.00-4.20 (m, 2H), 3.65-3.90 (m, 5H), 3.45 (s, 3H), 3.33 (s, 3H), 2.21 (s, 3H). 2-058 δ 7.69 (dd, J = 8.9, 4.8 Hz, 1H), 7.15-7.25 (m, 2H), 6.70-7.10 (m, 5H), 4.00-4.20 (m, 2H), 3.60 (s, 3H), 2.86 (t, J = 6.8 Hz, 2H), 2.20 (s, 3H), 2.15 (s, 3H). 2-059 δ 7.73 (dd, J = 8.9, 4.8 Hz, 1H), 7.35-7.40 (m, 2H), 7.00-7.15 (m, 2H), 6.80-6.90 (m, 2H), 4.74 (d, J = 5.8 Hz, 1H), 4.54 (d, J = 5.5 Hz, 1H), 4.15 (t, J = 6.6 Hz, 2H), 3.76 (s, 3H), 3.40-3.50 (m, 2H), 3.25-3.30 (m, 2H), 3.23 (s, 3H), 2.87 (t, J = 6.6 Hz, 2H), 2.28 (s, 3H), 2.20 (s, 3H). 2-060 δ 7.73 (dd, J = 8.9, 4.6 Hz, 1H), 7.25-7.40 (m, 2H), 7.08 (td, J = 8.9, 2.5 Hz, 1H), 6.99 (dd, J = 9.4, 2.5 Hz, 1H), 6.75-6.90 (m, 2H), 6.52 (s, 1H), 3.79 (d, J = 7.2 Hz, 2H), 3.73 (s, 3H), 2.20 (s, 3H), 1.15-1.35 (m, 1H), 0.60-0.70 (m, 2H), 0.25-0.45 (m, 2H). 2-066 δ 7.71 (dd, J = 8.8, 4.8 Hz, 1H), 7.20-7.35 (m, 2H), 7.08 (td, J = 8.8, 2.4 Hz, 1H), 6.94 (dd, J = 9.2, 2.4 Hz, 1H), 6.80-6.90 (m, 2H), 6.78 (brs, 1H), 4.73 (s, 2H), 3.58 (s, 3H), 2.15 (s, 3H). 2-067 δ 7.76 (dd, J = 8.5, 4.8 Hz, 1H), 7.40-7.55 (m, 2H), 7.00-7.20 (m, 2H), 6.90-7.00 (m, 2H), 4.50-4.80 (m, 4H), 3.76 (s, 3H), 3.45-3.50 (m, 2H), 3.25-3.35 (m, 2H), 3.25 (s, 3H), 2.30 (s, 3H). 2-068 δ 7.75 (dd, J = 8.9, 4.6 Hz, 1H), 7.30-7.40 (m, 2H), 7.10 (td, J = 8.9, 2.5 Hz, 1H), 7.00 (dd, J = 9.4, 2.5 Hz, 1H), 6.75-6.90 (m, 2H), 6.22 (brs, 1H), 4.52 (s, 2H), 3.71 (s, 3H), 2.26 (s, 3H), 2.21 (s, 3H). 2-069 δ 7.67 (dd, J = 8.9, 4.8 Hz, 1H), 7.15-7.25 (m, 2H), 7.03 (td, J = 8.9, 2.4 Hz, 1H), 6.90 (dd, J = 9.5, 2.4 Hz, 1H), 6.70-6.80 (m, 2H), 4.79 and 4.47 (s, 2H), 3.88 and 3.86 (s, 3H), 3.52 (s, 3H), 2.11 and 2.10 (s, 3H), 1.93 and 1.92 (s, 3H). 2-071 δ 7.70-7.77 (m, 1H), 7.39 (d, J = 8.9 Hz, 2H), 6.99-7.13 (m, 2H), 6.86 (d, J = 8.9 Hz, 2H), 4.71-4.75 (m, 1H), 4.63 (s, 2H), 4.52-4.56 (m, 1H), 3.80 (s, 3H), 3.74 (s, 3H), 3.43-3.49 (m, 2H), 3.26-3.32 (m, 2H), 3.23 (s, 3H), 2.28 (s, 3H). 2-073 δ 7.65-7.80 (m, 1H), 7.40-7.50 (m, 2H), 7.30-7.40 (m, 2H), 7.00-7.20 (m, 5H), 6.90-7.00 (m, 2H), 3.77 (s, 3H), 2.23 (s, 3H), 2.11 (td, J = 7.2, 3.9 Hz, 2H), 1.20-1.35 (m, 2H), 0.50-0.65 (m, 3H). 2-080 δ 7.75 (dd, J = 8.5, 4.8 Hz, 1H), 7.60-7.70 (m, 2H), 7.45-7.55 (m, 2H), 7.00-7.15 (m, 2H), 4.01 (s, 3H), 3.79 (s, 3H), 2.23 (s, 3H), 2.22 (s, 3H), 2.00-2.15 (m, 2H), 1.20-1.35 (m, 2H), 0.57 (t, J = 7.3 Hz, 3H). 2-096 δ 7.71 (d, J = 8.6 Hz, 1H), 7.39 (d, J = 2.2 Hz, 1H), 7.25-7.35 (m, 2H), 6.60-6.70 (m, 2H), 3.82 (s, 3H), 3.74 (s, 3H), 2.15 (s, 3H), 2.10-2.20 (m, 2H), 1.20-1.45 (m, 2H), 0.65 (t, J = 7.5H, 3H). 2-106 δ 7.73 (d, J = 8.6 Hz, 1H), 7.41 (d, J = 2.1 Hz, 1H), 7.15-7.35 (m, 3H), 6.80-6.95 (m, 2H), 4.03 (q, J = 6.9 Hz, 2H), 3.75 (s, 3H), 3.36 (s, 3H), 2.11 (s, 3H), 1.31 (t, J = 6.9 Hz, 3H). 2-108 δ 7.70 (d, J = 8.5 Hz, 1H), 7.25-7.40 (m, 4H), 6.80-6.85 (m, 2H), 4.45-4.60 (m, 1H), 3.78 (s, 3H), 2.23 (s, 3H), 2.10 (td, J = 7.2, 1.7 Hz, 2H), 1.20-1.40 (m, 8H), 0.58 (t, J = 7.3 Hz, 3H). 2-110 δ 7.70 (d, J = 8.5 Hz, 1H), 7.25-7.45 (m, 4H), 6.80-6.90 (m, 2H), 3.96 (t, J = 6.5 Hz, 2H), 3.78 (s, 3H), 2.23 (s, 3H), 2.10 (td, J = 7.2, 2.2 Hz, 2H), 1.65-1.85 (m, 2H), 1.40-1.55 (m, 2H), 1.20-1.35 (m, 2H), 0.97 (t, J = 7.16 Hz, 3H), 0.58 (t, J = 7.5 Hz, 3H). 2-114 δ 7.71 (d, 7.8 Hz, 1H), 7.25-7.35 (m, 3H), 6.55-6.70 (m, 2H), 3.95-4.10 (m, 2H), 3.83 (s, 3H), 3.67 (s, 3H), 3.35-3.45 (m, 2H), 3.27 (s, 3H), 2.18 (s, 3H). 2-117 δ 7.75-7.80 (m, 1H), 7.30-7.40 (m, 2H), 7.15-7.25 (m, 2H), 6.85-7.00 (m, 1H), 5.38 (s, 1H), 3.91 (s, 3H), 3.82 (s, 3H), 2.28 (s, 3H). 2-120 δ 7.70 (d, J = 8.5 Hz, 1H), 7.20-7.35 (m, 4H), 6.70-6.80 (m, 1H), 3.83 (s, 3H), 3.78 (s, 3H), 2.24 (s, 3H), 2.19 (s, 3H), 2.11 (td, J = 7.2, 2.0 Hz, 2H), 1.20-1.36 (m, 2H), 0.58 (t, J = 7.3 Hz, 3H). 2-123 δ 7.70-7.80 (m, 1H), 7.25-7.35 (m, 2H), 6.95-7.10 (m, 2H), 6.82 (d, J = 8.5 Hz, 1H), 5.63 (brs, 1H), 3.89 (s, 3H), 3.76 (s, 3H), 3.75 (s, 3H), 2.24 (s, 3H). 2-124 δ 7.72 (d, J = 8.5 Hz, 1H), 7.25-7.40 (m, 2H), 7.00-7.15 (m, 2H), 6.86 (d, J = 8.5 Hz, 1H), 3.89 (s, 3H), 3.76 (s, 3H), 3.73 (s, 3H), 2.26 (s, 3H), 2.12 (td, J = 7.1, 3.9 Hz, 2H), 1.25-1.35 (m, 2H), 0.56 (t, J = 7.5 Hz, 3H). 2-133 δ 7.65-7.75 (m, 1H), 7.40-7.50 (m, 2H), 7.25-7.40 (m, 3H), 7.10-7.20 (m, 2H), 3.79 (s, 3H), 2.42 (s, 3H), 2.20 (s, 3H), 2.06 (td, J = 7.2, 1.5 Hz, 2H), 1.15-1.35 (m, 2H), 0.58 (t, J = 7.5 Hz, 3H). 2-135 δ 7.65-7.70 (m, 1H), 7.40-7.50 (m, 2H), 7.10-7.20 (m, 2H), 7.00-7.10 (m, 2H), 3.78 (s, 3H), 2.42 (s, 3H), 2.23 (s, 3H), 2.00-2.15 (m, 2H), 1.15-1.35 (m, 2H), 0.57 (t, J = 7.4 Hz, 3H). 2-137 δ 7.67 (d, J = 8.6 Hz, 1H), 7.30-7.40 (m, 2H), 7.10-7.20 (m, 4H), 3.80 (s, 3H), 2.41 (s, 3H), 2.34 (s, 3H), 2.21 (s, 3H), 2.00-2.10 (m, 2H), 1.15-1.35 (m, 2H), 0.57 (t, J = 7.4 Hz, 3H). 2-140 δ 7.70 (d, J = 8.2 Hz, 1H), 7.25-7.40 (m, 2H), 7.17 (dd, J = 8.2, 1.4 Hz, 1H), 7.10-7.15 (m, 1H), 6.75-6.85 (m, 2H), 6.39 (s, 1H), 3.79 (s, 3H), 3.71 (s, 3H), 2.41 (s, 3H), 2.21 (s, 3H). 2-141 δ 7.60-7.70 (m, 1H), 7.35-7.45 (m, 2H), 7.10-7.20 (m, 2H), 6.80-6.95 (m, 2H), 3.81 (s, 3H), 3.80 (s, 3H), 2.42 (s, 3H), 2.23 (s, 3H), 2.00-2.15 (m, 2H), 1.20-1.35 (m, 2H), 0.58 (t, J = 7.3 Hz, 3H). 2-143 δ 7.69 (d, J = 8.2 Hz, 1H), 7.20-7.35 (m, 3H), 7.00-7.20 (m, 3H), 3.78 (s, 3H), 2.43 (s, 3H), 2.42 (s, 3H), 2.15-2.25 (m, 2H), 2.13 (s, 3H), 1.30-1.45 (m, 2H), 0.68 (t, J = 7.3 Hz, 3H). 2-145 δ 8.15-8.25 (m, 2H), 7.65-7.80 (m, 3H), 7.15-7.25 (m, 2H), 3.76 (s, 3H), 2.45 (s, 3H), 2.28 (s, 3H), 2.00-2.20 (m, 2H), 1.15-1.30 (m, 2H), 0.55 (t, J = 7.5 Hz, 3H). 2-147 δ 7.50-7.80 (m, 5H), 7.15-7.25 (m, 2H), 3.76 (s, 3H), 2.45 (s, 3H), 2.28 (s, 3H), 2.00-2.20 (m, 2H), 1.15-1.35 (m, 2H), 0.55 (t, J = 7.3 Hz, 3H). 2-155 δ 7.95-8.00 (m, 1H), 7.75-7.85 (m, 3H), 7.65-7.75 (m, 1H), 7.45-7.60 (m, 3H), 7.15-7.20 (m, 2H), 3.79 (s, 3H), 2.44 (s, 3H), 2.19 (s, 3H), 2.00-2.15 (m, 2H), 1.15-1.35 (m, 2H), 0.57 (t, J = 7.4 Hz, 3H). 2-159 δ 7.60-7.70 (m, 1H), 7.10-7.20 (m, 2H), 7.03 (d, J = 2.1 Hz, 1H), 6.96 (dd, J = 8.6, 2.1 Hz, 1H), 6.81 (d, J = 8.6 Hz, 1H), 4.26 (s, 4H), 3.81 (s, 3H), 2.41 (s, 3H), 2.24 (s, 3H), 2.08 (td, J = 7.3, 2.0 Hz, 2H), 1.15-1.35 (m, 2H), 0.57 (t, J = 7.4 Hz, 3H). 2-161 δ 7.69 (d, J = 7.8 Hz, 1H), 7.36-7.26 (m, 2H), 7.20 (d, J = 1.8 Hz, 1H), 7.00-6.85 (m, 3H), 3.74 (s, 3H), 3.68 (s, 3H), 3.37 (s, 3H), 2.12 (s, 3H), 2.05-1.95 (m, 1H), 1.00-0.92 (m, 2H), 0.70-0.62 (m, 2H). 2-182 δ 7.72 (d, J = 9.0 Hz, 1H), 7.40-7.50 (m, 1H), 7.28-7.38 (m, 3H), 6.88-6.95 (m, 1H), 6.87 (d, J = 9.0 Hz, 1H), 6.60 (brs, 1H), 3.74 (s, 3H), 3.69 (s, 3H), 3.36 (s, 3H), 2.08 (s, 3H), 1.50 (s, 9H). 2-186 δ 7.77 (d, J = 8.4 Hz, 1H), 7.48 (dd, J = 8.4, 1.8 Hz, 1H), 7.40-7.26 (m, 3H), 6.95-6.70 (m, 3H), 5.75 (dd, J = 18.0, 0.9 Hz, 1H), 5.75 (dd, J = 10.8 Hz, 0.9 Hz, 1H), 3.74 (s, 3H), 3.71 (s, 3H), 3.37 (s, 3H), 2.12 (s, 3H). 2-189 δ 7.74 (dd, J = 8.4, 0.9 Hz, 1H), 7.55-7.57 (m, 1H), 7.31 (dd, J = 8.4, 0.9 Hz, 1H), 7.45-7.25 (m, 2H), 6.60-6.70 (m, 2H), 3.75 (s, 3H), 3.71 (s, 3H), 3.24 (s, 3H), 2.11 (s, 3H), 0.25 (s, 9H). 2-193 δ 8.00-8.05 (m, 1H), 7.85-8.00 (m, 2H), 7.25-7.40 (m, 1H), 6.60-6.70 (m, 2H), 3.75 (s, 3H), 3.73 (s, 3H), 3.36 (s, 3H), 2.65 (s, 3H), 2.16 (s, 3H). 2-204 δ 7.75 (dd, J = 9.5, 4.8 Hz, 1H), 7.35-7.50 (m, 2H), 7.05-7.35 (m, 4H), 3.76 (s, 3H), 2.21 (t, J = 7.2 Hz, 2H), 2.13 (s, 3H), 1.30-1.45 (m, 2H), 0.65 (t, J = 7.5 Hz, 3H). 2-210 δ 7.72-7.76 (m, 1H), 7.23-7.29 (m, 1H), 7.03-7.13 (m, 4H), 6.86-6.90 (m, 1H), 3.76 (s, 3H), 3.74 (s, 3H), 2.23 (s, 3H), 2.09-2.14 (m, 2H), 1.21-1.33 (m, 2H), 0.56 (t, J = 7.2 Hz, 3H). 2-212 δ 7.74 (dd, J = 8.5, 4.8 Hz, 1H), 7.20-7.30 (m, 1H), 7.00-7.15 (m, 4H), 6.80-6.90 (m, 1H), 3.90-4.05 (m, 2H), 3.76 (s, 3H), 2.22 (s, 3H), 2.05-2.15 (m, 2H), 1.20-1.40 (m, 5H), 0.57 (t, J = 7.3 Hz, 3H). 2-216 δ 7.70-7.80 (m, 1H), 7.20-7.30 (m, 1H), 6.95-7.15 (m, 4H), 6.85 (ddd, J = 8.2, 2.4, 1.0 Hz, 1H), 4.40-4.55 (m, 1H), 3.76 (s, 3H), 2.22 (s, 3H), 2.05-2.15 (m, 2H), 1.20-1.35 (m, 8H), 0.57 (t, J = 7.5 Hz, 3H). 2-218 δ 7.65-7.75 (m, 1H), 7.35-7.45 (m, 2H), 6.95-7.15 (m, 4H), 3.77 (s, 3H), 3.65-3.75 (m, 1H), 2.24 (s, 3H), 2.05-2.15 (m, 2H), 1.20-1.35 (m, 2H), 0.75-0.80 (m, 4H), 0.57 (t, J = 7.2 Hz, 3H). 2-222 δ 7.65-7.75 (m, 1H), 7.35-7.45 (m, 2H), 7.00-7.10 (m, 2H), 6.80-6.90 (m, 2H), 3.78 (s, 3H), 3.72 (d, J = 6.5 Hz, 2H), 2.23 (s, 3H), 2.00-2.15 (m, 3H), 1.20-1.35 (m, 2H), 1.02 (d, J = 6.8 Hz, 6H), 0.57 (t, J = 7.3 Hz, 3H). 2-224 δ 7.70-7.75 (m, 1H), 7.30-7.40 (m, 2H), 7.00-7.15 (m, 2H), 6.90-7.00 (m, 2H), 3.77 (s, 3H), 2.20 (s, 3H), 2.05-2.15 (m, 2H), 1.36 (s, 9H), 1.20-1.35 (m, 2H), 0.59 (t, J = 7.5 Hz, 3H). 2-230 δ 7.19-7.77 (m, 5H), 7.03-7.15 (m, 2H), 3.84 and 3.75 (s, 3H), 2.13-2.28 (m, 5H), 1.34-1.41 (m, 2H), 0.64-0.70 (m, 3H). 2-235 δ 7.75-7.83 (m, 1H), 7.26-7.43 (m, 2H), 7.02-7.20 (m, 4H), 5.80 (t, 71.9 Hz, 1H), 3.82 (s, 3H), 2.50 (t, J = 7.2 Hz, 2H), 2.29 (s, 3H), 1.67-1.83 (m, 2H), 1.02 (t, J = 7.5 Hz, 3H). 2-237 δ 7.74-7.79 (m, 1H), 7.38-7.47 (m, 3H), 7.07-7.19 (m, 3H), 3.74 (s, 3H), 2.24 (s, 3H), 2.04-2.16 (m, 2H), 1.24-1.30 (m, 2H), 0.56 (t, J = 7.5 Hz, 3H). 2-239 δ 7.77-7.85 (m, 1H), 7.29-7.42 (m, 2H), 7.13-7.18 (m, 2H), 7.03-7.11 (m, 2H), 4.23-4.27 (m, 2H), 3.79 (s, 3H), 2.51 (t, J = 7.3 Hz, 2H), 2.26 (s, 3H), 1.68-1.83 (m, 2H), 1.03 (t, J = 7.3 Hz, 3H). 2-245 δ 7.73 (dd, J = 8.5, 5.1 Hz, 1H), 7.35-7.45 (m, 2H), 7.20-7.30 (m, 2H), 7.00-7.15 (m, 2H), 3.77 (s, 3H), 2.96 (q, J = 7.3 Hz, 2H), 2.23 (s, 3H), 2.05-2.15 (m, 2H), 1.20-1.40 (m, 5H), 0.57 (t, J = 7.3 Hz, 3H). 2-249 δ 7.73 (dd, J = 8.7, 4.9 Hz, 1H), 7.35-7.40 (m, 2H), 7.20-7.30 (m, 2H), 7.00-7.15 (m, 2H), 3.77 (s, 3H), 2.85-3.00 (m, 2H), 2.23 (s, 3H), 2.05-2.15 (m, 2H), 1.60-1.80 (m, 2H), 1.20-1.35 (m, 2H), 1.04 (t, J = 7.3 Hz, 3H), 0.57 (t, J = 7.3 Hz, 3H). 2-251 δ 7.71-7.79 (m, 1H), 7.46-7.51 (m, 1H), 7.27-7.37 (m, 3H), 7.03-7.14 (m, 2H), 3.75 (s, 3H), 3.24-3.60 (m, 1H), 2.22 (s, 3H), 2.07-2.15 (m, 2H), 1.25-1.33 (m, 2H), 1.24 (d, J = 4.1 Hz, 3H), 1.22 (d, J = 3.8 Hz, 3H), 0.57 (t, J = 7.3 Hz, 3H). 2-253 δ 7.74 (dd, J = 8.9, 4.8 Hz, 1H), 7.35-7.40 (m, 2H), 7.30-7.35 (m, 2H), 7.00-7.15 (m, 2H), 3.76 (s, 3H), 3.35-3.50 (m, 1H), 2.23 (s, 3H), 2.05-2.15 (m, 2H), 1.20-1.35 (m, 8H), 0.57 (t, J = 7.3 Hz, 3H). 2-255 δ 7.70-7.75 (m, 1H), 7.35-7.45 (m, 2H), 7.30-7.35 (m, 2H), 7.00-7.15 (m, 2H), 3.78 (s, 3H), 2.24 (s, 3H), 2.05-2.20 (m, 3H), 1.20-1.35 (m, 2H), 1.05-1.15 (m, 2H), 0.65-0.75 (m, 2H), 0.57 (t, J = 7.3 Hz, 3H). 2-256 δ 7.60-7.78 (m, 2H), 7.44-7.50 (m, 1H), 7.21-7.41 (m, 2H), 7.07-7.09 (m, 1H), 7.00-7.06 (m, 1H), 3.58-3.70 (m, 3H), 2.27-2.43 (m, 3H), 2.17-2.24 (m, 3H). 2-260 δ 7.69 (dd, J = 8.9, 4.8 Hz, 1H), 7.00-7.25 (m, 5H), 6.90 (dd, J = 9.4, 2.4 Hz, 1H), 5.65-6.10 (m, 1H), 3.49 (s, 3H), 3.15-3.30 (m, 2H), 2.10 (s, 3H). 2-266 δ 7.75 (dd, J = 8.5, 4.8 Hz, 1H), 7.35-7.40 (m, 2H), 7.25-7.35 (m, 2H), 7.00-7.15 (m, 2H), 3.76 (s, 3H), 3.60 (t, J = 6.7 Hz, 2H), 3.37 (s, 3H), 3.33 (s, 3H), 3.13 (t, J = 6.7 Hz, 2H), 2.22 (s, 3H). 2-268 δ 7.70-7.80 (m, 1H), 7.20-7.45 (m, 6H), 7.00-7.20 (m, 4H), 6.90-7.00 (m, 1H), 4.90-5.10 (m, 2H), 3.75 (s, 3H), 2.23 (s, 3H), 2.05-2.15 (m, 2H), 1.20-1.35 (m, 2H), 0.56 (t, J = 7.5 Hz, 3H). 2-270 δ 7.74-7.81 (m, 1H), 7.28-7.41 (m, 2H), 7.19-7.22 (m, 1H), 7.01-7.16 (m, 3H), 5.51-5.66 (m, 1H), 4.90-5.07 (m, 2H), 3.98-4.07 (m, 1H), 3.77-3.86 (m, 1H), 3.77 (s, 3H), 2.51 (t, J = 7.2 Hz, 2H), 2.25 (s, 3H), 1.69-1.83 (m, 2H), 1.04 (t, J = 7.5 Hz, 3H). 2-272 δ 7.73-7.80 (m, 1H), 7.29-7.35 (m, 2H), 7.18-7.21 (m, 1H), 7.01-7.15 (m, 3H), 3.75 (s, 3H), 3.61-3.70 (m, 1H), 3.35-3.43 (m, 1H), 3.23-3.43 (m, 2H), 2.94 (s, 3H), 2.50 (t, J = 7.8 Hz, 2H), 2.25 (s, 3H), 1.68-1.83 (m, 2H), 1.02 (t, J = 7.5 Hz, 3H). 2-274 δ 7.72-7.80 (m, 1H), 7.18-7.40 (m, 3H), 7.00-7.15 (m, 3H), 3.76 (s, 3H), 3.38-3.70 (m, 2H), 2.50 (t, J = 7.3 Hz, 2H), 2.40 (t, J = 6.5 Hz, 2H), 2.24 (s, 3H), 1.65-1.83 (m, 5H), 1.01 (t, J = 7.3 Hz, 3H). 2-278 δ 7.76-7.85 (m, 1H), 7.31-7.45 (m, 2H), 6.99-7.25 (m, 4H), 4.05-4.45 (m, 1H), 3.73-3.87 (m, 3H), 2.47-2.54 (m, 2H), 2.25-2.39 (m, 3H), 1.67-1.82 (m, 2H), 1.22-1.33 (m, 3H), 0.98-1.06 (m, 3H). 2-282 δ 7.69-7.73 (m, 1H), 7.30-7.48 (m, 4H), 7.03-7.15 (m, 5H), 6.90-6.98 (m, 2H), 6.51 (t, J = 74.4 Hz, 1H), 3.71 (s, 3H), 2.04 (s, 3H), 1.34 (s, 3H), 1.20 (s, 3H). 2-283 δ 7.73-7.77 (m, 1H), 7.56-7.51 (m, 2H), 7.03-7.15 (m, 4H), 6.53 (t, J = 74.7 Hz, 1H), 3.65-3.90 (m, 5H), 3.05 (s, 3H), 2.26 (s, 3H). 2-284 δ 7.76-7.80 (m, 1H), 7.42-7.47 (m, 2H), 7.04-7.25 (m, 6H), 6.89-6.95 (m, 1H), 6.51 (t, J = 74.1 Hz, 1H), 6.43-6.47 (m, 2H), 4.28-4.53 (m, 2H), 3.75 (s, 3H), 2.24 (s, 3H). 2-286 δ 7.65-7.70 (m, 1H), 7.56-7.60 (m, 2H), 7.37-7.42 (m, 2H), 7.29-7.35 (m, 2H), 7.05-7.17 (m, 4H), 6.55 (t, J = 73.8 Hz, 1H), 3.82 (s, 3H), 2.25 (s, 3H). 2-289 δ 7.72-7.78 (m, 1H), 7.46-7.54 (m, 2H), 7.00-7.15 (m, 4H), 6.53 (t, J = 74.1 Hz, 1H), 4.30-4.39 (m, 1H), 3.51-3.79 (m, 5H), 2.28 and 2.26 (s, 3H), 0.86-2.01 (m, 4H). 2-293 δ 7.73-7.78 (m, 1H), 7.44-7.49 (m, 2H), 7.04-7.14 (m, 4H), 6.53 (t, J = 74.1 Hz, 1H), 3.80 (s, 3H), 4.08-4.22 (m, 2H), 3.36-3.45 (m, 2H), 2.28 (s, 3H). 2-294 δ 7.72-7.77 (m, 1H), 7.43-7.50 (m, 2H), 7.03-7.14 (m, 4H), 6.52 (t, J = 74.1 Hz, 1H), 5.52-5.65 (m, 1H), 5.03-5.15 (m, 2H), 4.31-4.43 (m, 2H), 3.78 (s, 3H), 2.27 (s, 3H). 2-295 δ 7.72-7.77 (m, 1H), 7.44-7.49 (m, 2H), 7.04-7.14 (m, 4H), 6.53 (t, J = 74.1 Hz, 1H), 3.99-4.13 (m, 2H), 3.78 (s, 3H), 3.36 (t, J = 4.2 Hz, 2H), 3.24 (s, 3H), 2.27 (s, 3H). 2-297 δ 7.76-7.81 (m, 1H), 7.46-7.51 (m, 2H), 7.19-7.32 (m, 3H), 7.06-7.14 (m, 4H), 6.64-6.67 (m, 2H), 6.52 (t, J = 74.1 Hz, 1H), 3.86 (s, 3H), 2.33 (s, 3H). 2-299 δ 7.74-7.79 (m, 1H), 7.54-7.60 (m, 1H), 7.38-7.43 (m, 2H), 7.23-7.31 (m, 4H), 7.04-7.14 (m, 4H), 6.52 (t, J = 73.2 Hz, 1H), 3.83 (s, 3H), 2.35 (s, 3H). 2-300 δ 7.75-7.80 (m, 1H), 7.43-7.48 (m, 2H), 7.04-7.16 (m, 4H), 6.53 (t, J = 73.2 Hz, 1H), 5.53-5.66 (m, 1H), 4.93-5.07 (m, 2H), 3.99-4.06 (m, 1H), 3.80-3.87 (m, 1H), 3.77 (s, 3H), 2.25 (s, 3H). 2-301 δ 7.75-7.80 (m, 1H), 7.45-7.50 (m, 2H), 7.05-7.16 (m, 4H), 6.53 (t, J = 73.2 Hz, 1H), 4.02-4.25 (m, 2H), 3.77 (s, 3H), 2.37 (t, J = 2.4 Hz, 1H), 2.30 (s, 3H). 2-302 δ 7.78-7.83 (m, 1H), 7.39-7.43 (m, 2H), 7.04-7.19 (m, 4H), 6.54 (t, J = 74.1 Hz, 1H), 3.72-3.84 (m, 4H), 3.46-3.52 (m, 1H), 2.26 (s, 3H). 2-307 δ 7.73-7.78 (m, 1H), 7.45-7.50 (m , 2H), 7.03-7.15 (m, 4H), 6.53 (t, J = 74.1 Hz, 1H), 4.75 (d, J = 6.0 Hz, 1H), 4.57 (d, J = 6.0 Hz, 1H), 3.75 (s, 3H), 3.45-3.48 (m, 2H), 3.27-3.34 (m, 2H), 3.25 (s, 3H), 2.30 (s, 3H). 2-308 δ 7.75-7.80 (m, 1H), 7.66-7.70 (m, 1H), 7.33-7.37 (m, 1H), 6.92-7.23 (m, 4H), 6.53 (t, J = 74.1 Hz, 1H), 5.78 and 5.46 (q, J = 5.1 Hz, 1H), 4.01-4.11 (m, 2H), 3.83 and 3.70 (s, 3H), 2.30 and 2.14 (s, 3H), 1.20-1.26 (m, 3H), 1.07 and 0.83 (d, J = 5.1 Hz, 3H). 2-309 δ 7.76-7.81 (m, 1H), 7.50-7.55 (m, 2H), 7.04-7.17 (m, 4H), 6.54 (t, J = 73.5 Hz, 1H), 3.74 (s, 3H), 2.50 (s, 3H), 2.22-2.36 (m, 1H), 1.12 (d, J = 6.9 Hz, 3H), 0.81 (d, J = 6.9 Hz, 3H). 2-313 δ 7.45-7.52 (m, 1H), 7.33-7.38 (m, 2H), 7.08-7.13 (m, 2H), 6.89-7.04 (m, 3H), 6.30-6.81 (m, 4H), 3.73 (m, 3H), 3.63 (m, 3H), 2.53 (s, 3H). 2-316 δ 7.78 (dd, J = 8.5, 4.8 Hz, 1H), 7.45-7.55 (m, 2H), 7.30-7.40 (m, 2H), 7.05-7.15 (m, 2H), 4.68 (s, 2H), 3.87 (q.J = 8.5 Hz, 2H), 3.77 (s, 3H), 3.35 (s, 3H), 2.22 (s, 3H). 2-317 δ 7.72 (dd, J = 8.8, 4.7 Hz, 1H), 7.15-7.30 (m, 4H), 7.08 (ddd, J = 8.8, 8.8, 2.5 Hz, 1H), 6.96 (dd, J = 9.4, 2.5 Hz, 1H), 6.54 (brs, 1H), 3.63 (s, 2H), 3.60 (s, 3H), 2.14 (s, 3H), 1.97 (s, 3H). 2-319 δ 7.72 (dd, J = 8.8, 4.7 Hz, 1H), 7.15-7.30 (m, 4H), 7.08 (ddd, J = 8.8, 8.8, 2.5 Hz, 1H), 6.95 (dd, J = 9.6, 2.3 Hz, 1H), 6.52 (brs, 1H), 3.67 (s, 2H), 3.60 (s, 3H), 2.42 (q, J = 7.4 Hz, 2H), 2.13 (s, 3H), 1.21 (t, J = 7.4 Hz, 3H). 2-321 δ 7.76-7.82 (m, 1H), 7.36-7.41 (m, 2H), 7.28-7.34 (m, 2H), 7.09-7.18 (m, 1H), 7.02-7.08 (m, 1H), 5.55 (brs, 1H), 3.78 (s, 3H), 3.73 (s, 2H), 2.80 (sep, J = 6.8 Hz, 1H), 2.22 (s, 3H), 1.22-1.29 (m, 6H). 2-322 δ 7.73-7.79 (m, 1H), 7.37-7.43 (m, 2H), 7.28-7.34 (m, 2H), 7.02-7.15 (m, 2H), 3.76 (s, 3H), 3.73 (s, 2H), 3.33 (s, 3H), 2.81 (sep, J = 6.8 Hz, 1H), 2.20 (s, 3H), 1.26 (d, J = 6.8 Hz, 6H). 2-323 δ 7.75-7.82 (m, 1H), 7.36-7.41 (m, 2H), 7.26-7.31 (m, 2H), 7.09-7.18 (m, 1H), 7.02-7.08 (m, 1H), 5.71-5.86 (m, 1H), 5.58 (brs, 1H), 5.03-5.16 (m, 2H), 3.77 (s, 3H), 3.65 (s, 2H), 3.04 (dt, J = 7.2, 1.0 Hz, 2H), 2.22 (s, 3H). 2-324 δ 7.73-7.80 (m, 1H), 7.37-7.43 (m, 2H), 7.26-7.31 (m, 2H), 7.03-7.15 (m, 2H), 5.70-5.87 (m, 1H), 5.03-5.17 (m, 2H), 3.76 (s, 3H), 3.65 (s, 2H), 3.33 (s, 3H), 3.04 (dt, J = 7.2, 1.2 Hz, 2H), 2.21 (s, 3H). 2-325 δ 7.76-7.83 (m, 1H), 7.38-7.43 (m, 2H), 7.29-7.34 (m, 2H), 7.10-7.18 (m, 1H), 7.02-7.08 (m, 1H), 5.59 (brs, 1H), 3.86 (s, 2H), 3.77 (s, 3H), 3.09 (d, J = 2.7 Hz, 2H), 2.30 (t, J = 2.7 Hz, 1H), 2.23 (s, 3H). 2-327 δ 7.76-7.82 (m, 1H), 7.37-7.42 (m, 2H), 7.28-7.33 (m, 2H), 7.09-7.18 (m, 1H), 7.01-7.08 (m, 1H), 5.60 (brs, 1H), 3.78 (s, 3H), 3.75 (s, 2H), 3.51 (t, J = 6.5 Hz, 2H), 3.33 (s, 3H), 2.61 (t, J = 6.5 Hz, 2H), 2.23 (s, 3H). 2-328 δ 7.72-7.79 (m, 1H), 7.37-7.43 (m, 2H), 7.27-7.32 (m, 2H), 7.02-7.14 (m, 2H), 3.75 (s, 3H), 3.74 (s, 2H), 3.51 (t, J = 6.7 Hz, 2H), 3.329 (s, 3H), 3.326 (s, 3H), 2.61 (t, J = 6.7 Hz, 2H), 2.20 (s, 3H). 2-330 δ 7.75-7.85 (m, 1H), 7.35-7.45 (m, 2H), 7.25-7.35 (m, 2H), 7.10-7.20 (m, 1H), 7.00-7.10 (m, 1H), 5.60-6.05 (m, 1H), 3.78 (s, 2H), 3.78 (s, 3H), 2.65-2.80 (m, 2H), 2.23 (s, 3H). 2-331 δ 7.80 (dd, J = 8.8, 4.8 Hz, 1H), 7.35-7.45 (m, 2H), 7.25-7.35 (m, 2H), 7.14 (ddd, J = 8.8, 8.8, 2.4 Hz, 1H), 7.05 (dd, J = 9.6, 2.4 Hz, 1H), 5.71 (brs, 1H), 3.82 (s, 2H), 3.76 (s, 3H), 2.90 (q, J = 9.9 Hz, 2H), 2.23 (s, 3H). 2-335 δ 7.78 (dd, J = 8.8, 4.7, 1H), 7.40-7.45 (m, 2H), 7.30-7.40 (m, 2H), 7.14 (ddd = 8.8, 8.8, 2.7 Hz, 1H), 7.01 (dd, J = 9.4, 2.1 Hz, 1H), 6.09 (s, 1H), 4.18 (s, 2H), 3.69 (s, 3H), 2.87 (q, J = 7.4 Hz, 2H), 2.21 (s, 3H), 1.36 (t, J = 7.4 Hz, 3H). 2-361 δ 7.70-7.78 (m, 1H), 7.03-7.14 (m, 2H), 6.68 (d, J = 2.4 Hz, 2H), 6.43 (t, J = 2.4 Hz, 1H), 3.75 (s, 3H), 3.72 (s, 6H), 2.24 (s, 3H), 2.08-2.16 (m, 2H), 1.18-1.35 (m, 2H), 0.55 (t, J = 7.3 Hz, 3H). 2-367 δ 7.69-7.80 (m, 1H), 7.08-71.7 (m, 2H), 6.99-7.07 (m, 1H), 6.92-6.96 (m, 1H), 6.82-6.88 (m, 1H), 3.78 (s, 3H), 3.69 (s, 3H), 2.17 (s, 3H), 2.14 (t, J = 7.5 Hz, 2H), 1.25-1.37 (m, 2H), 0.62 (t, J = 7.2 Hz, 3H). 2-369 δ 7.65-7.75 (m, 1H), 7.20-7.30 (m, 1H), 7.05-7.15 (m, 2H), 6.85-6.95 (m, 2H), 3.81 (s, 3H), 3.74 (s, 3H), 2.05-2.25 (m, 5H), 1.25-1.40 (m, 2H), 0.63 (t, J = 7.4 Hz, 3H). 2-372 δ 7.86 (dd, J = 8.9, 4.4 Hz, 1H), 7.10-7.25 (m, 2H), 6.65-6.80 (m, 2H), 5.55 (brs, 1H), 3.68 (s, 3H), 2.30 (s, 3H). 2-380 δ 7.72-7.78 (m, 1H), 7.30-7.50 (m, 3H), 6.56-6.68 (m, 2H), 3.95-4.05 (m, 1H), 3.66-3.76 (m, 7H), 3.36 (s, 3H), 3.15 (t, J = 7.5 Hz, 2H), 2.62 (t, J = 7.5 Hz, 2H), 2.14 (s, 3H), 1.20-1.40 (m, 9H), 0.82-0.94 (m, 6H). 2-395 δ 10.00 (s, 1H), 7.96 (d, J = 8.7 Hz, 1H), 7.85-7.90 (m, 2H), 7.35-7.43 (m, 1H), 7.30 (dd, J = 7.8, 1.8 Hz, 1H), 6.94-7.02 (m, 2H), 6.46 (brs, 1H), 3.82 (s, 3H), 3.75 (s, 3H), 2.20 (s, 3H). 2-396 δ 10.05 (s, 1H), 7.94-8.00 (m, 2H), 7.85-7.90 (m, 1H), 7.30-7.38 (m, 2H), 6.88-7.00 (m, 2H), 3.76 (s, 3H), 3.73 (s, 3H), 3.36 (s, 3H), 2.13 (s, 3H). 2-420 δ 7.74 (dd, J = 8.5, 4.8 Hz, 1H), 7.30-7.45 (m, 2H), 6.95-7.15 (m, 2H), 6.80-6.90 (m, 2H), 4.15 (t, J = 6.8 Hz, 2H), 3.77 (s, 3H), 3.60-3.75 (m, 1H), 3.40-3.55 (m, 1H), 2.87 (t, J = 6.8 Hz, 2H), 2.40 (t, J = 6.5 Hz, 2H), 2.25 (s, 3H), 2.20 (s, 3H), 1.75 (s, 3H). 2-421 δ 7.77 (dd, J = 8.8 Hz, 1H), 7.20-7.35 (m, 4H), 7.12 (ddd, J = 8.8, 8.8, 2.5 Hz, 1H), 7.01 (dd, J = 9.6, 2.4 Hz, 1H), 5.98 (brs, 1H), 3.72 (s, 3H), 3.10-3.20 (m, 2H), 2.70-2.80 (m, 2H), 2.22 (s, 3H), 2.15 (s, 3H). 2-422 δ 7.77 (dd, J = 8.8, 4.8 Hz, 1H), 7.20-7.35 (m, 4H), 7.12 (td, J = 8.8, 2.5 Hz, 1H), 7.03 (dd, J = 9.2, 2.5 Hz, 1H), 5.80-5.95 (m, 1H), 5.05-5.25 (m, 2H), 3.75 (s, 3H), 3.55-3.60 (m, 2H), 2.23 (s, 3H). 2-423 δ 7.81 (dd, J = 8.8, 4.8 Hz, 1H), 7.10-7.50 (m, 4H), 7.16 (td, J = 8.8, 2.6 Hz, 1H), 7.05 (dd, J = 9.4, 2.6 Hz, 1H), 5.67 (s, 1H), 3.76 (s, 3H), 3.61 (s, 2H), 2.26 (s, 3H). 2-424 δ 7.78 (dd, J = 8.8, 4.8 Hz, 1H), 7.30-7.40 (m, 2H), 7.20-7.30 (m, 2H), 7.13 (td, J = 8.8, 2.4 Hz, 1H), 7.03 (dd, J = 9.2, 2.4 Hz, 1H), 5.74 (brs, 1H), 3.76 (s, 3H), 3.70 (s, 2H), 2.29 (s, 3H), 2.24 (s, 3H). 2-429 δ 7.73-7.76 (m, 1H), 7.31-7.39 (m, 2H), 7.07-7.14 (m, 1H), 6.94-7.02 (m, 3H), 6.22 (brs, 1H), 4.21-4.27 (m, 2H), 3.65-3.72 (m, 2H), 3.33 (s, 3H), 2.21 (s, 3H). 2-430 δ 7.77-7.82 (m, 1H), 7.33-7.38 (m, 2H), 7.12-7.19 (m, 1H), 6.99-7.08 (m, 3H), 6.11 (brs, 1H), 4.87-5.00 (m, 2H), 2.25 (s, 3H). 2-433 δ 7.71-7.76 (m, 1H), 7.40-7.46 (m, 2H), 7.22-7.32 (m, 5H), 7.03-7.13 (m, 2H), 6.91-6.99 (m, 2H), 5.45 (d, J = 14.1 Hz, 1H), 5.03 (d, J = 14.1 Hz, 1H), 2.25 (s, 3H), 2.00-2.19 (m, 2H), 1.19-1.32 (m, 2H), 0.54 (t, J = 7.2 Hz, 3H). 2-439 δ 7.68-7.73 (m, 1H), 7.43-7.47 (m, 2H), 7.26-7.35 (m, 5H), 7.00-7.12 (m, 2H), 6.78-6.93 (m, 2H), 5.59 (d, J = 13.5 Hz, 1H), 5.11 (d, J = 13.5 Hz, 1H), 3.31 (s, 3H), 2.08-2.30 (m, 5H), 1.27-1.39 (m, 2H), 0.65 (t, J = 6.9 Hz, 3H). 2-440 δ 7.74-7.78 (m, 1H), 7.29-7.34 (m, 2H), 7.07-7.14 (m, 1H), 7.00 (dd, J = 9.9 Hz, 3.3 Hz, 1H), 6.86-6.91 (m, 2H), 6.05 (brs, 1H), 4.07-4.12 (m, 2H), 3.78 (s, 3H), 3.73-3.76 (m, 2H), 3.44 (s, 3H). 2-442 δ 7.73 (dd, J = 8.5, 4.8 Hz, 1H), 7.25-7.35 (m, 2H), 7.09 (td, J = 8.8, 2.6 Hz, 1H), 6.98 (dd, J = 9.5, 2.4 Hz, 1H), 6.75-6.85 (m, 2H), 6.10-6.20 (m, 2H), 4.64 (d, J = 6.1 Hz, 2H), 3.67 (s, 3H), 2.19 (s, 3H). 2-444 δ 7.77 (dd, J = 8.9, 4.8 Hz, 1H), 7.35-7.45 (m, 2H), 7.12 (td, J = 8.8, 2.6 Hz, 1H), 7.03 (dd, J = 9.5, 2.4 Hz, 1H), 6.80-6.90 (m, 2H), 5.58 (s, 1H), 4.44 (t, J = 5.4 Hz, 2H), 3.78 (s, 3H), 3.44 (t, J = 5.4 Hz, 2H), 3.05 (s, 3H), 2.25 (s, 3H). 2-445 δ 7.74 (dd, J = 8.7, 4.7 Hz, 1H), 7.20-7.40 (m, 4H), 7.09 (td, J = 8.7, 2.5 Hz, 1H), 6.98 (dd, J = 9.3, 2.3 Hz, 1H), 6.33 (brs, 1H), 4.53 (s, 2H), 3.69 (s, 3H), 3.50-3.65 (m, 4H), 3.36 (s, 3H), 2.18 (s, 3H). 2-446 δ 7.73 (dd, J = 8.7, 4.7 Hz, 1H), 7.20-7.40 (m, 4H), 7.09 (td, J = 8.7, 2.5 Hz, 1H), 6.97 (dd, J = 9.5, 2.5 Hz, 1H), 6.36 (brs, 1H), 4.51 (s, 2H), 3.60-3.70 (m, 5H), 2.72 (t, J = 6.7 Hz, 2H), 2.16 (s, 3H), 2.13 (s, 3H). 2-448 δ 8.79 (brs, 1H), 7.73 (dd, J = 8.7, 0.9 Hz, 1H), 7.24-7.32 (m, 4H), 6.76-6.84 (m, 2H), 3.76 (s, 3H), 3.31 (s, 3H), 2.21 (s, 3H). 2-449 δ 7.73 (dd, J = 8.4, 0.6 Hz, 1H), 7.35-7.42 (m, 2H), 7.20-7.33 (m, 3H), 6.84-6.90 (m, 1H), 3.81 (s, 3H), 3.77 (s, 3H), 3.33 (s, 3H), 2.22 (s, 3H). 2-459 δ 7.74 (d, J = 8.1 Hz, 1H), 7.43-7.48 (m, 2H), 7.20-7.23 (m, 1H), 7.14-7.15 (m, 1H), 7.06-7.09 (m, 2H), 6.52 (t, J = 74.1 Hz, 1H), 5.63 (brs, 1H), 3.78 (s, 3H), 2.42 (s, 3H), 2.27 (s, 3H). 2-460 δ 7.65-7.75 (m, 1H), 7.53-7.65 (m, 1H), 7.45-7.52 (m, 1H), 7.25-7.42 (m, 3H), 7.00-7.13 (m, 2H), 3.53-3.65 (s, 3H), 2.33-2.72 (m, 2H), 2.13-2.24 (m, 3H), 0.80-0.94 (m, 3H). 2-465 δ 7.78 (dd, J = 8.9, 4.8 Hz, 1H), 7.30-7.45 (m, 4H), 7.00-7.20 (m, 2H), 5.60-5.75 (m, 1H), 3.75-3.80 (m, 3H), 3.64 (d, J = 2.4 Hz, 2H), 2.26 (t, 2.7 Hz, 1H), 2.24 (s, 3H). 2-467 δ 8.24-8.27 (m, 1H), 7.97-8.02 (m, 1H), 7.63-7.70 (m, 1H), 7.46 (brs, 1H), 7.27 (d, J = 8.7 Hz, 2H), 6.98-7.10 (m, 3H), 6.87-6.92 (m, 1H), 3.49 (s, 3H), 2.11 (s, 3H). 2-468 δ 8.27-8.35 (m, 1H), 7.98-8.01 (m, 1H), 7.73-7.80 (m, 1H), 7.55 (d, J = 8.5 Hz, 2H), 7.17 (d, J = 8.5 Hz, 2H), 7.05-7.12 (m, 2H), 4.78 (d, J = 5.8 Hz, 1H), 4.59 (d, J = 5.8 Hz, 1H), 3.76 (s, 3H), 3.45-3.51 (m, 2H), 3.27-3.33 (m, 2H), 3.24 (s, 3H), 2.30 (s, 3H). 3-004 δ 7.47 (dd, J = 9.0, 2.4 Hz, 1H), 7.25-7.40 (m, 3H), 7.00-7.10 (m, 1H), 6.85-7.00 (m, 2H), 3.83 (s, 3H), 3.72 (s, 3H), 2.12 (t, J = 7.2 Hz, 2H), 2.09 (s, 3H), 1.25-1.40 (m, 2H), 0.65 (t, J = 7.5 Hz, 3H). 3-007 δ 7.47 (dd, J = 9.0, 2.4 Hz, 1H), 7.20-7.40 (m, 3H), 7.00-7.15 (m, 1H), 6.80-6.95 (m, 2H), 4.05 (q, J = 6.9 Hz, 2H), 3.83 (s, 3H), 2.14 (t, J = 7.2 Hz, 2H), 2.10 (s, 3H), 1.25-1.40 (m, 5H), 0.65 (t, J = 7.5 Hz, 3H). 3-008 δ 7.48 (dd, J = 9.0, 2.4 Hz, 1H), 7.35-7.40 (m, 2H), 7.25-7.35 (m, 1H), 7.05-7.15 (m, 1H), 6.85-6.95 (m, 2H), 3.81 (s, 3H), 3.78 (s, 3H), 2.21 (s.3H), 2.05-2.15 (m, 2H), 1.25-1.35 (m, 2H), 0.58 (t, J = 7.5 Hz, 3H). 3-010 δ 7.47 (dd, J = 9.0, 2.7 Hz, 1H), 7.35-7.40 (m, 1H), 7.15-7.30 (m, 1H), 7.00-7.15 (m, 1H), 6.55-6.65 (m, 2H), 3.81 (s, 3H), 3.73 (s, 3H), 2.13 (s, 3H), 2.12 (t, J = 7.2 Hz, 2H), 1.25-1.40 (m, 2H), 0.64 (t, J = 7.8 Hz, 3H). 3-012 δ 7.47 (dd, J = 8.7, 1.8 Hz, 1H), 7.34 (dd, J = 9.0, 5.4 Hz, 1H), 7.15-7.25 (m, 1H), 7.00-7.10 (m, 1H), 6.50-6.70 (m, 2H), 4.04 (q, J = 6.9 Hz, 2H), 3.81 (s, 3H), 2.10-2.20 (m, 5H), 1.20-1.40 (m, 5H), 0.64 (t, J = 7.2 Hz, 3H). 3-016 δ 7.50 (dd, J = 8.5, 2.4 Hz, 1H), 7.25-7.45 (m, 5H), 7.05-7.15 (m, 1H), 3.77 (s, 3H), 2.23 (s, 3H), 1.95-2.20 (m, 2H), 1.20-1.35 (m, 2H), 0.57 (t, J = 7.3 Hz, 3H). 3-020 δ 7.48 (dd, J = 8.9, 2.4 Hz, 1H), 7.25-7.40 (m, 3H), 7.07 (td, J = 8.9, 2.4 Hz, 1H), 6.75-6.95 (m, 2H), 4.50-4.60 (m, 1H), 3.78 (s, 3H), 2.21 (s, 3H), 2.05-2.15 (m, 2H), 1.20-1.40 (m, 8H), 0.58 (t, J = 7.3 Hz, 3H). 3-032 δ 7.75-7.85 (m, 1H), 7.40-7.50 (m, 2H), 7.25-7.35 (m, 2H), 7.00-7.10 (m, 2H), 3.76 (s, 3H), 2.22 (s, 3H), 2.05-2.20 (m, 2H), 1.20-1.35 (m, 2H), 0.59 (t, J = 7.5 Hz, 3H). 3-034 δ 7.75-7.85 (m, 1H), 7.25-7.45 (m, 6H), 3.76 (s, 3H), 2.22 (s, 3H), 2.00-2.20 (m, 2H), 1.15-1.35 (m, 2H), 0.57 (t, J = 7.5 Hz, 3H). 3-036 δ 7.78 (d, J = 1.7 Hz, 1H), 7.25-7.40 (m, 4H), 6.85-7.00 (m, 2H), 3.83 (s, 3H), 3.72 (s, 3H), 2.05-2.25 (m, 5H), 1.25-1.45 (m, 2H), 0.66 (t, J = 7.5 Hz, 3H). 3-038 δ 7.75-7.80 (m, 1H), 7.20-7.45 (m, 4H), 6.85-6.90 (m, 2H), 3.81 (s, 3H), 3.78 (s, 3H), 2.22 (s, 3H), 2.05-2.15 (m, 2H), 1.20-1.40 (m, 2H), 0.59 (t, J = 7.3 Hz, 3H). 3-040 δ 7.78 (d, J = 1.4 Hz, 1H), 7.15-7.45 (m, 4H), 6.80-7.00 (m, 2H), 4.00-4.10 (m, 2H), 3.82 (s, 3H), 2.05-2.20 (m, 5H), 1.30-1.45 (m, 5H), 0.66 (t, J = 7.5 Hz, 3H). 3-042 δ 7.75-7.80 (m, 1H), 7.30-7.40 (m, 2H), 7.25-7.30 (m, 2H), 6.80-6.90 (m, 2H), 4.50-4.60 (m, 1H), 3.78 (s, 3H), 2.21 (s, 3H), 2.09 (td, J = 7.2, 2.7 Hz, 2H), 1.34 (dd, J = 6.0, 1.9 Hz, 6H), 1.20-1.30 (m, 2H), 0.59 (t, J = 7.3 Hz, 3H). 3-044 δ 7.75-7.80 (m, 1H), 7.20-7.45 (m, 3H), 6.55-6.75 (m, 2H), 3.81 (s, 3H), 3.73 (s, 3H), 2.05-2.25 (m, 5H), 1.25-1.45 (m, 2H), 0.65 (t, J = 7.5 Hz, 3H). 3-046 δ 7.75-7.80 (m, 1H), 7.15-7.35 (m, 3H), 6.55-6.70 (m, 2H), 4.04 (q, J = 6.8 Hz, 2H), 3.81 (s, 3H), 2.05-2.20 (m, 5H), 1.25-1.45 (m, 5H), 0.65 (t, J = 7.3 Hz, 3H). 3-048 δ 7.75-7.80 (m, 1H), 7.20-7.35 (m, 2H), 7.01 (d, J = 2.4 Hz, 1H), 6.90-7.00 (m, 1H), 6.75-6.90 (m, 1H), 4.20-4.35 (m, 4H), 3.79 (s, 3H), 2.23 (s, 3H), 2.10 (td, J = 7.2, 3.6 Hz, 2H), 1.25-1.35 (m, 2H), 0.58 (t, J = 7.3 Hz, 3H). 3-050 δ 7.55-7.65 (m, 1H), 7.25-7.35 (m, 3H), 7.14 (dd, J = 8.0, 1.2 Hz, 1H), 6.85-7.00 (m, 2H), 3.83 (s, 3H), 3.71 (s, 3H), 2.46 (s, 3H), 2.11 (t, J = 7.2 Hz, 2H), 2.10 (s.3H), 1.25-1.45 (m, 2H), 0.67 (t, J = 7.3 Hz, 3H). 3-054 δ 7.55-7.65 (m, 1H), 7.20-7.35 (m, 3H), 7.13 (dd, J = 8.3, 0.9 Hz, 1H), 6.80-6.95 (m, 2H), 4.04 (q, J = 7.1 Hz, 2H), 3.82 (s, 3H), 2.45 (s, 3H), 2.12 (t, J = 7.2 Hz, 2H), 2.10 (s, 3H), 1.25-1.40 (m, 5H), 0.66 (t, J = 7.5 Hz, 3H). 3-058 δ 7.59 (s, 1H), 7.05-7.35 (m, 3H), 6.50-6.70 (m, 2H), 4.03 (q, J = 6.8z, 2H), 3.81 (s, 3H), 2.45 (s, 3H), 2.13 (s, 3H), 2.11 (t, J = 7.2 Hz, 2H), 1.20-1.45 (m, 5H), 0.64 (t, J = 7.4 Hz, 3H). 3-062 δ 7.40-7.50 (m, 2H), 7.20-7.35 (m, 5H), 6.95 (dd, J = 9.0, 2.4 Hz, 1H), 3.87 (s, 3H), 3.77 (s, 3H), 2.20 (s, 3H), 2.00-2.15 (m, 2H), 1.20-1.35 (m, 2H), 0.60 (t, J = 7.2 Hz, 3H). 3-066 δ 7.25-7.35 (m, 4H), 6.85-7.00 (m, 3H), 3.86 (s, 3H), 3.83 (s, 3H), 3.72 (s, 3H), 2.12 (t, J = 7.5 Hz, 2H), 2.10 (s, 3H), 1.25-1.45 (m, 2H), 0.68 (t, J = 7.3 Hz, 3H). 3-071 δ 7.20-7.35 (m, 4H), 6.80-7.05 (m, 3H), 4.06 (q, J = 7.1 Hz, 2H), 3.87 (s, 3H), 3.83 (s, 3H), 2.14 (t, J = 6.7 Hz, 2H), 2.11 (s, 3H), 1.30-1.45 (m, 5H), 0.67 (t, J = 7.5 Hz, 3H). 3-075 δ 7.35-7.45 (m, 2H), 7.15-7.30 (m, 4H), 6.96 (dd, J = 8.9, 2.4 Hz, 1H), 3.88 (s, 3H), 3.78 (s, 3H), 2.49 (s, 3H), 2.23 (s, 3H), 2.05-2.15 (m, 2H), 1.20-1.35 (m, 2H), 0.59 (t, J = 7.3 Hz, 3H). 3-077 δ 7.20-7.30 (m, 3H), 6.94 (dd, J = 8.7, 2.4 Hz, 1H), 6.55-6.65 (m, 2H), 3.86 (s, 3H), 3.80 (s, 3H), 3.71 (s, 3H), 2.12 (s, 3H) 2.10 (t, J = 7.2 Hz, 2H), 1.25-1.40 (m, 2H), 0.66 (t, J = 7.5 Hz, 3H). 3-079 δ 7.15-7.35 (m, 3H), 6.95 (dd, J = 8.9, 2.5 Hz, 1H), 6.50-6.70 (m, 2H), 4.04 (q, J = 7.1 Hz, 2H), 3.87 (s, 3H), 3.81 (s, 3H), 2.10-2.20 (m, 5H), 1.39 (t, J = 7.1 Hz, 3H), 1.25-1.40 (m, 2H), 0.66 (t, J = 7.4 Hz, 3H). 3-090 δ 7.25-7.35 (m, 4H), 6.85-7.00 (m, 3H), 4.09 (q, J = 7.1 Hz, 2H), 3.83 (s, 3H), 3.72 (s, 3H), 2.05-2.15 (m, 5H), 1.44 (t, J = 7.1 Hz, 3H), 1.25-1.40 (m, 2H), 0.67 (t, J = 7.3 Hz, 3H). 3-092 δ 7.40-7.50 (m, 2H), 7.30-7.35 (m, 2H), 7.00 (dd, J = 8.9, 2.4 Hz, 1H), 6.85-6.95 (m, 2H), 4.14 (q, J = 6.9 Hz, 2H), 3.86 (s, 3H), 3.82 (s, 3H), 2.27 (s, 3H), 2.05-2.20 (m, 2H), 1.50 (t, J = 6.9 Hz, 1H), 1.25-1.40 (m, 2H), 0.64 (t, J = 7.5 Hz, 3H). 3-094 δ 7.20-7.35 (m, 4H), 6.80-7.05 (m, 3H), 4.00-4.20 (m, 4H), 3.83 (s, 3H), 2.10-2.20 (m, 5H), 1.30-1.50 (m, 8H), 0.67 (t, J = 7.5 Hz, 3H). 3-096 δ 7.20-7.35 (m, 3H), 6.94 (dd, J = 8.4, 2.4 Hz, 1H), 6.64 (dd, J = 10.9, 2.4 Hz, 1H), 6.58 (td, J = 8.4, 2.4 Hz, 1H), 3.95-4.20 (m, 4H), 3.81 (s, 3H), 2.05-2.20 (m, 5H), 1.25-1.50 (m, 8H), 0.65 (t, J = 7.5 Hz, 3H). 3-103 δ 7.23-7.34 (m, 4H), 6.97 (dd, J = 8.9, 2.4 Hz, 1H), 6.84-6.93 (m, 2H), 6.74 (brs, 1H), 4.02-4.12 (m, 2H), 3.97 (t, J = 6.7 Hz, 2H), 3.71 (s, 3H), 2.14 (s, 3H), 1.75-1.90 (m, 2H), 1.32 (t, J = 7.0 Hz, 3H), 1.04 (t, J = 7.3 Hz, 3H). 3-104 δ 7.33 (d, J = 8.5 Hz, 1H), 7.27-7.31 (m, 2H), 7.19-7.26 (m, 1H), 6.97 (dd, J = 8.5, 2.4 Hz, 1H), 6.81-6.90 (m, 2H), 3.94-4.06 (m, 4H), 3.74 (s, 3H), 3.38 (s, 3H), 2.09 (s, 3H), 1.75-1.90 (m, 2H), 1.31 (t, J = 7.0 Hz, 3H), 1.04 (t, J = 7.3 Hz, 3H). 3-106 δ 7.31-7.38 (m, 2H), 7.22-7.30 (m, 2H), 6.98 (dd, J = 8.9, 2.4 Hz, 1H), 6.90 (td, J = 7.5, 1.0 Hz, 1H), 6.82-6.87 (m, 1H), 4.01 (td, J = 6.5, 0.7 Hz, 2H), 3.73 (s, 3H), 3.68 (s, 3H), 3.37 (s, 3H), 2.09 (s, 3H), 1.73-1.84 (m, 2H), 1.43-1.57 (m, 2H), 0.97 (t, J = 7.3 Hz, 3H). 3-109 δ 7.27-7.38 (m, 4H), 6.90-6.98 (m, 3H), 6.36 (brs, 1H), 4.76-4.86 (m, 1H), 3.80 (s, 3H), 3.73 (s, 3H), 2.17 (s, 3H), 1.75-1.98 (m, 6H), 1.59-1.70 (m, 2H). 3-110 δ 7.32-7.37 (m, 2H), 7.22-7.29 (m, 2H), 6.82-6.97 (m, 3H), 4.77-4.85 (m, 1H), 3.73 (s, 3H), 3.68 (s, 3H), 3.37 (s, 3H), 2.09 (s, 3H), 1.72-1.95 (m, 6H), 1.54-1.70 (m, 2H). 3-114 δ 7.24-7.36 (m, 4H), 6.96-7.01 (m, 1H), 6.88-6.94 (m, 2H), 6.72 (brs, 1H), 6.10 (tt, J = 54.9 Hz, 4.4 Hz, 1H), 4.21 (tdd, J = 13.0 Hz, 3.8 Hz, 0.7 Hz, 2H), 3.76 (s, 3H), 3.68 (s, 3H), 2.15 (s, 3H). 3-117 δ 7.24-7.44 (m, 4H), 7.03 (dd, J = 8.9, 2.4 Hz, 1H), 6.83-6.95 (m, 2H), 4.40 (q, J = 8.2 Hz, 2H), 3.73 (s, 3H), 3.69 (s, 3H), 3.35 (s, 3H), 2.09 (s, 3H). 3-122 δ 7.29-7.39 (m, 3H), 7.26 (td, J = 7.8, 1.7 Hz, 1H), 7.02 (dd, J = 8.9, 2.4 Hz, 1H), 6.90 (td, J = 7.5, 1.0 Hz, 1H), 6.85 (d, J = 8.5 Hz, 1H), 4.16 (dd, J = 5.5, 4.1 Hz, 2H), 3.74-3.78 (m, 2H), 3.73 (s, 3H), 3.67 (s, 3H), 3.44 (s, 3H), 3.36 (s, 3H), 2.09 (s, 3H). 3-125 δ 7.38 (d, J = 8.5 Hz, 1H), 7.34 (dd, J = 7.5, 1.7 Hz, 1H), 7.31 (d, J = 2.1 Hz, 1H), 7.20-7.28 (m, 1H), 6.99 (dd, J = 8.9, 2.4 Hz, 1H), 6.89 (td, J = 7.5, 1.0 Hz, 1H), 6.84 (d, J = 8.2 Hz, 1H), 4.19 (t, J = 6.8 Hz, 2H), 3.73 (s, 3H), 3.66 (s, 3H), 3.36 (s, 3H), 2.87 (t, J = 7.2 Hz, 2H), 2.18 (s, 3H), 2.08 (s, 3H). 3-129 δ 7.28-7.36 (m, 4H), 7.00 (dd, J = 8.9 Hz, 2.1 Hz, 1H), 6.90-6.97 (m, 2H), 6.36 (brs, 1H), 3.87 (d, J = 7.2 Hz, 2H), 3.80 (s, 3H), 3.73 (s, 3H), 2.17 (s, 3H), 1.24-1.39 (m, 1H), 0.62-0.71 (m, 2H), 0.34-0.41 (m, 2H). 3-142 δ 7.44-7.52 (m, 3H), 7.30-7.34 (m, 1H), 7.06-7.13 (m, 3H), 6.52 (t, J = 74.1 Hz, 1H), 3.76 (s, 3H), 2.23 (s, 3H), 2.00-2.15 (m, 2H), 1.20-1.33 (m, 2H), 0.57 (t, J = 7.8 Hz, 3H). 3-148 δ 7.79-7.80 (m, 1H), 7.45-7.50 (m, 2H), 7.29-7.30 (m, 2H), 7.06-7.07 (m, 2H), 6.52 (t, J = 74.1 Hz, 1H), 3.76 (s, 3H), 2.23 (s, 3H), 2.00-2.18 (m, 2H), 1.21-1.34 (m, 2H), 0.58 (t, J = 7.5 Hz, 3H). 3-152 δ 7.59-7.60 (m, 1H), 7.45-7.50 (m, 2H), 7.24-7.26 (m, 1H), 7.13-7.16 (m, 1H), 7.04-7.09 (m, 2H), 6.52 (t, J = 74.7 Hz, 1H), 3.30 (s, 3H), 2.46 (s, 3H), 2.23 (s, 3H), 1.95-2.16 (m, 2H), 1.19-1.31 (m, 2H), 0.56 (t, J = 7.5 Hz, 3H). 3-155 δ 7.24-7.34 (m, 4H), 6.84-6.96 (m, 3H), 5.81-5.82 (m, 1H), 5.52-5.53 (m, 1H), 3.87 (s, 3H), 3.83 (s, 3H), 3.65 (s, 3H), 2.10 (s, 3H), 1.67-1.69 (m, 3H). 3-157 δ 7.09-7.33 (m, 7H), 6.84-7.00 (m, 5H), 3.89 and 3.87 (s, 3H), 3.77 (s, 3H), 3.70 and 3.65 (s, 3H), 3.53 (q, J = 7.5 Hz, 1H), 1.87 and 1.75 (s, 3H), 1.20 (dd, J = 15.3 Hz, 6.9 Hz, 3H). 3-158 δ 7.24-7.47 (m, 5H), 7.15-7.18 (m, 1H), 6.95 (dd, J = 9.0 Hz, 2.4 Hz, 1H), 6.79-6.88 (m, 4H), 3.85 (s, 6H), 3.66 (s, 3H), 3.53 (s, 3H), 2.17 (s, 3H). 3-167 δ 7.87 (dd, J = 1.5, 0.9 Hz, 1H), 7.10-7.45 (m, 4H), 6.85-7.00 (m, 2H), 4.15 (q, J = 7.1 Hz, 2H), 3.75 (s, 3H), 3.70 (s, 3H), 3.36 (s, 3H), 3.10-3.25 (m, 2H), 2.55-2.65 (m, 2H), 2.10 (s, 3H), 1.26 (t, J = 7.1 Hz, 3H). 3-171 δ 7.85-7.90 (m, 1H), 7.25-7.45 (m, 4H), 6.85-7.00 (m, 2H), 3.95-4.10 (m, 2H), 3.74 (s, 3H), 3.70 (s, 3H), 3.36 (s, 3H), 3.10-3.25 (m, 2H), 2.55-2.70 (m, 2H), 2.10 (s, 3H), 1.50-1.65 (m, 1H), 1.20-1.45 (m, 8H), 0.85-0.95 (m , 6H). 3-172 δ 7.74 (s, 1H), 7.27-7.40 (m, 2H), 7.03-7.11 (m, 1H), 6.82-6.99 (m, 2H), 6.68-6.73 (m, 1H), 6.56-6.61 (m, 1H), 3.81 (s, 3H), 3.71 (s, 3H), 3.45 (s, 3H), 2.13 (s, 3H). 4-002 δ 7.43-7.51 (m, 2H), 7.25-7.34 (m, 1H), 7.16-7.18 (m, 1H), 7.00-7.09 (m, 3H), 3.76 (s, 3H), 2.23 (s, 3H), 2.03-2.12 (m, 2H), 1.21-1.33 (m, 2H), 0.58 (t, J = 7.5 Hz, 3H). 4-004 δ 7.20-7.36 (m, 4H), 6.89-7.04 (m, 3H), 3.82 (s, 3H), 3.73 (s, 3H), 2.12 (t, J = 7.2 Hz, 2H), 2.10 (s, 3H), 1.28-1.40 (m, 2H), 0.66 (t, J = 7.5 Hz, 3H). 4-006 δ 7.38-7.43 (m, 2H), 7.24-7.31 (m, 1H), 7.13-7.16 (m, 1H), 6.97-7.03 (m, 1H), 6.85-6.90 (m, 2H), 3.82 (s, 3H), 3.78 (s, 3H), 2.22 (s, 3H), 2.05-2.12 (m, 2H), 1.23-1.33 (m, 2H), 0.58 (t, J = 7.5 Hz, 3H). 4-008 δ 7.19-7.32 (m, 4H), 6.85-7.03 (m, 3H), 4.06 (q, J = 7.2 Hz, 2H), 3.82 (s, 3H), 2.13 (t, J = 7.2 Hz, 3H), 2.10 (s, 3H), 1.30-1.40 (m, 4H), 0.65 (t, J = 7.5 Hz, 3H). 4-010 δ 7.35-7.45 (m, 2H), 7.20-7.35 (m, 1H), 7.10-7.20 (m, 1H), 6.95-7.05 (m, 1H), 6.80-6.90 (m, 2H), 3.92 (t, J = 6.5 Hz, 2H), 3.78 (s, 3H), 2.21 (s, 3H), 2.08 (td, J = 7.2, 2.2 Hz, 2H), 1.70-1.90 (m, 2H), 1.20-1.40 (m, 2H), 1.03 (t, J = 7.3 Hz, 3H), 0.58 (t, J = 7.5 Hz, 3H). 4-012 δ 7.19-7.32 (m, 3H), 6.98-7.04 (m, 1H), 6.60-6.66 (m, 2H), 3.81 (s, 3H), 3.74 (s, 3H), 2.13 (s, 3H), 2.11 (t, J = 7.2 Hz, 2H), 1.27-1.40 (m, 2H), 0.65 (t, J = 7.5 Hz, 3H). 4-016 δ 7.42-7.50 (m, 2H), 7.27-7.36 (m, 3H), 7.02-7.10 (m, 2H), 3.76 (s, 3H), 2.22 (s, 3H), 2.15-2.05 (m, 2H), 1.32-1.22 (m, 2H), 0.58 (t, J = 7.2 Hz, 3H). 4-018 δ 7.28-7.44 (m, 7H), 3.77 (s, 3H), 2.22 (s, 3H), 2.04-2.14 (m, 2H), 1.22-1.32 (m, 2H), 0.58 (t, J = 7.2 Hz, 3H). 4-020 δ 7.26-7.38 (m, 5H), 7.12-7.18 (m, 2H), 3.78 (s, 3H), 2.36 (s, 3H), 2.20 (s, 3H), 2.12-2.05 (m, 2H), 1.34-1.20 (m, 2H), 0.59 (t, J = 7.2 Hz, 3H). 4-022 δ 7.24-7.36 (m, 5H), 6.88-6.98 (m, 2H), 3.83 (s, 3H), 3.73 (s, 3H), 2.12 (t, J = 7.2 Hz, 2H), 2.09 (s, 3H), 1.28-1.42 (m, 2H), 0.66 (3H, J = 7.2 Hz, 3H). 4-024 δ 7.38-7.44 (m, 2H), 7.25-7.33 (m, 3H), 6.84-6.90 (m, 2H), 3.82 (s, 3H), 3.78 (s, 3H), 2.21 (s, 3H), 2.15-2.05 (m, 2H), 1.22-1.32 (m, 2H), 0.59 (t, J = 7.2 Hz, 3H). 4-026 δ 7.22-7.36 (m, 5H), 6.84-6.98 (m, 2H), 4.06 (q, J = 7.2 Hz, 3H), 3.82 (s, 3H), 2.13 (t, J = 7.2 Hz, 2H), 2.10 (s, 3H), 1.30-1.40 (m, 2H), 1.37 (t, J = 7.2 Hz, 3H), 0.66 (t, J = 7.2 Hz, 3H). 4-028 δ 7.35-7.45 (m, 2H), 7.25-7.35 (m, 3H), 6.80-6.90 (m, 2H), 3.92 (t, J = 6.6 Hz, 2H), 3.79 (s, 3H), 2.20 (s, 3H), 2.08 (td, J = 7.2, 2.0 Hz, 2H), 1.70-1.90 (m, 2H), 1.20-1.35 (m, 2H), 1.03 (t, J = 7.5 Hz, 3H), 0.58 (t, J = 7.3 Hz, 3H). 4-030 δ 7.60-7.65 (m, 4H), 7.30-7.40 (m, 3H), 3.75 (s, 3H), 2.24 (s, 3H), 2.02-2.15 (m, 2H), 1.20-1.34 (m, 2H), 0.57 (t, J = 7.2 Hz, 3H). 4-032 δ 7.62-7.66 (m, 4H), 7.32-7.42 (m, 3H), 3.74 (s, 3H), 2.26 (s, 3H), 2.06-2.12 (m, 2H), 1.22-1.32 (m, 2H), 0.56 (t, J = 7.5 Hz, 3H). 4-034 δ 7.24-7.36 (m, 4H), 6.68-6.60 (m, 2H), 3.80 (s, 3H), 3.74 (s, 3H), 2.08-2.16 (m, 2H), 2.04 (s, 3H), 1.42-1.28 (m, 2H), 0.65 (t, J = 7.2 Hz, 3H). 4-036 δ 7.20-7.34 (m, 4H), 6.55-6.70 (m, 2H), 4.03 (q, J = 7.2 Hz, 2H), 3.81 (s, 3H), 2.05-2.16 (m, 2H), 2.04 (s, 3H), 1.28-1.42 (m, 2H), 1.26 (t, J = 7.2 Hz, 3H), 0.65 (t, J = 7.2 Hz, 3H). 4-038 δ 7.50-7.60 (m, 2H), 7.30-7.40 (m, 4H), 3.77 (s, 3H), 2.10-2.20 (m, 2H), 2.18 (s, 3H), 1.22-1.42 (m, 2H), 0.63 (t, J = 7.2 Hz, 3H). 4-039 δ 7.25-7.40 (m, 3H), 7.06 (dd, J = 7.8, 0.7 Hz, 1H), 6.90-7.00 (m, 2H), 6.75-6.85 (m, 1H), 6.40 (brs 1H), 4.02 (s, 3H), 3.80 (s, 3H), 3.74 (s, 3H), 2.19 (s, 3H). 4-043 δ 7.38-7.41 (m, 2H), 7.24-7.32 (m, 1H), 7.15-7.21 (m, 3H), 6.98-7.04 (m, 1H), 3.77 (s, 3H), 2.91 (q, J = 6.6 Hz, 1H), 2.21 (s, 3H), 2.06-2.12 (m, 2H), 1.23-1.32 (m, 8H), 0.58 (t, J = 7.5 Hz, 3H). 4-045 δ 7.62 (s, 4H), 7.30-7.37 (m, 1H), 7.19-7.22 (m, 1H), 7.04-7.10 (m, 1H), 3.75 (s, 3H), 2.28 (s, 3H), 2.01-2.18 (m, 2H), 1.21-1.33 (m, 2H), 0.57 (t, J = 7.8 Hz, 3H). 4-047 δ 7.47-7.52 (m, 2H), 7.27-7.34 (m, 1H), 7.17 (d, J = 8.4 Hz, 1H), 7.01-7.12 (m, 3H), 6.53 (t, J = 74.1 Hz, 1H), 3.75 (s, 3H), 2.23 (s, 3H), 2.00-2.18 (m, 2H), 1.21-133 (m, 2H), 0.57 (t, J = 7.5 Hz, 3H). 4-049 δ 7.51-7.56 (m, 2H), 7.28-7.35 (m, 1H), 7.18-7.22 (m, 3H), 7.03-7.09 (m, 1H), 3.75 (s, 3H), 2.24 (s, 3H), 2.00-2.16 (m, 2H), 1.21-1.33 (m, 2H), 0.57 (t, J = 6.9 Hz, 3H). 4-053 δ 7.69-7.79 (m, 1H), 7.64 (s, 4H), 7.31-7.38 (m, 1H), 7.06-7.12 (m, 1H), 3.73 (s, 3H), 2.26 (s, 3H), 2.01-2.16 (m, 2H), 1.22-1.30 (m, 2H), 0.56 (t, J = 7.8 Hz, 3H). 4-055 δ 7.17-7.41 (m, 5H), 7.03-7.09 (m, 1H), 3.76 (s, 3H), 2.26 (s, 3H), 2.02-2.17 (m, 2H), 1.23-1.30 (m, 2H), 0.57 (t, J = 7.5 Hz, 3H). 4-059 δ 7.28-7.40 (m, 5H), 7.08-7.16 (m, 2H), 3.80 (s, 3H), 2.14 (t, J = 7.2 Hz, 2H), 2.13 (s, 3H), 1.30-1.40 (m, 2H), 0.65 (t, J = 7.2 Hz, 3H). 4-065 δ 7.22-7.36 (m, 4H), 7.02-7.10 (m, 2H), 6.86-6.92 (m, 1H), 3.77 (s, 3H), 3.75 (s, 3H), 2.08-2.12 (m, 2H), 2.21 (s, 3H), 1.20-1.34 (m, 2H), 0.58 (t, J = 7.2 Hz, 3H). 4-067 δ 7.20-7.35 (m, 4H), 7.00-7.06 (m, 2H), 6.84-6.90 (m, 1H), 3.97 (q, J = 7.2 Hz, 2H), 3.77 (s, 3H), 2.20 (s, 3H), 2.09 (dt, J = 7.2, 1.5 Hz, 2H), 1.37 (t, J = 7.2 Hz, 3H), 1.22-1.32 (m, 2H), 0.58 (t, J = 7.2 Hz, 3H). 4-069 δ 7.20-7.36 (m, 5H), 6.82-6.96 (m, 2H), 3.99 (t, J = 7.2 Hz, 2H), 3.82 (s, 3H), 2.12 (t, J = 7.2 Hz, 2H), 2.09 (s, 3H), 1.70-1.82 (m, 2H), 1.45-1.60 (m, 2H), 1.28-1.42 (m, 2H), 0.97 (t, J = 7.2 Hz, 3H), 0.65 (t, J = 7.2 Hz, 3H). 4-073 δ 7.78-7.82 (m, 1H), 7.64-7.70 (m, 1H), 7.58-7.64 (m, 1H), 7.44-7.52 (m, 1H), 7.32-7.40 (m, 3H), 3.76 (s, 3H), 2.21 (s, 3H), 2.02-2.14 (m, 2H), 1.20-1.35 (m, 2H), 0.59 (t, J = 7.2 Hz, 3H). 4-075 δ 7.48-7.53 (m, 2H), 7.28-7.36 (m, 3H), 7.07-7.12 (m, 2H), 6.53 (t, J = 74.1 Hz, 1H), 3.76 (s, 3H), 2.23 (s, 3H), 2.01-2.15 (m, 2H), 1.21-1.31 (m, 2H), 0.58 (t, J = 7.5 Hz, 3H). 4-077 δ 7.20-7.50 (m, 7H), 3.77 (s, 3H), 2.08-2.16 (m, 5H), 1.22-1.42 (m, 2H), 0.65 (t, J = 7.2 Hz, 3H). 4-079 δ 7.50-7.56 (m, 2H), 7.30-7.38 (m, 3H), 7.16-7.22 (m, 2H), 3.75 (s, 3H), 2.23 (s, 3H), 2.00-2.16 (m, 2H), 1.22-1.32 (m, 2H), 0.57 (t, J = 7.2 Hz, 3H). 4-080 δ 7.25-7.35 (m, 5H), 6.88-6.96 (m, 2H), 5.03 (brs, 1H), 3.75 (s, 3H), 2.12 (s, 3H), 1.95-2.05 (m, 2H), 1.20-1.30 (m, 2H), 0.66 (t, J = 7.2 Hz, 3H). 4-085 δ 7.25-7.35 (m, 10H), 6.88-6.96 (m, 2H), 5.13 (d, J = 1.8 Hz, 2H), 3.69 (s, 3H), 2.10 (s, 3H), 1.96-2.04 (m, 2H), 1.16-1.26 (m, 2H), 0.50 (t, J = 7.2 Hz, 3H). 4-087 δ 7.27-7.36 (m, 6H), 7.06-7.14 (m, 1H), 3.76 (s, 3H), 2.44 (s, 3H), 2.23 (t, J = 7.2 Hz, 2H), 2.11 (s, 3H), 1.32-1.46 (m, 2H), 0.68 (t, J = 7.2 Hz, 3H). 4-093 δ 7.40-7.44 (m, 1H), 7.28-7.36 (m, 6H), 3.77 (s, 3H), 2.80-2.94 (m, 2H), 2.20 (s, 3H), 2.06-2.12 (m, 2H), 1.20-1.32 (m, 5H), 0.58 (t, J = 7.2 Hz, 3H). 4-095 δ 7.22-7.42 (m, 7H), 3.77 (s, 3H), 2.97 (q, J = 7.2 Hz, 2H), 2.21 (s, 3H), 2.09 (dt, J = 7.2 Hz, 2.4 Hz, 2H), 1.34 (t, J = 7.2 Hz, 3H), 1.22-1.32 (m, 2H), 0.58 (t, J = 7.2 Hz, 3H). 4-097 δ 7.36-7.42 (m, 2H), 7.28-7.35 (m, 5H), 3.77 (s, 3H), 3.40-3.50 (m, 1H), 2.21 (s, 3H), 2.09 (dt, J = 7.2, 2.4 Hz, 2H), 1.32 (d, J = 7.2 Hz, 6H), 1.22-1.30 (m, 2H), 0.58 (t, J = 7.2 Hz, 3H). 4-101 δ 7.44-7.52 (m, 2H), 7.20-7.30 (m, 2H), 7.10-7.15 (m, 1H), 6.98-7.08 (m, 2H), 3.75 (s, 3H), 2.56 (s, 3H), 2.23 (s, 3H), 2.06-2.14 (m, 2H), 1.24-1.30 (m, 2H), 0.55 (t, J = 7.2 Hz, 3H). 4-105 δ 7.35-7.40 (m, 2H), 7.20-7.30 (m, 3H), 7.10-7.15 (m, 2H), 3.76 (s, 3H), 2.56 (s, 3H), 2.23 (s, 3H), 2.10-2.18 (m, 2H), 1.20-1.30 (m, 2H), 0.54 (t, J = 7.2 Hz, 3H). 4-109 δ 7.20-7.30 (m, 3H), 7.05-7.15 (m, 3H), 6.82-6.88 (m, 1H), 3.76 (s, 3H), 3.74 (s, 3H), 2.57 (s, 3H), 2.21 (s, 3H), 2.04-2.10 (m, 2H), 1.20-1.30 (m, 2H), 0.55 (t, J = 7.2 Hz, 3H). 4-113 δ 7.22-7.30 (m, 4H), 7.08-7.15 (m, 1H), 6.84-6.94 (m, 2H), 4.04 (q, J = 7.2 Hz, 2H), 3.81 (s, 3H), 2.55 (s, 3H), 2.08-2.16 (m, 5H), 1.30-1.40 (m, 5H), 0.64 (t, J = 7.2 Hz, 3H). 4-115 δ 7.18-7.28 (m, 3H), 7.10-7.14 (m, 1H), 7.04-7.08 (m, 2H), 6.80-6.88 (m, 1H), 3.92-4.02 (m, 2H), 3.76 (s, 3H), 2.56 (s, 3H), 2.21 (s, 3H), 2.05-2.10 (m, 2H), 1.36 (t, J = 7.2 Hz, 3H), 1.20-1.30 (m, 2H), 0.55 (t, J = 7.2 Hz, 3H). 4-117 δ 7.20-7.34 (m, 5H), 7.05-7.15 (m, 2H), 3.75 (s, 3H), 2.56 (s, 3H), 2.43 (s, 3H), 2.20 (t, J = 7.5 Hz, 2H), 2.11 (s, 3H), 1.30-1.45 (m, 2H), 0.66 (t, J = 7.5 Hz, 3H). 4-123 δ 7.42-7.46 (m, 1H), 7.20-7.32 (m, 5H), 7.10-7.14 (m, 1H), 3.76 (s, 3H), 2.80-2.94 (m, 2H), 2.57 (s, 3H), 2.21 (s, 3H), 2.05-2.10 (m, 2H), 1.30-1.40 (m, 5H), 0.55 (t, J = 7.2 Hz, 3H). 4-131 δ 7.52-7.58 (m, 2H), 7.15-7.30 (m, 5H), 3.74 (s, 3H), 2.57 (s, 3H), 2.24 (s, 3H), 2.00-2.15 (m, 2H), 1.20-1.30 (m, 2H), 0.54 (t, J = 7.5 Hz, 3H). 5-010 δ 7.56-7.61 (m, 1H), 7.39-7.42 (m, 2H), 7.30-7.33 (m, 2H), 7.12-7.18 (m, 1H), 4.56 (s, 2H), 3.79 (s, 3H), 3.41 (s, 3H), 2.20 (s, 3H), 2.09-2.14 (m, 2H), 1.29 (q, J = 6.0 Hz, 2H), 0.60 (t, J = 6.0 Hz, 3H). 5-042 δ 7.88 (s, 1H), 7.50 (s, 1H), 7.25-7.40 (m, 2H), 6.85-7.00 (m, 2H), 3.84 (s, 3H), 3.73 (s, 3H), 2.05-2.20 (m, 5H), 1.30-1.45 (m, 2H), 0.69 (t, J = 7.4 Hz, 3H). 5-052 δ 7.88 (s, 1H), 7.49 (s, 1H), 7.20-7.35 (m, 1H), 6.60-6.70 (m, 2H), 3.82 (s, 3H), 3.73 (s, 3H), 2.10-2.25 (m, 5H), 1.30-1.45 (m, 2H), 0.68 (t, J = 7.4 Hz, 3H). 5-054 δ 7.88 (s, 1H), 7.47 (s, 1H), 7.21 (dd, J = 8.3, 6.7 Hz, 1H), 6.50-6.70 (m, 2H), 4.04 (q, J = 7.0 Hz, 2H), 3.82 (s, 3H), 2.10-2.20 (m, 5H), 1.30-1.45 (m, 5H), 0.67 (t, J = 7.4 Hz, 3H). 5-061 δ 7.25-7.30 (m, 1H), 7.21 (s, 1), 6.79 (s, 1H), 6.55-6.65 (m, 2H), 3.94 (s, 3H), 3.87 (s, 3H), 3.79 (s, 3H), 3.70 (s, 3H), 2.14 (s, 3H), 2.12 (t, J = 7.5 Hz, 2H), 1.30-1.40 (m, 2H), 0.66 (t, J = 7.5 Hz, 3H). 5-076 δ 7.40 (s, 1H), 7.20-7.30 (m, 2H), 6.55-6.70 (m, 2H), 3.96 (s, 3H), 3.80 (s, 3H), 3.73 (s, 3H), 2.05-2.20 (m, 5H), 1.25-1.45 (m, 2H), 0.67 (t, J = 7.5 Hz, 3H). 5-080 δ 7.15-7.35 (m, 6H), 6.80-7.05 (m, 4H), 3.95-4.15 (m, 4H), 3.83 (s, 3H), 3.74 (s, 3H), 2.14 (td, J = 7.2, 1.5 Hz, 2H), 2.09 (s, 3H), 1.20-1.45 (m, 8H), 0.66 (t, J = 7.3 Hz, 3H). 8-009 δ 7.60-7.70 (m, 2H), 7.15-7.55 (m, 9H), 6.95-7.00 (m, 2H), 5.08 (s, 2H), 3.76 (s, 3H), 3.48 (s, 3H), 2.32 (s, 3H). 9-005 δ 7.60-7.70 (m, 2H), 7.38 (d, J = 8.7 Hz, 1H), 7.00-7.15 (m, 4H), 3.80 (s, 3H), 2.42 (s, 3H), 2.30 (s, 3H), 2.00-2.15 (m, 2H), 1.20-1.35 (m, 2H), 0.58 (t, J = 7.2H, 3H). 9-008 δ 7.55-7.65 (m, 2H), 7.30-7.40 (m, 1H), 7.00-7.10 (m, 2H), 6.85-6.95 (m, 2H), 3.83 (s, 3H), 3.81 (s, 3H), 2.41 (s, 3H), 2.29 (s, 3H), 2.00-2.15 (m, 2H), 1.20-1.35 (m, 2H), 0.58 (t, J = 7.5 Hz, 3H). 9-010 δ 7.60-7.70 (m, 1H), 7.36 (d, J = 8.1 Hz, 1H), 7.15-7.25 (m, 1H), 7.05-7.15 (m, 1H), 6.65-6.75 (m, 1H), 6.55-6.65 (m, 1H), 3.85-4.00 (m, 2H), 3.83 (s, 3H), 2.42 (s, 3H), 2.18 (s, 3H), 1.90-2.05 (m, 2H), 1.25-1.40 (m, 2H), 1.13 (t, J = 7.2 Hz, 3H), 0.70 (t, J = 7.5 Hz, 3H). 9-026 δ 7.55-7.60 (m, 2H), 7.35-7.45 (m, 1H), 6.90-7.05 (m, 2H), 6.80-6.90 (m, 2H), 4.50-4.65 (m, 1H), 3.80 (s, 3H), 2.29 (s, 3H), 2.00-2.20 (m, 2H), 1.20-1.40 (m, 8H), 0.59 (t, J = 7.5 Hz, 3H). 9-040 δ 7.55-7.60 (m, 2H), 7.40-7.50 (m, 1H), 7.25-7.30 (m, 2H), 6.95-7.05 (m, 2H), 3.81 (s, 3H), 2.98 (q, J = 7.3 Hz, 2H), 2.29 (s, 3H), 2.05-2.20 (m, 2H), 1.20-1.40 (m, 5H), 0.59 (t, J = 7.5 Hz, 3H). 9-042 δ 7.55-7.60 (m, 2H), 7.40-7.50 (m, 1H), 7.30-7.40 (m, 2H), 6.95-7.05 (m, 2H), 3.81 (s, 3H), 3.40-3.50 (m, 1H), 2.29 (s, 3H), 2.00-2.20 (m, 2H), 1.20-1.40 (m, 8H), 0.59 (t, J = 7.5 Hz, 3H). 9-048 δ 7.69 (dd, J = 8.6, 4.6 Hz, 1H), 6.95-7.15 (m, 3H), 6.83 (d, J = 4.0 Hz, 1H), 3.83 (s, 3H), 2.29 (s, 3H), 2.05-2.20 (m, 2H), 1.15-1.35 (m, 2H), 0.56 (t, J = 7.4 Hz, 3H). 9-058 δ 7.50-7.60 (m, 2H), 7.35-7.40 (m, 1H), 7.20-7.30 (m, 2H), 7.05-7.15 (m, 2H), 3.81 (s, 3H), 2.97 (q, J = 7.2 Hz, 2H), 2.41 (s, 3H), 2.29 (s, 3H), 1.95-2.15 (m, 2H), 1.20-1.40 (m, 5H), 0.58 (t, J = 7.3 Hz, 3H). 9-060 δ 7.55-7.60 (m, 2H), 7.30-7.40 (m, 3H), 7.05-7.15 (m, 2H), 3.81 (s, 3H), 3.35-3.55 (m, 1H), 2.41 (s, 3H), 2.29 (s, 3H), 1.95-2.15 (m, 2H), 1.20-1.35 (m, 8H), 0.58 (t, J = 7.5 Hz, 3H). 12-018 δ 7.73 (d, 8.2 Hz, 1H), 7.35-7.65 (m, 6H), 7.21 (d, 8.2 Hz, 1H), 3.87 (s, 2H), 3.75 (s, 3H), 2.51 (s, 3H). 12-020 δ 7.61 (d, J = 8.9 Hz, 1H), 7.35-7.45 (m, 2H), 7.32 (d, J = 2.4 Hz, 1H), 6.95-7.10 (m, 3H), 3.89 (s, 3H), 3.79 (s, 3H), 3.69 (s, 2H), 3.67 (s, 3H). 12-024 δ 7.66 (ddd, J = 8.9, 8.9, 5.1 Hz, 1H), 7.50 (dd, J = 8.9, 2.4 Hz, 1H), 7.35-7.45 (m, 2H), 6.95-7.20 (m, 3H), 4.12 (q, J = 7.2 Hz, 2H), 3.78 (s, 3H), 3.68 (s, 2H), 1.21 (t, J = 7.2 Hz, 3H). 12-036 δ 7.70 (d, J = 8.3 Hz, 1H), 7.30-7.60 (m, 6H), 7.10-7.20 (m, 1H), 4.15-4.40 (m, 4H), 3.39 (s, 3H), 2.46 (s, 3H), 2.26 (s, 3H), 1.20-1.40 (m, 3H). 12-039 δ 7.25-7.50 (m, 4H), 6.90-7.10 (m, 2H), 6.70-6.85 (m, 1H), 4.15-4.30 (m, 2H), 4.07 (s, 2H), 3.99 (s, 3H), 3.77 (s, 3H), 3.31 (s, 3H), 2.18 (s, 3H), 1.20-1.35 (m, 3H). 12-040 δ 7.28-7.50 (m, 3H), 6.90-7.08 (m, 3H), 4.00-4.32 (m, 4H), 3.75 (s, 3H), 3.30 (s, 3H), 2.51 (s, 3H), 2.44 (s, 3H), 2.17 (s, 3H), 1.27 (t, J = 7.2 Hz, 3H).

Referential Example 1 Synthesis of 4-(2-bromobenzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one Step 1: production of 4-(benzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one

Firstly, 1.00 g of benzo[b]thiophene-3-boronic acid, 2.39 g of potassium phosphate, 350 mg of 2-dicyclohexylphosphino-2′,6′-diisopropoxybiphenyl, and 84 mg of palladium acetate were added to a mixture of 873 mg of 4-bromo-5-methoxy-2,6-dimethylpyridazin-3(2H)-one and 7.5 mL of toluene at room temperature. After completion of the addition, air in the reaction container was replaced with nitrogen gas. After completion of the gas replacement, the reaction mixture was stirred at 90° C. for four hours. After completion of the stirring, 10 mL of water and 10 mL of ethyl acetate were added to the reaction mixture, and insoluble matter was filtered with celite. The residue was washed with ethyl acetate (10 mL×2). The organic phase was separated from the resultant filtrate, and the resultant organic phase was washed with water (10 mL×1). Thereafter, the organic phase was dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate, and then the solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel chromatography (elution with a gradient of ethyl acetate:n-hexane=5:95 to 20:80), to thereby yield 1.05 g of the target product as a yellow oily product.

¹H NMR: δ 7.80-7.90 (m, 1H), 7.61 (s, 1H), 7.50-7.55 (m, 1H), 7.30-7.40 (m, 2H), 3.75 (s, 3H), 3.26 (s, 3H), 2.31 (s, 3H).

Step 2: production of 4-(2-bromobenzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one

Firstly, 746 mg of N-bromosuccinimide was added to a mixture of 1.0 g of 4-(benzo[b]thiophen-3-yl)-5-methoxy-2,6-dimethylpyridazin-3(2H)-one and 5 mL of N,N-dimethylformamide at room temperature. After completion of the addition, the reaction mixture was stirred at 80° C. for two hours. After completion of the stirring, 20 mL of 1 mol/L aqueous sodium hydroxide solution was added to the reaction mixture, and the resultant mixture was subjected to extraction with 60 mL of diethyl ether. The resultant organic phase was washed with water (10 mL×1), and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate. The solvent was distilled off under reduced pressure. The resultant residue was purified by silica gel column chromatography (elution with a gradient of ethyl acetate:n-hexane=2:98 to 20:80), to thereby yield 962 mg of the target product as a white solid.

Melting point: 250-252° C.

¹H NMR: δ 7.70-7.80 (m, 1H), 7.30-7.45 (m, 3H), 3.77 (s, 3H), 3.42 (s, 3H), 2.34 (s, 3H).

Referential Example 2 Production of 2-(5-fluorobenzo[b]thiophen-3-yl)acetic Acid Step 1: Synthesis of ethyl 2-(5-fluorobenzo[b]thiophen-3-yl)acetate

Firstly, a mixture of 32.3 g of potassium carbonate, 120 mL of N,N-dimethylformamide, and 25.0 g of 4-fluorobenzenethiol was cooled with ice, and ethyl 4-chloroacetoacetate was added dropwise to the mixture under ice cooling over one hour. After completion of the dropwise addition, the reaction mixture was stirred under ice cooling for one hour. After completion of the stirring, 250 mL of water was added to the reaction mixture, and the resultant mixture was subjected to extraction with 200 mL of toluene. The resultant organic phase was washed with 100 mL of water and 50 mL of aqueous saturated ammonium chloride solution, and then dehydrated and dried with anhydrous sodium sulfate. Thereafter, the solvent was distilled off under reduced pressure, to thereby yield a residue. The resultant residue was added dropwise under ice cooling over one hour to a suspension of 78.0 g of aluminum trichloride and 200 mL of 1,2-dichloroethane prepared in another reaction container. After completion of the dropwise addition, the reaction mixture was stirred at room temperature for 16 hours. After completion of the stirring, the reaction mixture was added dropwise over one hour to a mixture of 500 mL of ice and 100 mL of 1,2-dichloroethane. After completion of the dropwise addition, the reaction mixture was stirred at room temperature for two hours. After completion of the stirring, the organic phase was separated from the reaction mixture. The resultant organic phase washed with 200 mL of water, and then dehydrated and dried sequentially with saturated salt water and anhydrous sodium sulfate, followed by addition of 4.0 g of powdery activated carbon. After completion of the addition, the resultant suspension was stirred at room temperature for 30 minutes. After completion of the stirring, insoluble matter was filtered with celite, and the residue was washed with chloroform (50 mL×2). The solvent was distilled off under reduced pressure, to thereby yield 32.5 g of the target product as a brown oily product. This product was used in the next step without further purification.

¹H NMR: δ 7.77 (dd, J=8.9, 4.9 Hz, 1H), 7.40-7.50 (m, 2H), 7.12 (ddd, 8.9, 8.9, 2.5 Hz, 1H), 4.18 (q, J=7.2 Hz, 2H), 3.81 (s, 2H), 1.27 (t, J=7.2 Hz, 3H).

Step 2: Synthesis of 2-(5-fluorobenzo[b]thiophen-3-yl)acetic Acid

Firstly, a solution of 13.5 g of potassium hydroxide in 100 mL of water was added to a mixture of 32.5 g of ethyl 2-(5-fluorobenzo[b]thiophen-3-yl)acetate, 150 mL of tetrahydrofuran, and 50 mL of ethanol at room temperature. After completion of the addition, the reaction mixture was stirred at room temperature for 18 hours. After completion of the stirring, the solvent contained in the reaction mixture was distilled off under reduced pressure, and 100 mL of water was added to the resultant residue. The resultant mixture was washed sequentially with 100 mL of toluene and 50 mL of hexane. After completion of the washing, 35% by mass hydrochloric acid was added to the resultant mixture under ice cooling so as to achieve a pH of 1, and the precipitated solid was recovered through filtration. The resultant solid was washed with water (50 mL×2), to thereby yield 27.5 g of the target product as a white solid.

Melting point: 106-108° C.

¹H NMR: δ 7.77 (dd, J=9.00, 4.9 Hz, 1H), 7.45 (s, 1H), 7.41 (dd, J=9.4, 2.5 Hz, 1H), 7.12 (ddd, J=8.8, 8.8, 2.5 Hz, 1H), 3.85 (s, 2H).

Test Examples

The usefulness of the compound of the present invention as herbicide will next be described in detail with reference to the following Test Examples. However, the present invention should not be construed as being limited to these Examples.

[Test Example 1] Herbicidal Activity Test by Application before Weed Generation under Submerged Conditions

After alluvial soil was placed into 1/10000 are of Wagner pot, water was poured and mixed to form a submerged condition having a water depth of 4 cm. Seeds of late watergrass, Japanese bulrush, and oval-leafed pondweed were sowed in a mixed manner in the aforementioned pot, and then 2.5 leaf stage rice plant seedlings were transplanted thereto. On the day of sowing seeds, the emulsion agent of the compound of the present invention prepared according to Formulation Example 2 was diluted with water so as to achieve a predetermined herbicide amount, and the diluted emulsion agent was applied to the surface of the water. The pot was placed in a greenhouse at 25° C. to 30° C. for growth of the plants. Three weeks after the herbicide application, the effect of the herbicide on each plant was evaluated according to the following criteria. The results are shown in Table 16.

Evaluation Criteria

5: Herbicidal rate of 90% or more (almost completely withered)

4: Herbicidal rate of 70% or more and less than 90%

3: Herbicidal rate of 40% or more and less than 70%

2: Herbicidal rate of 20% or more and less than 40%

1: Herbicidal rate of 5% or more and less than 20%

0: Herbicidal rate of 5% or less (almost no effect)

[Test Example 2] Herbicidal Activity Test by Application during Weed Generation under Submerged Conditions

After alluvial soil was placed into 1/10000 are of Wagner pot, water was poured and mixed to form a submerged condition having a water depth of 4 cm. Seeds of late watergrass, Japanese bulrush, and oval-leafed pondweed were sowed in a mixed manner in the aforementioned pot, and the pot was placed in a greenhouse at 25° C. to 30° C. for growth of the plants. When late watergrass, Japanese bulrush, and oval-leafed pondweed were grown to one leaf stage to two leaf stage, the emulsion agent of the compound of the present invention prepared according to Formulation Example 2 was diluted with water so as to achieve a predetermined herbicide amount, and the diluted emulsion agent was applied to the surface of the water. Three weeks after the herbicide application, the effect of the herbicide on each plant was evaluated according to the criteria of Test Example 1. The results are shown in Table 17.

[Test Example 3] Herbicidal Effect Test by Foliage Application

After alluvial soil was placed into 1/10000 are of Wagner pot, water was poured and mixed to form a submerged condition having a water depth of 0.1 cm to 0.5 cm. Seeds of barnyard grass, Chinese sprangletop, rice flat sedge, and rice were sowed and the pot was placed in a greenhouse at 25° C. to 30° C. for growth of the plants. After 14-day growth of the plants, the emulsion agent of the compound of the present invention prepared according to Formulation Example 2 was diluted with water so as to achieve a predetermined herbicide amount, and the diluted emulsion agent was uniformly applied to a foliage part with a small-sized spray. Three weeks after the herbicide application, the effect of the herbicide on each plant was evaluated according to the criteria of Test Example 1. The results are shown in Table 18.

[Test Example 4] Herbicidal Effect Test by Soil Treatment

Sterilized diluvial soil was placed in a plastic box having a length of 21 cm, a width of 13 cm, and a depth of 7 cm. The seeds of each of southern crabgrass, green foxtail, barnyard grass, wild oat, blackgrass, Italian ryegrass, windgrass, velvetleaf, redroot pigweed, lambsquarters, chickweed, false cleavers, persian speedwell, corn, soybean, rice, wheat, beet, and rapeseed were sowed in a spot-like manner and covered with the soil having a thickness of about 1.5 cm. Subsequently, the emulsion agent of the compound of the present invention prepared according to Formulation Example 2 was diluted with water so as to achieve a predetermined herbicide amount, and the diluted emulsion agent was uniformly applied to the surface of the soil with a small-sized spray. The plastic box was placed in a greenhouse at 25° C. to 30° C. for growth of the plants. Three weeks after the herbicide application, the effect of the herbicide on each plant was evaluated according to the criteria of Test Example 1. The results are shown in Table 19.

[Test Example 5] Herbicidal Effect Test by Foliage Application

Sterilized diluvial soil was placed in a plastic box having a length of 21 cm, a width of 13 cm, and a depth of 7 cm. The seeds of each of southern crabgrass, green foxtail, barnyard grass, wild oat, blackgrass, Italian ryegrass, windgrass, velvetleaf, redroot pigweed, lambsquarters, chickweed, false cleavers, persian speedwell, corn, soybean, rice, wheat, beet, and rapeseed were sowed in a spot-like manner and covered with the soil having a thickness of about 1.5 cm. Thereafter, the plants were grown in a greenhouse at 25° C. to 30° C. After 14-day growth of the plants, the emulsion agent of the compound of the present invention prepared according to Formulation Example 2 was diluted with water so as to achieve a predetermined herbicide amount, and the diluted emulsion agent was uniformly applied to a foliage part with a small-sized spray. Three weeks after the herbicide application, the effect of the herbicide on each plant was evaluated according to the criteria of Test Example 1. The results are shown in Table 20.

The symbols in Tables 16 to 20 have the following meanings.

A: late watergrass, B: Japanese bulrush, C: oval-leafed pondweed, D: Chinese sprangletop, E: rice flat sedge, F: southern crabgrass, G: green foxtail, H: barnyard grass, I: wild oat, J: blackgrass, K: Italian ryegrass, L: windgrass, M: velvetleaf, N: redroot pigweed, 0: lambsquarters, P: chickweed, Q: false cleavers, R: persian speedwell, a: transplanted rice, b: directly sowed rice, c: corn, d: soybean, e: wheat, f: beet, and g: rapeseed.

The term “amount of applied herbicide (g/ha)” refers to the case where the concentration is adjusted so that the herbicide is applied in a described amount (g) per hectare (ha).

TABLE 16 (AAH hereinbelow indicates “Amount of Applied Herbicide”) A A H No. (g/ha) A B C a 1-005 320 2 0 0 0 1-006 320 3 1 0 0 1-011 320 5 0 0 0 1-012 320 3 1 3 0 1-013 320 4 4 3 0 1-014 320 5 5 5 0 1-015 320 3 3 3 0 1-017 320 3 3 3 1 1-019 320 5 5 4 1 1-020 320 4 5 4 2 1-021 320 4 5 4 0 1-022 320 2 3 3 1-024 320 5 5 5 3 1-025 320 3 5 4 1 1-026 320 1 2 1 0 1-027 320 0 2 0 0 1-028 320 1 2 0 2 1-029 320 0 1 2 1 1-030 320 2 5 4 0 1-037 320 4 4 3 1 1-040 320 3 3 1 0 1-041 320 3 4 4 0 1-042 320 3 4 3 0 1-044 320 5 5 5 1 1-045 320 1 4 4 0 1-047 320 3 0 0 0 1-049 320 4 1 0 1 1-051 320 4 0 0 0 1-052 320 3 1 3 0 1-053 320 3 2 1 0 1-055 272 4 0 0 0 1-059 320 3 2 1 0 1-061 320 3 3 3 0 1-062 320 2 2 0 0 1-065 320 3 0 0 2 1-069 320 3 3 3 0 1-070 320 3 3 1 1 1-072 320 3 3 0 0 1-073 320 5 4 0 0 1-087 320 3 1 0 0 1-089 320 5 4 4 0 1-090 320 5 4 5 1 1-091 320 5 4 4 2 1-092 320 5 3 2 0 1-093 320 3 1 0 0 1-101 320 4 5 5 0 1-102 320 4 5 4 0 1-105 320 3 3 2 0 1-108 320 3 2 0 0 1-110 320 3 0 4 0 1-113 320 3 0 0 0 1-115 320 2 0 2 0 1-120 320 3 0 0 0 1-125 320 3 0 0 0 1-126 320 3 3 3 0 1-128 246 0 5 5 0 1-130 320 3 3 3 0 1-131 320 2 1 0 0 1-133 320 5 5 3 1 1-135 320 4 3 3 0 1-136 320 3 2 0 0 1-138 320 3 3 3 0 1-140 320 3 2 0 0 1-141 320 3 0 0 0 1-142 320 3 5 5 0 1-143 320 3 0 0 0 1-146 320 3 0 0 0 1-148 368 3 3 3 0 1-151 320 3 3 3 0 1-152 320 4 3 5 0 1-154 320 2 0 0 0 1-158 320 0 2 0 0 1-159 320 2 0 0 0 1-198 320 3 0 0 0 1-201 320 3 4 1 0 1-203 320 5 5 4 3 1-204 320 3 3 3 0 1-206 320 5 5 5 5 1-207 320 5 5 5 3 1-208 320 5 5 5 3 1-210 320 5 5 5 4 1-211 80 5 3 3 0 1-213 320 5 5 5 1 1-215 320 5 4 4 0 1-217 320 4 5 3 2 1-218 100 4 3 0 2 1-219 80 5 3 3 0 1-221 320 5 3 3 3 1-222 320 5 4 4 4 1-223 246 5 4 4 3 1-224 320 5 5 3 3 1-226 320 5 4 4 3 1-227 320 5 5 5 0 1-228 320 5 5 4 0 1-230 320 5 5 4 3 1-236 320 3 0 0 0 1-241 320 0 3 2 0 1-245 320 3 3 0 0 1-247 320 2 2 0 0 1-253 320 3 3 0 0 2-001 320 2 3 1 0 2-004 320 0 2 2 0 2-005 320 0 2 2 0 2-007 320 2 0 0 0 2-010 320 3 3 1 0 2-011 320 3 3 3 0 2-012 320 3 0 0 0 2-013 320 3 2 2 0 2-014 320 3 0 0 2 2-016 320 5 3 5 0 2-017 320 2 0 0 0 2-018 320 0 3 0 0 2-020 320 0 2 0 0 2-022 320 2 5 5 0 2-023 320 2 0 0 0 2-026 320 3 4 4 0 2-027 320 4 5 4 0 2-029 266 2 0 0 0 2-030 320 3 0 0 0 2-031 320 3 4 4 0 2-032 320 4 4 4 0 2-033 320 4 5 4 0 2-034 320 3 4 2 2 2-035 320 5 4 4 0 2-036 320 3 4 4 0 2-037 320 3 2 3 0 2-038 320 3 0 0 0 2-039 320 3 4 5 0 2-041 320 3 0 0 0 2-043 320 0 2 1 0 2-044 320 3 0 0 0 2-046 320 4 4 3 0 2-047 320 3 3 2 0 2-049 320 2 3 3 0 2-051 320 3 4 4 0 2-053 320 2 3 4 3 2-055 320 0 3 1 0 2-056 320 3 5 5 0 2-058 320 0 2 0 0 2-059 269 3 3 4 0 2-060 320 0 5 4 0 2-062 320 4 4 3 0 2-064 320 4 4 3 0 2-071 320 3 0 0 0 2-073 320 3 0 0 0 2-075 320 2 2 0 0 2-076 320 3 0 0 0 2-077 320 3 4 5 0 2-078 320 5 4 4 3 2-079 320 1 3 1 2 2-080 320 5 5 4 1 2-081 320 4 2 0 0 2-082 320 2 3 0 0 2-083 320 2 1 3 0 2-084 320 1 1 2 0 2-085 320 4 3 1 0 2-087 320 5 4 4 0 2-088 320 3 2 0 0 2-089 320 5 4 4 0 2-091 320 3 4 5 0 2-092 320 2 3 2 1 2-095 320 2 0 0 0 2-096 320 1 3 2 0 2-100 320 3 3 2 0 2-101 320 0 3 3 0 2-107 320 2 0 0 0 2-109 320 0 3 0 0 2-111 320 3 3 0 0 2-112 320 0 2 0 0 2-113 320 3 0 0 0 2-118 320 4 3 0 0 2-125 320 0 2 0 0 2-129 320 5 0 0 0 2-130 320 0 3 0 0 2-138 176 5 0 0 0 2-139 320 4 3 1 0 2-149 320 3 1 0 0 2-164 320 3 0 0 0 2-165 320 3 0 1 0 2-166 80 2 0 0 0 2-173 320 2 0 0 0 2-175 320 3 0 0 0 2-179 320 3 0 0 0 2-183 320 2 0 0 0 2-185 320 0 5 5 0 2-188 320 4 0 0 0 2-190 320 3 0 0 0 2-197 320 3 3 3 0 2-198 320 5 3 3 0 2-199 320 1 3 2 0 2-200 320 3 0 0 0 2-201 320 2 2 0 0 2-202 320 3 0 0 0 2-203 320 2 0 0 0 2-205 320 4 3 1 0 2-206 320 5 5 4 0 2-207 320 2 4 3 0 2-208 320 0 2 0 0 2-210 320 3 0 0 0 2-211 320 2 0 0 0 2-213 320 3 0 0 0 2-215 320 3 0 0 0 2-217 320 5 5 4 4 2-218 320 5 5 5 2 2-219 320 3 0 0 1 2-221 320 5 5 5 2 2-222 320 5 4 4 0 2-223 320 4 4 2 1 2-224 320 5 0 0 0 2-225 320 0 3 3 0 2-226 320 2 0 0 0 2-227 320 3 0 0 2 2-228 320 5 4 4 0 2-230 320 3 0 0 0 2-232 320 3 0 0 0 2-236 320 3 3 2 0 2-237 320 3 0 0 0 2-238 224 3 0 0 0 2-244 320 3 0 0 1 2-245 320 4 3 3 0 2-246 320 2 0 0 0 2-249 320 3 2 0 0 2-252 320 3 2 1 1 2-253 320 5 3 0 0 2-254 320 5 3 1 3 2-255 320 5 3 3 3 2-256 320 2 0 0 0 2-257 320 1 0 2 0 2-258 320 5 3 0 5 2-260 320 3 0 0 0 2-264 320 4 4 3 1 2-267 320 2 0 0 0 2-269 320 3 3 3 0 2-273 320 3 0 0 0 2-275 320 3 3 3 0 2-277 320 1 0 2 0 2-280 320 5 3 0 0 2-281 320 5 5 4 0 2-283 320 3 5 3 0 2-284 320 3 3 3 0 2-285 320 5 3 0 0 2-286 320 5 3 1 0 2-287 320 5 4 4 0 2-288 320 5 5 4 0 2-289 320 4 3 3 0 2-292 320 5 5 4 0 2-293 320 5 5 4 0 2-294 320 5 5 4 0 2-295 320 4 3 2 0 2-298 320 3 3 3 0 2-302 320 3 0 0 0 2-305 320 3 5 2 0 2-307 320 0 3 0 0 2-310 320 0 2 0 0 2-311 320 3 3 3 0 2-312 320 2 3 0 0 2-313 320 2 3 0 0 2-315 320 4 0 0 0 2-317 320 3 0 0 0 2-319 320 4 2 3 0 2-321 320 3 3 0 0 2-323 320 4 2 0 0 2-325 320 3 2 0 0 2-327 320 3 3 3 0 2-329 320 2 0 0 0 2-330 320 3 0 0 0 2-331 320 3 3 0 0 2-332 320 2 0 0 0 2-333 320 2 0 0 0 2-334 320 3 0 0 0 2-335 320 3 0 0 1 2-336 320 0 3 0 0 2-337 320 4 3 3 0 2-339 320 4 5 5 5 2-340 320 5 5 4 1 2-341 320 3 4 5 0 2-342 320 2 3 0 0 2-344 320 0 2 0 0 2-345 320 4 4 3 0 2-347 320 3 0 0 0 2-348 320 2 3 0 0 2-349 320 3 0 0 0 2-350 320 3 0 0 0 2-351 320 5 3 3 0 2-352 320 3 2 2 0 2-353 320 2 0 0 0 2-355 320 4 3 0 0 2-357 320 4 2 0 0 2-358 320 3 0 0 0 2-360 320 3 2 0 0 2-369 320 0 0 2 0 2-370 320 3 0 0 0 2-371 320 3 3 4 0 2-374 320 3 0 0 0 2-376 246 3 0 0 0 2-386 320 2 0 0 0 2-387 320 3 3 0 0 2-388 320 5 0 0 0 2-389 320 3 0 0 0 2-390 320 2 0 0 0 2-391 320 5 4 5 0 2-392 320 3 0 0 0 2-393 320 3 0 0 0 2-395 320 0 2 0 0 2-398 320 3 3 0 0 2-407 320 3 0 0 0 2-409 320 3 3 2 0 2-411 320 3 0 0 0 2-413 320 3 0 0 0 2-414 320 2 3 2 0 2-416 320 3 3 2 0 2-418 320 4 4 2 0 2-420 320 2 3 0 0 2-425 320 3 3 0 0 2-429 320 3 2 3 0 2-430 320 3 0 0 0 2-431 320 2 0 0 0 2-432 320 2 0 0 0 2-440 320 3 4 3 0 2-441 320 3 3 3 0 2-442 320 3 2 2 0 2-443 320 3 0 0 1 2-444 320 3 0 0 3 2-445 320 3 0 0 0 2-450 320 2 3 0 0 2-451 320 2 0 0 0 2-453 320 3 3 3 0 2-454 320 3 0 0 0 2-455 320 3 0 0 0 2-460 403 3 0 0 0 2-461 320 3 0 0 0 2-465 320 4 2 3 3 3-002 320 5 3 4 0 3-003 320 3 4 5 0 3-004 320 5 3 3 3 3-005 320 4 4 4 0 3-006 320 5 5 4 2 3-007 320 5 5 4 0 3-008 320 5 5 5 0 3-009 320 1 3 1 0 3-010 320 5 4 3 1 3-011 320 5 4 3 1 3-012 320 5 5 4 0 3-013 320 3 3 2 0 3-014 320 5 3 5 0 3-018 49 3 2 0 0 3-019 320 3 3 3 2 3-020 320 3 3 2 0 3-021 320 3 3 4 0 3-023 320 3 3 4 0 3-024 320 3 0 0 0 3-025 320 0 0 3 0 3-026 320 2 0 3 0 3-027 320 2 3 5 0 3-028 320 2 0 0 0 3-030 320 2 0 3 0 3-034 320 3 3 3 0 3-035 320 3 3 0 0 3-039 320 2 1 0 0 3-040 320 4 3 2 0 3-041 320 2 0 0 0 3-043 320 0 1 2 0 3-044 320 3 0 0 0 3-045 320 2 1 0 0 3-046 320 4 0 0 0 3-047 320 3 2 0 0 3-049 274 5 3 3 1 3-050 224 2 0 1 0 3-053 320 5 5 4 3 3-054 304 5 5 4 1 3-055 320 4 4 3 0 3-056 320 3 0 0 0 3-057 320 5 5 5 4 3-058 320 5 5 3 2 3-059 320 2 1 2 0 3-060 320 1 2 0 0 3-062 320 3 4 4 0 3-064 320 0 3 4 0 3-065 214 1 3 3 0 3-066 296 5 5 5 1 3-069 320 0 3 2 0 3-070 80 5 5 4 3 3-071 320 5 5 5 3 3-072 320 1 5 4 0 3-074 320 0 2 0 1 3-075 320 1 1 2 0 3-076 320 4 5 5 3 3-077 320 5 5 5 0 3-078 80 5 5 4 2 3-079 320 5 5 5 0 3-082 320 3 5 4 1 3-083 320 4 4 4 0 3-084 320 0 3 1 0 3-085 320 5 5 4 0 3-086 320 0 2 0 0 3-088 320 5 5 5 0 3-089 320 5 5 5 3 3-090 310 5 5 4 0 3-091 320 0 4 4 0 3-092 320 0 3 3 0 3-093 320 5 5 5 3 3-094 323 5 5 5 3 3-095 320 5 5 5 3 3-096 320 5 5 5 0 3-099 320 5 5 5 3 3-101 320 5 5 5 1 3-103 320 5 5 5 3 3-105 320 5 5 5 3 3-107 320 4 5 5 4 3-108 320 3 3 5 0 3-109 320 5 5 5 0 3-111 320 5 5 5 1 3-113 320 4 3 2 0 3-114 320 5 5 5 4 3-116 320 5 5 5 4 3-118 320 3 3 5 0 3-119 320 3 3 3 0 3-121 320 5 5 5 5 3-123 320 5 5 5 3 3-125 320 3 3 1 3 3-129 320 5 5 5 3 3-131 320 5 5 5 5 3-133 320 3 3 4 3 3-134 320 3 4 0 3-135 320 2 2 0 2 3-137 320 3 0 0 1 3-140 320 5 3 3 0 3-141 320 3 0 0 0 3-144 320 5 3 0 0 3-145 320 3 2 0 0 3-153 320 3 3 3 0 3-155 320 5 5 5 3 3-156 320 5 4 4 2 3-157 320 5 3 3 1 3-158 320 5 5 5 3 3-159 320 0 3 3 0 3-163 320 3 3 3 3 4-003 320 3 0 0 0 4-006 320 3 3 0 0 4-007 320 3 0 0 0 4-008 320 3 3 0 0 4-009 320 2 1 0 0 4-010 320 3 0 3 0 4-013 320 3 0 3 0 4-020 320 4 3 0 0 4-023 320 3 0 0 0 4-024 320 3 2 3 0 4-026 320 5 3 4 0 4-028 320 3 3 0 0 4-031 320 2 0 0 0 4-032 320 0 2 0 0 4-035 320 2 0 0 0 4-036 320 4 3 4 0 4-041 320 3 0 0 0 4-042 320 3 3 0 0 4-045 320 4 2 0 0 4-049 320 3 0 0 0 4-050 320 3 0 0 0 4-051 320 4 3 0 0 4-053 320 5 3 2 0 4-054 320 3 3 0 0 4-061 320 3 0 0 0 4-062 320 0 2 0 0 4-065 320 4 0 1 0 4-070 320 3 2 1 0 4-076 320 0 3 0 0 4-077 320 3 0 0 0 4-079 320 2 0 0 0 4-083 320 3 0 0 0 4-098 320 3 0 0 0 4-100 320 3 3 1 0 4-102 320 4 0 0 0 4-106 320 2 0 0 0 4-110 320 5 5 4 0 4-112 320 3 3 0 0 4-114 320 3 0 0 0 4-118 320 3 2 2 0 4-124 320 4 3 2 0 4-126 320 3 0 0 0 5-001 320 3 1 0 0 5-004 320 2 3 0 0 5-008 320 3 0 0 0 5-009 320 2 0 0 0 5-010 320 0 2 0 0 5-011 320 2 2 0 0 5-012 320 4 3 2 0 5-015 320 3 0 0 0 5-016 320 3 1 0 0 5-017 320 3 2 2 0 5-018 320 0 5 5 0 5-019 320 3 0 0 0 5-020 320 3 0 0 0 5-024 320 3 0 5 0 5-026 320 3 0 0 0 5-028 320 0 2 2 0 5-030 320 3 1 0 0 5-031 320 2 0 0 0 5-032 320 4 1 0 0 5-034 320 3 0 0 0 5-036 320 2 2 2 0 5-038 320 4 3 4 0 5-041 320 0 5 5 0 5-043 320 5 2 0 0 5-045 320 0 3 0 0 5-046 320 0 3 0 0 5-050 320 3 0 0 0 5-052 320 0 3 0 0 5-053 320 0 3 0 0 5-055 320 2 0 0 0 5-061 320 5 3 3 1 5-064 320 2 0 0 0 5-068 320 0 5 0 5-069 320 3 1 0 0 5-070 320 0 2 0 0 5-072 320 0 2 0 0 5-073 320 5 4 4 0 5-076 344 2 0 1 0 5-077 320 2 0 4 0 5-080 370 0 3 0 0 5-083 320 0 3 0 0 5-084 320 3 2 0 0 5-089 320 3 0 0 0 5-090 320 3 3 3 0 5-091 320 3 3 3 0 5-093 320 2 0 0 0 5-094 320 4 4 4 0 5-095 320 5 4 4 0 5-097 320 3 0 0 0 5-098 320 3 0 0 0 5-101 320 3 3 3 0 5-102 320 4 3 2 0 5-103 320 5 4 4 0 5-104 320 4 0 0 0 5-105 320 2 0 0 0 5-107 320 3 0 0 0 7-001 320 3 3 2 0 7-002 320 3 3 3 0 7-003 320 2 3 0 0 7-004 320 3 3 0 0 8-002 320 4 5 4 0 8-003 320 5 5 5 2 8-004 320 5 5 4 2 8-005 320 5 5 4 1 8-007 320 5 5 4 3 8-008 320 5 5 4 3 9-002 320 0 3 2 0 9-005 390 5 4 3 0 9-007 320 5 5 5 0 9-008 320 5 5 5 0 9-010 246 5 3 3 1 9-011 320 3 2 1 0 9-012 320 4 5 5 0 9-013 320 3 4 4 0 9-016 320 3 0 0 0 9-019 320 3 0 0 0 9-020 320 5 5 5 0 9-021 320 5 5 5 0 9-023 320 5 5 5 3 9-025 320 5 5 5 0 9-027 320 5 5 5 3 9-031 320 2 0 0 0 9-033 320 2 0 0 0 9-035 320 2 0 0 0 9-037 320 3 0 0 0 9-043 320 3 0 2 0 9-045 320 5 5 5 0 9-049 320 5 5 5 5 9-050 320 5 5 5 1 9-051 320 5 5 5 5 9-052 320 5 5 4 0 9-055 320 5 4 4 0 9-056 438 5 4 4 1 9-057 320 5 4 4 5 9-058 320 5 5 5 5 9-059 320 5 3 3 0 9-060 402 5 4 5 5 9-062 320 5 5 5 3 9-063 320 5 5 5 5 9-064 320 5 5 5 4 10-001  320 0 0 3 0 11-001  320 3 5 5 0

TABLE 17 (AAH hereinbelow indicates “Amount of Applied Herbicide”) A A H No. (g/ha) A B C 1-013 320 3 3 1-014 320 3 3 3 1-015 320 3 1 2 1-019 320 3 4 1-020 320 2 3 3 1-021 320 2 3 0 1-024 320 4 4 5 1-025 320 0 3 3 1-026 320 2 3 1-030 320 1 3 3 1-032 320 0 1 3 1-037 320 0 1 3 1-041 320 0 3 3 1-044 320 4 3 1 1-045 320 1 3 4 1-051 320 2 0 0 1-061 320 0 3 4 1-068 320 0 1 3 1-072 320 2 3 5 1-073 320 4 5 5 1-085 320 1 1 2 1-087 320 2 1 3 1-088 320 1 3 4 1-089 320 5 1 1 1-090 320 4 3 4 1-091 320 3 4 4 1-092 320 3 1 0 1-101 320 3 5 5 1-102 320 3 5 5 1-108 320 0 2 0 1-110 320 3 2 0 1-118 320 3 0 0 1-126 320 2 3 1 1-130 320 2 2 0 1-131 320 0 1 3 1-133 320 1 3 3 1-136 320 0 2 0 1-138 320 0 3 0 1-140 320 3 3 0 1-141 320 0 3 0 1-142 320 0 2 0 1-144 320 2 0 0 1-148 368 3 3 1 1-151 320 0 2 0 1-152 320 3 3 0 1-154 320 0 2 0 1-201 320 0 3 3 1-202 178 2 3 0 1-203 320 4 3 4 1-204 320 0 3 2 1-206 320 5 3 5 1-207 320 5 4 5 1-208 320 5 3 3 1-210 320 3 3 4 1-213 320 3 3 4 1-215 320 3 3 3 1-217 320 0 3 3 1-218 100 3 3 4 1-221 320 5 3 3 1-222 320 5 3 4 1-223 246 3 3 3 1-224 320 3 3 1-226 320 5 3 3 1-227 320 4 3 3 1-228 320 5 3 3 1-230 320 4 3 4 1-232 320 3 0 0 1-241 320 3 3 1-247 320 3 0 0 1-253 320 3 0 0 2-001 320 1 2 3 2-002 320 2 0 3 2-011 320 2 3 3 2-012 320 3 3 0 2-013 320 4 2 3 2-015 320 4 0 0 2-016 320 3 4 4 2-018 320 3 2 3 2-021 320 0 2 0 2-022 320 2 2 4 2-023 320 3 0 0 2-026 320 1 4 5 2-027 320 3 4 5 2-028 320 3 1 3 2-029 266 3 2 3 2-030 320 0 2 0 2-031 320 4 3 3 2-032 320 1 4 5 2-033 320 1 4 4 2-034 320 1 3 3 2-035 320 1 4 4 2-036 320 0 3 3 2-037 320 0 1 3 2-038 320 2 0 0 2-039 320 0 0 2 2-043 320 0 2 0 2-044 320 2 3 3 2-046 320 1 3 0 2-047 320 0 3 2 2-049 320 0 2 2 2-051 320 0 3 1 2-053 320 0 3 3 2-055 320 0 3 3 2-056 320 3 3 3 2-060 320 0 3 1 2-062 320 0 3 2 2-064 320 3 3 0 2-065 320 3 0 0 2-067 320 2 0 0 2-068 320 2 3 3 2-074 320 0 3 0 2-076 320 2 3 0 2-077 320 4 3 3 2-078 320 3 4 4 2-079 320 0 0 2 2-080 320 2 4 4 2-084 320 2 1 3 2-085 320 2 3 3 2-087 320 0 2 0 2-088 320 3 0 2 2-089 320 4 3 4 2-091 320 0 3 4 2-092 320 0 3 4 2-093 320 3 5 5 2-100 320 3 0 0 2-101 320 0 3 5 2-104 320 0 0 2 2-108 320 3 0 0 2-111 320 2 1 0 2-112 320 3 0 0 2-113 320 2 0 0 2-117 320 0 2 3 2-122 320 0 0 2 2-126 320 0 0 2 2-128 320 0 0 3 2-139 320 3 3 0 2-166 80 0 3 0 2-185 320 3 0 0 2-197 320 3 3 4 2-198 320 2 3 4 2-199 320 0 2 0 2-202 320 4 3 4 2-205 320 2 3 2 2-206 320 4 3 4 2-207 320 3 3 1 2-215 320 2 0 0 2-217 320 3 3 0 2-218 320 1 3 3 2-221 320 5 3 3 2-222 320 2 3 3 2-223 320 3 2 0 2-225 320 3 3 0 2-227 320 0 2 0 2-228 320 3 3 3 2-244 320 5 3 4 2-245 320 5 3 4 2-248 320 4 0 0 2-249 320 4 0 2 2-252 320 4 3 2 2-253 320 3 3 3 2-254 320 4 0 0 2-255 320 4 3 2 2-257 320 2 0 0 2-258 320 4 0 3 2-264 320 3 3 3 2-271 320 3 0 0 2-280 320 4 3 2-281 320 5 4 5 2-283 320 5 3 4 2-284 320 3 3 3 2-285 320 3 3 0 2-286 320 3 3 3 2-287 320 3 3 4 2-288 320 3 3 3 2-289 320 3 3 4 2-292 320 5 5 5 2-293 320 4 3 4 2-294 320 3 3 3 2-295 320 5 3 3 2-298 320 3 3 0 2-305 320 3 3 0 2-308 320 3 0 0 2-313 320 3 3 3 2-323 320 3 0 0 2-325 320 2 2 0 2-327 320 0 2 0 2-331 320 3 0 0 2-332 320 3 0 0 2-334 320 3 0 0 2-337 320 0 2 0 2-339 320 3 3 3 2-340 320 5 4 3 2-341 320 3 3 3 2-345 320 5 5 4 2-348 320 3 2 0 2-349 320 3 3 3 2-350 320 0 2 0 2-351 320 3 3 4 2-352 320 0 2 0 2-353 320 4 3 3 2-355 320 3 3 3 2-357 320 2 0 0 2-360 320 2 0 0 2-371 320 0 3 4 2-387 320 4 4 4 2-391 320 3 4 5 2-392 320 2 0 0 2-406 320 2 0 0 2-409 320 2 3 3 2-411 320 3 0 0 2-413 320 3 1 0 2-416 320 2 3 2 2-418 320 2 3 0 2-440 320 3 3 3 2-441 320 3 0 0 2-445 320 3 0 0 2-450 320 3 2 0 2-453 320 3 4 4 2-454 320 2 0 0 2-455 320 3 0 0 2-459 320 3 0 0 3-002 320 3 3 4 3-003 320 2 3 4 3-004 320 4 2 4 3-005 320 3 3 4 3-006 320 3 4 5 3-007 320 3 4 4 3-008 320 0 2 4 3-009 320 0 1 3 3-010 320 3 4 3-011 320 3 3 4 3-012 320 4 5 4 3-013 320 0 0 3 3-014 320 3 0 5 3-016 320 3 0 0 3-020 320 1 0 2 3-023 320 2 2 4 3-024 320 2 3 3 3-027 320 3 2 3 3-028 320 2 0 0 3-029 285 0 3 1 3-034 320 3 0 0 3-039 320 2 2 0 3-040 320 2 2 3 3-043 320 3 0 0 3-045 320 2 2 0 3-046 320 0 2 1 3-049 274 4 3 2 3-050 224 0 1 3 3-053 320 3 3 3 3-054 304 2 3 3 3-055 320 1 1 3 3-056 320 2 0 0 3-057 320 4 4 3 3-058 320 4 5 4 3-062 320 0 3 3 3-064 320 0 1 3 3-065 214 0 1 3 3-066 296 3 4 5 3-069 320 0 3 4 3-070 80 3 5 4 3-071 320 5 5 5 3-072 320 3 2 3 3-076 320 3 4 4 3-077 320 2 4 4 3-078 80 1 5 4 3-079 320 5 5 5 3-082 320 2 1 3 3-083 320 2 3 4 3-085 320 0 3 3 3-088 320 3 3 3 3-089 320 4 5 5 3-090 310 4 4 5 3-091 320 0 3 3 3-092 320 0 1 3 3-093 320 3 5 5 3-094 323 3 4 4 3-095 320 4 5 5 3-096 320 4 5 4 3-099 320 3 4 3 3-101 320 3 3 2 3-103 320 2 3 3 3-105 320 3 3 4 3-107 320 3 5 5 3-108 320 2 2 0 3-109 320 0 3 2 3-111 320 4 3 3 3-113 320 0 2 0 3-114 320 3 4 5 3-116 320 4 3 4 3-118 320 1 2 0 3-121 320 3 3 3 3-123 320 3 3 2 3-125 320 0 3 3 3-129 320 3 3 3 3-131 320 5 3 5 3-133 320 2 3 1 3-140 320 3 3 3 3-144 320 2 3 2 3-145 320 3 2 0 3-155 320 5 5 5 3-156 320 3 4 5 3-157 320 4 3 4 3-158 320 4 3 5 3-163 320 3 0 0 3-170 320 2 0 0 4-004 320 3 0 2 4-006 320 3 3 2 4-010 320 4 0 3 4-016 320 2 0 0 4-018 320 0 3 3 4-019 320 4 0 0 4-020 320 0 3 0 4-022 320 0 2 0 4-024 320 3 0 0 4-026 320 3 3 2 4-028 320 3 3 0 4-030 320 3 3 3 4-032 320 0 3 0 4-036 320 3 0 0 4-038 320 2 3 0 4-041 320 0 3 0 4-045 320 3 0 0 4-051 320 3 3 0 4-053 320 4 2 4-054 320 2 2 0 4-076 320 3 2 0 4-102 320 2 0 0 4-110 320 0 3 5 4-124 320 3 0 0 5-008 320 2 0 0 5-012 320 0 2 2 5-021 320 0 2 0 5-024 320 0 2 0 5-026 320 2 0 0 5-039 320 3 0 0 5-043 320 2 0 0 5-050 320 0 2 0 5-089 320 3 0 0 5-090 320 0 2 0 5-091 320 3 2 3 5-093 320 2 0 0 5-094 320 2 3 3 5-095 320 4 4 4 5-101 320 0 2 2 5-102 320 3 3 2 5-103 320 2 3 3 5-104 320 4 4 4 5-107 320 3 3 3 5-109 320 2 0 0 7-001 320 3 3 3 7-002 320 3 2 2 7-003 320 0 3 0 7-004 320 3 3 2 8-002 320 3 4 5 8-003 320 4 3 3 8-004 320 3 3 3 8-005 320 4 3 3 8-007 320 5 4 3 8-008 320 2 3 2 9-002 320 0 0 3 9-005 390 0 1 3 9-007 320 4 5 5 9-008 320 1 5 5 9-010 246 0 0 2 9-012 320 1 4 5 9-013 320 0 0 5 9-020 320 3 3 3 9-021 320 4 3 4 9-023 320 5 3 5 9-025 320 4 3 4 9-027 320 4 3 4 9-037 320 0 2 2 9-045 320 3 3 5 9-049 320 5 4 4 9-050 320 3 3 5 9-051 320 5 4 5 9-052 320 3 3 4 9-055 320 4 3 3 9-056 438 3 3 4 9-057 320 5 3 4 9-058 320 4 3 4 9-059 320 4 3 4 9-060 402 4 3 4 9-062 320 3 3 3 9-063 320 5 4 4 9-064 320 4 3 4 11-001  320 2 3 3

TABLE 18 (AAH hereinbelow indicates “Amount of Applied Herbicide”) A A H No. (g/ha) H D E b 1-001 320 3 0 5 0 1-003 320 1 3 3 0 1-005 320 4 0 5 3 1-006 320 3 0 5 1 1-007 320 5 5 4 0 1-009 320 3 2 2 0 1-011 320 5 3 5 1 1-012 320 5 0 5 0 1-013 320 5 1 5 0 1-014 320 4 0 5 0 1-015 320 5 3 5 1 1-017 320 5 0 3 0 1-019 320 5 4 5 5 1-020 320 5 1 5 3 1-021 320 5 1 5 2 1-022 320 3 0 4 0 1-023 320 1 0 3 0 1-024 320 5 4 5 5 1-025 320 5 4 5 1 1-026 320 4 1 4 3 1-027 320 3 2 1 1 1-028 320 3 0 4 1 1-030 320 5 3 4 2 1-031 320 4 0 5 0 1-032 320 4 0 5 0 1-033 320 1 0 1 0 1-034 320 1 0 3 0 1-035 320 3 0 4 0 1-036 320 5 3 5 0 1-037 320 5 3 5 3 1-038 123 0 4 3 0 1-039 295 3 1 3 0 1-040 320 4 3 5 0 1-041 320 1 4 5 2 1-042 320 3 0 5 1 1-043 320 5 5 0 3 1-044 320 4 4 5 3 1-045 320 5 4 5 0 1-046 320 3 0 5 0 1-047 320 2 0 5 0 1-048 320 4 5 4 0 1-049 320 5 3 5 1 1-051 320 4 0 5 1 1-052 320 3 2 5 0 1-053 320 3 0 1 0 1-054 320 5 3 4 0 1-055 272 5 2 5 0 1-056 320 4 2 5 0 1-058 320 4 3 5 0 1-059 320 3 1 5 0 1-060 320 4 3 4 0 1-061 320 5 4 5 2 1-062 320 5 3 5 0 1-063 320 2 0 3 0 1-064 320 3 0 3 0 1-065 320 3 3 5 0 1-066 320 2 0 5 0 1-067 99 3 0 0 0 1-068 320 3 1 5 1 1-069 320 3 0 5 0 1-070 320 1 0 3 0 1-071 320 2 0 0 0 1-072 320 5 5 5 4 1-073 320 5 3 5 1 1-074 320 3 0 5 1 1-075 320 3 0 5 0 1-076 320 1 0 5 0 1-077 320 4 1 4 0 1-078 144 1 0 3 0 1-080 320 0 0 4 0 1-081 320 3 0 4 0 1-083 320 3 3 4 0 1-085 320 5 4 5 3 1-087 320 4 3 5 0 1-088 320 5 3 5 0 1-089 320 5 0 5 0 1-090 320 5 1 5 1 1-091 320 5 1 5 1 1-092 320 4 1 5 0 1-093 320 3 0 5 0 1-094 320 3 0 3 1 1-095 197 4 0 1 0 1-096 485 5 2 0 2 1-097 320 0 0 4 0 1-098 320 0 0 4 0 1-099 320 0 0 5 0 1-100 320 0 0 4 0 1-101 320 5 5 5 1 1-102 320 4 3 5 0 1-103 320 3 4 3 0 1-105 320 4 3 4 0 1-108 320 0 3 5 0 1-110 320 4 3 4 0 1-112 320 4 3 3 0 1-113 320 4 0 3 0 1-115 320 4 2 2 0 1-116 320 5 2 4 0 1-118 320 4 2 2 0 1-120 320 3 0 2 1 1-123 296 3 3 3 0 1-124 320 0 2 3 0 1-125 320 5 4 5 4 1-126 320 5 5 4 1 1-127 320 0 3 5 0 1-128 246 4 5 3 0 1-129 320 3 3 5 0 1-130 320 4 3 5 0 1-131 320 5 4 5 0 1-133 320 5 3 5 1 1-135 320 2 3 3 0 1-136 320 5 4 5 1 1-137 320 3 3 5 0 1-138 320 5 3 5 4 1-139 320 5 0 5 0 1-140 320 5 3 5 5 1-141 320 5 3 5 4 1-142 320 3 1 5 0 1-143 320 5 0 0 1-144 320 5 3 5 2 1-146 320 5 2 0 1-148 368 5 4 5 3 1-149 320 3 3 5 0 1-150 320 2 3 3 0 1-151 320 4 3 5 0 1-152 320 5 5 3 1 1-153 320 4 2 3 0 1-154 320 2 3 2 0 1-155 320 3 0 3 0 1-156 320 3 3 3 0 1-158 320 2 0 0 0 1-159 320 2 0 0 0 1-160 320 0 1 4 0 1-161 320 1 0 3 0 1-162 80 4 3 5 0 1-163 80 1 3 0 0 1-164 80 4 4 4 1 1-165 80 2 0 0 0 1-166 80 4 4 5 1 1-168 320 0 0 3 0 1-169 320 1 0 2 0 1-170 320 2 1 5 0 1-171 320 3 0 4 0 1-172 320 0 0 5 0 1-173 320 1 0 5 0 1-174 320 1 0 3 0 1-175 320 0 0 3 0 1-176 320 4 3 5 1 1-177 320 4 0 4 1 1-178 320 4 0 5 0 1-179 320 4 0 3 0 1-180 320 1 0 4 0 1-182 80 4 3 5 3 1-183 80 3 2 0 0 1-187 320 0 0 3 0 1-191 80 2 5 4 0 1-192 80 1 4 4 0 1-193 80 2 1 0 0 1-194 320 0 0 2 0 1-196 320 3 0 5 1 1-197 320 4 2 4 0 1-198 320 5 3 5 1 1-199 320 0 0 5 0 1-200 320 4 3 3 1 1-201 320 5 4 5 0 1-202 178 5 3 5 2 1-203 320 5 4 5 5 1-204 320 4 2 5 0 1-206 320 5 5 5 5 1-207 320 5 5 4 4 1-208 320 5 5 4 3 1-210 320 5 5 4 5 1-211 80 4 4 4 2 1-213 320 5 4 3 5 1-215 320 5 5 5 3 1-217 320 5 5 3 2 1-218 100 4 4 4 0 1-219 80 5 5 3 4 1-221 320 5 5 5 5 1-222 320 5 5 4 5 1-223 246 5 5 4 3 1-224 320 5 3 5 2 1-226 320 5 5 4 5 1-227 320 5 4 4 5 1-228 320 5 5 4 5 1-230 320 5 5 3 5 1-232 320 3 3 3 1 1-236 320 5 5 5 3 1-237 320 5 4 4 0 1-238 320 4 4 4 0 1-241 320 5 3 4 2 1-243 320 5 4 4 1 1-245 320 5 3 3 2 1-247 320 5 1 4 0 1-249 320 5 3 3 0 1-251 320 5 3 3 2 1-253 320 5 3 3 0 1-255 320 5 3 5 1 2-001 320 5 5 5 1 2-002 320 5 5 5 0 2-003 320 5 3 5 0 2-004 320 5 3 4 0 2-005 320 5 3 5 0 2-006 320 2 0 0 0 2-007 320 1 3 3 0 2-008 320 2 1 4 0 2-009 320 5 3 4 0 2-010 320 5 4 5 0 2-011 320 5 4 5 0 2-012 320 5 5 5 1 2-013 320 5 5 5 3 2-014 320 5 5 5 5 2-015 320 5 5 5 3 2-016 320 5 5 5 5 2-017 320 5 3 2 0 2-018 320 5 4 5 1 2-019 320 5 3 4 4 2-020 320 5 3 5 3 2-021 320 5 3 5 0 2-022 320 5 4 4 3 2-023 320 5 4 5 1 2-024 294 4 3 4 0 2-025 283 4 0 4 0 2-026 320 5 4 5 3 2-027 320 5 4 5 0 2-028 320 4 3 5 1 2-029 266 5 3 3 0 2-030 320 5 3 5 1 2-031 320 5 4 4 0 2-032 320 5 3 5 4 2-033 320 5 1 5 1 2-034 320 5 0 5 4 2-035 320 5 0 5 1 2-036 320 5 3 5 4 2-037 320 4 2 4 0 2-038 320 4 4 4 0 2-039 320 5 5 3 1 2-041 320 3 3 1 0 2-042 320 5 3 5 1 2-043 320 5 3 5 0 2-044 320 3 2 5 0 2-045 320 5 2 5 1 2-046 320 5 3 5 0 2-047 320 5 4 5 4 2-049 320 5 5 5 4 2-051 320 5 5 5 4 2-053 320 5 5 4 4 2-054 320 4 5 3 0 2-055 320 5 5 4 1 2-056 320 5 5 5 4 2-058 320 5 5 5 5 2-059 269 5 5 5 4 2-060 320 3 3 5 3 2-062 320 5 5 5 5 2-064 320 3 3 0 0 2-065 320 3 3 3 0 2-066 320 4 3 1 1 2-067 320 4 5 3 0 2-068 320 5 4 5 3 2-069 320 5 4 5 5 2-070 320 2 0 0 2 2-071 320 2 3 2 0 2-072 320 2 3 5 0 2-073 320 4 3 3 0 2-074 320 5 5 5 5 2-075 320 2 2 4 0 2-076 320 5 5 5 2 2-077 320 5 5 5 2 2-078 320 3 5 5 4 2-079 320 5 4 5 5 2-080 320 5 5 5 5 2-081 320 5 3 5 1 2-082 320 4 2 4 0 2-083 320 5 4 5 1 2-084 320 5 4 5 1 2-085 320 5 0 4 0 2-086 320 3 3 5 0 2-087 320 3 2 5 0 2-088 320 5 3 5 0 2-089 320 4 3 5 0 2-090 320 5 2 5 0 2-091 320 3 3 5 0 2-092 320 5 4 5 3 2-093 320 5 2 5 0 2-094 96 2 0 0 2-095 320 5 4 5 1 2-096 320 3 1 3 0 2-097 320 5 3 4 0 2-098 320 5 4 2 0 2-099 320 5 4 5 2 2-100 320 5 4 3 1 2-101 320 4 0 5 0 2-103 320 3 2 5 0 2-104 320 3 0 5 0 2-105 320 4 0 3 0 2-107 320 4 0 2 3 2-108 320 4 0 2 0 2-109 320 4 2 2 1 2-110 320 4 4 4 0 2-111 320 4 2 3 0 2-112 320 5 4 5 0 2-113 320 3 1 0 0 2-114 320 4 3 5 0 2-115 320 5 1 3 1 2-117 320 3 3 5 0 2-118 320 2 0 0 0 2-119 320 3 2 3 0 2-122 320 2 0 0 0 2-123 320 3 0 5 0 2-124 320 3 1 0 0 2-125 320 4 3 5 0 2-127 320 3 0 5 0 2-128 320 3 0 0 0 2-129 320 3 0 0 0 2-130 320 3 0 4 0 2-132 320 0 0 5 0 2-133 320 0 0 5 0 2-134 320 3 0 5 0 2-135 320 1 0 3 0 2-136 320 2 0 5 0 2-137 320 1 1 5 1 2-138 176 5 1 4 0 2-139 320 4 0 4 0 2-142 320 2 0 2 1 2-144 320 2 0 3 0 2-145 320 3 0 4 0 2-146 221 4 0 3 0 2-147 320 1 0 5 0 2-148 320 5 3 5 3 2-149 320 5 0 3 0 2-150 320 4 2 5 0 2-151 320 3 0 3 0 2-152 320 0 0 3 0 2-154 320 3 0 3 0 2-156 320 3 0 4 0 2-157 320 3 0 0 0 2-158 320 0 1 4 0 2-159 320 0 0 3 0 2-160 320 4 3 3 0 2-162 320 3 0 3 0 2-164 320 2 3 4 0 2-165 320 5 3 5 5 2-173 320 3 2 2 0 2-175 320 4 3 1 2-177 320 3 4 3 0 2-179 320 2 2 4 0 2-181 320 2 3 0 0 2-183 320 4 3 0 0 2-185 320 3 0 2 0 2-187 320 4 0 0 0 2-188 320 4 3 0 0 2-190 320 2 2 4 0 2-192 320 4 2 2 1 2-195 320 3 0 0 0 2-197 320 5 5 5 0 2-198 320 5 5 5 0 2-199 320 5 5 5 0 2-200 320 4 5 5 0 2-201 320 5 4 5 0 2-202 320 5 5 5 0 2-203 320 4 4 5 0 2-204 320 4 3 3 0 2-205 320 5 4 5 0 2-206 320 5 4 5 0 2-207 320 4 5 5 3 2-208 320 5 5 5 1 2-209 320 5 4 5 0 2-210 320 5 5 5 0 2-211 320 5 5 4 2 2-212 320 5 3 4 0 2-213 320 4 3 3 0 2-214 320 3 3 4 0 2-215 320 5 5 4 2 2-216 320 5 3 4 0 2-217 320 5 5 5 5 2-218 320 5 3 5 0 2-219 320 5 3 3 0 2-220 320 5 3 3 0 2-221 320 5 5 5 4 2-222 320 5 5 4 0 2-223 320 5 3 4 3 2-224 320 4 4 3 0 2-225 320 4 3 4 0 2-226 320 4 3 3 0 2-227 320 5 3 5 3 2-228 320 5 4 5 0 2-229 320 4 3 4 0 2-230 320 4 5 5 0 2-231 320 4 3 5 0 2-232 320 4 5 5 0 2-234 320 3 0 0 0 2-236 320 4 3 5 0 2-237 320 3 4 5 0 2-238 224 3 2 3 0 2-240 320 4 3 4 3 2-242 320 3 0 2 0 2-244 320 5 5 5 5 2-245 320 5 4 4 3 2-246 320 3 0 3 0 2-248 320 5 5 4 3 2-249 320 5 3 5 2 2-250 320 3 2 3 0 2-252 320 5 5 5 2 2-253 320 5 3 4 0 2-254 320 5 5 5 5 2-255 320 5 4 5 2 2-256 320 5 4 4 3 2-257 320 5 3 5 2 2-258 320 5 5 5 5 2-259 320 4 3 1 2-260 320 5 3 3 4 2-262 320 3 0 2 0 2-264 320 5 3 5 1 2-265 320 5 4 5 0 2-267 320 5 5 3 0 2-268 320 4 3 3 0 2-269 320 3 0 3 0 2-271 320 3 0 3 0 2-275 320 3 0 0 0 2-280 320 5 3 4 0 2-281 320 5 3 5 0 2-282 320 3 0 0 0 2-283 320 5 4 5 0 2-284 320 5 3 5 0 2-285 320 5 3 5 0 2-286 320 5 4 4 0 2-287 320 5 3 5 0 2-288 320 5 4 5 0 2-289 320 5 3 5 1 2-290 320 4 4 3 0 2-291 320 4 3 2 0 2-292 320 5 4 4 1 2-293 320 5 3 5 0 2-294 320 5 4 5 0 2-295 320 5 4 5 0 2-296 320 5 2 3 0 2-297 310 5 0 5 0 2-298 320 5 3 5 0 2-300 320 3 3 0 2-301 320 3 0 2 0 2-302 320 3 0 3 0 2-303 320 5 4 3 0 2-304 320 3 3 3 0 2-305 320 5 5 3 0 2-306 320 3 3 3 0 2-307 320 5 5 4 0 2-308 320 5 3 4 0 2-309 320 5 3 5 0 2-310 320 5 4 3 0 2-311 320 5 2 4 0 2-312 320 5 3 5 0 2-313 320 5 2 5 0 2-315 320 5 3 5 4 2-317 320 5 2 5 3 2-319 320 5 4 5 5 2-321 320 5 3 5 4 2-323 320 5 2 3 4 2-325 320 5 3 5 4 2-327 320 5 3 4 4 2-329 320 5 4 4 4 2-330 320 5 2 4 3 2-331 320 5 0 4 3 2-332 320 5 3 3 2 2-333 320 5 2 5 1 2-334 320 5 4 5 4 2-335 320 5 3 5 3 2-336 320 5 0 3 0 2-337 320 3 0 3 0 2-339 320 5 4 4 4 2-340 320 5 5 5 0 2-341 320 4 3 3 0 2-342 320 5 5 5 0 2-343 320 5 5 4 0 2-344 320 5 4 5 0 2-345 320 5 5 5 0 2-346 320 4 3 1 0 2-347 320 4 4 4 0 2-348 320 5 5 5 0 2-349 320 5 5 4 0 2-350 320 5 5 5 0 2-351 320 5 5 4 0 2-352 320 5 5 5 1 2-353 320 5 5 5 0 2-354 320 5 5 5 3 2-355 320 5 5 5 0 2-356 320 4 4 4 0 2-357 320 5 3 2 0 2-358 320 3 1 3 0 2-359 320 3 5 3 0 2-360 320 5 4 3 1 2-362 320 3 0 3 0 2-364 320 4 4 5 0 2-365 320 4 5 5 0 2-366 320 3 0 3 0 2-368 320 4 3 3 0 2-369 320 4 5 4 0 2-370 320 3 2 5 0 2-371 320 4 4 4 0 2-372 84 4 4 3 0 2-374 320 5 4 5 5 2-376 246 5 3 3 1 2-377 101 4 3 3 0 2-378 320 5 5 3 0 2-382 280 0 0 3 0 2-383 320 5 5 5 0 2-384 320 3 3 3 0 2-385 320 5 5 5 2 2-386 320 5 4 3 0 2-387 320 5 5 5 2-388 320 5 3 3 0 2-389 320 5 3 5 2 2-390 320 5 3 5 1 2-391 320 5 4 5 1 2-392 320 5 4 5 1 2-393 320 5 1 3 0 2-394 320 5 3 5 0 2-395 320 3 3 3 0 2-398 320 0 3 0 2-400 320 5 5 0 2-402 320 5 3 3 1 2-404 320 3 0 3 0 2-406 320 4 4 5 0 2-407 320 5 4 4 0 2-408 320 4 4 5 0 2-409 320 5 4 5 0 2-410 80 4 0 1 0 2-411 320 5 3 3 0 2-412 320 4 0 4 0 2-413 320 5 4 4 0 2-414 320 4 3 3 0 2-416 320 5 3 4 0 2-418 320 5 3 5 4 2-420 320 5 3 4 0 2-421 320 5 2 5 0 2-422 320 5 3 5 0 2-424 320 5 3 4 0 2-425 320 4 2 5 1 2-427 320 3 0 2 0 2-428 125 4 0 0 0 2-429 320 3 0 0 0 2-430 320 2 0 3 0 2-431 320 5 3 5 0 2-432 320 3 0 2 0 2-434 320 2 2 0 2-436 320 3 0 2 0 2-438 320 2 0 2 0 2-440 320 5 0 0 3 2-441 320 5 0 1 2-442 320 5 2 3 1 2-443 320 5 4 5 5 2-444 320 5 4 5 5 2-450 320 3 0 5 0 2-451 320 5 3 5 2 2-452 320 5 0 5 0 2-453 320 5 3 2 4 2-454 320 5 2 5 3 2-455 320 5 2 0 1 2-456 320 3 0 0 0 2-457 320 5 3 5 3 2-459 320 3 0 0 0 2-460 403 4 0 0 2 2-461 320 4 0 4 0 2-463 320 3 0 0 0 2-465 320 5 3 5 1 2-467 320 3 4 4 0 2-468 320 3 2 2 0 3-001 320 5 5 5 0 3-002 320 5 0 3 0 3-003 320 5 3 5 3 3-004 320 5 4 5 1 3-005 320 5 3 5 3 3-006 320 5 4 5 1 3-007 320 5 5 5 1 3-008 320 4 4 5 0 3-009 320 5 5 5 0 3-010 320 5 0 4 3 3-011 320 5 4 5 3 3-012 320 5 2 5 3 3-013 320 4 4 5 0 3-014 320 5 0 4 0 3-015 320 3 3 3 0 3-016 320 3 4 4 0 3-017 320 3 0 0 0 3-018 45 3 0 2 0 3-019 320 3 0 3 3 3-020 320 4 3 5 0 3-021 320 5 3 5 0 3-022 320 4 2 0 0 3-023 320 5 3 5 0 3-024 320 5 3 5 0 3-025 320 3 0 2 0 3-026 320 4 0 2 0 3-027 320 5 3 5 0 3-028 320 4 3 5 0 3-029 285 5 3 5 1 3-030 320 4 2 0 0 3-031 320 5 2 3 1 3-032 320 5 3 3 0 3-033 320 4 3 5 0 3-034 320 5 4 5 0 3-035 320 4 3 5 0 3-036 320 5 0 4 0 3-037 320 4 3 4 0 3-038 320 3 1 3 0 3-039 320 4 3 5 0 3-040 320 5 0 5 0 3-041 320 2 0 1 0 3-042 320 4 0 3 0 3-043 320 5 3 5 2 3-044 320 5 0 3 0 3-045 320 5 4 5 1 3-046 320 5 2 5 0 3-047 320 3 3 2 0 3-048 320 4 0 2 0 3-049 274 5 5 3 5 3-050 224 4 3 3 2 3-051 320 1 0 3 1 3-053 320 5 4 5 5 3-054 304 5 3 5 3 3-055 320 5 4 5 5 3-056 320 3 1 3 0 3-057 320 5 3 4 5 3-058 320 5 4 5 5 3-059 320 4 0 4 0 3-060 320 3 4 3 1 3-061 320 2 3 5 0 3-062 320 2 1 5 1 3-063 320 0 0 5 0 3-065 214 5 2 5 1 3-066 296 5 1 5 2 3-068 320 3 2 3 1 3-069 320 0 0 3 0 3-070 80 5 5 5 4 3-071 320 5 5 5 5 3-072 320 4 3 4 0 3-074 320 4 3 5 0 3-075 320 0 3 3 0 3-076 320 5 3 5 3 3-077 320 5 1 5 2 3-078 80 5 3 5 5 3-079 320 5 4 5 5 3-080 320 1 0 4 0 3-082 320 5 3 5 1 3-083 320 4 4 4 0 3-084 320 5 0 3 0 3-085 320 5 0 4 4 3-086 320 3 0 0 0 3-087 320 4 0 3 1 3-088 320 5 4 5 0 3-089 320 5 4 5 5 3-090 310 5 5 5 4 3-091 320 2 0 4 0 3-092 320 0 4 0 3-093 320 5 5 5 4 3-094 323 5 5 5 3 3-095 320 5 5 5 5 3-096 320 5 5 5 4 3-097 320 4 4 3 1 3-099 320 5 5 5 5 3-101 320 5 3 5 5 3-103 320 4 5 5 5 3-105 320 5 5 4 4 3-107 320 4 3 4 5 3-108 320 3 2 1 0 3-109 320 3 4 4 1 3-111 320 5 3 5 5 3-113 320 5 3 5 5 3-114 320 5 4 5 5 3-116 320 5 5 5 5 3-118 320 4 0 5 1 3-119 320 4 4 5 0 3-121 320 5 4 5 5 3-123 320 5 5 5 5 3-125 320 5 3 5 4 3-127 320 4 3 5 3 3-129 320 5 4 5 4 3-131 320 5 3 5 5 3-133 320 3 3 5 5 3-134 320 3 4 3 0 3-135 320 4 3 2 3 3-137 320 3 5 5 3 3-139 320 4 4 4 0 3-140 320 5 4 5 0 3-141 320 5 2 5 0 3-143 320 5 4 5 0 3-144 320 5 4 5 1 3-145 320 3 5 4 0 3-146 320 3 3 3 1 3-147 320 4 2 3 0 3-149 320 4 5 4 0 3-150 320 5 3 2 0 3-151 320 3 0 3 0 3-153 320 5 2 0 0 3-154 320 3 2 3 0 3-155 320 5 4 4 2 3-156 320 5 4 3 1 3-157 320 5 3 3 2 3-158 320 5 3 4 1 3-159 320 2 0 3 0 3-161 320 5 3 3 0 3-163 320 5 5 3 5 3-165 320 5 4 3 2 3-170 320 3 0 0 0 4-001 320 4 3 5 0 4-002 320 5 2 5 0 4-003 320 3 3 3 0 4-004 320 4 3 4 0 4-005 320 4 3 5 1 4-006 320 5 5 5 0 4-007 320 5 3 5 1 4-008 320 5 3 5 0 4-009 320 5 3 5 0 4-010 320 5 4 5 1 4-011 320 4 3 5 0 4-012 320 5 3 5 0 4-013 320 3 3 4 0 4-014 320 3 0 0 0 4-015 320 3 3 5 0 4-016 320 3 5 4 0 4-017 320 4 0 3 0 4-018 320 4 4 3 0 4-019 320 3 4 5 0 4-020 320 4 5 5 0 4-021 320 4 4 5 0 4-022 320 5 5 4 0 4-023 320 5 3 5 0 4-024 320 4 3 5 0 4-025 320 5 3 5 0 4-026 320 5 5 5 0 4-027 320 5 0 0 0 4-028 320 5 3 5 0 4-029 320 3 0 0 0 4-030 320 3 5 3 0 4-031 320 3 3 5 0 4-032 320 4 3 5 0 4-033 320 4 2 3 0 4-034 320 4 5 4 0 4-035 320 5 3 5 1 4-036 320 5 5 5 1 4-037 320 3 1 0 0 4-038 320 4 5 4 0 4-039 320 4 3 3 1 4-040 320 5 4 5 0 4-041 320 5 4 5 0 4-044 320 5 5 5 0 4-045 320 5 3 5 0 4-046 320 5 1 5 1 4-048 320 5 5 5 0 4-049 320 5 3 5 0 4-050 320 5 4 4 0 4-051 320 5 3 3 0 4-052 320 5 3 4 0 4-053 320 4 3 4 0 4-054 320 2 0 0 0 4-056 320 4 4 4 0 4-058 320 4 3 3 0 4-059 320 4 4 4 0 4-060 320 3 1 3 0 4-061 320 3 3 4 0 4-062 320 4 4 3 0 4-063 320 5 3 4 0 4-064 320 4 3 4 0 4-065 320 4 3 3 0 4-066 320 0 3 0 4-068 320 4 3 3 0 4-069 320 4 3 3 1 4-070 320 5 4 4 0 4-072 320 3 3 4 0 4-074 320 4 0 3 0 4-076 320 4 3 3 0 4-077 320 5 4 5 0 4-078 320 3 2 3 0 4-079 320 2 2 2 0 4-080 320 2 3 4 0 4-081 320 3 0 0 0 4-083 320 5 4 5 0 4-084 320 5 4 4 0 4-085 320 2 0 2 0 4-086 320 4 3 3 0 4-088 320 5 3 5 1 4-090 320 5 3 2 0 4-091 320 5 5 3 0 4-092 320 5 3 4 0 4-093 320 5 4 4 1 4-094 320 5 4 4 1 4-096 320 5 3 3 1 4-098 320 4 3 3 0 4-099 320 5 5 4 0 4-100 320 2 0 0 0 4-102 320 1 3 5 0 4-104 320 2 0 0 0 4-106 320 4 0 5 0 4-108 320 4 0 5 0 4-110 320 5 0 5 0 4-112 320 5 4 5 0 4-114 320 4 3 4 0 4-116 320 3 4 3 0 4-118 320 4 3 4 0 4-120 320 2 3 2 0 4-122 320 5 0 4 0 4-124 320 5 3 5 1 4-126 320 3 0 3 0 4-128 320 3 0 5 0 4-130 320 3 0 4 0 5-001 320 4 3 5 0 5-002 320 4 3 0 0 5-003 320 3 3 5 0 5-004 320 3 0 0 0 5-005 320 3 5 4 0 5-006 320 4 1 3 0 5-007 320 4 1 2 0 5-008 320 4 0 0 0 5-009 320 4 3 3 1 5-010 320 3 3 4 0 5-011 320 5 3 5 0 5-012 320 4 2 3 0 5-014 320 4 0 5 0 5-015 320 2 2 3 0 5-016 320 5 2 5 0 5-017 320 5 0 5 0 5-018 320 4 0 3 0 5-019 320 4 0 1 0 5-020 320 3 0 0 0 5-021 320 4 3 5 0 5-022 272 4 3 3 0 5-023 320 4 3 0 0 5-024 320 4 3 0 4 5-025 320 3 4 4 0 5-026 320 3 4 5 0 5-027 320 3 0 0 0 5-028 344 5 0 0 0 5-029 320 4 4 5 0 5-030 320 4 0 0 0 5-031 320 5 4 5 3 5-032 320 4 3 0 0 5-033 320 4 3 4 0 5-034 320 4 1 0 0 5-035 320 4 3 3 0 5-036 320 2 0 0 0 5-037 320 4 4 5 0 5-038 320 2 2 4 0 5-039 320 4 3 5 0 5-040 320 4 1 0 0 5-041 320 4 3 3 0 5-042 320 5 2 4 0 5-043 320 3 3 4 0 5-044 320 3 3 3 0 5-045 320 4 3 3 1 5-046 320 5 3 5 0 5-047 320 3 0 0 0 5-048 320 3 4 0 0 5-049 320 3 0 0 0 5-050 320 2 4 0 0 5-051 320 4 3 3 0 5-052 320 5 3 5 1 5-053 320 3 3 5 0 5-054 320 4 2 5 0 5-055 320 1 0 3 0 5-058 320 0 0 3 0 5-059 320 5 3 4 4 5-060 320 5 2 3 3 5-061 320 5 3 4 3 5-063 320 3 0 2 0 5-064 320 5 2 5 3 5-065 320 4 3 4 2 5-067 320 3 5 4 0 5-068 320 4 0 1 0 5-069 320 4 0 0 0 5-070 320 3 0 0 0 5-072 320 5 3 5 4 5-073 320 5 0 0 2 5-074 320 3 5 3 0 5-075 320 5 3 3 1 5-076 344 5 0 0 0 5-077 320 5 2 4 2 5-078 270 4 4 3 3 5-079 320 3 0 0 0 5-080 370 3 3 2 0 5-081 320 2 2 0 0 5-082 320 5 4 4 3 5-083 320 1 0 2 0 5-084 320 4 0 3 0 5-086 320 3 0 0 0 5-088 320 3 2 2 0 5-089 320 1 3 3 0 5-090 320 5 2 5 4 5-091 320 4 4 3 3 5-092 320 2 0 0 0 5-093 320 1 2 2 0 5-094 320 5 3 4 3 5-095 320 5 5 4 5 5-096 320 3 2 2 0 5-097 320 4 2 1 2 5-101 320 5 2 3 3 5-102 320 4 4 3 4 5-103 320 5 4 5 4 5-104 320 5 5 4 5 5-105 320 5 0 0 1 5-107 320 3 0 0 0 6-001 320 3 2 4 0 6-002 320 4 5 3 3 7-001 320 5 1 4 0 7-002 320 5 2 4 1 7-003 320 4 3 5 3 7-004 320 5 5 5 4 8-001 320 4 3 1 0 8-002 320 4 3 4 0 8-003 320 5 3 4 0 8-004 320 5 3 4 0 8-005 320 5 4 4 1 8-007 320 5 3 5 2 8-008 320 5 4 4 3 9-002 320 3 0 2 1 9-003 320 3 0 1 0 9-005 390 3 0 2 0 9-006 147 1 0 2 0 9-007 320 4 1 5 0 9-008 320 2 3 5 0 9-009 320 3 0 1 0 9-010 246 4 5 4 1 9-011 320 5 0 4 1 9-012 320 4 0 5 0 9-013 320 1 0 3 0 9-014 320 3 3 5 0 9-016 320 5 5 4 0 9-017 320 5 3 5 2 9-019 320 4 4 4 0 9-020 320 5 4 5 0 9-021 320 3 3 5 0 9-023 320 5 3 5 1 9-025 320 5 2 5 0 9-027 320 5 2 5 5 9-029 320 4 3 5 0 9-031 320 5 1 5 1 9-033 320 4 3 5 0 9-035 320 5 3 5 5 9-037 320 5 2 5 3 9-039 320 5 1 5 3 9-041 320 5 2 5 1 9-043 320 4 3 5 2 9-045 320 5 3 5 4 9-047 320 2 0 3 0 9-049 320 5 2 3 1 9-050 320 4 3 5 1 9-051 320 5 3 4 4 9-052 320 5 0 4 1 9-053 320 4 0 4 0 9-055 320 5 5 5 1 9-056 438 5 3 4 2 9-057 320 5 3 5 5 9-058 320 5 3 5 5 9-059 320 5 3 5 5 9-060 402 4 2 5 3 9-061 320 5 4 5 5 9-062 320 5 3 5 2 9-063 320 5 3 4 5 9-064 320 5 1 5 3 10-001  320 3 0 2 0 11-001  320 3 3 5 0

TABLE 19 (AAH hereinbelow indicates “Amount of Applied Herbicide”) A A H No. (g/ha) F G H I J K L M N O P Q R b c d e f g 1-001 320 0 0 0 0 0 0 0 0 4 0 0 0 0 0 3 0 1-003 320 3 4 0 0 0 0 0 0 2 3 4 3 2 0 0 0 3 0 1-005 320 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 1-006 320 0 0 0 0 0 0 0 0 0 4 0 0 3 0 0 0 0 0 1-007 320 0 0 0 3 0 0 0 0 0 3 0 0 0 0 0 0 0 1-011 320 3 5 5 2 4 3 0 4 4 5 5 0 0 0 0 1 1-012 320 4 5 5 1 5 0 3 0 0 0 0 0 0 0 0 0 0 1-013 320 0 5 4 0 0 0 0 3 0 0 0 0 0 1-014 320 0 1 2 0 0 0 0 0 0 2 4 5 0 0 0 0 1 1-015 320 3 4 4 0 4 0 5 0 0 0 3 3 4 0 0 0 0 1 1-017 320 0 0 0 1 2 0 0 0 0 0 4 0 4 0 0 0 3 1 1-019 320 0 2 3 0 0 3 0 0 4 4 5 0 5 0 0 0 5 4 1-020 320 0 5 5 0 1 3 0 0 0 4 3 0 5 0 0 0 0 2 1-021 320 0 1 0 0 0 1 0 3 0 0 5 5 0 0 0 0 4 1-023 320 0 2 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1-024 320 0 0 3 0 0 0 0 4 4 5 4 0 4 0 0 0 3 5 1-025 320 0 0 0 0 0 0 0 5 2 0 3 0 0 0 1 3 1-026 320 0 0 0 0 0 0 0 0 5 0 2 0 3 0 0 0 1 3 1-027 320 0 0 0 0 0 0 0 0 0 0 2 3 2 0 0 0 0 0 1-028 320 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 1 0 1-030 320 5 4 4 1 1 3 5 3 5 5 5 5 5 0 0 0 5 5 1-031 320 0 3 4 0 4 5 1-032 320 0 0 4 0 3 5 0 2 4 1-034 320 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 1-036 320 0 4 0 0 5 0 2 5 5 5 0 5 0 0 0 5 3 1-037 320 0 5 2 0 0 1 0 3 5 3 4 0 3 0 0 0 0 0 1-040 320 0 0 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 1-041 320 2 3 0 1 0 5 3 4 5 0 5 0 0 0 5 5 1-042 320 2 3 0 0 0 3 0 3 5 3 4 0 5 0 0 0 5 5 1-043 320 0 5 3 0 0 5 0 0 5 5 4 0 4 0 0 0 2 4 1-044 320 2 4 0 0 0 2 0 0 4 4 5 4 5 0 0 0 1 3 1-045 320 4 4 5 0 0 5 0 5 3 5 4 4 5 0 3 0 5 5 1-046 320 0 0 0 0 0 0 0 0 0 0 5 5 5 0 0 0 5 3 1-047 320 0 2 3 0 0 0 0 0 0 3 5 5 0 0 0 2 3 1-048 320 0 0 0 0 0 0 0 0 0 0 3 0 1 0 0 0 0 0 1-049 320 2 3 3 0 0 0 0 0 4 3 3 0 4 0 0 0 3 3 1-051 320 4 5 3 0 0 3 4 4 4 3 0 4 0 0 0 5 0 1-052 320 1 4 3 0 0 1 0 0 0 2 4 0 3 0 0 0 5 0 1-053 320 2 3 1 0 0 3 0 2 4 5 5 0 3 0 0 0 2 0 1-054 320 0 0 2 0 3 3 0 0 0 0 0 0 0 0 0 0 0 0 1-055 272 2 5 4 3 3 3 3 0 5 4 5 5 0 0 1 5 1 1-056 320 3 5 3 3 1 0 5 0 5 3 3 4 0 0 0 3 2 1-058 320 2 5 3 1 2 0 0 0 2 3 5 4 0 0 0 0 0 1-059 320 0 3 3 0 3 1 3 0 0 3 0 0 0 0 0 0 0 1-060 320 0 0 0 0 0 0 1 0 0 0 4 3 5 0 0 0 5 0 1-061 320 5 5 4 3 5 3 5 0 4 3 5 4 5 0 0 0 5 5 1-062 320 5 4 4 1 5 4 3 3 5 0 3 5 4 0 0 0 5 5 1-064 320 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 1-065 320 0 0 0 0 0 0 0 0 0 0 3 0 4 0 0 0 0 0 1-066 320 0 0 0 0 0 0 0 0 0 0 2 4 0 0 0 1 0 1-068 320 0 4 4 0 0 2 0 0 2 0 4 0 0 0 0 0 1-069 320 0 0 0 0 0 0 0 0 0 0 3 0 4 0 0 0 0 0 1-072 320 5 5 5 2 0 5 0 5 5 5 4 5 0 0 1 5 5 1-073 320 5 5 4 2 2 5 1 4 4 5 4 5 0 0 3 4 2 1-074 320 0 0 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 1-075 320 0 0 1 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 1-076 320 0 1 0 0 0 0 0 0 0 0 5 5 0 0 0 0 0 1-077 320 0 0 0 0 0 0 0 0 0 0 4 4 0 0 0 0 0 1-078 144 0 0 2 0 0 0 0 0 0 3 0 0 2 0 0 0 0 0 1-083 320 0 0 0 2 0 3 0 0 0 0 5 3 5 0 0 0 5 1 1-084 320 1 2 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1-085 320 5 4 4 0 5 3 5 5 4 4 4 0 0 0 5 3 1-087 320 2 5 4 0 0 3 0 0 5 5 5 5 0 0 0 1 0 1-088 320 3 4 4 0 0 1 0 0 0 3 4 0 5 0 0 0 0 0 1-089 320 3 5 5 0 0 0 0 2 4 5 5 0 0 0 0 0 1-090 320 0 3 1 0 0 0 0 0 2 2 4 5 0 0 0 0 0 1-091 320 3 5 5 0 0 0 0 5 3 4 5 3 5 0 0 0 1 1 1-092 320 0 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 1-097 320 0 0 0 0 0 0 0 1 1 4 0 0 0 0 0 0 0 0 1-098 320 0 0 0 0 0 0 0 3 0 4 3 0 0 0 0 0 5 0 1-099 320 0 0 0 0 0 0 0 0 0 0 4 2 5 0 0 0 0 0 1-100 320 0 0 0 0 0 3 0 0 0 0 2 2 5 0 0 0 0 0 1-101 320 3 5 5 0 0 4 4 0 4 5 5 3 5 0 0 0 2 0 1-102 320 2 5 3 1 0 3 0 1 4 4 5 0 5 0 0 0 1 0 1-103 320 2 3 2 0 0 0 0 0 3 3 1 0 2 0 0 0 1 0 1-108 320 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 1-110 320 3 3 3 1 2 2 1 0 0 3 3 0 0 0 0 5 1-112 320 0 1 0 0 4 0 5 3 1 0 5 5 0 0 0 1 4 1-113 320 2 1 3 1 0 0 0 3 2 4 5 0 0 0 0 4 1-115 320 0 0 2 0 0 0 0 3 0 0 0 0 0 0 0 0 1-116 320 0 0 0 1 1 0 3 2 5 3 5 5 0 0 0 4 2 1-118 320 1 3 4 3 3 0 3 3 5 5 3 4 0 0 0 5 4 1-123 296 0 0 0 0 0 0 0 0 4 4 1 3 0 0 0 0 0 1-124 320 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 1-125 320 1 3 3 0 0 5 0 1 5 5 1 5 0 0 0 5 1 1-126 320 0 0 0 0 0 3 0 0 3 2 2 3 0 0 0 0 3 1-127 320 0 0 0 0 0 5 0 2 5 4 0 4 0 0 0 0 1 1-128 246 0 0 0 0 0 2 0 0 4 0 3 3 0 0 0 0 0 1-129 320 0 0 0 0 0 5 0 2 5 5 1 4 0 0 0 5 3 1-130 320 1 3 3 0 0 4 0 1 3 4 3 3 0 0 0 4 4 1-131 320 4 5 5 2 1 5 2 5 5 5 5 0 5 0 0 0 2 2 1-133 320 2 3 2 0 0 0 0 0 5 1 0 5 0 0 0 0 0 1-135 320 2 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 1-136 320 2 4 4 0 0 5 0 3 4 5 1 4 0 0 0 0 0 1-137 320 0 2 0 0 0 0 0 0 3 2 0 3 0 0 0 0 0 1-138 320 0 4 5 0 3 5 0 3 5 5 4 5 0 0 0 1 5 1-139 320 0 3 4 0 0 5 3 2 5 4 5 5 0 0 0 0 4 1-140 320 5 5 5 0 0 5 5 5 5 4 5 1 0 0 5 5 1-141 320 4 5 4 0 0 5 3 4 5 5 4 5 0 0 0 5 0 1-142 320 0 0 3 0 0 0 0 3 4 5 2 5 0 0 0 0 4 1-143 320 3 4 4 0 0 0 0 4 4 5 0 3 0 0 0 5 5 1-144 320 0 0 0 0 1 3 0 0 0 0 3 3 0 0 0 0 0 1-146 320 4 5 5 0 0 4 0 5 5 5 4 5 0 0 0 5 5 1-147 320 0 0 0 0 0 0 0 0 2 3 5 5 0 0 0 0 0 1-148 368 4 5 5 2 1 5 0 4 5 5 5 5 0 1 0 5 5 1-151 320 0 0 0 0 0 3 0 0 3 2 0 5 0 0 0 3 0 1-152 320 1 2 3 0 0 0 0 0 3 0 3 3 0 0 0 1 0 1-153 320 2 3 0 0 0 0 0 0 3 5 0 0 0 0 0 0 1-156 320 0 0 0 0 3 0 0 3 0 0 0 0 0 0 0 1-162 80 0 0 0 0 0 0 0 0 1 4 2 0 0 0 0 0 0 1-166 80 0 0 0 0 0 0 0 0 0 0 4 1 0 0 0 0 0 1-168 320 0 0 0 0 0 0 0 0 1 0 4 3 0 0 0 1 0 1-169 320 0 0 0 0 0 0 0 0 0 0 1 0 3 0 0 0 0 0 1-170 320 0 0 0 0 0 0 0 0 5 0 4 5 0 0 0 3 2 1-171 320 5 0 0 0 0 0 0 0 5 3 5 4 0 0 0 4 3 1-172 320 2 5 0 0 0 1 0 1 5 5 5 5 0 0 0 5 4 1-173 320 0 5 0 0 0 2 0 4 5 5 3 5 0 0 0 5 4 1-174 320 0 0 0 0 0 0 0 0 0 5 0 4 0 0 0 5 0 1-175 320 0 1 0 0 0 2 1 3 4 4 0 0 0 3 0 1-176 320 4 5 5 3 5 1 5 1 5 4 5 5 0 0 0 5 5 1-177 320 3 5 3 3 0 0 0 0 5 2 5 4 0 0 0 4 1 1-178 320 0 0 0 0 1 0 0 4 0 4 4 0 0 0 2 1 1-179 320 0 0 0 0 0 0 0 0 3 0 4 4 0 0 0 1 1 1-180 320 0 0 0 2 0 0 0 0 0 0 4 4 0 0 0 4 1 1-181 320 0 0 0 0 0 0 0 0 0 0 1 1 0 0 0 0 0 1-182 80 1 5 0 0 0 0 0 1 5 4 4 0 5 0 0 0 0 1-183 80 0 0 0 0 0 0 0 0 0 0 3 4 0 0 0 0 1-186 283 0 0 0 0 0 0 0 0 2 0 5 4 0 0 0 2 3 1-187 320 0 0 0 0 0 0 0 0 4 5 4 0 0 0 4 0 1-192 80 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 1-196 320 0 0 4 0 5 5 0 5 3 1-197 320 0 0 0 0 0 0 0 0 0 0 5 5 0 0 0 5 1 1-198 320 0 5 2 0 0 0 0 5 0 0 5 1 5 0 0 0 4 1 1-199 320 1 2 0 0 0 0 0 0 3 4 0 5 0 0 0 0 0 1-200 320 0 0 0 0 0 0 0 0 0 0 1 3 0 0 0 0 0 1-201 320 2 5 5 0 0 4 3 5 5 4 5 0 0 0 3 1 1-202 178 0 4 3 0 0 4 0 2 5 4 3 3 4 0 0 0 0 0 1-203 320 4 5 5 1 3 5 0 5 5 5 5 5 1 2 0 5 5 1-204 320 0 0 0 0 0 0 0 0 3 3 0 0 4 0 0 0 0 0 1-206 320 4 5 5 0 4 5 3 3 5 5 3 5 2 1 0 1 4 1-208 320 0 0 0 0 0 4 0 0 0 0 3 0 5 0 0 0 4 0 1-211 80 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 1-213 320 0 0 0 0 1 3 2 0 0 0 3 0 0 0 3 0 1-215 320 0 0 0 0 0 0 0 0 5 3 1 3 0 0 0 0 0 1-217 320 0 3 0 0 0 0 0 4 2 5 3 5 0 0 0 0 2 1-218 187 0 3 2 0 0 0 0 0 2 3 1 0 5 0 0 0 0 0 1-221 320 2 5 3 0 0 5 0 2 5 4 4 5 0 1 0 0 0 1-223 246 0 2 3 0 0 0 0 0 4 3 0 0 0 0 0 0 0 2 1-224 320 2 3 1 0 0 0 0 5 4 3 0 3 0 2 0 0 0 1-228 320 4 5 4 0 4 4 4 5 5 4 5 0 0 0 5 4 1-230 320 0 4 3 0 4 4 0 4 5 5 2 5 0 0 0 3 5 1-236 320 4 4 5 0 0 3 0 1 5 4 4 4 0 0 0 0 0 1-237 320 1 4 0 0 0 3 0 1 5 3 3 0 5 0 0 0 0 0 1-241 320 1 3 3 0 2 3 0 5 4 3 5 0 0 0 0 0 1-243 320 0 0 0 0 0 0 0 1 4 3 0 0 0 0 0 0 1-245 320 0 0 0 0 0 2 0 0 3 3 4 0 0 0 0 0 1-247 320 0 0 0 0 0 3 0 0 3 3 4 4 0 0 0 0 0 1-249 320 0 0 0 0 0 3 0 0 3 3 0 0 4 0 0 0 0 0 1-251 320 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 1-253 320 0 0 0 0 0 0 0 0 3 3 3 5 0 0 0 0 0 1-255 320 3 4 5 0 2 4 0 4 5 5 4 0 5 0 0 0 0 0 2-001 320 5 4 3 3 2 4 0 5 5 5 4 5 0 0 0 5 5 2-002 320 5 5 4 3 1 5 1 5 5 4 3 4 5 0 0 0 5 4 2-003 320 5 5 5 0 3 5 5 5 5 3 4 0 0 0 4 0 2-004 320 4 5 4 0 0 5 0 3 5 5 5 1 0 0 0 4 0 2-005 320 5 5 4 0 0 4 0 4 4 4 4 3 0 0 0 4 0 2-007 320 1 2 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 2-008 320 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 2-009 320 1 3 0 0 0 4 0 2 5 3 4 3 0 0 0 1 0 2-010 320 5 5 5 1 0 5 0 5 5 5 4 5 0 0 0 3 3 2-011 320 3 2 3 0 0 5 2 3 4 5 2 4 0 0 0 5 3 2-012 320 5 5 5 0 0 4 0 4 5 5 4 5 0 0 0 5 4 2-013 320 5 5 4 0 3 4 0 3 4 5 3 4 0 0 0 0 0 2-014 320 0 2 4 0 0 4 3 3 5 5 4 5 0 0 0 4 4 2-015 320 0 0 0 0 0 0 0 0 5 2 0 4 0 0 0 0 0 2-016 320 0 0 1 0 2 3 1 3 5 5 1 4 0 0 0 5 4 2-017 320 0 1 2 0 0 0 0 0 4 2 0 0 0 0 0 0 0 2-018 320 0 1 0 0 0 4 2 1 4 4 3 4 0 0 0 0 0 2-019 320 0 2 0 0 0 5 1 0 5 3 4 5 0 0 0 0 1 2-020 320 3 4 2 0 3 5 5 3 5 5 3 5 0 0 0 2 4 2-021 320 5 5 4 0 0 5 5 4 5 5 5 5 0 0 0 4 3 2-022 320 3 5 5 0 4 5 5 4 5 4 3 5 0 0 0 1 1 2-023 320 4 5 4 0 3 4 0 2 5 5 3 5 0 0 0 0 3 2-024 294 3 3 1 0 2 0 0 2 5 5 3 4 0 0 0 3 2 2-025 283 3 4 3 3 0 0 0 2 3 4 4 4 3 0 0 0 4 4 2-026 320 4 3 4 3 3 3 1 5 5 5 4 5 0 0 0 5 5 2-027 320 3 4 4 2 0 4 0 3 5 5 4 0 5 0 0 0 2 4 2-028 320 3 2 3 0 0 0 0 3 5 3 4 5 0 0 0 5 4 2-029 266 3 3 3 3 0 0 0 0 4 4 3 3 3 0 0 0 2 4 2-030 320 0 0 0 0 0 0 0 3 4 5 3 5 0 0 1 0 5 2-031 320 1 2 3 0 0 0 0 3 4 4 1 4 0 0 0 0 0 2-032 320 2 3 2 0 0 0 0 5 5 5 4 0 5 0 0 0 4 5 2-033 320 0 0 0 0 0 0 0 3 5 5 4 4 0 0 0 0 4 2-034 320 5 4 2 0 1 1 0 4 5 5 4 0 4 0 0 0 0 4 2-035 320 3 3 2 0 0 0 0 3 5 5 3 5 0 0 0 0 4 2-036 320 2 0 0 0 0 0 0 4 5 5 3 4 0 0 0 3 4 2-037 320 2 2 0 0 0 0 0 4 5 2 1 3 0 0 0 0 2 2-038 320 0 0 0 0 0 0 0 0 3 1 1 4 0 0 0 0 0 2-039 320 0 0 0 0 0 0 0 0 3 0 3 4 0 0 0 0 0 2-041 320 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 2-042 320 3 5 4 0 3 5 3 5 5 5 4 5 0 0 0 1 5 2-043 320 5 5 4 0 0 0 0 3 5 5 1 0 0 0 2 3 2-044 320 3 4 3 2 0 0 0 3 5 5 3 4 0 0 0 2 3 2-045 320 3 4 1 0 0 5 0 4 4 5 5 5 0 0 0 4 4 2-046 320 2 4 3 0 0 3 0 3 4 5 5 5 0 0 0 0 5 2-047 320 5 5 5 2 0 1 0 5 5 5 4 5 0 0 0 2 5 2-049 320 4 5 5 0 4 4 5 5 5 5 5 4 0 0 0 5 3 2-051 320 5 5 4 0 0 0 3 3 5 5 1 4 2 0 0 0 2 2-053 320 0 4 2 0 0 0 0 3 0 3 1 5 0 0 0 0 4 2-054 320 0 0 0 0 0 0 0 0 3 0 0 3 0 0 0 0 0 2-055 320 1 4 3 0 0 0 0 3 4 3 5 0 0 0 3 4 2-056 320 5 5 5 0 0 0 0 5 5 5 5 5 1 2 0 5 4 2-058 320 5 4 1 0 5 4 4 3 5 5 3 4 0 0 0 5 0 2-059 269 4 5 1 0 0 4 4 1 5 5 4 5 0 0 0 0 0 2-060 320 3 1 3 0 0 0 0 0 5 4 1 5 0 0 0 0 3 2-062 320 1 3 0 0 0 0 0 1 4 3 0 3 0 0 0 0 0 2-066 320 0 0 0 0 0 0 0 0 0 0 4 4 0 0 0 3 0 2-067 320 0 0 0 0 0 0 0 0 3 3 0 3 0 0 0 0 0 2-068 320 1 4 3 0 0 0 0 5 5 4 0 4 0 0 0 5 5 2-069 320 5 5 5 0 0 5 0 3 5 5 4 5 1 0 0 5 5 2-074 320 5 5 5 0 1 3 3 3 5 5 3 5 0 0 0 5 1 2-075 320 0 0 0 0 0 0 0 0 1 3 0 0 0 0 0 0 2-076 320 3 4 3 0 0 4 4 2 5 3 4 5 0 0 0 5 4 2-077 320 2 4 3 2 2 3 3 3 5 5 5 5 0 0 0 5 5 2-078 320 0 0 0 0 1 4 3 4 4 3 5 0 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5 0 4 5 5 4 5 5 5 5 0 1 0 1 5 3-114 320 4 5 5 0 5 5 5 4 5 5 5 5 0 0 0 5 5 3-116 320 5 5 5 3 4 5 4 4 5 5 4 5 0 1 1 5 5 3-118 320 0 0 0 0 0 3 3 0 3 1 0 5 0 0 0 1 1 3-119 320 4 3 0 0 0 0 0 0 3 3 0 5 0 0 0 0 0 3-121 320 5 5 5 3 5 5 5 5 5 5 5 5 0 3 0 5 5 3-123 320 5 5 5 4 4 5 5 2 5 5 5 5 0 0 3 5 5 3-125 320 3 2 0 0 5 5 3 4 5 5 5 5 0 0 0 3 5 3-127 320 0 0 0 0 3 4 5 0 0 0 1 0 0 0 0 0 3-129 320 4 5 4 1 4 5 5 0 5 5 3 4 0 0 0 0 3 3-131 320 3 4 2 3 4 5 3 3 5 5 4 0 0 0 1 5 3-133 320 2 5 1 1 3 5 5 1 5 5 4 0 0 0 3 0 3-134 320 0 0 0 0 4 4 5 1 5 3 1 3 0 0 0 5 4 3-137 320 0 1 5 1 0 1 0 0 0 0 5 4 0 0 0 0 0 3-139 320 0 0 0 0 0 0 0 2 4 3 0 1 0 0 0 0 0 3-140 320 0 0 0 0 0 0 0 0 4 3 0 0 0 0 0 0 0 3-141 320 0 1 3 0 3 3 3 3 5 5 3 0 4 0 0 0 1 0 3-143 320 0 2 0 0 0 0 4 0 4 4 0 3 3 0 0 0 1 0 3-144 320 1 0 3 0 0 0 0 0 4 3 0 0 0 0 0 0 0 3-149 320 0 0 0 0 0 0 0 1 3 0 0 0 0 0 0 0 0 3-151 320 0 0 0 0 0 0 0 0 0 0 1 5 0 0 0 0 0 3-155 320 0 0 2 0 4 3 4 0 4 0 1 0 0 0 1 0 0 3-156 320 0 0 0 0 0 0 0 0 0 0 3 4 0 0 0 3 3 3-158 320 0 0 0 0 0 0 0 0 2 0 1 0 0 0 0 0 0 3-159 320 0 0 0 0 0 0 0 1 4 4 0 3 0 0 0 0 0 3-161 320 0 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 3-163 320 4 3 5 0 3 3 3 1 5 3 4 3 0 0 0 1 0 3-165 320 5 3 3 0 3 4 3 1 4 0 5 5 0 0 0 1 0 3-168 320 0 0 0 0 3 0 0 0 3-170 320 0 0 0 0 4 1 0 0 4-001 320 0 0 0 0 0 0 0 3 2 5 4 4 0 0 0 1 0 4-002 320 0 2 4 0 0 0 0 2 3 3 0 0 0 0 0 0 0 4-003 320 0 0 0 0 0 0 0 0 4 3 1 1 0 0 0 1 0 4-004 320 0 0 1 0 0 0 0 0 3 3 1 0 0 0 0 3 0 4-005 320 0 5 4 0 0 0 0 0 0 4 4 0 5 0 0 0 2 4 4-006 320 0 4 4 0 0 0 0 1 4 4 0 0 0 0 0 0 0 4-007 320 0 0 0 0 3 0 0 0 0 0 3 3 0 0 0 0 0 4-008 320 2 3 3 0 0 0 0 1 2 2 1 0 0 0 0 0 0 4-009 320 0 0 0 0 0 0 0 0 5 3 4 4 0 0 0 5 0 4-010 320 0 0 0 0 0 2 0 0 4 3 3 3 0 0 0 1 2 4-011 320 0 3 3 0 0 0 0 0 2 3 3 0 0 0 0 2 0 4-012 320 0 0 0 0 0 0 0 1 3 1 0 0 0 0 0 0 0 4-015 320 0 0 0 0 0 0 0 0 2 3 0 0 0 0 0 0 0 4-016 320 2 3 1 0 0 0 0 0 3 1 1 0 0 0 0 1 0 4-017 320 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 0 4-021 320 0 0 0 0 0 0 0 0 2 1 4 3 0 0 0 0 0 4-022 320 3 3 3 0 0 0 0 0 3 2 1 0 0 0 0 3 3 4-023 320 0 0 0 0 0 5 0 0 2 3 5 0 0 0 0 0 0 4-024 320 0 2 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 4-025 320 2 4 3 0 1 0 0 2 3 1 0 0 0 0 1 1 4-026 320 3 3 3 0 0 0 0 0 2 0 1 2 0 0 0 0 1 4-027 320 0 0 0 0 0 0 0 0 4 2 5 1 0 0 0 1 0 4-028 320 0 0 0 0 0 0 0 1 4 4 0 1 0 0 0 4 4 4-030 320 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 4-032 320 0 0 0 0 0 0 0 0 3 0 3 3 0 0 0 0 0 4-033 320 0 0 0 0 0 0 0 0 2 0 4 4 0 0 0 0 0 4-034 320 3 4 3 0 0 0 0 2 4 3 0 0 0 0 0 0 0 4-035 320 4 3 5 0 0 0 0 2 3 0 3 1 0 0 0 0 0 4-036 320 4 3 3 0 0 0 0 2 4 1 2 2 0 0 0 1 1 4-040 320 0 0 0 0 0 2 0 0 3 3 1 4 0 0 0 5 0 4-042 320 0 0 1 0 0 0 0 1 4 3 5 0 3 0 0 0 3 1 4-044 320 0 0 0 0 0 0 0 0 0 1 3 0 0 0 5 0 4-045 320 0 0 0 0 0 0 3 0 4 0 3 3 0 0 0 3 0 4-046 320 0 3 3 0 3 0 3 5 1 3 5 0 0 0 5 0 4-048 320 1 0 2 0 0 0 0 0 3 1 1 5 0 0 0 4 1 4-049 320 0 0 0 0 0 0 0 0 4 3 3 4 0 0 0 0 0 4-050 320 2 3 2 0 0 1 0 3 4 3 4 0 4 0 0 0 1 0 4-051 320 0 1 0 0 0 4 0 0 5 4 4 5 0 0 0 3 0 4-052 320 0 0 0 0 0 0 0 1 4 2 3 0 4 0 0 0 1 0 4-053 320 0 2 0 0 0 4 0 2 5 3 4 5 0 0 0 3 3 4-054 320 0 0 0 0 0 0 0 0 2 1 4 0 4 0 0 0 2 0 4-056 320 0 0 0 0 0 0 3 0 0 0 3 0 0 0 0 0 0 4-058 320 0 0 0 0 0 2 0 0 0 0 5 0 0 0 5 0 4-059 320 0 0 0 0 0 0 0 0 0 0 4 4 0 0 0 0 0 4-066 320 0 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 0 4-068 320 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 4-076 320 0 0 0 0 0 0 0 2 4 3 1 3 0 0 0 0 0 4-077 320 0 0 0 0 0 0 0 0 3 0 0 3 0 0 0 3 1 4-078 320 0 0 0 0 0 0 0 0 2 0 3 4 0 0 0 0 0 4-079 320 0 0 0 0 0 0 0 0 2 0 0 3 0 0 0 1 0 4-083 320 0 0 1 0 0 0 1 3 0 3 3 0 0 0 0 0 4-088 320 0 0 0 0 0 3 0 0 5 4 0 3 0 0 0 0 0 4-094 320 0 0 0 0 0 2 0 0 5 3 0 3 0 0 0 0 0 4-096 320 0 0 0 0 0 0 0 0 5 3 3 4 0 0 0 0 0 4-100 320 0 1 0 0 0 0 0 3 3 4 3 0 0 0 1 0 4-102 320 0 0 0 0 0 3 0 2 4 3 0 0 0 0 0 0 1 0 4-104 320 0 0 0 0 0 0 0 2 4 1 3 3 0 0 0 0 0 4-106 320 3 1 0 0 0 0 3 0 4 1 1 1 0 0 0 5 0 4-108 320 2 0 0 0 2 1 0 3 5 4 1 3 0 0 0 3 4 4-110 320 0 0 0 0 0 5 0 3 5 5 5 4 0 0 0 5 4 4-112 320 3 4 3 0 2 3 4 3 4 3 3 5 0 1 0 3 4 4-114 320 4 4 1 0 0 4 0 0 3 4 3 4 0 0 0 1 0 4-118 320 0 0 0 0 0 5 0 3 5 5 4 4 0 0 0 5 5 4-124 320 4 5 3 0 2 4 0 3 5 5 4 4 0 1 0 3 1 4-126 320 0 0 0 0 0 1 0 0 5 3 4 0 0 0 0 1 4 4-130 320 0 0 0 0 0 0 0 2 5 1 1 4 0 0 0 0 0 5-001 320 5 5 0 3 4 5 5 4 5 5 4 5 0 0 0 1 3 5-002 320 0 4 3 3 2 5 5 3 5 5 4 5 0 1 0 0 1 5-003 320 1 4 3 0 0 0 0 2 3 5 4 4 0 0 0 1 1 5-004 320 0 0 0 0 0 0 0 0 3 4 0 0 0 0 0 0 0 5-007 320 0 3 0 0 0 0 0 0 3 1 3 3 0 0 0 0 0 5-009 320 0 2 0 0 0 0 0 2 4 4 5 5 0 0 0 1 1 5-010 320 0 0 2 0 0 0 0 2 3 3 0 2 0 0 0 0 0 5-011 320 3 4 4 0 3 3 4 5 5 5 3 5 0 1 0 4 5 5-012 320 3 3 1 3 3 0 3 3 5 5 3 3 0 2 0 3 3 5-014 320 0 1 2 0 0 0 0 4 5 5 3 5 0 0 0 2 2 5-015 320 0 0 0 0 0 0 0 0 4 4 3 5 0 0 0 0 0 5-016 320 4 5 5 0 4 3 5 4 5 5 5 5 0 0 0 5 5 5-017 320 4 4 4 3 0 0 2 3 5 4 4 4 5 0 0 0 3 2 5-018 320 0 3 2 0 0 0 0 0 2 1 4 3 0 0 0 0 0 5-019 320 0 3 0 0 0 0 0 3 4 2 1 4 0 0 0 0 1 5-020 320 0 0 0 0 0 0 0 0 3 0 0 3 0 0 0 0 0 5-021 320 5 5 4 0 0 0 4 4 4 3 2 5 0 0 0 5 5 5-022 272 1 3 0 0 0 0 0 3 4 3 3 3 0 0 0 1 0 5-023 320 0 0 0 0 0 0 0 0 3 2 3 0 0 0 0 5 4 5-025 320 1 4 3 1 0 1 0 3 5 5 3 4 0 0 0 2 1 5-026 320 0 0 0 0 0 0 0 0 4 4 0 4 0 0 0 1 5-028 320 0 0 0 0 0 0 0 0 3 2 1 1 0 0 0 0 0 5-029 320 0 3 0 2 4 1 3 5 5 3 3 0 0 0 3 4 5-030 320 1 4 2 0 5 0 5 3 5 5 5 0 5 0 0 0 5 0 5-031 320 4 5 3 1 3 0 5 4 5 5 3 0 0 0 4 4 5-032 320 0 3 0 0 3 0 5 1 4 4 0 0 0 0 0 0 0 5-033 320 3 3 3 0 0 0 0 0 3 4 1 0 0 1 0 0 0 5-035 320 1 2 3 0 0 0 0 0 1 3 1 5 0 0 0 0 1 5-036 320 0 1 0 0 0 0 0 0 4 3 3 0 3 0 0 0 0 0 5-037 320 0 0 0 0 0 0 5 4 5 0 5 0 0 0 1 4 5-038 320 0 0 0 0 0 0 0 0 2 4 0 0 0 0 0 0 5-039 320 0 0 0 0 0 0 0 0 3 1 0 0 0 0 0 0 0 5-040 320 0 3 0 0 0 0 0 2 4 0 0 0 0 0 0 0 0 5-042 320 0 0 0 0 0 0 0 0 3 1 3 0 0 0 0 0 0 5-043 320 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 5-046 320 0 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 5-051 320 0 2 0 0 0 0 0 0 1 4 1 0 0 0 0 0 0 5-052 320 0 0 0 0 0 0 0 0 2 3 3 0 0 0 0 0 0 5-053 320 0 0 0 0 0 0 0 0 3 0 0 1 0 0 0 0 0 5-054 320 0 0 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 5-059 320 0 0 0 0 3 4 3 0 0 0 0 0 0 0 0 0 0 0 5-060 320 0 0 0 0 0 1 1 0 0 0 5 0 3 0 0 0 0 0 5-061 320 0 0 0 0 0 0 0 0 0 0 3 0 2 0 0 0 3 0 5-064 320 3 4 4 0 1 0 2 4 3 4 5 0 0 0 2 1 5-065 320 0 4 4 1 3 3 3 2 5 5 5 5 0 0 0 5 4 5-069 320 0 0 0 0 0 0 0 0 2 0 0 0 0 0 0 0 0 5-070 320 0 0 0 0 0 0 0 0 0 0 1 3 0 0 0 0 0 5-072 320 5 4 1 0 0 0 0 1 3 3 2 3 0 0 0 1 4 5-073 320 0 2 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 5-076 344 3 3 1 0 0 0 0 1 4 3 0 0 0 0 0 0 0 5-077 320 2 0 0 0 0 0 0 0 3 3 0 0 0 0 0 0 0 5-082 320 0 1 0 0 0 4 4 0 4 3 3 0 0 0 0 0 5-084 320 0 2 1 0 0 0 5 4 5 5 0 2 3 0 0 0 1 0 5-089 320 0 0 0 0 0 0 4 0 0 0 0 0 0 0 0 0 0 5-090 320 0 0 0 0 0 5 3 0 0 0 1 1 0 0 0 0 0 5-094 320 4 4 1 0 1 3 3 1 3 3 1 3 0 0 0 0 1 5-095 320 0 0 0 0 0 0 0 0 0 0 3 3 0 0 0 0 1 5-101 320 0 0 0 0 0 4 0 0 1 2 0 0 0 0 0 0 5-103 320 4 3 1 0 0 1 3 1 2 2 3 4 0 0 0 3 4 5-105 320 0 0 0 2 3 4 0 0 7-001 320 0 0 3 0 3 0 3 5 5 5 5 0 0 0 5 5 7-002 320 1 0 2 0 0 0 0 1 5 4 3 3 0 0 0 1 1 7-003 320 0 0 0 0 0 0 0 3 5 4 4 5 0 0 0 3 4 7-004 320 3 5 3 0 0 4 0 3 4 4 4 5 0 0 0 0 1 8-001 320 0 0 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8-002 320 3 3 3 0 0 0 0 0 2 0 5 0 5 0 0 0 2 1 8-003 320 3 2 5 0 1 4 0 1 5 3 1 4 0 0 0 5 0 8-004 320 4 3 4 0 0 4 0 2 5 2 1 3 0 0 0 0 0 8-005 320 4 4 5 0 3 5 0 3 5 4 2 4 0 0 0 5 0 8-007 320 5 5 5 0 3 4 0 3 5 4 0 2 0 1 0 4 1 8-008 320 3 1 5 0 0 4 0 2 4 4 5 5 0 0 0 5 0 9-002 320 2 1 2 0 1 3 5 2 4 4 4 0 4 0 0 0 1 0 9-004 194 2 2 3 0 0 4 0 0 3 5 3 1 0 0 0 3 1 9-005 390 0 0 0 0 0 0 0 0 3 3 5 3 0 0 0 3 1 9-006 147 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 0 0 9-007 320 5 3 3 1 4 5 0 3 5 4 4 5 0 0 0 5 5 9-008 320 3 2 3 0 0 4 0 0 5 4 0 4 0 0 0 0 1 9-009 320 2 3 3 0 0 0 0 0 0 3 0 0 0 0 0 0 0 9-010 246 0 3 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9-011 320 2 0 0 0 2 0 3 0 3 4 1 3 0 0 0 3 0 9-012 320 2 3 2 0 0 4 0 2 3 3 3 4 0 0 0 3 5 9-013 320 4 3 1 0 0 0 0 2 3 0 0 0 0 0 0 0 2 9-014 320 4 5 4 1 4 5 0 4 5 3 5 0 4 0 1 0 3 0 9-016 320 3 4 4 2 0 4 4 1 5 4 3 5 0 0 0 3 3 9-019 320 0 0 0 0 0 1 0 0 2 1 0 0 0 0 0 3 0 9-020 320 4 1 4 2 3 5 2 2 5 0 4 5 0 0 2 4 5 9-021 320 4 4 4 0 4 5 3 3 5 4 0 0 5 0 0 3 4 3 9-023 320 4 5 5 0 0 5 3 3 5 5 0 0 4 1 1 1 3 4 9-025 320 4 5 4 0 3 5 3 3 4 0 0 4 0 2 0 3 0 9-027 320 5 5 4 0 4 4 4 5 5 5 1 0 5 0 0 0 5 1 9-031 320 4 4 4 0 0 5 4 2 5 3 4 3 5 0 0 0 5 5 9-035 320 5 5 5 2 5 5 5 4 5 5 5 3 5 3 0 0 4 2 9-037 320 4 1 2 0 0 5 0 3 5 2 0 4 0 1 0 5 1 9-039 320 4 5 2 0 0 5 0 3 5 4 3 0 5 0 0 0 5 0 9-041 320 3 4 1 0 0 5 0 1 5 4 1 0 4 0 0 0 0 0 9-043 320 4 5 4 0 4 5 0 4 5 3 0 0 0 0 4 4 9-045 320 5 5 5 0 5 5 5 5 5 1 0 4 1 0 0 4 5 9-047 320 0 0 0 0 0 4 0 0 3 0 0 0 1 0 0 0 1 0 9-049 320 4 4 4 0 0 5 0 3 5 4 4 0 5 0 0 0 5 3 9-051 320 1 5 4 0 5 5 4 3 5 5 5 5 0 0 0 5 4 9-053 320 2 4 4 0 5 0 4 5 5 3 0 4 0 0 0 5 5 9-055 320 0 4 3 0 5 0 5 5 4 5 0 5 0 0 1 5 4 9-057 320 5 5 3 0 0 5 0 4 5 5 5 5 0 1 0 5 4 9-058 320 5 5 2 0 0 5 0 3 5 5 3 0 5 0 1 0 0 1 9-059 320 0 3 1 0 0 4 0 3 5 5 5 5 0 0 0 5 3 9-060 402 1 3 0 0 0 4 0 3 5 4 1 0 5 0 0 0 0 1 9-061 320 5 5 5 2 5 0 4 5 5 4 5 3 1 0 5 5 9-062 320 4 5 4 0 4 5 0 5 5 4 3 0 5 2 1 0 1 1 9-063 320 5 5 5 0 5 5 5 5 5 4 5 3 0 0 5 5 10-001  320 0 0 0 0 0 0 0 0 0 0 0 0 5 0 0 0 0 0 11-001  320 0 0 0 0 0 0 2 5 4 4 0 5 0 2 0 5 4

TABLE 20 (AAH hereinbelow indicates “Amount of Applied Herbicide”) A A H No. (g/ha) F G H I J K L M N O P Q R b c d e f g 1-001 320 0 0 0 0 0 0 0 4 1 2 5 3 0 0 0 5 5 1-003 320 4 5 3 3 3 3 5 4 3 0 5 5 5 0 0 0 5 5 1-005 320 0 0 0 0 0 0 0 3 4 5 5 0 5 0 0 0 5 5 1-006 320 0 0 0 0 0 0 0 4 5 4 5 0 5 0 0 0 5 5 1-007 320 3 5 3 3 0 3 5 5 5 5 5 5 5 0 3 1 5 5 1-009 320 3 3 2 0 0 0 0 0 0 0 4 0 4 0 0 0 2 4 1-011 320 5 5 5 4 5 4 4 3 5 2 5 5 0 0 0 5 5 1-012 320 5 5 5 4 4 3 4 3 3 2 5 5 0 0 0 5 5 1-013 320 0 5 4 0 0 3 0 5 3 3 5 5 0 0 0 4 5 1-014 320 0 4 4 1 0 3 0 4 0 2 5 5 0 0 1 3 5 1-015 320 3 4 3 3 5 4 5 5 3 0 5 5 5 0 0 0 5 5 1-017 320 3 4 4 4 4 2 4 4 4 3 5 5 5 0 1 0 5 5 1-019 320 4 5 5 3 4 4 5 5 5 5 5 3 5 0 1 0 5 5 1-020 320 3 3 4 0 4 3 5 3 3 2 5 5 0 1 0 4 5 1-021 320 3 4 4 0 1 3 0 3 4 1 5 5 0 0 0 5 5 1-022 320 0 0 3 0 0 0 0 0 3 0 5 4 5 0 0 0 2 5 1-023 320 0 0 0 0 0 0 0 0 0 0 5 2 3 0 0 0 3 4 1-024 320 5 5 5 4 4 4 4 5 5 5 5 4 5 3 0 0 5 5 1-025 320 3 3 4 0 0 1 0 5 5 4 5 3 5 0 0 0 5 5 1-026 320 4 5 3 2 4 2 4 5 5 0 5 4 5 3 0 0 5 5 1-027 320 0 0 3 0 0 0 0 3 5 3 5 3 4 0 0 0 4 5 1-028 320 0 4 0 3 0 2 3 3 5 3 5 4 3 0 0 0 5 5 1-029 320 0 0 0 0 0 0 0 2 4 2 5 1 0 0 0 0 3 5 1-030 320 5 5 4 4 5 4 5 5 5 5 5 5 5 0 4 1 5 5 1-031 320 0 4 3 0 3 5 0 5 5 5 5 5 0 1 0 5 5 1-032 320 0 4 3 0 2 3 0 5 4 5 5 5 0 1 0 5 5 1-033 320 3 0 2 0 0 0 0 0 0 0 1 4 3 0 0 0 0 5 1-034 320 0 0 0 2 0 0 0 0 0 0 4 1 0 0 0 4 5 1-035 320 0 0 0 3 0 0 0 0 0 0 1 0 0 0 0 4 4 1-036 320 0 4 4 2 4 4 3 5 5 4 5 4 5 0 1 1 5 5 1-037 320 3 5 4 1 4 4 0 5 5 5 5 5 0 0 1 5 5 1-038 123 0 0 0 0 0 0 0 0 0 0 5 3 0 0 0 0 2 1 1-039 295 3 4 0 0 1 2 0 3 5 4 5 0 5 0 0 0 5 5 1-040 320 4 5 3 0 0 4 0 5 5 4 5 3 5 0 0 1 5 5 1-041 320 4 1 0 1 0 5 4 5 5 3 5 4 5 0 0 1 5 5 1-042 320 3 3 3 0 0 4 5 4 3 5 2 5 0 0 1 5 5 1-043 320 4 4 3 2 4 5 1 5 5 4 5 2 5 0 0 1 5 5 1-044 320 4 5 3 4 3 4 3 5 5 4 5 3 5 0 1 1 5 5 1-045 320 3 3 4 3 0 5 0 5 5 5 5 5 5 0 1 0 5 5 1-046 320 4 4 4 3 0 3 0 5 5 4 5 5 5 0 1 0 5 5 1-047 320 0 0 0 0 0 0 0 5 3 3 5 3 0 0 0 5 5 1-048 320 0 0 0 0 0 0 0 0 0 0 5 0 4 0 0 0 4 4 1-049 320 4 4 4 1 0 4 0 5 3 3 5 3 5 0 0 1 5 5 1-051 320 3 5 3 3 0 3 4 5 5 3 5 0 5 0 1 0 5 5 1-052 320 2 5 3 0 0 0 0 5 3 3 5 1 0 3 0 5 5 1-053 320 3 4 3 3 2 3 3 5 4 4 5 3 5 0 0 0 5 5 1-054 320 2 4 3 3 0 4 0 5 5 5 5 4 1 0 0 0 5 5 1-055 272 4 4 4 5 5 4 5 3 3 2 5 4 0 0 2 5 5 1-056 320 5 5 4 4 4 1 5 4 3 2 5 3 0 0 1 5 5 1-058 320 3 4 3 1 4 4 4 1 2 0 5 4 0 0 0 5 5 1-059 320 0 2 3 2 3 2 4 2 3 3 5 2 0 0 1 5 5 1-060 320 3 3 3 3 3 3 5 3 3 5 5 5 5 0 0 1 5 5 1-061 320 5 5 5 5 5 4 5 5 5 4 5 5 5 1 0 1 5 5 1-062 320 5 5 4 3 5 3 5 5 5 3 5 5 5 0 0 1 5 5 1-063 320 0 0 0 2 3 1 0 0 3 5 2 4 0 0 0 5 5 1-064 320 0 0 0 0 0 0 0 0 0 0 4 0 0 0 0 5 5 1-065 320 3 3 3 0 0 2 0 5 3 3 5 3 5 0 0 0 5 5 1-066 320 2 3 2 1 0 0 0 4 4 0 5 2 5 0 0 0 5 5 1-067 99 0 0 0 0 0 0 2 1 0 2 0 0 0 0 2 4 1-068 320 3 3 3 1 0 3 0 3 0 3 5 0 5 0 0 1 5 5 1-069 320 0 0 0 1 0 3 0 5 5 0 4 0 4 0 0 0 4 5 1-070 320 3 3 0 1 0 1 3 2 0 5 2 4 0 0 0 4 5 1-071 320 0 0 0 0 0 0 0 3 0 0 2 0 1 0 0 0 2 5 1-072 320 5 5 5 4 3 5 1 5 5 5 5 5 1 4 2 5 5 1-073 320 5 5 5 2 4 5 0 5 5 5 5 5 0 2 0 5 5 1-074 320 0 0 0 0 0 4 0 0 0 0 5 0 5 0 0 1 5 5 1-075 320 0 0 0 0 0 3 0 0 3 0 0 0 5 0 0 0 4 5 1-076 320 0 0 0 0 0 1 0 3 2 1 5 5 0 0 0 4 5 1-077 320 0 1 2 1 1 1 0 4 0 0 3 5 0 0 0 3 5 1-078 144 0 0 0 0 0 0 0 5 0 2 5 1 5 0 0 0 5 5 1-079 320 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 4 4 1-081 320 0 0 0 0 0 3 0 3 2 0 3 2 4 0 0 0 4 5 1-083 320 2 0 0 3 1 4 3 5 3 0 5 4 3 0 0 0 5 5 1-084 320 0 0 0 0 0 1 0 0 0 0 5 0 0 0 0 0 3 3 1-085 320 5 5 5 4 4 5 5 5 5 5 5 5 5 0 4 1 5 5 1-087 320 5 5 4 1 3 3 0 4 5 3 5 5 0 1 0 5 5 1-088 320 3 4 3 0 0 3 0 5 3 3 5 0 5 0 0 0 5 5 1-089 320 4 5 5 0 0 5 4 5 1 3 5 5 0 0 0 5 5 1-090 320 3 5 4 0 2 3 0 4 0 2 4 5 0 0 0 5 5 1-091 320 5 5 5 2 3 4 1 5 5 4 5 4 5 0 0 0 5 5 1-092 320 3 3 3 0 0 0 0 5 0 3 5 0 5 0 0 0 4 4 1-093 320 0 0 0 0 0 0 0 5 3 2 1 0 4 0 0 0 3 4 1-094 320 0 0 0 0 0 0 0 3 1 1 0 0 4 0 0 0 3 3 1-095 197 0 0 0 0 0 0 0 0 0 0 3 3 4 0 0 0 2 4 1-096 485 2 2 3 0 0 0 0 1 4 4 3 1 5 0 0 0 2 3 1-097 320 0 0 0 0 0 2 0 5 3 0 5 0 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2 0 1 5 5-044 320 0 0 0 0 0 0 0 1 0 3 5 4 0 0 0 3 5 5-045 320 2 3 3 0 0 0 0 4 3 1 5 5 0 3 0 5 5 5-046 320 3 3 4 0 0 0 0 5 5 3 5 4 0 3 0 5 5 5-047 320 0 0 0 0 0 0 2 0 3 1 0 0 0 2 0 1 4 5-049 320 0 2 0 0 0 0 3 1 5 4 0 0 0 2 0 0 4 5-050 320 0 0 0 0 0 0 0 0 0 0 3 3 0 0 0 1 1 5-051 320 2 4 3 0 5 0 4 5 3 3 5 3 0 3 0 5 5 5-052 320 0 3 4 0 4 0 4 4 3 5 5 4 0 1 0 5 5 5-053 320 3 4 1 0 0 0 3 5 3 3 5 5 0 1 0 5 5 5-054 320 2 2 4 0 0 0 1 4 2 3 5 4 0 3 0 5 5 5-055 320 0 0 0 0 0 4 0 2 0 4 0 4 0 1 0 4 4 5-057 320 0 0 0 0 0 0 0 0 0 0 3 0 4 0 0 0 3 4 5-058 320 0 0 0 0 0 1 0 0 0 2 0 0 0 0 0 1 5-059 320 4 4 3 4 5 4 4 3 0 4 5 0 4 0 3 3 5 5 5-060 320 3 4 4 4 4 3 3 0 3 3 5 0 4 0 1 1 5 5 5-061 320 4 4 4 4 4 4 2 0 3 3 5 0 2 2 5 5 5-063 320 0 0 0 0 0 1 0 0 0 0 3 0 0 0 0 0 1 5-064 320 4 5 4 4 4 3 5 4 4 3 5 5 0 4 0 5 5 5-065 320 4 5 5 4 4 4 5 5 5 5 5 5 5 0 4 2 5 5 5-067 320 0 0 0 0 1 0 1 0 3 3 5 4 0 0 0 3 5 5-068 320 1 3 3 0 0 0 0 1 3 3 5 2 0 3 0 5 5 5-069 320 4 3 3 0 0 0 2 3 4 3 5 0 0 1 0 3 5 5-070 320 0 0 0 0 0 0 0 0 0 0 4 4 0 0 0 2 4 5-072 320 5 5 5 2 3 0 5 5 4 4 5 5 0 4 0 5 5 5-073 320 5 5 5 0 0 0 3 4 4 4 5 0 0 1 0 4 5 5-075 320 3 5 4 0 3 0 3 0 4 4 5 4 0 3 0 5 5 5-076 344 1 4 3 0 1 0 3 3 3 4 4 0 0 1 0 5 5 5-077 320 5 5 5 3 3 0 3 5 5 5 4 0 3 0 5 5 5-078 270 4 5 4 0 0 0 0 3 3 1 0 0 0 0 0 0 1 5-079 320 0 0 0 0 0 0 0 0 3 0 2 5 0 0 0 0 0 4 5-082 320 3 3 4 3 3 5 5 5 5 5 5 5 3 3 3 5 5 5-084 320 4 4 2 3 4 5 5 5 5 5 5 5 0 3 1 5 5 5-086 320 0 0 0 0 5 0 5 3 5 5 5 5 0 4 0 5 5 5-088 320 0 0 0 0 0 1 0 2 4 0 3 4 0 1 0 4 5 5-089 320 0 0 0 0 0 0 0 0 0 0 4 1 0 0 0 4 4 5-090 320 1 5 4 0 4 5 4 5 5 4 5 4 0 3 1 4 5 5-091 320 2 3 3 0 4 4 4 4 3 3 5 3 0 3 1 3 5 5-092 320 0 0 0 0 0 0 0 0 0 0 4 4 0 0 0 3 5 5-093 320 0 0 0 0 0 0 0 1 5 3 0 0 0 0 0 3 4 5-094 320 5 5 5 1 4 5 4 4 5 4 5 5 0 4 1 5 5 5-095 320 5 5 4 3 4 4 4 4 4 3 5 5 0 4 1 5 5 5-097 320 0 0 0 0 0 0 0 0 3 0 0 0 0 0 0 3 4 5-098 320 0 0 0 0 0 0 0 0 2 0 4 5 0 1 0 2 5 5-100 320 0 0 0 0 0 0 0 0 0 0 3 2 0 0 0 1 4 5-101 320 4 4 3 0 4 4 3 4 5 4 5 4 0 3 0 4 5 5-102 320 1 0 1 0 3 3 2 3 3 3 5 3 0 2 0 4 5 5-103 320 5 5 5 4 4 4 5 5 5 4 5 5 0 4 1 5 5 5-104 320 5 4 4 4 4 4 4 4 3 4 5 5 0 3 1 5 5 5-105 320 4 5 5 4 4 5 0 3 5-107 320 2 2 3 3 4 4 1 3 6-001 320 0 2 3 0 0 0 0 4 5 3 5 0 0 3 0 5 5 6-002 320 0 3 0 0 4 4 1 1 5 2 5 4 1 0 0 3 5 7-001 320 0 4 5 0 4 5 5 5 5 4 5 5 0 4 0 5 5 7-002 320 0 5 5 0 0 5 5 4 5 4 5 5 0 3 1 5 5 7-003 320 1 4 2 0 4 4 3 5 5 5 5 5 5 0 4 0 5 5 7-004 320 5 5 5 0 5 4 0 4 3 4 5 5 0 4 0 5 5 8-001 320 0 3 3 3 0 3 5 3 5 3 3 4 4 0 0 1 5 5 8-002 320 1 3 4 2 0 4 1 5 4 0 5 0 5 0 0 0 5 5 8-003 320 2 5 5 1 4 4 0 5 3 3 5 5 0 3 0 5 5 8-004 320 4 3 3 3 3 4 4 2 4 3 5 5 0 3 0 5 5 8-005 320 5 5 5 0 4 5 3 5 5 5 5 5 0 3 1 5 5 8-007 320 5 5 5 1 5 5 0 5 5 4 5 5 3 4 1 5 5 8-008 320 5 5 5 5 5 5 4 5 5 3 5 5 0 5 4 5 5 9-001 320 0 0 0 0 0 0 0 2 2 3 5 0 0 1 0 4 5 9-002 320 0 0 0 0 0 3 1 5 5 4 5 5 0 0 1 5 5 9-003 320 0 0 0 0 0 0 0 3 3 0 5 3 0 0 0 4 5 9-004 194 2 3 3 0 3 5 0 3 5 3 5 4 5 0 0 0 5 5 9-005 390 0 0 0 0 0 4 0 5 2 3 5 4 5 0 0 0 5 5 9-006 147 0 0 0 0 0 0 0 2 3 0 4 3 0 0 0 0 5 5 9-007 320 5 4 4 4 4 5 4 5 5 5 5 1 5 0 1 1 5 5 9-008 320 3 3 3 3 1 5 0 5 3 4 5 0 5 0 1 0 5 5 9-009 320 2 2 3 2 0 1 0 2 3 3 5 4 3 0 0 0 5 5 9-010 246 3 2 3 1 0 0 0 4 2 3 5 3 3 0 0 0 5 4 9-011 320 2 2 4 3 4 0 1 3 3 4 5 4 4 0 0 0 5 5 9-012 320 3 2 3 0 0 5 2 5 5 3 5 3 5 0 2 0 5 5 9-013 320 0 0 0 0 0 2 0 5 3 3 4 0 5 0 0 0 5 5 9-014 320 2 4 4 3 4 5 4 3 3 4 5 5 0 1 0 2 5 9-016 320 4 5 5 4 4 5 4 5 5 5 5 5 0 3 0 5 5 9-019 320 0 0 0 0 0 0 0 0 3 0 5 4 0 0 0 4 5 9-020 320 4 5 5 3 4 4 5 5 5 5 5 5 0 3 3 5 5 9-021 320 4 4 3 4 1 5 0 5 5 3 5 5 0 2 0 5 5 9-023 320 4 5 5 3 4 5 4 5 5 5 5 5 0 3 1 5 5 9-025 320 5 0 4 3 4 5 0 5 5 4 5 5 0 3 0 5 5 9-027 320 5 5 5 4 5 5 5 5 5 5 5 5 4 3 2 5 5 9-031 320 4 5 4 4 4 5 4 5 5 5 5 5 1 4 1 5 5 9-035 320 5 5 5 5 5 5 5 5 5 4 5 5 3 1 2 5 5 9-037 320 4 5 4 5 2 5 5 5 5 5 5 5 0 3 1 5 5 9-039 320 5 5 3 4 4 5 5 5 5 5 5 5 0 1 1 5 5 9-041 320 0 4 3 3 3 5 4 3 5 4 5 5 0 3 1 5 5 9-043 320 3 4 3 0 4 5 0 4 5 4 5 5 2 3 0 5 5 9-045 320 5 5 5 2 5 5 3 5 5 5 5 5 1 4 0 5 5 9-047 320 3 2 3 1 0 4 0 2 3 1 5 4 0 2 0 3 4 9-049 320 5 5 5 0 4 5 0 5 5 5 5 5 3 3 0 5 5 9-051 320 5 5 4 1 5 5 2 5 5 5 5 5 5 3 2 5 5 9-053 320 3 4 3 0 4 5 3 5 5 5 5 5 1 4 0 5 5 9-055 320 4 3 4 0 5 5 4 5 5 5 5 5 1 4 2 5 5 9-057 320 5 5 3 3 5 5 3 5 5 5 5 5 1 4 3 5 5 9-058 320 4 5 4 2 3 5 0 5 5 5 5 5 0 3 2 5 5 9-059 320 2 5 3 3 1 5 1 5 5 5 5 5 0 3 2 5 5 9-060 402 0 5 3 3 1 5 0 5 5 5 5 5 1 4 1 4 5 9-061 320 5 5 5 3 5 5 4 5 5 5 5 5 4 4 0 5 5 9-062 320 5 5 4 0 4 5 0 5 5 5 5 5 2 3 0 5 5 9-063 320 5 5 5 1 5 5 4 5 5 5 5 5 4 5 1 5 5 10-001  320 2 3 3 0 0 0 3 3 3 4 5 4 5 0 3 1 1 4 11-001  320 0 0 0 0 0 3 0 5 5 5 5 5 0 4 0 5 5

INDUSTRIAL APPLICABILITY

The pyridazinone compound of the present invention is a novel compound and is very useful as a selective herbicide for rice, corn, soybean, wheat, beet, and rapeseed. 

1. A pyridazinone compound of the following Formula (1) or a salt thereof:

[wherein W¹ is an oxygen atom or a sulfur atom; X is an oxygen atom or a sulfur atom; Z¹ is a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R²², (C₂₋₆) alkynyl substituted with R¹⁹, (C₃₋₆) cycloalkyl substituted with R⁴⁴, phenyl, phenyl substituted with (Z⁴)_(p5c), Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-10, Q-11, Q-12, Q-13, —NR¹⁵R¹⁶, —OR³⁵, —S(O)_(r1)R³⁶, —CN, —NO₂, —C(O)OH, —C(═W³)R²⁰, or —N═C(C₆H₅)₂, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other; G is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R⁴, —C(═W⁴)R⁵, or —S(O)₂R⁶; R¹ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, or C₁₋₆ alkyl substituted with R³⁴; R² is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₁₋₆ alkoxy, C₃₋₆ cycloalkyl, or —NR³⁰R³¹; R³ is D-1, D-2, D-3, D-4, D-5, D-6, D-7, D-8, D-9, D-10, D-11, D-12, D-13, D-14, D-15, D-16, D-17, D-18, D-19, D-20, D-21, D-22, D-23, D-24, D-25, D-26, D-27, D-28, D-29, D-30, D-31, D-32, D-33, D-34, D-35, D-36, D-37, D-38, D-39, D-40, D-41, D-42, D-43, D-44, D-45, D-46, D-47, D-48, D-49, D-50, D-51, D-52, D-53, D-54, D-55, or D-56; D-1, D-2, D-3, D-4, D-5, D-6, D-7, D-8, D-9, D-10, D-11, D-12, D-13, D-14, D-15, D-16, D-17, D-18, D-19, D-20, D-21, D-22, D-23, D-24, D-25, D-26, D-27, D-28, D-29, D-30, D-31, D-32, D-33, D-34, D-35, D-36, D-37, D-38, D-39, D-40, D-41, D-42, D-43, D-44, D-45, D-46, D-47, D-48, D-49, D-50, D-51, D-52, D-53, D-54, D-55, and D-56 are respectively the following structures:

Y¹ is substituted on the aromatic ring of each of D-1 to D-56, and Y³ is substituted on the aliphatic ring of D-19, D-20, D-21, D-22, D-24, D-29, D-30, D-31, or D-32; Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, (C₁₋₆) alkyl substituted with R¹⁰, C₃₋₆ cycloalkyl substituted with R⁴⁴, —OR¹¹, —S(O)_(r2)R³⁸, —NR⁸R⁹, —CN, —NO₂, —C(O)OH, —C(═W²)R¹³, phenyl, phenyl substituted with (Z⁴)_(p5c), tri(C₁₋₆ alkyl)silyl, Q-6, Q-7, Q-10, Q-11, Q-12, or Q-13, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other; R⁴ is a halogen atom, —CN, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, —OR²⁴, —S(O)_(r4)R⁵⁴, —C(O)R²³, phenyl, phenyl substituted with (Z⁴)_(p5c), U-1, U-2, U-3, U-4, U-5, U-9, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, U-35, Q-1, Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, or Q-36; R⁵ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R²⁶, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₁₋₆ alkoxy, —OR⁵⁸, —SR⁵⁹, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, —NR⁵⁶R⁵⁷, U-1, U-2, U-3, U-4, U-5, U-6, U-7, U-8, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, U-35, Q-1, Q-2, Q-3, Q-4, Q-5, Q-7, Q-8, Q-9, Q-10, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, Q-36, Q-37, Q-38, Q-39, Q-40, phenyl, phenyl substituted with (Z²)_(p5a), or —C(O)R⁵³; R⁶ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, phenyl, phenyl substituted with (Z²)_(p5a), U-6, U-7, U-8, Q-10, or —NR²⁸R²⁹; R⁷ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy (C₁₋₂) alkyl, C₁₋₆ alkylthio (C₁₋₂) alkyl, C₃₋₆ cycloalkyl (C₁₋₂) alkyl, benzyl, or benzyl substituted with (Z⁴)_(p5c); R⁸ and R⁹ are each independently a hydrogen atom, or C₁₋₆ alkyl; R¹⁰ is a halogen atom, —OR⁴⁰, —S(O)_(r3)R⁴¹, —CN, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R44, Q-6, Q-7, Q-10, Q-11, Q-12, or Q-13; R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, phenyl, phenyl substituted with (Z⁴)_(p5c), tri(C₁₋₄ alkyl)silyl, C₁₋₆ alkylcarbonyl, C₁₋₆ alkoxycarbonyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, —C(═W²)R¹³, —S(O)_(r5)R⁴⁹, U-1, U-2, U-3, U-4, U-5, U-12, U-14, U-15, U-16, Q-17, Q-18, Q-19, or Q-20; R¹² is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, —OR⁴⁸, —S(O)_(r5)R⁴⁹, —CN, phenyl, phenyl substituted with (Z³)_(p5b), —C(═W²)R¹³, U-1, U-2, U-3, U-4, U-5, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, U-35, Q-1, Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, Q-36, or —ON═CR⁴²R⁴³; Q-1, Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, Q-36, Q-37, Q-38, Q-39, and Q-40 are respectively the following structures:

Y² is substituted on the aromatic ring of each of Q-1 to Q-40; U-1, U-2, U-3, U-4, U-5, U-6, U-7, U-8, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, and U-35 are respectively the following structures:

R¹³ is a hydrogen atom, C₁₋₆ alkyl, C₁₋₆ alkoxy, C₁₋₆ alkylamino, di(C₁₋₆) alkylamino, C₁₋₆ haloalkylamino, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, or —NH₂; R¹⁴ is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, C₁₋₆ alkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkoxy, C₁₋₆ haloalkylthio, C₁₋₆ haloalkylsulfinyl, C₁₋₆ haloalkylsulfonyl, phenyl, phenyl substituted with (Z⁴)_(p5c), —CN, U-1, U-2, U-3, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, U-35, Q-1, Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, or Q-36; R¹⁵ and R¹⁶ are each independently a hydrogen atom, C₁₋₆ alkyl, —C(O)R¹⁷, or —S(O)₂R¹⁸; R¹⁷ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or C₁₋₆ alkoxy (C₁₋₂) alkyl; R¹⁸ is C₁₋₆ alkyl or C₁₋₆ haloalkyl; R¹⁹ is C₃₋₆ cycloalkyl or tri(C₁₋₆ alkyl)silyl; R²⁰ is a hydrogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy; R²¹ is a hydrogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy (C₁₋₂) alkyl, or C₁-6 alkylthio (C₁₋₂) alkyl; R²² is a halogen atom, —OH, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆haloalkylthio, —CN, or Q-7; R²³ is C₁₋₆ alkyl, C₁₋₆ alkoxy, di(C₁₋₆) alkylamino, phenyl, phenyl substituted with (Z⁴)_(p5c), U-6, U-7, or U-8; R²⁴ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, C₃₋₆ haloalkenyl, C₃₋₆ alkynyl, C₃₋₆ haloalkynyl, (C₁₋₆) alkoxy (C₁₋₂) alkyl, —C(O)R²⁵, —S(O)₂R³³, phenyl, or phenyl substituted with (Z⁴)_(p5c); R²⁵ is C₁₋₆ alkyl, C₁₋₆ alkoxy, phenyl, phenyl substituted with (Z⁴)_(p5c), di(C₁₋₆) alkylamino, U-6, U-7, or U-8; R²⁶ is a halogen atom, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, —CN, —OR³², phenyl, phenyl substituted with (Z⁴)_(p5c), Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, Q-36, U-1, U-2, U-3, U-4, U-5, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, or U-35; R²⁷ is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₃₋₆ cycloalkyl, C₃₋₆ halocycloalkyl, C₁₋₆ alkylthio, C₁₋₆haloalkylthio, —CN, phenyl, phenyl substituted with (Z³)_(p5b), 9-fluorenyl, Q-2, Q-3, Q-4, Q-5, Q-17, U-1, U-2, U-3, U-4, U-5, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, or U-35; R²⁸ and R²⁹ are each independently a hydrogen atom or C₁₋₆ alkyl; R³⁰ and R³¹ are each independently a hydrogen atom, C₁₋₆ alkyl, or benzyl; R³² is phenyl, phenyl substituted with (Z⁴)_(p5c), or Q-17; R³³ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, or di(C₁₋₆ alkyl)amino; R³⁴ is a halogen atom, C₁₋₆ alkoxy, phenyl, or —CN; R³⁵ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R¹⁴, (C₁₋₆) cycloalkyl substituted with R⁴⁴, or —S(O)₂R³³; R³⁶ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R³⁷, C₃₋₆ cycloalkyl, or (C₁₋₆) cycloalkyl substituted with R⁴⁴; R³⁷ is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₃₋₆ cycloalkyl, C₃₋₆ halocycloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, phenyl, phenyl substituted with (Z⁴)_(p5c), —CN, U-1, U-2, U-3, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, U-35, Q-1, Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, or C₁₋₁₀ alkoxycarbonyl; R³⁸ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₃₋₆ cycloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, (C₁₋₆) alkyl substituted with R³⁹, (C₃₋₆) cycloalkyl substituted with R⁴⁴, U-1, U-2, U-4, U-5, U-6, U-7, U-8, U-12, U-14, U-15, U-16, or —NR⁶⁰R⁶¹; R³⁹ is a halogen atom, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, —OR⁵¹, —S(O)_(r6)R⁵², —C(═W²)R¹³, —CN, phenyl, phenyl substituted with (Z³)_(p5b), U-1, U-2, U-3, U-4, U-5, U-9, U-10, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, U-34, U-35, Q-1, Q-2, Q-3, Q-4, Q-5, Q-8, Q-9, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, Q-36, or —ON═CR⁴²R⁴³; R⁴⁰ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R⁴⁶, (C₃₋₆) cycloalkyl substituted with R⁴⁴, or U-4; R⁴¹ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, or (C₁₋₆) alkyl substituted with R⁴⁷; R⁴² and R⁴³ are each independently a hydrogen atom, C₁₋₆ alkyl, phenyl, or phenyl substituted with (Z⁴)_(p5c), or R⁴² and R⁴³ form C₃₋₆ cycloalkyl together with the carbon atom to which R⁴² and R⁴³ are bonded; R⁴⁴ is a halogen atom, C₁₋₆ alkyl, or —CN; R⁴⁵ is a halogen atom, C₁₋₆ alkyl, or —CN; R⁴⁶ is C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆haloalkylsulfonyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, —CN, U-1, U-2, U-3, U-4, U-5, U-9, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, Q-1, Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, or Q-36; R⁴⁷ is C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆haloalkylsulfonyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, U-1, U-2, U-3, U-4, U-5, U-9, U-11, U-12, U-13, U-14, U-15, U-16, U-17, U-18, U-19, U-20, U-21, U-22, U-23, U-24, U-25, U-26, U-27, U-28, U-29, U-30, U-31, U-32, U-33, Q-1, Q-2, Q-3, Q-4, Q-5, Q-6, Q-7, Q-8, Q-9, Q-10, Q-11, Q-12, Q-13, Q-14, Q-15, Q-16, Q-17, Q-18, Q-19, Q-20, Q-21, Q-22, Q-23, Q-24, Q-25, Q-26, Q-27, Q-28, Q-29, Q-30, Q-31, Q-32, Q-33, Q-34, Q-35, Q-36, or —CN; R⁴⁸ is a hydrogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, C₃₋₆ haloalkenyl, C₃₋₆ alkynyl, C₃₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, —C(O)R⁵⁰, or —S(O)₂R³³; R⁴⁹ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, C₃₋₆ haloalkenyl, C₃₋₆ alkynyl, C₃₋₆ haloalkynyl, C₃₋₆ cycloalkyl, or (C₃₋₆) cycloalkyl substituted with R⁴⁴; R⁵⁰ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or di(C₁₋₆ alkyl)amino; R⁵¹ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₃₋₆ haloalkenyl, or C₃₋₆ haloalkynyl; R⁵² is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, or C₃₋₆ cycloalkyl; R⁵³ is C₁₋₆ alkyl, C₁₋₆ alkoxy, phenyl, or phenyl substituted with (Z⁴)_(p5c); R⁵⁴ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, phenyl, or phenyl substituted with (Z⁴)_(p5c); R⁵⁵ is C₁₋₆ alkyl, C₁₋₆ alkoxy, —OH, or NR⁵⁶R⁵⁷; R⁵⁶ and R⁵⁷ are each independently a hydrogen atom or C₁₋₆ alkyl; R⁵⁸ is (C₁₋₆) alkyl substituted with R²⁷, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, phenyl, or phenyl substituted with (Z³)_(p5b); R⁵⁹ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkenyl, C₁₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, phenyl, or phenyl substituted with (Z³)_(p5b); R⁶⁰ and R⁶¹ are each independently a hydrogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy (C₁₋₆) alkyl, phenyl, phenyl substituted with (Z⁴)_(p5c), benzyl, or benzyl substituted with (Z⁴)_(p5c); R^(N) is a hydrogen atom or C₁₋₆ alkyl; Y² is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁-6 alkylthio, C₁₋₆ haloalkylthio, —CN, —NH₂, or —NO₂, and when q4, q3, or q2 is an integer of 2 or more, each Y² is the same as or different from each other; Y³ is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkoxycarbonyl, —CN, —C(O)OH, —OH, or —NH₂, and when t is 2, each Y³ is the same as or different from each other; Z² is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, —S(O)₂NR⁵⁶R⁵⁷, —OH, —NH₂, —CN, —NO₂, or —C(O)R⁵⁵, and when p5a is an integer of 2 or more, each Z² is the same as or different from each other; Z³ is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁-6 alkylthio, C₁₋₆ haloalkylthio, —CN, C₁₋₆ alkoxycarbonyl, or —NO₂, and when p5b is an integer of 2 or more, each Z³ is the same as or different from each other; Z⁴ is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, —CN, —NO₂, C₁₋₆ alkoxycarbonyl, and when p5c is an integer of 2 or more, each Z⁴ is the same as or different from each other; W² is an oxygen atom or N—OR⁷; W³ is an oxygen atom or N—OR²¹; W⁴ is an oxygen atom or a sulfur atom; r1 is an integer of 0, 1, or 2; r2 is an integer of 0, 1, or 2; r3 is an integer of 0, 1, or 2; r4 is an integer of 0, 1, or 2; r5 is an integer of 0, 1, or 2; r6 is an integer of 0, 1, or 2; n is an integer of 0, 1, 2, 3, or 4; t is an integer of 0, 1, or 2; p2 is an integer of 0, 1, or 2; p3 is an integer of 0, 1, 2, or 3; p4 is an integer of 0, 1, 2, 3, or 4; p5 is an integer of 0, 1, 2, 3, 4, or 5; p6 is an integer of 0, 1, 2, 3, 4, 5, or 6; p7 is an integer of 0, 1, 2, 3, 4, 5, 6, or 7; p5a is an integer of 1, 2, 3, 4, or 5; p5b is an integer of 1, 2, 3, 4, or 5; p5c is an integer of 1, 2, 3, 4, or 5; q1 is an integer of 0 or 1; q2 is an integer of 0, 1, or 2; q3 is an integer of 0, 1, 2, or 3; and q4 is an integer of 0, 1, 2, 3, or 4].
 2. The pyridazinone compound or a salt thereof according to claim 1, wherein: W¹ is an oxygen atom; Z¹ is a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R²², (C₂₋₆) alkynyl substituted with R¹⁹, (C₃₋₆) cycloalkyl substituted with R⁴⁴, phenyl, phenyl substituted with (Z⁴)_(p5c), Q-3, —NR¹⁵R¹⁶, —OR³⁵, —S(O)_(r1)R³⁶, —CN, —NO₂, —C(O)OH, —C(═W³)R²⁰, or —N═C(C₆H₅)₂, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other; R¹ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, or C₁₋₆ alkyl substituted with R³⁴; R² is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₁₋₆ alkoxy, or —NR³⁰R³¹; R³ is D-1, D-2, D-3, D-4, D-5, D-6, D-7, D-8, D-9, D-10, D-13, D-14, D-15, D-16, D-17, D-18, D-19, D-20, D-21, D-22, D-23, D-24, D-25, D-26, D-27, or D-28; Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, (C₁₋₆) alkyl substituted with R¹⁰, C₃₋₆ cycloalkyl substituted with R⁴⁴, —OR¹¹, —S(O)_(r2)R³⁸, —NR⁸R⁹, —CN, —NO₂, —C(O)OH, —C(═W²)R¹³, phenyl, phenyl substituted with (Z⁴)_(p5c), or tri(C₁₋₆ alkyl)silyl, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other; R⁴ is a halogen atom, —CN, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, —OR²⁴, —S(O)_(r4)R⁵⁴, —C(O)R²³, phenyl, or phenyl substituted with (Z⁴)_(p5c); R⁵ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R²⁶, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ alkoxy, —OR⁵⁸, —SR⁵⁹, C₃₋₆ cycloalkyl, C₃₋₆ cycloalkyl substituted with R⁴⁴, —NR⁵⁶R⁵⁷, U-1, U-6, U-7, U-8, Q-1, Q-2, Q-3, Q-4, Q-5, Q-7, Q-8, Q-9, Q-10, Q-17, Q-18, Q-19, Q-20, phenyl, phenyl substituted with (Z²)_(p5a), or —C(O)R⁵³; R⁶ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, phenyl, phenyl substituted with (Z²)_(p5a), or —NR²⁸R²⁹; R⁷ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy (C₁₋₂) alkyl, or C₁₋₆ alkylthio (C₁₋₂) alkyl; R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁴, phenyl, phenyl substituted with (Z⁴)_(p5c), C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, U-2, U-4, Q-17, Q-18, or Q-19; R¹² is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, —OR⁴⁸, —S(O)_(r5)R⁴⁹, —CN, phenyl, phenyl substituted with (Z³)_(p5b), —C(═W²)R¹³, U-1, U-2, U-3, Q-1, Q-2, Q-3, Q-4, Q-5, Q-18, or —ON═CR⁴²R⁴³; R¹⁴ is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, C₁₋₆ alkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, phenyl, phenyl substituted with (Z⁴)_(p5c), —CN, U-1, U-2, U-3, U-9, Q-17, Q-18, Q-19, or Q-20; R¹⁹ is tri(C₁₋₆ alkyl)silyl; R²² is a halogen atom, —OH, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, or —CN; R²³ is C₁₋₆ alkyl, C₁₋₆ alkoxy, di(C₁₋₆) alkylamino, phenyl, phenyl substituted with (Z⁴)_(p5c)—U-7, or U-8; R²⁴ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, (C₁₋₆) alkoxy (C₁₋₂) alkyl, —C(O)R²⁵, or —S(O)₂R³³; R²⁵ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or di(C₁₋₆) alkylamino; R²⁶ is a halogen atom, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, —OR³², phenyl, or phenyl substituted with (Z⁴)_(p5c); R²⁷ is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ alkoxy, or C₁₋₆ alkylthio; R³⁶ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R³⁷, or C₃₋₆ cycloalkyl; R³⁷ is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₁₋₆ alkoxy, C₁₋₆ alkylthio, or C₁₋₁₀ alkoxycarbonyl; R³⁸ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₃₋₆ cycloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, (C₁₋₆) alkyl substituted with R³⁹, or (C₃₋₆) cycloalkyl substituted with R⁴⁴; R³⁹ is a halogen atom, C₃₋₆ cycloalkyl, —OR⁵¹, —S(O)_(r6)R⁵², —C(═W²)R¹³, —CN, phenyl, phenyl substituted with (Z³)_(p5b), U-1, U-3, U-9, Q-1, or Q-18; R⁴⁰ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R⁴⁶, or U-4; R⁴¹ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, C₃₋₆ cycloalkyl, or (C₁₋₆) alkyl substituted with R⁴⁷; R⁴⁶ is C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl, C₃₋₆ cycloalkyl, —CN, U-1, U-3, or U-9; R⁴⁷ is C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, or —CN; R⁴⁸ is a hydrogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, C₃₋₆ haloalkenyl, C₃₋₆ alkynyl, C₃₋₆ haloalkynyl, or C₃₋₆ cycloalkyl; R⁴⁹ is C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₃₋₆ alkenyl, or C₃₋₆ alkynyl; R⁵¹ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, or C₁₋₆ haloalkyl; R⁵² is C₁₋₆ alkyl, C₃₋₆ alkenyl, or C₃₋₆ alkynyl; R⁵⁴ is C₁₋₆ alkyl or C₃₋₆ alkenyl; R⁵⁹ is C₁₋₆ alkyl, C₁₋₆ alkenyl, or phenyl; Y² is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁-6 alkylthio, or C₁₋₆ haloalkylthio; and Z² is a halogen atom, C₁₋₆ alkyl, C₁₋₆ haloalkyl, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₂₋₆ haloalkynyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, —OH, —NH₂, —CN, —NO₂, or —C(O)R⁵⁵, and when p5a is an integer of 2 or more, each Z² is the same as or different from each other.
 3. The pyridazinone compound or a salt thereof according to claim 2, wherein: Z¹ is a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R²², (C₂₋₆) alkynyl substituted with R¹⁹, phenyl, phenyl substituted with (Z⁴)_(p5c), Q-3, —NR¹⁵R¹⁶, —OR³⁵, —S(O)_(r1)R³⁶, —CN, —C(═W³)R²⁰, or —N═C(C₆H₅)₂, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other; R¹ is a hydrogen atom, C₁₋₆ alkyl, or C₁₋₆ alkyl substituted with R³⁴; R³ is D-1, D-2, D-3, D-4, D-6, D-7, D-8, D-9, D-10, D-17, D-18, D-19, D-20, D-21, D-22, D-23, D-24, D-25, D-26, or D-28; Y¹ is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, (C₁₋₆) alkyl substituted with R¹⁰, —C(O)OH, —OR¹¹, —S(O)_(r2)R³⁸, —NR⁸R⁹, —CN, —NO₂, —C(═W²)R¹³, phenyl, or tri(C₁₋₆ alkyl)silyl, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other; R⁴ is a halogen atom, —CN, C₂₋₆ alkenyl, C₂₋₆ alkynyl, —OR²⁴, —S(O)_(r4)R⁵⁴, —C(O)R²³, or phenyl; R⁵ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R²⁶, C₂₋₆ alkenyl, C₁₋₆ alkoxy, —OR⁵⁸, —SR⁵⁹, C₃₋₆ cycloalkyl, —NR⁵⁶R⁵⁷, U-1, U-6, Q-2, Q-4, phenyl substituted with (Z²)_(p5a), or —C(O)R⁵³; R⁶ is C₁₋₆ alkyl, phenyl substituted with (Z²)_(p5a), or —NR²⁸R²⁹; R⁷ is a hydrogen atom or C₁₋₆ alkyl; R⁸ and R⁹ are each independently C₁₋₆ alkyl; R¹⁰ is a halogen atom, —OR⁴⁰, or —S(O)_(r3)R⁴¹; R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², C₃₋₆ cycloalkyl, phenyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, U-2, U-4, or Q-17; R¹² is a halogen atom, C₂₋₆ alkenyl, C₂₋₆ haloalkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, —OR⁴⁸, —S(O)_(r5)R⁴⁹, —CN, phenyl, —C(═W²)R¹³, U-3, Q-1, or —ON═CR⁴²R⁴³; R¹³ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or C₁₋₆ haloalkylamino; R¹⁴ is a halogen atom, C₂₋₆ alkenyl, C₃₋₆ cycloalkyl, (C₃₋₆) cycloalkyl substituted with R⁴⁵, C₁₋₆ alkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfonyl, phenyl, or U-1; R¹⁸ is C₁₋₆ alkyl; R²¹ is a hydrogen atom or C₁₋₆ alkyl; R²² is a halogen atom, —OH, or C₁₋₆ alkoxy; R²³ is C₁₋₆ alkyl, C₁₋₆ alkoxy, or phenyl; R²⁴ is C₁₋₆ alkyl, (C₁₋₆) alkoxy (C₁₋₂) alkyl, or —C(O)R²⁵; R²⁵ is C₁₋₆ alkoxy; R²⁶ is C₁₋₆ alkoxy, —OR³², or phenyl; R²⁷ is a halogen atom, C₂₋₆ alkenyl, or C₁₋₆ alkoxy; R²⁸ and R²⁹ are each independently C₁₋₆ alkyl; R³⁰ and R³¹ are each independently a hydrogen atom or benzyl; R³² is phenyl; R³³ is C₁₋₆ haloalkyl or di(C₁₋₆) alkylamino; R³⁴ is C₁₋₆ alkoxy, phenyl, or —CN; R³⁵ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R¹⁴, or —S(O)₂R³³; R³⁶ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R³⁷; R³⁷ is a halogen atom or (C₁₋₁₀) alkoxycarbonyl; R³⁸ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₃₋₆ cycloalkyl, C₃₋₆ haloalkenyl, C₃₋₆ haloalkynyl, or (C₁₋₆) alkyl substituted with R³⁹; R³⁹ is a halogen atom, —OR⁵¹, —S(O)_(r6)R⁵², —C(═W²)R¹³, or —CN; R⁴⁰ is a hydrogen atom, C₁₋₆ alkyl, C₃₋₆ alkenyl, C₁₋₆ haloalkyl, or (C₁₋₆) alkyl substituted with R⁴⁶; R⁴¹ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, C₁₋₆ haloalkyl, or (C₁₋₆) alkyl substituted with R⁴⁷; R⁴² and R⁴³ are each independently C₁₋₆ alkyl; R⁴⁵ is a halogen atom; R⁴⁶ is C₁₋₆ alkoxy or C₁₋₆ alkylthio; R⁴⁷ is C₁₋₆ alkoxy or C₁₋₆ alkylthio; R⁴⁸ is C₁₋₆ alkyl or C₁₋₆ haloalkyl; R⁴⁹ is C₁₋₆ alkyl; R⁵¹ is C₁₋₆ alkyl; R⁵² is C₁₋₆ alkyl; R⁵³ is phenyl; R⁵⁴ is C₁₋₆ alkyl; R⁵⁶ and R⁵⁷ are each independently C₁₋₆ alkyl; R⁵⁸ is (C₁₋₆) alkyl substituted with R²⁷ or phenyl; R⁵⁹ is C₁₋₆ alkyl or phenyl; Y² is a halogen atom or C₁₋₆ haloalkyl; Z² is a halogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy, and when p5a is an integer of 2 or more, each Z² is the same as or different from each other; Z⁴ is a halogen atom or C₁₋₆ alkoxy, and when p5c is an integer of 2 or more, each Z⁴ is the same as or different from each other; and t is
 0. 4. The pyridazinone compound or a salt thereof according to claim 3, wherein: Z¹ is a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, (C₁₋₆) alkyl substituted with R²², (C₂₋₆) alkynyl substituted with R¹⁹, —NR¹⁵R¹⁶, —OR³⁵, —S(O)_(r1)R³⁶, or —CN, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other; R² is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy; R³ is D-1, D-2, D-3, D-4, D-6, D-7, D-8, D-9, D-10, D-17, D-18, D-20, D-21, D-22, D-23, D-24, or D-28; Y¹ is a halogen atom, C₁₋₆ alkyl, C₂₋₆ alkenyl, (C₁₋₆) alkyl substituted with R¹⁰, —OR¹¹, —S(O)_(r2)R³⁸, —NR⁸R⁹, —CN, —NO₂, or —C(═W²)R¹³, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other; R¹¹ is a hydrogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹², C₃₋₆ cycloalkyl, phenyl, C₁₋₆ alkylsulfonyl, haloalkylsulfonyl, U-2, or U-4; and R³⁷ is a halogen atom.
 5. The pyridazinone compound or a salt thereof according to claim 3, wherein X is a sulfur atom.
 6. The pyridazinone compound or a salt thereof according to claim 2, wherein: X is an oxygen atom; Z¹ is a halogen atom, C₁₋₆ alkyl, —OR³⁵, or —S(O)_(r1)R³⁶, and when n is an integer of 2 or more, each Z¹ is the same as or different from each other; R¹ is C₁₋₆ alkyl; R² is a hydrogen atom, a halogen atom, C₁₋₆ alkyl, or C₁₋₆ alkoxy; R³ is D-1, D-3, D-7, D-20, D-21, D-22, or D-24; Y¹ is a halogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹⁰, —OR¹¹, or —S(O)_(r2)R³⁸, and when p7, p6, p5, p4, p3, or p2 is an integer of 2 or more, each Y¹ is the same as or different from each other; R⁴ is —OR²⁴ or —S(O)_(r4)R⁵⁴; R⁵ is C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R²⁶, or C₁₋₆ alkoxy; R⁶ is C₁₋₆ alkyl or —NR²⁸R²⁹; R¹⁰ is a halogen atom, —OR⁴⁰, or —S(O)_(r3)R⁴¹; R¹¹ is a hydrogen atom, C₁₋₆ alkyl, or (C₁₋₆) alkyl substituted with R¹²; R¹² is a halogen atom, C₂₋₆ alkenyl, —OR⁴⁸, —S(O)_(r5)R⁴⁹, phenyl, or —C(═W²)R¹³; R¹³ is a hydrogen atom or C₁₋₆ alkyl; R¹⁴ is a halogen atom, C₂₋₆ alkenyl, C₁₋₆ alkoxy, or C₁₋₆ alkylthio; R²⁴ is C₁₋₆ alkyl; R²⁶ is C₁₋₆ alkoxy; R²⁸ and R²⁹ are each independently C₁₋₆ alkyl; R³⁴ is C₁₋₆ alkoxy or —CN; R³⁵ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R¹⁴; R³⁶ is C₁₋₆ alkyl or (C₁₋₆) alkyl substituted with R³⁷; R³⁷ is a halogen atom, C₁₋₆ alkoxy, or C₁₋₆ alkylthio; R³⁸ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, or (C₁₋₆) alkyl substituted with R³⁹; R³⁹ is —OR⁵¹ or —S(O)_(r6)R⁵²; R⁴⁰ is C₁₋₆ alkyl, C₃₋₆ alkenyl, or C₃₋₆ alkynyl; R⁴¹ is C₁₋₆ alkyl, C₃₋₆ alkenyl, C₃₋₆ alkynyl, or (C₁₋₆) alkyl substituted with R⁴⁷; R⁴⁸ is C₁₋₆ alkyl; r1 is an integer of 0, 1, or 2; r4 is an integer of 0, 1, or 2; r5 is an integer of 0, 1, or 2; r6 is an integer of 0, 1, or 2; n is an integer of 0, 1, 2, 3, or 4; p3 is an integer of 0, 1, 2, or 3; p4 is an integer of 0, 1, 2, 3, or 4; and p5 is an integer of 0, 1, 2, 3, 4, or
 5. 7. The pyridazinone compound or a salt thereof according to claim 6, wherein: Z¹ is a halogen atom, C₁₋₆ alkyl, or —OR³⁵; R¹ is C₁₋₆ alkyl; R² is C₁₋₆ alkyl or C₁₋₆ alkoxy; R³ is D-1, D-7, or D-24; Y¹ is a halogen atom, C₁₋₆ alkyl, (C₁₋₆) alkyl substituted with R¹⁰, —OR¹¹, or —S(O)_(r2)R³⁸; G is a hydrogen atom, C₁₋₆ alkyl, or —C(═W⁴)R⁵; R⁵ is C₁₋₆ alkyl; R¹⁰ is a halogen atom or —OR⁴⁰; R¹² is a halogen atom, C₂₋₆ alkenyl, —OR⁴⁸, —S(O)_(r5)R⁴⁹, or phenyl; R³⁵ is C₁₋₆ alkyl; R³⁸ is C₁₋₆ alkyl; R⁴⁰ is C₁₋₆ alkyl; R⁴⁸ s C₁₋₆ alkyl; and R⁴⁹ is C₁₋₆ alkyl.
 8. An agricultural chemical comprising, as an active ingredient, one or more selected from the pyridazinone compound or a salt thereof according to claim
 1. 9. A herbicide comprising, as an active ingredient, one or more selected from the pyridazinone compound or a salt thereof according to claim
 1. 